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7EGH

TFIID lobe C subcomplex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000209biological_processprotein polyubiquitination
A0000785cellular_componentchromatin
A0000979molecular_functionRNA polymerase II core promoter sequence-specific DNA binding
A0001091molecular_functionRNA polymerase II general transcription initiation factor binding
A0001181molecular_functionRNA polymerase I general transcription initiation factor activity
A0002039molecular_functionp53 binding
A0003677molecular_functionDNA binding
A0004402molecular_functionhistone acetyltransferase activity
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005667cellular_componenttranscription regulator complex
A0005669cellular_componenttranscription factor TFIID complex
A0005730cellular_componentnucleolus
A0006325biological_processchromatin organization
A0006338biological_processchromatin remodeling
A0006352biological_processDNA-templated transcription initiation
A0006361biological_processtranscription initiation at RNA polymerase I promoter
A0006366biological_processtranscription by RNA polymerase II
A0006367biological_processtranscription initiation at RNA polymerase II promoter
A0006468biological_processprotein phosphorylation
A0006511biological_processubiquitin-dependent protein catabolic process
A0006974biological_processDNA damage response
A0010629biological_processnegative regulation of gene expression
A0016251molecular_functionRNA polymerase II general transcription initiation factor activity
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016746molecular_functionacyltransferase activity
A0016922molecular_functionnuclear receptor binding
A0017025molecular_functionTBP-class protein binding
A0018105biological_processpeptidyl-serine phosphorylation
A0018107biological_processpeptidyl-threonine phosphorylation
A0030901biological_processmidbrain development
A0032092biological_processpositive regulation of protein binding
A0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
A0034644biological_processcellular response to UV
A0042789biological_processmRNA transcription by RNA polymerase II
A0043565molecular_functionsequence-specific DNA binding
A0044024molecular_functionhistone H2AS1 kinase activity
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046777biological_processprotein autophosphorylation
A0046982molecular_functionprotein heterodimerization activity
A0050821biological_processprotein stabilization
A0051123biological_processRNA polymerase II preinitiation complex assembly
A0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
A0061628molecular_functionH3K27me3 modified histone binding
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0061631molecular_functionubiquitin conjugating enzyme activity
A0061733molecular_functionpeptide-lysine-N-acetyltransferase activity
A0070577molecular_functionlysine-acetylated histone binding
A0071318biological_processcellular response to ATP
A0071339cellular_componentMLL1 complex
A0106310molecular_functionprotein serine kinase activity
A0140416molecular_functiontranscription regulator inhibitor activity
A0140566molecular_functionhistone reader activity
A1901796biological_processregulation of signal transduction by p53 class mediator
A1902806biological_processregulation of cell cycle G1/S phase transition
A1905502molecular_functionacetyl-CoA binding
A1905524biological_processnegative regulation of protein autoubiquitination
A2000059biological_processnegative regulation of ubiquitin-dependent protein catabolic process
A2000825biological_processpositive regulation of androgen receptor activity
B0000086biological_processG2/M transition of mitotic cell cycle
B0000976molecular_functiontranscription cis-regulatory region binding
B0003682molecular_functionchromatin binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005669cellular_componenttranscription factor TFIID complex
B0006282biological_processregulation of DNA repair
B0006357biological_processregulation of transcription by RNA polymerase II
B0006367biological_processtranscription initiation at RNA polymerase II promoter
B0014070biological_processresponse to organic cyclic compound
B0016251molecular_functionRNA polymerase II general transcription initiation factor activity
B0033276cellular_componenttranscription factor TFTC complex
B0042789biological_processmRNA transcription by RNA polymerase II
B0045893biological_processpositive regulation of DNA-templated transcription
B0051123biological_processRNA polymerase II preinitiation complex assembly
B0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
F0000124cellular_componentSAGA complex
F0003677molecular_functionDNA binding
F0003713molecular_functiontranscription coactivator activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005669cellular_componenttranscription factor TFIID complex
F0005829cellular_componentcytosol
F0006282biological_processregulation of DNA repair
F0006352biological_processDNA-templated transcription initiation
F0006357biological_processregulation of transcription by RNA polymerase II
F0006366biological_processtranscription by RNA polymerase II
F0006367biological_processtranscription initiation at RNA polymerase II promoter
F0006915biological_processapoptotic process
F0016251molecular_functionRNA polymerase II general transcription initiation factor activity
F0017162molecular_functionaryl hydrocarbon receptor binding
F0032991cellular_componentprotein-containing complex
F0033276cellular_componenttranscription factor TFTC complex
F0042789biological_processmRNA transcription by RNA polymerase II
F0045786biological_processnegative regulation of cell cycle
F0045893biological_processpositive regulation of DNA-templated transcription
F0046695cellular_componentSLIK (SAGA-like) complex
F0046982molecular_functionprotein heterodimerization activity
F0051123biological_processRNA polymerase II preinitiation complex assembly
F0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
F0071339cellular_componentMLL1 complex
G0000122biological_processnegative regulation of transcription by RNA polymerase II
G0000296biological_processspermine transport
G0000976molecular_functiontranscription cis-regulatory region binding
G0001097molecular_functionTFIIH-class transcription factor complex binding
G0001673cellular_componentmale germ cell nucleus
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005667cellular_componenttranscription regulator complex
G0005669cellular_componenttranscription factor TFIID complex
G0005737cellular_componentcytoplasm
G0006282biological_processregulation of DNA repair
G0006352biological_processDNA-templated transcription initiation
G0006357biological_processregulation of transcription by RNA polymerase II
G0006366biological_processtranscription by RNA polymerase II
G0006367biological_processtranscription initiation at RNA polymerase II promoter
G0006469biological_processnegative regulation of protein kinase activity
G0016251molecular_functionRNA polymerase II general transcription initiation factor activity
G0030520biological_processestrogen receptor signaling pathway
G0033276cellular_componenttranscription factor TFTC complex
G0035035molecular_functionhistone acetyltransferase binding
G0042789biological_processmRNA transcription by RNA polymerase II
G0042809molecular_functionnuclear vitamin D receptor binding
G0045344biological_processnegative regulation of MHC class I biosynthetic process
G0045347biological_processnegative regulation of MHC class II biosynthetic process
G0045892biological_processnegative regulation of DNA-templated transcription
G0045893biological_processpositive regulation of DNA-templated transcription
G0045944biological_processpositive regulation of transcription by RNA polymerase II
G0046966molecular_functionnuclear thyroid hormone receptor binding
G0046982molecular_functionprotein heterodimerization activity
G0051123biological_processRNA polymerase II preinitiation complex assembly
G0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
G0061628molecular_functionH3K27me3 modified histone binding
G0071339cellular_componentMLL1 complex
G0106140molecular_functionP-TEFb complex binding
G0140297molecular_functionDNA-binding transcription factor binding
H0001112biological_processDNA-templated transcription open complex formation
H0001833biological_processinner cell mass cell proliferation
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005669cellular_componenttranscription factor TFIID complex
H0005737cellular_componentcytoplasm
H0006367biological_processtranscription initiation at RNA polymerase II promoter
H0016251molecular_functionRNA polymerase II general transcription initiation factor activity
H0030154biological_processcell differentiation
H0042789biological_processmRNA transcription by RNA polymerase II
H0045598biological_processregulation of fat cell differentiation
H0046982molecular_functionprotein heterodimerization activity
H0048471cellular_componentperinuclear region of cytoplasm
H0051123biological_processRNA polymerase II preinitiation complex assembly
H0051457biological_processmaintenance of protein location in nucleus
H0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
f0000124cellular_componentSAGA complex
f0003677molecular_functionDNA binding
f0003713molecular_functiontranscription coactivator activity
f0005515molecular_functionprotein binding
f0005634cellular_componentnucleus
f0005654cellular_componentnucleoplasm
f0005669cellular_componenttranscription factor TFIID complex
f0005829cellular_componentcytosol
f0006282biological_processregulation of DNA repair
f0006352biological_processDNA-templated transcription initiation
f0006357biological_processregulation of transcription by RNA polymerase II
f0006366biological_processtranscription by RNA polymerase II
f0006367biological_processtranscription initiation at RNA polymerase II promoter
f0006915biological_processapoptotic process
f0016251molecular_functionRNA polymerase II general transcription initiation factor activity
f0017162molecular_functionaryl hydrocarbon receptor binding
f0032991cellular_componentprotein-containing complex
f0033276cellular_componenttranscription factor TFTC complex
f0042789biological_processmRNA transcription by RNA polymerase II
f0045786biological_processnegative regulation of cell cycle
f0045893biological_processpositive regulation of DNA-templated transcription
f0046695cellular_componentSLIK (SAGA-like) complex
f0046982molecular_functionprotein heterodimerization activity
f0051123biological_processRNA polymerase II preinitiation complex assembly
f0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
f0071339cellular_componentMLL1 complex
Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues58
DetailsBROMODOMAIN_1 Bromodomain signature. TypFhtpvNakvvk..DYYkiItrpMdlqtLrenvrkrl..Ypsreefrehlel.IvkNSatY
ChainResidueDetails
ATHR1402-TYR1459
ASER1525-TYR1582

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
HALA2
fTHR120

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648
ChainResidueDetails
HTHR130
GSER201
BSER1198

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
HSER271
fTYR253

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:22711989, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
GSER264
fSER264

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Omega-N-methylarginine => ECO:0007744|PubMed:24129315
ChainResidueDetails
FARG524
fARG524
ASER1799
ASER1802
AILE1820

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q62311
ChainResidueDetails
FSER626
fSER626

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
FSER634
FSER636
fSER634
fSER636

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
FSER653
fSER653

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
FTHR660
fTHR660

site_idSWS_FT_FI10
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
FLYS196
fLYS196

226707

PDB entries from 2024-10-30

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