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7EJ1

human voltage-gated potassium channel KV1.3

Functional Information from GO Data
ChainGOidnamespacecontents
A0004033molecular_functionaldo-keto reductase (NADPH) activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005874cellular_componentmicrotubule
A0005886cellular_componentplasma membrane
A0006813biological_processpotassium ion transport
A0008076cellular_componentvoltage-gated potassium channel complex
A0009898cellular_componentcytoplasmic side of plasma membrane
A0015459molecular_functionpotassium channel regulator activity
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0030424cellular_componentaxon
A0035579cellular_componentspecific granule membrane
A0043005cellular_componentneuron projection
A0044224cellular_componentjuxtaparanode region of axon
A0044325molecular_functiontransmembrane transporter binding
A0045202cellular_componentsynapse
A0055114biological_processobsolete oxidation-reduction process
A0070821cellular_componenttertiary granule membrane
A0070995biological_processNADPH oxidation
A0071805biological_processpotassium ion transmembrane transport
A0098900biological_processregulation of action potential
A1901379biological_processregulation of potassium ion transmembrane transport
A1990002molecular_functionmethylglyoxal reductase (NADPH) (acetol producing) activity
A1990031cellular_componentpinceau fiber
A2000008biological_processregulation of protein localization to cell surface
B0001508biological_processaction potential
B0005216molecular_functionmonoatomic ion channel activity
B0005244molecular_functionvoltage-gated monoatomic ion channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005251molecular_functiondelayed rectifier potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0008076cellular_componentvoltage-gated potassium channel complex
B0015271molecular_functionoutward rectifier potassium channel activity
B0016020cellular_componentmembrane
B0021554biological_processoptic nerve development
B0022038biological_processcorpus callosum development
B0030424cellular_componentaxon
B0034702cellular_componentmonoatomic ion channel complex
B0042734cellular_componentpresynaptic membrane
B0044305cellular_componentcalyx of Held
B0045121cellular_componentmembrane raft
B0045211cellular_componentpostsynaptic membrane
B0048471cellular_componentperinuclear region of cytoplasm
B0051260biological_processprotein homooligomerization
B0055085biological_processtransmembrane transport
B0071805biological_processpotassium ion transmembrane transport
B0098978cellular_componentglutamatergic synapse
C0004033molecular_functionaldo-keto reductase (NADPH) activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005874cellular_componentmicrotubule
C0005886cellular_componentplasma membrane
C0006813biological_processpotassium ion transport
C0008076cellular_componentvoltage-gated potassium channel complex
C0009898cellular_componentcytoplasmic side of plasma membrane
C0015459molecular_functionpotassium channel regulator activity
C0016020cellular_componentmembrane
C0016491molecular_functionoxidoreductase activity
C0030424cellular_componentaxon
C0035579cellular_componentspecific granule membrane
C0043005cellular_componentneuron projection
C0044224cellular_componentjuxtaparanode region of axon
C0044325molecular_functiontransmembrane transporter binding
C0045202cellular_componentsynapse
C0055114biological_processobsolete oxidation-reduction process
C0070821cellular_componenttertiary granule membrane
C0070995biological_processNADPH oxidation
C0071805biological_processpotassium ion transmembrane transport
C0098900biological_processregulation of action potential
C1901379biological_processregulation of potassium ion transmembrane transport
C1990002molecular_functionmethylglyoxal reductase (NADPH) (acetol producing) activity
C1990031cellular_componentpinceau fiber
C2000008biological_processregulation of protein localization to cell surface
D0001508biological_processaction potential
D0005216molecular_functionmonoatomic ion channel activity
D0005244molecular_functionvoltage-gated monoatomic ion channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005251molecular_functiondelayed rectifier potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0008076cellular_componentvoltage-gated potassium channel complex
D0015271molecular_functionoutward rectifier potassium channel activity
D0016020cellular_componentmembrane
D0021554biological_processoptic nerve development
D0022038biological_processcorpus callosum development
D0030424cellular_componentaxon
D0034702cellular_componentmonoatomic ion channel complex
D0042734cellular_componentpresynaptic membrane
D0044305cellular_componentcalyx of Held
D0045121cellular_componentmembrane raft
D0045211cellular_componentpostsynaptic membrane
D0048471cellular_componentperinuclear region of cytoplasm
D0051260biological_processprotein homooligomerization
D0055085biological_processtransmembrane transport
D0071805biological_processpotassium ion transmembrane transport
D0098978cellular_componentglutamatergic synapse
E0004033molecular_functionaldo-keto reductase (NADPH) activity
E0005249molecular_functionvoltage-gated potassium channel activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0005874cellular_componentmicrotubule
E0005886cellular_componentplasma membrane
E0006813biological_processpotassium ion transport
E0008076cellular_componentvoltage-gated potassium channel complex
E0009898cellular_componentcytoplasmic side of plasma membrane
E0015459molecular_functionpotassium channel regulator activity
E0016020cellular_componentmembrane
E0016491molecular_functionoxidoreductase activity
E0030424cellular_componentaxon
E0035579cellular_componentspecific granule membrane
E0043005cellular_componentneuron projection
E0044224cellular_componentjuxtaparanode region of axon
E0044325molecular_functiontransmembrane transporter binding
E0045202cellular_componentsynapse
E0055114biological_processobsolete oxidation-reduction process
E0070821cellular_componenttertiary granule membrane
E0070995biological_processNADPH oxidation
E0071805biological_processpotassium ion transmembrane transport
E0098900biological_processregulation of action potential
E1901379biological_processregulation of potassium ion transmembrane transport
E1990002molecular_functionmethylglyoxal reductase (NADPH) (acetol producing) activity
E1990031cellular_componentpinceau fiber
E2000008biological_processregulation of protein localization to cell surface
F0001508biological_processaction potential
F0005216molecular_functionmonoatomic ion channel activity
F0005244molecular_functionvoltage-gated monoatomic ion channel activity
F0005249molecular_functionvoltage-gated potassium channel activity
F0005251molecular_functiondelayed rectifier potassium channel activity
F0005267molecular_functionpotassium channel activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005886cellular_componentplasma membrane
F0006811biological_processmonoatomic ion transport
F0006813biological_processpotassium ion transport
F0008076cellular_componentvoltage-gated potassium channel complex
F0015271molecular_functionoutward rectifier potassium channel activity
F0016020cellular_componentmembrane
F0021554biological_processoptic nerve development
F0022038biological_processcorpus callosum development
F0030424cellular_componentaxon
F0034702cellular_componentmonoatomic ion channel complex
F0042734cellular_componentpresynaptic membrane
F0044305cellular_componentcalyx of Held
F0045121cellular_componentmembrane raft
F0045211cellular_componentpostsynaptic membrane
F0048471cellular_componentperinuclear region of cytoplasm
F0051260biological_processprotein homooligomerization
F0055085biological_processtransmembrane transport
F0071805biological_processpotassium ion transmembrane transport
F0098978cellular_componentglutamatergic synapse
G0004033molecular_functionaldo-keto reductase (NADPH) activity
G0005249molecular_functionvoltage-gated potassium channel activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005856cellular_componentcytoskeleton
G0005874cellular_componentmicrotubule
G0005886cellular_componentplasma membrane
G0006813biological_processpotassium ion transport
G0008076cellular_componentvoltage-gated potassium channel complex
G0009898cellular_componentcytoplasmic side of plasma membrane
G0015459molecular_functionpotassium channel regulator activity
G0016020cellular_componentmembrane
G0016491molecular_functionoxidoreductase activity
G0030424cellular_componentaxon
G0035579cellular_componentspecific granule membrane
G0043005cellular_componentneuron projection
G0044224cellular_componentjuxtaparanode region of axon
G0044325molecular_functiontransmembrane transporter binding
G0045202cellular_componentsynapse
G0055114biological_processobsolete oxidation-reduction process
G0070821cellular_componenttertiary granule membrane
G0070995biological_processNADPH oxidation
G0071805biological_processpotassium ion transmembrane transport
G0098900biological_processregulation of action potential
G1901379biological_processregulation of potassium ion transmembrane transport
G1990002molecular_functionmethylglyoxal reductase (NADPH) (acetol producing) activity
G1990031cellular_componentpinceau fiber
G2000008biological_processregulation of protein localization to cell surface
H0001508biological_processaction potential
H0005216molecular_functionmonoatomic ion channel activity
H0005244molecular_functionvoltage-gated monoatomic ion channel activity
H0005249molecular_functionvoltage-gated potassium channel activity
H0005251molecular_functiondelayed rectifier potassium channel activity
H0005267molecular_functionpotassium channel activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005886cellular_componentplasma membrane
H0006811biological_processmonoatomic ion transport
H0006813biological_processpotassium ion transport
H0008076cellular_componentvoltage-gated potassium channel complex
H0015271molecular_functionoutward rectifier potassium channel activity
H0016020cellular_componentmembrane
H0021554biological_processoptic nerve development
H0022038biological_processcorpus callosum development
H0030424cellular_componentaxon
H0034702cellular_componentmonoatomic ion channel complex
H0042734cellular_componentpresynaptic membrane
H0044305cellular_componentcalyx of Held
H0045121cellular_componentmembrane raft
H0045211cellular_componentpostsynaptic membrane
H0048471cellular_componentperinuclear region of cytoplasm
H0051260biological_processprotein homooligomerization
H0055085biological_processtransmembrane transport
H0071805biological_processpotassium ion transmembrane transport
H0098978cellular_componentglutamatergic synapse
Functional Information from PDB Data
site_idAC1
Number of Residues27
Detailsbinding site for residue NAP A 401
ChainResidue
AGLY55
ATRP243
ASER244
APRO245
ALEU246
AALA247
ACYS248
AGLY249
ASER252
ALYS254
AARG264
ATHR56
APRO304
ALEU321
ALEU322
AGLY323
ASER325
AGLN329
AGLU332
AASN333
ATRP57
AASP85
ATYR90
AASN158
ASER188
AARG189
AGLN214

site_idAC2
Number of Residues27
Detailsbinding site for residue NAP C 401
ChainResidue
CGLY55
CTHR56
CTRP57
CASP85
CTYR90
CASN158
CSER188
CARG189
CGLN214
CTRP243
CSER244
CPRO245
CLEU246
CALA247
CCYS248
CGLY249
CSER252
CLYS254
CARG264
CPRO304
CLEU321
CLEU322
CGLY323
CSER325
CGLN329
CGLU332
CASN333

site_idAC3
Number of Residues27
Detailsbinding site for residue NAP E 401
ChainResidue
EGLY55
ETHR56
ETRP57
EASP85
ETYR90
EASN158
ESER188
EARG189
EGLN214
ETRP243
ESER244
EPRO245
ELEU246
EALA247
ECYS248
EGLY249
ESER252
ELYS254
EARG264
EPRO304
ELEU321
ELEU322
EGLY323
ESER325
EGLN329
EGLU332
EASN333

site_idAC4
Number of Residues27
Detailsbinding site for residue NAP G 401
ChainResidue
GARG264
GPRO304
GLEU321
GLEU322
GGLY323
GSER325
GGLN329
GGLU332
GASN333
GGLY55
GTHR56
GTRP57
GASP85
GTYR90
GASN158
GSER188
GARG189
GGLN214
GTRP243
GSER244
GPRO245
GLEU246
GALA247
GCYS248
GGLY249
GSER252
GLYS254

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1404
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
BMET1-ARG234
FCYS317-ILE327
FLYS382-GLU397
FASN482-VAL575
HMET1-ARG234
HCYS317-ILE327
HLYS382-GLU397
HASN482-VAL575
BCYS317-ILE327
BLYS382-GLU397
BASN482-VAL575
DMET1-ARG234
DCYS317-ILE327
DLYS382-GLU397
DASN482-VAL575
FMET1-ARG234

site_idSWS_FT_FI2
Number of Residues72
DetailsTRANSMEM: Helical; Name=Segment S1 => ECO:0000255
ChainResidueDetails
BGLY235-LEU253
APRO245
ALEU246
AALA247
ACYS248
ALYS254
AARG264
ASER325
AGLN329
AGLU332
AASN333
DGLY235-LEU253
CTHR56
CTRP57
CGLN63
CASP85
CSER188
CARG189
CGLN214
CTRP243
CSER244
CPRO245
FGLY235-LEU253
CLEU246
CALA247
CCYS248
CLYS254
CARG264
CSER325
CGLN329
CGLU332
CASN333
ETHR56
HGLY235-LEU253
ETRP57
EGLN63
EASP85
ESER188
EARG189
EGLN214
ETRP243
ESER244
EPRO245
ELEU246
ASER188
EALA247
ECYS248
ELYS254
EARG264
ESER325
EGLN329
EGLU332
EASN333
GTHR56
GTRP57
AARG189
GGLN63
GASP85
GSER188
GARG189
GGLN214
GTRP243
GSER244
GPRO245
GLEU246
GALA247
AGLN214
GCYS248
GLYS254
GARG264
GSER325
GGLN329
GGLU332
GASN333
ATRP243
ASER244

site_idSWS_FT_FI3
Number of Residues372
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
BGLU254-PRO294
HGLU254-PRO294
HGLU349-ILE362
HPHE418-LYS458
BGLU349-ILE362
BPHE418-LYS458
DGLU254-PRO294
DGLU349-ILE362
DPHE418-LYS458
FGLU254-PRO294
FGLU349-ILE362
FPHE418-LYS458

site_idSWS_FT_FI4
Number of Residues84
DetailsTRANSMEM: Helical; Name=Segment S2 => ECO:0000255
ChainResidueDetails
BPHE295-ALA316
DPHE295-ALA316
FPHE295-ALA316
HPHE295-ALA316

site_idSWS_FT_FI5
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S3 => ECO:0000255
ChainResidueDetails
BMET328-ALA348
DMET328-ALA348
FMET328-ALA348
HMET328-ALA348

site_idSWS_FT_FI6
Number of Residues72
DetailsTRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000255
ChainResidueDetails
BLEU363-SER381
DLEU363-SER381
FLEU363-SER381
HLEU363-SER381

site_idSWS_FT_FI7
Number of Residues76
DetailsTRANSMEM: Helical; Name=Segment S5 => ECO:0000255
ChainResidueDetails
BLEU398-TYR417
DLEU398-TYR417
FLEU398-TYR417
HLEU398-TYR417

site_idSWS_FT_FI8
Number of Residues88
DetailsTRANSMEM: Helical; Name=Segment S6 => ECO:0000255
ChainResidueDetails
BILE459-SER481
DILE459-SER481
FILE459-SER481
HILE459-SER481
ESER31
ESER112
GSER31
GSER112

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P15384
ChainResidueDetails
BTYR499
DTYR499
FTYR499
HTYR499

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000255
ChainResidueDetails
BSER520
DSER520
FSER520
HSER520

site_idSWS_FT_FI11
Number of Residues4
DetailsLIPID: S-palmitoyl cysteine => ECO:0000255
ChainResidueDetails
BCYS317
DCYS317
FCYS317
HCYS317

site_idSWS_FT_FI12
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN279
DASN279
FASN279
HASN279

227344

PDB entries from 2024-11-13

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