Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7EJ2

human voltage-gated potassium channel KV1.3 H451N mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004033	molecular_function	aldo-keto reductase (NADPH) activity
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005886	cellular_component	plasma membrane
A	0006813	biological_process	potassium ion transport
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0015459	molecular_function	potassium channel regulator activity
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0030424	cellular_component	axon
A	0035579	cellular_component	specific granule membrane
A	0043005	cellular_component	neuron projection
A	0044224	cellular_component	juxtaparanode region of axon
A	0044325	molecular_function	transmembrane transporter binding
A	0045202	cellular_component	synapse
A	0055114	biological_process	obsolete oxidation-reduction process
A	0070821	cellular_component	tertiary granule membrane
A	0070995	biological_process	NADPH oxidation
A	0071805	biological_process	potassium ion transmembrane transport
A	0098900	biological_process	regulation of action potential
A	1901379	biological_process	regulation of potassium ion transmembrane transport
A	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
A	1990031	cellular_component	pinceau fiber
A	2000008	biological_process	regulation of protein localization to cell surface
B	0001508	biological_process	action potential
B	0005216	molecular_function	monoatomic ion channel activity
B	0005244	molecular_function	voltage-gated monoatomic ion channel activity
B	0005249	molecular_function	voltage-gated potassium channel activity
B	0005251	molecular_function	delayed rectifier potassium channel activity
B	0005267	molecular_function	potassium channel activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0015271	molecular_function	outward rectifier potassium channel activity
B	0016020	cellular_component	membrane
B	0021554	biological_process	optic nerve development
B	0022038	biological_process	corpus callosum development
B	0030424	cellular_component	axon
B	0034702	cellular_component	monoatomic ion channel complex
B	0042734	cellular_component	presynaptic membrane
B	0044305	cellular_component	calyx of Held
B	0045121	cellular_component	membrane raft
B	0045211	cellular_component	postsynaptic membrane
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0051260	biological_process	protein homooligomerization
B	0055085	biological_process	transmembrane transport
B	0071805	biological_process	potassium ion transmembrane transport
B	0098978	cellular_component	glutamatergic synapse
C	0004033	molecular_function	aldo-keto reductase (NADPH) activity
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0005886	cellular_component	plasma membrane
C	0006813	biological_process	potassium ion transport
C	0008076	cellular_component	voltage-gated potassium channel complex
C	0009898	cellular_component	cytoplasmic side of plasma membrane
C	0015459	molecular_function	potassium channel regulator activity
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0030424	cellular_component	axon
C	0035579	cellular_component	specific granule membrane
C	0043005	cellular_component	neuron projection
C	0044224	cellular_component	juxtaparanode region of axon
C	0044325	molecular_function	transmembrane transporter binding
C	0045202	cellular_component	synapse
C	0055114	biological_process	obsolete oxidation-reduction process
C	0070821	cellular_component	tertiary granule membrane
C	0070995	biological_process	NADPH oxidation
C	0071805	biological_process	potassium ion transmembrane transport
C	0098900	biological_process	regulation of action potential
C	1901379	biological_process	regulation of potassium ion transmembrane transport
C	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
C	1990031	cellular_component	pinceau fiber
C	2000008	biological_process	regulation of protein localization to cell surface
D	0001508	biological_process	action potential
D	0005216	molecular_function	monoatomic ion channel activity
D	0005244	molecular_function	voltage-gated monoatomic ion channel activity
D	0005249	molecular_function	voltage-gated potassium channel activity
D	0005251	molecular_function	delayed rectifier potassium channel activity
D	0005267	molecular_function	potassium channel activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0008076	cellular_component	voltage-gated potassium channel complex
D	0015271	molecular_function	outward rectifier potassium channel activity
D	0016020	cellular_component	membrane
D	0021554	biological_process	optic nerve development
D	0022038	biological_process	corpus callosum development
D	0030424	cellular_component	axon
D	0034702	cellular_component	monoatomic ion channel complex
D	0042734	cellular_component	presynaptic membrane
D	0044305	cellular_component	calyx of Held
D	0045121	cellular_component	membrane raft
D	0045211	cellular_component	postsynaptic membrane
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0051260	biological_process	protein homooligomerization
D	0055085	biological_process	transmembrane transport
D	0071805	biological_process	potassium ion transmembrane transport
D	0098978	cellular_component	glutamatergic synapse
E	0004033	molecular_function	aldo-keto reductase (NADPH) activity
E	0005249	molecular_function	voltage-gated potassium channel activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0005886	cellular_component	plasma membrane
E	0006813	biological_process	potassium ion transport
E	0008076	cellular_component	voltage-gated potassium channel complex
E	0009898	cellular_component	cytoplasmic side of plasma membrane
E	0015459	molecular_function	potassium channel regulator activity
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0030424	cellular_component	axon
E	0035579	cellular_component	specific granule membrane
E	0043005	cellular_component	neuron projection
E	0044224	cellular_component	juxtaparanode region of axon
E	0044325	molecular_function	transmembrane transporter binding
E	0045202	cellular_component	synapse
E	0055114	biological_process	obsolete oxidation-reduction process
E	0070821	cellular_component	tertiary granule membrane
E	0070995	biological_process	NADPH oxidation
E	0071805	biological_process	potassium ion transmembrane transport
E	0098900	biological_process	regulation of action potential
E	1901379	biological_process	regulation of potassium ion transmembrane transport
E	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
E	1990031	cellular_component	pinceau fiber
E	2000008	biological_process	regulation of protein localization to cell surface
F	0001508	biological_process	action potential
F	0005216	molecular_function	monoatomic ion channel activity
F	0005244	molecular_function	voltage-gated monoatomic ion channel activity
F	0005249	molecular_function	voltage-gated potassium channel activity
F	0005251	molecular_function	delayed rectifier potassium channel activity
F	0005267	molecular_function	potassium channel activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0006813	biological_process	potassium ion transport
F	0008076	cellular_component	voltage-gated potassium channel complex
F	0015271	molecular_function	outward rectifier potassium channel activity
F	0016020	cellular_component	membrane
F	0021554	biological_process	optic nerve development
F	0022038	biological_process	corpus callosum development
F	0030424	cellular_component	axon
F	0034702	cellular_component	monoatomic ion channel complex
F	0042734	cellular_component	presynaptic membrane
F	0044305	cellular_component	calyx of Held
F	0045121	cellular_component	membrane raft
F	0045211	cellular_component	postsynaptic membrane
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0051260	biological_process	protein homooligomerization
F	0055085	biological_process	transmembrane transport
F	0071805	biological_process	potassium ion transmembrane transport
F	0098978	cellular_component	glutamatergic synapse
G	0004033	molecular_function	aldo-keto reductase (NADPH) activity
G	0005249	molecular_function	voltage-gated potassium channel activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0005886	cellular_component	plasma membrane
G	0006813	biological_process	potassium ion transport
G	0008076	cellular_component	voltage-gated potassium channel complex
G	0009898	cellular_component	cytoplasmic side of plasma membrane
G	0015459	molecular_function	potassium channel regulator activity
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0030424	cellular_component	axon
G	0035579	cellular_component	specific granule membrane
G	0043005	cellular_component	neuron projection
G	0044224	cellular_component	juxtaparanode region of axon
G	0044325	molecular_function	transmembrane transporter binding
G	0045202	cellular_component	synapse
G	0055114	biological_process	obsolete oxidation-reduction process
G	0070821	cellular_component	tertiary granule membrane
G	0070995	biological_process	NADPH oxidation
G	0071805	biological_process	potassium ion transmembrane transport
G	0098900	biological_process	regulation of action potential
G	1901379	biological_process	regulation of potassium ion transmembrane transport
G	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
G	1990031	cellular_component	pinceau fiber
G	2000008	biological_process	regulation of protein localization to cell surface
H	0001508	biological_process	action potential
H	0005216	molecular_function	monoatomic ion channel activity
H	0005244	molecular_function	voltage-gated monoatomic ion channel activity
H	0005249	molecular_function	voltage-gated potassium channel activity
H	0005251	molecular_function	delayed rectifier potassium channel activity
H	0005267	molecular_function	potassium channel activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005886	cellular_component	plasma membrane
H	0006811	biological_process	monoatomic ion transport
H	0006813	biological_process	potassium ion transport
H	0008076	cellular_component	voltage-gated potassium channel complex
H	0015271	molecular_function	outward rectifier potassium channel activity
H	0016020	cellular_component	membrane
H	0021554	biological_process	optic nerve development
H	0022038	biological_process	corpus callosum development
H	0030424	cellular_component	axon
H	0034702	cellular_component	monoatomic ion channel complex
H	0042734	cellular_component	presynaptic membrane
H	0044305	cellular_component	calyx of Held
H	0045121	cellular_component	membrane raft
H	0045211	cellular_component	postsynaptic membrane
H	0048471	cellular_component	perinuclear region of cytoplasm
H	0051260	biological_process	protein homooligomerization
H	0055085	biological_process	transmembrane transport
H	0071805	biological_process	potassium ion transmembrane transport
H	0098978	cellular_component	glutamatergic synapse

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	binding site for residue NAP A 401

Chain	Residue
A	GLY55
A	ARG189
A	GLN214
A	TRP243
A	SER244
A	PRO245
A	LEU246
A	ALA247
A	CYS248
A	GLY249
A	LYS254
A	THR56
A	ARG264
A	PRO304
A	LEU322
A	GLY323
A	SER325
A	GLN329
A	GLU332
A	ASN333
A	TRP57
A	GLN63
A	ASP85
A	TYR90
A	LYS118
A	ASN158
A	SER188

site_id	AC2
Number of Residues	27
Details	binding site for residue NAP C 401

Chain	Residue
C	GLY55
C	THR56
C	TRP57
C	GLN63
C	ASP85
C	TYR90
C	LYS118
C	ASN158
C	SER188
C	ARG189
C	GLN214
C	TRP243
C	SER244
C	PRO245
C	LEU246
C	ALA247
C	CYS248
C	GLY249
C	LYS254
C	ARG264
C	PRO304
C	LEU322
C	GLY323
C	SER325
C	GLN329
C	GLU332
C	ASN333

site_id	AC3
Number of Residues	27
Details	binding site for residue NAP E 401

Chain	Residue
E	GLY55
E	THR56
E	TRP57
E	GLN63
E	ASP85
E	TYR90
E	LYS118
E	ASN158
E	SER188
E	ARG189
E	GLN214
E	TRP243
E	SER244
E	PRO245
E	LEU246
E	ALA247
E	CYS248
E	GLY249
E	LYS254
E	ARG264
E	PRO304
E	LEU322
E	GLY323
E	SER325
E	GLN329
E	GLU332
E	ASN333

site_id	AC4
Number of Residues	27
Details	binding site for residue NAP G 401

Chain	Residue
G	LYS254
G	ARG264
G	PRO304
G	LEU322
G	GLY323
G	SER325
G	GLN329
G	GLU332
G	ASN333
G	GLY55
G	THR56
G	TRP57
G	GLN63
G	ASP85
G	TYR90
G	LYS118
G	ASN158
G	SER188
G	ARG189
G	GLN214
G	TRP243
G	SER244
G	PRO245
G	LEU246
G	ALA247
G	CYS248
G	GLY249

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1404
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
B	MET1-ARG234
F	CYS317-ILE327
F	LYS382-GLU397
F	ASN482-VAL575
H	MET1-ARG234
H	CYS317-ILE327
H	LYS382-GLU397
H	ASN482-VAL575
B	CYS317-ILE327
B	LYS382-GLU397
B	ASN482-VAL575
D	MET1-ARG234
D	CYS317-ILE327
D	LYS382-GLU397
D	ASN482-VAL575
F	MET1-ARG234

site_id	SWS_FT_FI2
Number of Residues	72
Details	TRANSMEM: Helical; Name=Segment S1 => ECO:0000255

Chain	Residue	Details
B	GLY235-LEU253
A	PRO245
A	LEU246
A	ALA247
A	CYS248
A	LYS254
A	ARG264
A	SER325
A	GLN329
A	GLU332
A	ASN333
D	GLY235-LEU253
C	THR56
C	TRP57
C	GLN63
C	ASP85
C	SER188
C	ARG189
C	GLN214
C	TRP243
C	SER244
C	PRO245
F	GLY235-LEU253
C	LEU246
C	ALA247
C	CYS248
C	LYS254
C	ARG264
C	SER325
C	GLN329
C	GLU332
C	ASN333
E	THR56
H	GLY235-LEU253
E	TRP57
E	GLN63
E	ASP85
E	SER188
E	ARG189
E	GLN214
E	TRP243
E	SER244
E	PRO245
E	LEU246
A	SER188
E	ALA247
E	CYS248
E	LYS254
E	ARG264
E	SER325
E	GLN329
E	GLU332
E	ASN333
G	THR56
G	TRP57
A	ARG189
G	GLN63
G	ASP85
G	SER188
G	ARG189
G	GLN214
G	TRP243
G	SER244
G	PRO245
G	LEU246
G	ALA247
A	GLN214
G	CYS248
G	LYS254
G	ARG264
G	SER325
G	GLN329
G	GLU332
G	ASN333
A	TRP243
A	SER244

site_id	SWS_FT_FI3
Number of Residues	372
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
B	GLU254-PRO294
H	GLU254-PRO294
H	GLU349-ILE362
H	PHE418-LYS458
B	GLU349-ILE362
B	PHE418-LYS458
D	GLU254-PRO294
D	GLU349-ILE362
D	PHE418-LYS458
F	GLU254-PRO294
F	GLU349-ILE362
F	PHE418-LYS458

site_id	SWS_FT_FI4
Number of Residues	84
Details	TRANSMEM: Helical; Name=Segment S2 => ECO:0000255

Chain	Residue	Details
B	PHE295-ALA316
D	PHE295-ALA316
F	PHE295-ALA316
H	PHE295-ALA316

site_id	SWS_FT_FI5
Number of Residues	80
Details	TRANSMEM: Helical; Name=Segment S3 => ECO:0000255

Chain	Residue	Details
B	MET328-ALA348
D	MET328-ALA348
F	MET328-ALA348
H	MET328-ALA348

site_id	SWS_FT_FI6
Number of Residues	72
Details	TRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000255

Chain	Residue	Details
B	LEU363-SER381
D	LEU363-SER381
F	LEU363-SER381
H	LEU363-SER381

site_id	SWS_FT_FI7
Number of Residues	76
Details	TRANSMEM: Helical; Name=Segment S5 => ECO:0000255

Chain	Residue	Details
B	LEU398-TYR417
D	LEU398-TYR417
F	LEU398-TYR417
H	LEU398-TYR417

site_id	SWS_FT_FI8
Number of Residues	88
Details	TRANSMEM: Helical; Name=Segment S6 => ECO:0000255

Chain	Residue	Details
B	ILE459-SER481
D	ILE459-SER481
F	ILE459-SER481
H	ILE459-SER481
E	SER31
E	SER112
G	SER31
G	SER112

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P15384

Chain	Residue	Details
B	TYR499
D	TYR499
F	TYR499
H	TYR499

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKA => ECO:0000255

Chain	Residue	Details
B	SER520
D	SER520
F	SER520
H	SER520

site_id	SWS_FT_FI11
Number of Residues	4
Details	LIPID: S-palmitoyl cysteine => ECO:0000255

Chain	Residue	Details
B	CYS317
D	CYS317
F	CYS317
H	CYS317

site_id	SWS_FT_FI12
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN279
D	ASN279
F	ASN279
H	ASN279

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)