Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7EGG

TFIID lobe B subcomplex

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0000785	cellular_component	chromatin
D	0001046	molecular_function	core promoter sequence-specific DNA binding
D	0001541	biological_process	ovarian follicle development
D	0001673	cellular_component	male germ cell nucleus
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005669	cellular_component	transcription factor TFIID complex
D	0005829	cellular_component	cytosol
D	0006282	biological_process	regulation of DNA repair
D	0006351	biological_process	DNA-templated transcription
D	0006352	biological_process	DNA-templated transcription initiation
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006366	biological_process	transcription by RNA polymerase II
D	0006367	biological_process	transcription initiation at RNA polymerase II promoter
D	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
D	0017162	molecular_function	aryl hydrocarbon receptor binding
D	0032991	cellular_component	protein-containing complex
D	0033276	cellular_component	transcription factor TFTC complex
D	0042789	biological_process	mRNA transcription by RNA polymerase II
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0046982	molecular_function	protein heterodimerization activity
D	0051123	biological_process	RNA polymerase II preinitiation complex assembly
D	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
D	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
D	0071339	cellular_component	MLL1 complex
E	0000785	cellular_component	chromatin
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005669	cellular_component	transcription factor TFIID complex
E	0005730	cellular_component	nucleolus
E	0006282	biological_process	regulation of DNA repair
E	0006352	biological_process	DNA-templated transcription initiation
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0006367	biological_process	transcription initiation at RNA polymerase II promoter
E	0015629	cellular_component	actin cytoskeleton
E	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
E	0033276	cellular_component	transcription factor TFTC complex
E	0042789	biological_process	mRNA transcription by RNA polymerase II
E	0042802	molecular_function	identical protein binding
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0051123	biological_process	RNA polymerase II preinitiation complex assembly
E	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
F	0000124	cellular_component	SAGA complex
F	0003677	molecular_function	DNA binding
F	0003713	molecular_function	transcription coactivator activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005669	cellular_component	transcription factor TFIID complex
F	0005829	cellular_component	cytosol
F	0006282	biological_process	regulation of DNA repair
F	0006352	biological_process	DNA-templated transcription initiation
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006366	biological_process	transcription by RNA polymerase II
F	0006367	biological_process	transcription initiation at RNA polymerase II promoter
F	0006915	biological_process	apoptotic process
F	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
F	0017162	molecular_function	aryl hydrocarbon receptor binding
F	0032991	cellular_component	protein-containing complex
F	0033276	cellular_component	transcription factor TFTC complex
F	0042789	biological_process	mRNA transcription by RNA polymerase II
F	0045786	biological_process	negative regulation of cell cycle
F	0045893	biological_process	positive regulation of DNA-templated transcription
F	0046695	cellular_component	SLIK (SAGA-like) complex
F	0046982	molecular_function	protein heterodimerization activity
F	0051123	biological_process	RNA polymerase II preinitiation complex assembly
F	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
F	0071339	cellular_component	MLL1 complex
H	0001112	biological_process	DNA-templated transcription open complex formation
H	0001833	biological_process	inner cell mass cell proliferation
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005669	cellular_component	transcription factor TFIID complex
H	0005737	cellular_component	cytoplasm
H	0006367	biological_process	transcription initiation at RNA polymerase II promoter
H	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
H	0030154	biological_process	cell differentiation
H	0042789	biological_process	mRNA transcription by RNA polymerase II
H	0045598	biological_process	regulation of fat cell differentiation
H	0046982	molecular_function	protein heterodimerization activity
H	0048471	cellular_component	perinuclear region of cytoplasm
H	0051123	biological_process	RNA polymerase II preinitiation complex assembly
H	0051457	biological_process	maintenance of protein location in nucleus
H	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
I	0000124	cellular_component	SAGA complex
I	0000492	biological_process	box C/D snoRNP assembly
I	0000976	molecular_function	transcription cis-regulatory region binding
I	0002039	molecular_function	p53 binding
I	0003677	molecular_function	DNA binding
I	0003713	molecular_function	transcription coactivator activity
I	0004402	molecular_function	histone acetyltransferase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005669	cellular_component	transcription factor TFIID complex
I	0006282	biological_process	regulation of DNA repair
I	0006338	biological_process	chromatin remodeling
I	0006352	biological_process	DNA-templated transcription initiation
I	0006355	biological_process	regulation of DNA-templated transcription
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0006974	biological_process	DNA damage response
I	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
I	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
I	0033276	cellular_component	transcription factor TFTC complex
I	0042789	biological_process	mRNA transcription by RNA polymerase II
I	0043066	biological_process	negative regulation of apoptotic process
I	0043484	biological_process	regulation of RNA splicing
I	0045893	biological_process	positive regulation of DNA-templated transcription
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0046982	molecular_function	protein heterodimerization activity
I	0050821	biological_process	protein stabilization
I	0051117	molecular_function	ATPase binding
I	0051123	biological_process	RNA polymerase II preinitiation complex assembly
I	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
I	0060760	biological_process	positive regulation of response to cytokine stimulus
I	0070555	biological_process	response to interleukin-1
I	0070742	molecular_function	C2H2 zinc finger domain binding
I	0070761	cellular_component	pre-snoRNP complex
I	0071339	cellular_component	MLL1 complex
I	0140297	molecular_function	DNA-binding transcription factor binding
I	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
J	0000082	biological_process	G1/S transition of mitotic cell cycle
J	0000124	cellular_component	SAGA complex
J	0001673	cellular_component	male germ cell nucleus
J	0001701	biological_process	in utero embryonic development
J	0001756	biological_process	somitogenesis
J	0001889	biological_process	liver development
J	0001892	biological_process	embryonic placenta development
J	0003677	molecular_function	DNA binding
J	0004402	molecular_function	histone acetyltransferase activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005669	cellular_component	transcription factor TFIID complex
J	0005737	cellular_component	cytoplasm
J	0006282	biological_process	regulation of DNA repair
J	0006338	biological_process	chromatin remodeling
J	0006352	biological_process	DNA-templated transcription initiation
J	0006355	biological_process	regulation of DNA-templated transcription
J	0006357	biological_process	regulation of transcription by RNA polymerase II
J	0006366	biological_process	transcription by RNA polymerase II
J	0006367	biological_process	transcription initiation at RNA polymerase II promoter
J	0006915	biological_process	apoptotic process
J	0010467	biological_process	gene expression
J	0010468	biological_process	regulation of gene expression
J	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
J	0019899	molecular_function	enzyme binding
J	0030331	molecular_function	nuclear estrogen receptor binding
J	0033276	cellular_component	transcription factor TFTC complex
J	0035264	biological_process	multicellular organism growth
J	0036285	biological_process	SAGA complex assembly
J	0042789	biological_process	mRNA transcription by RNA polymerase II
J	0042802	molecular_function	identical protein binding
J	0043484	biological_process	regulation of RNA splicing
J	0045893	biological_process	positive regulation of DNA-templated transcription
J	0048371	biological_process	lateral mesodermal cell differentiation
J	0048471	cellular_component	perinuclear region of cytoplasm
J	0051123	biological_process	RNA polymerase II preinitiation complex assembly
J	0060173	biological_process	limb development
J	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
J	0065003	biological_process	protein-containing complex assembly
J	0070063	molecular_function	RNA polymerase binding
J	0070365	biological_process	hepatocyte differentiation
J	0097550	cellular_component	transcription preinitiation complex
J	1905069	biological_process	allantois development
J	1990841	molecular_function	promoter-specific chromatin binding
L	0000124	cellular_component	SAGA complex
L	0003677	molecular_function	DNA binding
L	0003713	molecular_function	transcription coactivator activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005669	cellular_component	transcription factor TFIID complex
L	0006282	biological_process	regulation of DNA repair
L	0006352	biological_process	DNA-templated transcription initiation
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0006366	biological_process	transcription by RNA polymerase II
L	0006367	biological_process	transcription initiation at RNA polymerase II promoter
L	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
L	0017025	molecular_function	TBP-class protein binding
L	0033276	cellular_component	transcription factor TFTC complex
L	0042789	biological_process	mRNA transcription by RNA polymerase II
L	0043484	biological_process	regulation of RNA splicing
L	0045893	biological_process	positive regulation of DNA-templated transcription
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0046982	molecular_function	protein heterodimerization activity
L	0051123	biological_process	RNA polymerase II preinitiation complex assembly
L	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
L	0140297	molecular_function	DNA-binding transcription factor binding

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. VATGsaDrTVRLWDV

Chain	Residue	Details
E	VAL642-VAL656
E	LEU684-ILE698
E	LEU726-ALA740

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
L	THR43

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:18691976, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
L	SER51
D	ARG435

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:18691976

Chain	Residue	Details
L	THR59
D	LYS595
D	LYS597
D	LYS605
D	LYS611
D	LYS621
D	LYS631
D	LYS658

site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
L	LYS19
I	SER196

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q8VI33

Chain	Residue	Details
I	SER155

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:19690332

Chain	Residue	Details
I	SER158

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:19690332

Chain	Residue	Details
I	THR159
F	SER636

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
I	THR161

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:Q8VI33

Chain	Residue	Details
I	THR164

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
I	THR178

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
I	SER181

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)