7EGF

TFIID lobe A subcomplex

Functional Information from GO Data

Chain	GOid	namespace	contents
c	0000122	biological_process	negative regulation of transcription by RNA polymerase II
c	0001673	cellular_component	male germ cell nucleus
c	0002039	molecular_function	p53 binding
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005669	cellular_component	transcription factor TFIID complex
c	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
c	0031965	cellular_component	nuclear membrane
c	0042789	biological_process	mRNA transcription by RNA polymerase II
c	0043433	biological_process	negative regulation of DNA-binding transcription factor activity
c	0045944	biological_process	positive regulation of transcription by RNA polymerase II
c	0046872	molecular_function	metal ion binding
c	0046982	molecular_function	protein heterodimerization activity
c	0051123	biological_process	RNA polymerase II preinitiation complex assembly
c	0051457	biological_process	maintenance of protein location in nucleus
c	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
c	0140416	molecular_function	transcription regulator inhibitor activity
d	0000785	cellular_component	chromatin
d	0001046	molecular_function	core promoter sequence-specific DNA binding
d	0001541	biological_process	ovarian follicle development
d	0001673	cellular_component	male germ cell nucleus
d	0003677	molecular_function	DNA binding
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005667	cellular_component	transcription regulator complex
d	0005669	cellular_component	transcription factor TFIID complex
d	0005829	cellular_component	cytosol
d	0006282	biological_process	regulation of DNA repair
d	0006351	biological_process	DNA-templated transcription
d	0006352	biological_process	DNA-templated transcription initiation
d	0006357	biological_process	regulation of transcription by RNA polymerase II
d	0006366	biological_process	transcription by RNA polymerase II
d	0006367	biological_process	transcription initiation at RNA polymerase II promoter
d	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
d	0017162	molecular_function	aryl hydrocarbon receptor binding
d	0032991	cellular_component	protein-containing complex
d	0033276	cellular_component	transcription factor TFTC complex
d	0042789	biological_process	mRNA transcription by RNA polymerase II
d	0045893	biological_process	positive regulation of DNA-templated transcription
d	0046982	molecular_function	protein heterodimerization activity
d	0051123	biological_process	RNA polymerase II preinitiation complex assembly
d	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
d	0071339	cellular_component	MLL1 complex
e	0000785	cellular_component	chromatin
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005669	cellular_component	transcription factor TFIID complex
e	0005730	cellular_component	nucleolus
e	0006282	biological_process	regulation of DNA repair
e	0006352	biological_process	DNA-templated transcription initiation
e	0006357	biological_process	regulation of transcription by RNA polymerase II
e	0006367	biological_process	transcription initiation at RNA polymerase II promoter
e	0015629	cellular_component	actin cytoskeleton
e	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
e	0033276	cellular_component	transcription factor TFTC complex
e	0042789	biological_process	mRNA transcription by RNA polymerase II
e	0042802	molecular_function	identical protein binding
e	0045893	biological_process	positive regulation of DNA-templated transcription
e	0051123	biological_process	RNA polymerase II preinitiation complex assembly
e	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
f	0000124	cellular_component	SAGA complex
f	0003677	molecular_function	DNA binding
f	0003713	molecular_function	transcription coactivator activity
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005669	cellular_component	transcription factor TFIID complex
f	0005829	cellular_component	cytosol
f	0006282	biological_process	regulation of DNA repair
f	0006352	biological_process	DNA-templated transcription initiation
f	0006357	biological_process	regulation of transcription by RNA polymerase II
f	0006366	biological_process	transcription by RNA polymerase II
f	0006367	biological_process	transcription initiation at RNA polymerase II promoter
f	0006915	biological_process	apoptotic process
f	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
f	0017162	molecular_function	aryl hydrocarbon receptor binding
f	0032991	cellular_component	protein-containing complex
f	0033276	cellular_component	transcription factor TFTC complex
f	0042789	biological_process	mRNA transcription by RNA polymerase II
f	0045786	biological_process	negative regulation of cell cycle
f	0045893	biological_process	positive regulation of DNA-templated transcription
f	0046695	cellular_component	SLIK (SAGA-like) complex
f	0046982	molecular_function	protein heterodimerization activity
f	0051123	biological_process	RNA polymerase II preinitiation complex assembly
f	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
f	0071339	cellular_component	MLL1 complex
i	0000124	cellular_component	SAGA complex
i	0000492	biological_process	box C/D snoRNP assembly
i	0000976	molecular_function	transcription cis-regulatory region binding
i	0002039	molecular_function	p53 binding
i	0003677	molecular_function	DNA binding
i	0003713	molecular_function	transcription coactivator activity
i	0004402	molecular_function	histone acetyltransferase activity
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005669	cellular_component	transcription factor TFIID complex
i	0006282	biological_process	regulation of DNA repair
i	0006338	biological_process	chromatin remodeling
i	0006352	biological_process	DNA-templated transcription initiation
i	0006355	biological_process	regulation of DNA-templated transcription
i	0006357	biological_process	regulation of transcription by RNA polymerase II
i	0006974	biological_process	DNA damage response
i	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
i	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
i	0033276	cellular_component	transcription factor TFTC complex
i	0042789	biological_process	mRNA transcription by RNA polymerase II
i	0043066	biological_process	negative regulation of apoptotic process
i	0043484	biological_process	regulation of RNA splicing
i	0045893	biological_process	positive regulation of DNA-templated transcription
i	0045944	biological_process	positive regulation of transcription by RNA polymerase II
i	0046982	molecular_function	protein heterodimerization activity
i	0050821	biological_process	protein stabilization
i	0051117	molecular_function	ATPase binding
i	0051123	biological_process	RNA polymerase II preinitiation complex assembly
i	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
i	0060760	biological_process	positive regulation of response to cytokine stimulus
i	0070555	biological_process	response to interleukin-1
i	0070742	molecular_function	C2H2 zinc finger domain binding
i	0070761	cellular_component	pre-snoRNP complex
i	0071339	cellular_component	MLL1 complex
i	0140297	molecular_function	DNA-binding transcription factor binding
i	1902065	biological_process	response to L-glutamate
i	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
j	0000082	biological_process	G1/S transition of mitotic cell cycle
j	0000124	cellular_component	SAGA complex
j	0001673	cellular_component	male germ cell nucleus
j	0001701	biological_process	in utero embryonic development
j	0001756	biological_process	somitogenesis
j	0001889	biological_process	liver development
j	0001892	biological_process	embryonic placenta development
j	0003677	molecular_function	DNA binding
j	0004402	molecular_function	histone acetyltransferase activity
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005669	cellular_component	transcription factor TFIID complex
j	0005737	cellular_component	cytoplasm
j	0006282	biological_process	regulation of DNA repair
j	0006338	biological_process	chromatin remodeling
j	0006352	biological_process	DNA-templated transcription initiation
j	0006355	biological_process	regulation of DNA-templated transcription
j	0006357	biological_process	regulation of transcription by RNA polymerase II
j	0006366	biological_process	transcription by RNA polymerase II
j	0006367	biological_process	transcription initiation at RNA polymerase II promoter
j	0006915	biological_process	apoptotic process
j	0010467	biological_process	gene expression
j	0010468	biological_process	regulation of gene expression
j	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
j	0019899	molecular_function	enzyme binding
j	0030331	molecular_function	nuclear estrogen receptor binding
j	0033276	cellular_component	transcription factor TFTC complex
j	0035264	biological_process	multicellular organism growth
j	0036285	biological_process	SAGA complex assembly
j	0042789	biological_process	mRNA transcription by RNA polymerase II
j	0042802	molecular_function	identical protein binding
j	0043484	biological_process	regulation of RNA splicing
j	0045893	biological_process	positive regulation of DNA-templated transcription
j	0048371	biological_process	lateral mesodermal cell differentiation
j	0048471	cellular_component	perinuclear region of cytoplasm
j	0051123	biological_process	RNA polymerase II preinitiation complex assembly
j	0060173	biological_process	limb development
j	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
j	0065003	biological_process	protein-containing complex assembly
j	0070063	molecular_function	RNA polymerase binding
j	0070365	biological_process	hepatocyte differentiation
j	0097550	cellular_component	transcription preinitiation complex
j	1905069	biological_process	allantois development
j	1990841	molecular_function	promoter-specific chromatin binding
k	0003713	molecular_function	transcription coactivator activity
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0005669	cellular_component	transcription factor TFIID complex
k	0005794	cellular_component	Golgi apparatus
k	0006366	biological_process	transcription by RNA polymerase II
k	0006367	biological_process	transcription initiation at RNA polymerase II promoter
k	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
k	0017025	molecular_function	TBP-class protein binding
k	0042789	biological_process	mRNA transcription by RNA polymerase II
k	0042809	molecular_function	nuclear vitamin D receptor binding
k	0043923	biological_process	positive regulation by host of viral transcription
k	0046966	molecular_function	nuclear thyroid hormone receptor binding
k	0046982	molecular_function	protein heterodimerization activity
k	0051123	biological_process	RNA polymerase II preinitiation complex assembly
k	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
l	0000124	cellular_component	SAGA complex
l	0003677	molecular_function	DNA binding
l	0003713	molecular_function	transcription coactivator activity
l	0005515	molecular_function	protein binding
l	0005634	cellular_component	nucleus
l	0005654	cellular_component	nucleoplasm
l	0005669	cellular_component	transcription factor TFIID complex
l	0006282	biological_process	regulation of DNA repair
l	0006352	biological_process	DNA-templated transcription initiation
l	0006355	biological_process	regulation of DNA-templated transcription
l	0006357	biological_process	regulation of transcription by RNA polymerase II
l	0006366	biological_process	transcription by RNA polymerase II
l	0006367	biological_process	transcription initiation at RNA polymerase II promoter
l	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
l	0017025	molecular_function	TBP-class protein binding
l	0033276	cellular_component	transcription factor TFTC complex
l	0042789	biological_process	mRNA transcription by RNA polymerase II
l	0043484	biological_process	regulation of RNA splicing
l	0045893	biological_process	positive regulation of DNA-templated transcription
l	0045944	biological_process	positive regulation of transcription by RNA polymerase II
l	0046982	molecular_function	protein heterodimerization activity
l	0051123	biological_process	RNA polymerase II preinitiation complex assembly
l	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
l	0140297	molecular_function	DNA-binding transcription factor binding
m	0003677	molecular_function	DNA binding
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005669	cellular_component	transcription factor TFIID complex
m	0005730	cellular_component	nucleolus
m	0006352	biological_process	DNA-templated transcription initiation
m	0006366	biological_process	transcription by RNA polymerase II
m	0006367	biological_process	transcription initiation at RNA polymerase II promoter
m	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
m	0017025	molecular_function	TBP-class protein binding
m	0042789	biological_process	mRNA transcription by RNA polymerase II
m	0046982	molecular_function	protein heterodimerization activity
m	0051123	biological_process	RNA polymerase II preinitiation complex assembly
m	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
P	0000785	cellular_component	chromatin
P	0000791	cellular_component	euchromatin
P	0000976	molecular_function	transcription cis-regulatory region binding
P	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
P	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
P	0000995	molecular_function	RNA polymerase III general transcription initiation factor activity
P	0001046	molecular_function	core promoter sequence-specific DNA binding
P	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
P	0001093	molecular_function	TFIIB-class transcription factor binding
P	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
P	0001188	biological_process	RNA polymerase I preinitiation complex assembly
P	0001673	cellular_component	male germ cell nucleus
P	0001674	cellular_component	female germ cell nucleus
P	0001939	cellular_component	female pronucleus
P	0001940	cellular_component	male pronucleus
P	0003677	molecular_function	DNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005668	cellular_component	RNA polymerase transcription factor SL1 complex
P	0005669	cellular_component	transcription factor TFIID complex
P	0005672	cellular_component	transcription factor TFIIA complex
P	0005737	cellular_component	cytoplasm
P	0006352	biological_process	DNA-templated transcription initiation
P	0006366	biological_process	transcription by RNA polymerase II
P	0006367	biological_process	transcription initiation at RNA polymerase II promoter
P	0006383	biological_process	transcription by RNA polymerase III
P	0007283	biological_process	spermatogenesis
P	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
P	0017162	molecular_function	aryl hydrocarbon receptor binding
P	0019899	molecular_function	enzyme binding
P	0032991	cellular_component	protein-containing complex
P	0042789	biological_process	mRNA transcription by RNA polymerase II
P	0045120	cellular_component	pronucleus
P	0045893	biological_process	positive regulation of DNA-templated transcription
P	0051123	biological_process	RNA polymerase II preinitiation complex assembly
P	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
P	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
P	0140297	molecular_function	DNA-binding transcription factor binding

Functional Information from PROSITE/UniProt

site_id	PS00351
Number of Residues	50
Details	TFIID Transcription factor TFIID repeat signature. YnPkrFaaVImRirePRttaLIFsSGKMvctGAKseeqsrlAarkyarvV

Chain	Residue	Details
P	TYR192-VAL241
P	TYR283-LEU332

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. VATGsaDrTVRLWDV

Chain	Residue	Details
e	VAL642-VAL656
e	LEU684-ILE698
e	LEU726-ALA740

---

site_id	PS01359
Number of Residues	45
Details	ZF_PHD_1 Zinc finger PHD-type signature. CpgCnkpddgspm....................................IgCdd..Cddw.YHwpCvgimtappeemq.................................WfCpkC

Chain	Residue	Details
c	CYS868-CYS912

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
l	THR43
P	ARG203
P	LYS218
P	ASN257
P	ARG294

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
l	SER51
d	ARG435
c	CYS883
c	CYS886
c	HIS891
c	CYS894
c	CYS909
c	CYS912

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976

Chain	Residue	Details
l	THR59
d	LYS595
d	LYS597
d	LYS605
d	LYS611
d	LYS621
d	LYS631
d	LYS658

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
l	LYS19
i	SER196
c	SER755

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8VI33

Chain	Residue	Details
i	SER155
c	SER243

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
i	SER158
c	LYS776

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
i	THR159
f	SER636

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
i	THR161
c	SER301

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q8VI33

Chain	Residue	Details
i	THR164

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
i	THR178

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
i	SER181
c	LYS746

---