7EGH

TFIID lobe C subcomplex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000166	molecular_function	nucleotide binding
A	0000209	biological_process	protein polyubiquitination
A	0000785	cellular_component	chromatin
A	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
A	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
A	0001181	molecular_function	RNA polymerase I general transcription initiation factor activity
A	0002039	molecular_function	p53 binding
A	0003677	molecular_function	DNA binding
A	0004402	molecular_function	histone acetyltransferase activity
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005667	cellular_component	transcription regulator complex
A	0005669	cellular_component	transcription factor TFIID complex
A	0005730	cellular_component	nucleolus
A	0006325	biological_process	chromatin organization
A	0006338	biological_process	chromatin remodeling
A	0006352	biological_process	DNA-templated transcription initiation
A	0006361	biological_process	transcription initiation at RNA polymerase I promoter
A	0006366	biological_process	transcription by RNA polymerase II
A	0006367	biological_process	transcription initiation at RNA polymerase II promoter
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006974	biological_process	DNA damage response
A	0010629	biological_process	negative regulation of gene expression
A	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016922	molecular_function	nuclear receptor binding
A	0017025	molecular_function	TBP-class protein binding
A	0030901	biological_process	midbrain development
A	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0034644	biological_process	cellular response to UV
A	0042789	biological_process	mRNA transcription by RNA polymerase II
A	0043565	molecular_function	sequence-specific DNA binding
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046777	biological_process	protein autophosphorylation
A	0046982	molecular_function	protein heterodimerization activity
A	0050821	biological_process	protein stabilization
A	0051123	biological_process	RNA polymerase II preinitiation complex assembly
A	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
A	0061628	molecular_function	histone H3K27me3 reader activity
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0061631	molecular_function	ubiquitin conjugating enzyme activity
A	0061733	molecular_function	protein-lysine-acetyltransferase activity
A	0071318	biological_process	cellular response to ATP
A	0071339	cellular_component	MLL1 complex
A	0106310	molecular_function	protein serine kinase activity
A	0140046	molecular_function	histone H4K16ac reader activity
A	0140416	molecular_function	transcription regulator inhibitor activity
A	0140566	molecular_function	histone reader activity
A	0160207	biological_process	positive regulation of androgen receptor signaling pathway
A	1901796	biological_process	regulation of signal transduction by p53 class mediator
A	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
A	1902806	biological_process	regulation of cell cycle G1/S phase transition
A	1905502	molecular_function	acetyl-CoA binding
A	1905524	biological_process	negative regulation of protein autoubiquitination
A	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
B	0000086	biological_process	G2/M transition of mitotic cell cycle
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0003682	molecular_function	chromatin binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005669	cellular_component	transcription factor TFIID complex
B	0006282	biological_process	regulation of DNA repair
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006367	biological_process	transcription initiation at RNA polymerase II promoter
B	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
B	0033276	cellular_component	transcription factor TFTC complex
B	0042789	biological_process	mRNA transcription by RNA polymerase II
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0051123	biological_process	RNA polymerase II preinitiation complex assembly
B	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
B	1901562	biological_process	response to paraquat
F	0000124	cellular_component	SAGA complex
F	0003677	molecular_function	DNA binding
F	0003713	molecular_function	transcription coactivator activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005669	cellular_component	transcription factor TFIID complex
F	0005829	cellular_component	cytosol
F	0006282	biological_process	regulation of DNA repair
F	0006352	biological_process	DNA-templated transcription initiation
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006366	biological_process	transcription by RNA polymerase II
F	0006367	biological_process	transcription initiation at RNA polymerase II promoter
F	0006915	biological_process	apoptotic process
F	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
F	0017162	molecular_function	aryl hydrocarbon receptor binding
F	0032991	cellular_component	protein-containing complex
F	0033276	cellular_component	transcription factor TFTC complex
F	0042789	biological_process	mRNA transcription by RNA polymerase II
F	0045786	biological_process	negative regulation of cell cycle
F	0045893	biological_process	positive regulation of DNA-templated transcription
F	0046695	cellular_component	SLIK (SAGA-like) complex
F	0046982	molecular_function	protein heterodimerization activity
F	0051123	biological_process	RNA polymerase II preinitiation complex assembly
F	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
F	0071339	cellular_component	MLL1 complex
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0000296	biological_process	spermine transport
G	0000976	molecular_function	transcription cis-regulatory region binding
G	0001097	molecular_function	TFIIH-class transcription factor complex binding
G	0001673	cellular_component	male germ cell nucleus
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005667	cellular_component	transcription regulator complex
G	0005669	cellular_component	transcription factor TFIID complex
G	0005737	cellular_component	cytoplasm
G	0006282	biological_process	regulation of DNA repair
G	0006325	biological_process	chromatin organization
G	0006352	biological_process	DNA-templated transcription initiation
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0006366	biological_process	transcription by RNA polymerase II
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0006469	biological_process	negative regulation of protein kinase activity
G	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
G	0030520	biological_process	estrogen receptor signaling pathway
G	0033276	cellular_component	transcription factor TFTC complex
G	0035035	molecular_function	histone acetyltransferase binding
G	0042789	biological_process	mRNA transcription by RNA polymerase II
G	0042809	molecular_function	nuclear vitamin D receptor binding
G	0045344	biological_process	negative regulation of MHC class I biosynthetic process
G	0045347	biological_process	negative regulation of MHC class II biosynthetic process
G	0045892	biological_process	negative regulation of DNA-templated transcription
G	0045893	biological_process	positive regulation of DNA-templated transcription
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0046966	molecular_function	nuclear thyroid hormone receptor binding
G	0046982	molecular_function	protein heterodimerization activity
G	0051123	biological_process	RNA polymerase II preinitiation complex assembly
G	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
G	0061628	molecular_function	histone H3K27me3 reader activity
G	0071339	cellular_component	MLL1 complex
G	0106140	molecular_function	P-TEFb complex binding
G	0140297	molecular_function	DNA-binding transcription factor binding
H	0001112	biological_process	DNA-templated transcription open complex formation
H	0001833	biological_process	inner cell mass cell proliferation
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005669	cellular_component	transcription factor TFIID complex
H	0005737	cellular_component	cytoplasm
H	0006367	biological_process	transcription initiation at RNA polymerase II promoter
H	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
H	0030154	biological_process	cell differentiation
H	0042789	biological_process	mRNA transcription by RNA polymerase II
H	0045598	biological_process	regulation of fat cell differentiation
H	0046982	molecular_function	protein heterodimerization activity
H	0048471	cellular_component	perinuclear region of cytoplasm
H	0051123	biological_process	RNA polymerase II preinitiation complex assembly
H	0051457	biological_process	maintenance of protein location in nucleus
H	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
f	0000124	cellular_component	SAGA complex
f	0003677	molecular_function	DNA binding
f	0003713	molecular_function	transcription coactivator activity
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005669	cellular_component	transcription factor TFIID complex
f	0005829	cellular_component	cytosol
f	0006282	biological_process	regulation of DNA repair
f	0006352	biological_process	DNA-templated transcription initiation
f	0006357	biological_process	regulation of transcription by RNA polymerase II
f	0006366	biological_process	transcription by RNA polymerase II
f	0006367	biological_process	transcription initiation at RNA polymerase II promoter
f	0006915	biological_process	apoptotic process
f	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
f	0017162	molecular_function	aryl hydrocarbon receptor binding
f	0032991	cellular_component	protein-containing complex
f	0033276	cellular_component	transcription factor TFTC complex
f	0042789	biological_process	mRNA transcription by RNA polymerase II
f	0045786	biological_process	negative regulation of cell cycle
f	0045893	biological_process	positive regulation of DNA-templated transcription
f	0046695	cellular_component	SLIK (SAGA-like) complex
f	0046982	molecular_function	protein heterodimerization activity
f	0051123	biological_process	RNA polymerase II preinitiation complex assembly
f	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
f	0071339	cellular_component	MLL1 complex

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. TypFhtpvNakvvk..DYYkiItrpMdlqtLrenvrkrl..Ypsreefrehlel.IvkNSatY

Chain	Residue	Details
A	THR1402-TYR1459
A	SER1525-TYR1582

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q63801","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q63801","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q63801","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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