Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7EGR

Co-crystal structure of Ac-AChBPP in complex with RgIA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005231	molecular_function	excitatory extracellular ligand-gated monoatomic ion channel activity
B	0005515	molecular_function	protein binding
B	0006811	biological_process	monoatomic ion transport
B	0007165	biological_process	signal transduction
B	0007268	biological_process	chemical synaptic transmission
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042391	biological_process	regulation of membrane potential
B	0042802	molecular_function	identical protein binding
B	0043005	cellular_component	neuron projection
B	0045202	cellular_component	synapse
B	0046872	molecular_function	metal ion binding
B	0050877	biological_process	nervous system process
B	0060078	biological_process	regulation of postsynaptic membrane potential
B	0060079	biological_process	excitatory postsynaptic potential
B	0098794	cellular_component	postsynapse
B	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005231	molecular_function	excitatory extracellular ligand-gated monoatomic ion channel activity
C	0005515	molecular_function	protein binding
C	0006811	biological_process	monoatomic ion transport
C	0007165	biological_process	signal transduction
C	0007268	biological_process	chemical synaptic transmission
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042391	biological_process	regulation of membrane potential
C	0042802	molecular_function	identical protein binding
C	0043005	cellular_component	neuron projection
C	0045202	cellular_component	synapse
C	0046872	molecular_function	metal ion binding
C	0050877	biological_process	nervous system process
C	0060078	biological_process	regulation of postsynaptic membrane potential
C	0060079	biological_process	excitatory postsynaptic potential
C	0098794	cellular_component	postsynapse
C	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
F	0004888	molecular_function	transmembrane signaling receptor activity
F	0005216	molecular_function	monoatomic ion channel activity
F	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
F	0006811	biological_process	monoatomic ion transport
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
G	0004888	molecular_function	transmembrane signaling receptor activity
G	0005216	molecular_function	monoatomic ion channel activity
G	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
G	0006811	biological_process	monoatomic ion transport
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
H	0004888	molecular_function	transmembrane signaling receptor activity
H	0005216	molecular_function	monoatomic ion channel activity
H	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
H	0006811	biological_process	monoatomic ion transport
H	0016020	cellular_component	membrane
H	0034220	biological_process	monoatomic ion transmembrane transport
I	0004888	molecular_function	transmembrane signaling receptor activity
I	0005216	molecular_function	monoatomic ion channel activity
I	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
I	0006811	biological_process	monoatomic ion transport
I	0016020	cellular_component	membrane
I	0034220	biological_process	monoatomic ion transmembrane transport
J	0004888	molecular_function	transmembrane signaling receptor activity
J	0005216	molecular_function	monoatomic ion channel activity
J	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
J	0006811	biological_process	monoatomic ion transport
J	0016020	cellular_component	membrane
J	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS60014
Number of Residues	11
Details	ALPHA_CONOTOXIN Alpha-conotoxin family signature. CCSdPRCR....YRC

Chain	Residue	Details
K	CYS402-CYS412

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	SITE: Key residue for potent inhibition of the rat CHRNA9-CHRNA10 nAChR => ECO:0000269\|PubMed:18295795

Chain	Residue	Details
K	ASP405
M	PRO406
M	ARG407
M	ARG409
N	ASP405
N	PRO406
N	ARG407
N	ARG409
O	ASP405
O	PRO406
O	ARG407
K	PRO406
O	ARG409
P	ASP405
P	PRO406
P	ARG407
P	ARG409
R	ASP405
R	PRO406
R	ARG407
R	ARG409
Q	ASP405
K	ARG407
Q	PRO406
Q	ARG407
Q	ARG409
K	ARG409
L	ASP405
L	PRO406
L	ARG407
L	ARG409
M	ASP405

site_id	SWS_FT_FI2
Number of Residues	8
Details	SITE: Binds to the Glu-221 of the rat nAChR CHRNA10 subunit => ECO:0000305\|PubMed:25740413

Chain	Residue	Details
K	ARG411
L	ARG411
M	ARG411
N	ARG411
O	ARG411
P	ARG411
R	ARG411
Q	ARG411

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)