7EKI

human alpha 7 nicotinic acetylcholine receptor in apo-form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0045211	cellular_component	postsynaptic membrane
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0045211	cellular_component	postsynaptic membrane
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0045211	cellular_component	postsynaptic membrane
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0045211	cellular_component	postsynaptic membrane
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0045211	cellular_component	postsynaptic membrane

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CyIdVrwFPfDvqhC

Chain	Residue	Details
A	CYS150-CYS164

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1050
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"33735609","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7KOO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	425
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"33735609","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7KOO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	35
Details	Region: {"description":"Essential for TMEM35A/NACHO-mediated proper subunit assembly and trafficking to cell membrane","evidences":[{"source":"UniProtKB","id":"P49582","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33735609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38382524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7KOX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UT1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UZJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33735609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38382524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7KOX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UT1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UZJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38382524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UT1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UZJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38382524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8V8D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	15
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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