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7EM3

Crystal structure of the PI5P4Kbeta-2a-ATP complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005776cellular_componentautophagosome
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006629biological_processlipid metabolic process
A0007166biological_processcell surface receptor signaling pathway
A0010506biological_processregulation of autophagy
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0016308molecular_function1-phosphatidylinositol-4-phosphate 5-kinase activity
A0016309molecular_function1-phosphatidylinositol-5-phosphate 4-kinase activity
A0016740molecular_functiontransferase activity
A0042803molecular_functionprotein homodimerization activity
A0046488biological_processphosphatidylinositol metabolic process
A0046627biological_processnegative regulation of insulin receptor signaling pathway
A0046854biological_processphosphatidylinositol phosphate biosynthetic process
A0052742molecular_functionphosphatidylinositol kinase activity
A0061909biological_processautophagosome-lysosome fusion
A1902635biological_process1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
A2000786biological_processpositive regulation of autophagosome assembly
B0000166molecular_functionnucleotide binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005776cellular_componentautophagosome
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006629biological_processlipid metabolic process
B0007166biological_processcell surface receptor signaling pathway
B0010506biological_processregulation of autophagy
B0016020cellular_componentmembrane
B0016301molecular_functionkinase activity
B0016308molecular_function1-phosphatidylinositol-4-phosphate 5-kinase activity
B0016309molecular_function1-phosphatidylinositol-5-phosphate 4-kinase activity
B0016740molecular_functiontransferase activity
B0042803molecular_functionprotein homodimerization activity
B0046488biological_processphosphatidylinositol metabolic process
B0046627biological_processnegative regulation of insulin receptor signaling pathway
B0046854biological_processphosphatidylinositol phosphate biosynthetic process
B0052742molecular_functionphosphatidylinositol kinase activity
B0061909biological_processautophagosome-lysosome fusion
B1902635biological_process1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
B2000786biological_processpositive regulation of autophagosome assembly
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue CX0 A 501
ChainResidue
AARG202
AASN203
AVAL204
APHE205
ATHR237
AASP369

site_idAC2
Number of Residues8
Detailsbinding site for residue CXC A 502
ChainResidue
AALA158
AHIS161
AARG188
AGLU195
ATYR197
ALYS96
ATYR98
ASER154

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsRegion: {"description":"Required for interaction with PIP5K1A","evidences":[{"source":"UniProtKB","id":"Q8TBX8","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"26774281","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3X03","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"26774281","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3X04","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P48426","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idMCSA1
Number of Residues2
DetailsM-CSA 662
ChainResidueDetails
ALYS150electrostatic stabiliser
AASP278proton shuttle (general acid/base)

site_idMCSA2
Number of Residues2
DetailsM-CSA 662
ChainResidueDetails
BLYS150electrostatic stabiliser
BASP278proton shuttle (general acid/base)

239492

PDB entries from 2025-07-30

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