Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7EGC

p53-bound TFIID-based holo PIC on HDM2 promoter

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0000082	biological_process	G1/S transition of mitotic cell cycle
0	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
0	0000439	cellular_component	transcription factor TFIIH core complex
0	0005515	molecular_function	protein binding
0	0005634	cellular_component	nucleus
0	0005654	cellular_component	nucleoplasm
0	0005675	cellular_component	transcription factor TFIIH holo complex
0	0006281	biological_process	DNA repair
0	0006289	biological_process	nucleotide-excision repair
0	0006355	biological_process	regulation of DNA-templated transcription
0	0006357	biological_process	regulation of transcription by RNA polymerase II
0	0006367	biological_process	transcription initiation at RNA polymerase II promoter
0	0007512	biological_process	adult heart development
0	0008270	molecular_function	zinc ion binding
0	0021591	biological_process	ventricular system development
0	0043066	biological_process	negative regulation of apoptotic process
0	0045737	biological_process	positive regulation of cyclin-dependent protein serine/threonine kinase activity
0	0046872	molecular_function	metal ion binding
0	0048661	biological_process	positive regulation of smooth muscle cell proliferation
0	0051592	biological_process	response to calcium ion
0	0061575	molecular_function	cyclin-dependent protein serine/threonine kinase activator activity
0	0070516	cellular_component	CAK-ERCC2 complex
0	0070985	cellular_component	transcription factor TFIIK complex
0	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
1	0000079	biological_process	regulation of cyclin-dependent protein serine/threonine kinase activity
1	0000439	cellular_component	transcription factor TFIIH core complex
1	0003682	molecular_function	chromatin binding
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005654	cellular_component	nucleoplasm
1	0005675	cellular_component	transcription factor TFIIH holo complex
1	0006281	biological_process	DNA repair
1	0006289	biological_process	nucleotide-excision repair
1	0006351	biological_process	DNA-templated transcription
1	0006360	biological_process	transcription by RNA polymerase I
1	0006366	biological_process	transcription by RNA polymerase II
1	0006367	biological_process	transcription initiation at RNA polymerase II promoter
1	0006974	biological_process	DNA damage response
1	0009755	biological_process	hormone-mediated signaling pathway
1	0045893	biological_process	positive regulation of DNA-templated transcription
1	0046966	molecular_function	nuclear thyroid hormone receptor binding
2	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
2	0000439	cellular_component	transcription factor TFIIH core complex
2	0002031	biological_process	G protein-coupled receptor internalization
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005669	cellular_component	transcription factor TFIID complex
2	0005675	cellular_component	transcription factor TFIIH holo complex
2	0006281	biological_process	DNA repair
2	0006289	biological_process	nucleotide-excision repair
2	0006351	biological_process	DNA-templated transcription
2	0006357	biological_process	regulation of transcription by RNA polymerase II
2	0006366	biological_process	transcription by RNA polymerase II
2	0006367	biological_process	transcription initiation at RNA polymerase II promoter
2	0006974	biological_process	DNA damage response
2	0008270	molecular_function	zinc ion binding
2	0009411	biological_process	response to UV
2	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
2	0016607	cellular_component	nuclear speck
2	0046872	molecular_function	metal ion binding
3	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
3	0000439	cellular_component	transcription factor TFIIH core complex
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005669	cellular_component	transcription factor TFIID complex
3	0005675	cellular_component	transcription factor TFIIH holo complex
3	0006281	biological_process	DNA repair
3	0006289	biological_process	nucleotide-excision repair
3	0006355	biological_process	regulation of DNA-templated transcription
3	0006366	biological_process	transcription by RNA polymerase II
3	0006974	biological_process	DNA damage response
3	0008270	molecular_function	zinc ion binding
3	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
3	0046872	molecular_function	metal ion binding
3	0097550	cellular_component	transcription preinitiation complex
4	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
4	0000439	cellular_component	transcription factor TFIIH core complex
4	0001671	molecular_function	ATPase activator activity
4	0003690	molecular_function	double-stranded DNA binding
4	0005515	molecular_function	protein binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005669	cellular_component	transcription factor TFIID complex
4	0005675	cellular_component	transcription factor TFIIH holo complex
4	0006281	biological_process	DNA repair
4	0006289	biological_process	nucleotide-excision repair
4	0006366	biological_process	transcription by RNA polymerase II
4	0006974	biological_process	DNA damage response
4	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
4	0016607	cellular_component	nuclear speck
5	0000439	cellular_component	transcription factor TFIIH core complex
5	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
5	0005515	molecular_function	protein binding
5	0005634	cellular_component	nucleus
5	0005654	cellular_component	nucleoplasm
5	0005669	cellular_component	transcription factor TFIID complex
5	0005675	cellular_component	transcription factor TFIIH holo complex
5	0005730	cellular_component	nucleolus
5	0005737	cellular_component	cytoplasm
5	0006281	biological_process	DNA repair
5	0006289	biological_process	nucleotide-excision repair
5	0006294	biological_process	nucleotide-excision repair, preincision complex assembly
5	0006362	biological_process	transcription elongation by RNA polymerase I
5	0006366	biological_process	transcription by RNA polymerase II
5	0006367	biological_process	transcription initiation at RNA polymerase II promoter
5	0006974	biological_process	DNA damage response
5	0071480	biological_process	cellular response to gamma radiation
6	0000112	cellular_component	nucleotide-excision repair factor 3 complex
6	0000166	molecular_function	nucleotide binding
6	0000439	cellular_component	transcription factor TFIIH core complex
6	0003677	molecular_function	DNA binding
6	0003678	molecular_function	DNA helicase activity
6	0003684	molecular_function	damaged DNA binding
6	0004386	molecular_function	helicase activity
6	0005515	molecular_function	protein binding
6	0005524	molecular_function	ATP binding
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0005669	cellular_component	transcription factor TFIID complex
6	0005675	cellular_component	transcription factor TFIIH holo complex
6	0006265	biological_process	DNA topological change
6	0006281	biological_process	DNA repair
6	0006283	biological_process	transcription-coupled nucleotide-excision repair
6	0006289	biological_process	nucleotide-excision repair
6	0006366	biological_process	transcription by RNA polymerase II
6	0006367	biological_process	transcription initiation at RNA polymerase II promoter
6	0006368	biological_process	transcription elongation by RNA polymerase II
6	0006915	biological_process	apoptotic process
6	0006974	biological_process	DNA damage response
6	0006979	biological_process	response to oxidative stress
6	0008104	biological_process	intracellular protein localization
6	0009411	biological_process	response to UV
6	0009650	biological_process	UV protection
6	0016787	molecular_function	hydrolase activity
6	0016853	molecular_function	isomerase activity
6	0016887	molecular_function	ATP hydrolysis activity
6	0035315	biological_process	hair cell differentiation
6	0043065	biological_process	positive regulation of apoptotic process
6	0043138	molecular_function	3'-5' DNA helicase activity
6	0048568	biological_process	embryonic organ development
6	0097550	cellular_component	transcription preinitiation complex
6	1901990	biological_process	regulation of mitotic cell cycle phase transition
6	1990841	molecular_function	promoter-specific chromatin binding
7	0000166	molecular_function	nucleotide binding
7	0000439	cellular_component	transcription factor TFIIH core complex
7	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
7	0001666	biological_process	response to hypoxia
7	0001701	biological_process	in utero embryonic development
7	0003676	molecular_function	nucleic acid binding
7	0003677	molecular_function	DNA binding
7	0003678	molecular_function	DNA helicase activity
7	0003684	molecular_function	damaged DNA binding
7	0004386	molecular_function	helicase activity
7	0005515	molecular_function	protein binding
7	0005524	molecular_function	ATP binding
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005669	cellular_component	transcription factor TFIID complex
7	0005675	cellular_component	transcription factor TFIIH holo complex
7	0005737	cellular_component	cytoplasm
7	0005819	cellular_component	spindle
7	0005829	cellular_component	cytosol
7	0006139	biological_process	nucleobase-containing compound metabolic process
7	0006281	biological_process	DNA repair
7	0006283	biological_process	transcription-coupled nucleotide-excision repair
7	0006289	biological_process	nucleotide-excision repair
7	0006351	biological_process	DNA-templated transcription
7	0006357	biological_process	regulation of transcription by RNA polymerase II
7	0006362	biological_process	transcription elongation by RNA polymerase I
7	0006366	biological_process	transcription by RNA polymerase II
7	0006367	biological_process	transcription initiation at RNA polymerase II promoter
7	0006915	biological_process	apoptotic process
7	0006974	biological_process	DNA damage response
7	0006979	biological_process	response to oxidative stress
7	0007059	biological_process	chromosome segregation
7	0008340	biological_process	determination of adult lifespan
7	0009411	biological_process	response to UV
7	0009650	biological_process	UV protection
7	0009791	biological_process	post-embryonic development
7	0016787	molecular_function	hydrolase activity
7	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
7	0016853	molecular_function	isomerase activity
7	0016887	molecular_function	ATP hydrolysis activity
7	0021510	biological_process	spinal cord development
7	0022405	biological_process	hair cycle process
7	0030198	biological_process	extracellular matrix organization
7	0030282	biological_process	bone mineralization
7	0030674	molecular_function	protein-macromolecule adaptor activity
7	0032289	biological_process	central nervous system myelin formation
7	0035264	biological_process	multicellular organism growth
7	0035315	biological_process	hair cell differentiation
7	0040016	biological_process	embryonic cleavage
7	0042274	biological_process	ribosomal small subunit biogenesis
7	0043139	molecular_function	5'-3' DNA helicase activity
7	0043249	biological_process	erythrocyte maturation
7	0043588	biological_process	skin development
7	0045951	biological_process	positive regulation of mitotic recombination
7	0046872	molecular_function	metal ion binding
7	0048009	biological_process	insulin-like growth factor receptor signaling pathway
7	0048568	biological_process	embryonic organ development
7	0048820	biological_process	hair follicle maturation
7	0051536	molecular_function	iron-sulfur cluster binding
7	0051539	molecular_function	4 iron, 4 sulfur cluster binding
7	0060218	biological_process	hematopoietic stem cell differentiation
7	0070516	cellular_component	CAK-ERCC2 complex
7	0071425	biological_process	hematopoietic stem cell proliferation
7	0071817	cellular_component	MMXD complex
7	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
7	1901990	biological_process	regulation of mitotic cell cycle phase transition
8	0000166	molecular_function	nucleotide binding
8	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
8	0000439	cellular_component	transcription factor TFIIH core complex
8	0001650	cellular_component	fibrillar center
8	0001673	cellular_component	male germ cell nucleus
8	0004672	molecular_function	protein kinase activity
8	0004674	molecular_function	protein serine/threonine kinase activity
8	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
8	0005515	molecular_function	protein binding
8	0005524	molecular_function	ATP binding
8	0005634	cellular_component	nucleus
8	0005654	cellular_component	nucleoplasm
8	0005675	cellular_component	transcription factor TFIIH holo complex
8	0005737	cellular_component	cytoplasm
8	0005829	cellular_component	cytosol
8	0005886	cellular_component	plasma membrane
8	0006281	biological_process	DNA repair
8	0006366	biological_process	transcription by RNA polymerase II
8	0006367	biological_process	transcription initiation at RNA polymerase II promoter
8	0006468	biological_process	protein phosphorylation
8	0006974	biological_process	DNA damage response
8	0008094	molecular_function	ATP-dependent activity, acting on DNA
8	0008353	molecular_function	RNA polymerase II CTD heptapeptide repeat kinase activity
8	0016301	molecular_function	kinase activity
8	0016740	molecular_function	transferase activity
8	0042795	biological_process	snRNA transcription by RNA polymerase II
8	0045944	biological_process	positive regulation of transcription by RNA polymerase II
8	0048471	cellular_component	perinuclear region of cytoplasm
8	0050821	biological_process	protein stabilization
8	0051301	biological_process	cell division
8	0051726	biological_process	regulation of cell cycle
8	0070516	cellular_component	CAK-ERCC2 complex
8	0070985	cellular_component	transcription factor TFIIK complex
8	0106310	molecular_function	protein serine kinase activity
8	0140836	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 kinase activity
8	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
9	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
9	0000439	cellular_component	transcription factor TFIIH core complex
9	0001673	cellular_component	male germ cell nucleus
9	0005515	molecular_function	protein binding
9	0005634	cellular_component	nucleus
9	0005654	cellular_component	nucleoplasm
9	0005675	cellular_component	transcription factor TFIIH holo complex
9	0006351	biological_process	DNA-templated transcription
9	0006357	biological_process	regulation of transcription by RNA polymerase II
9	0006367	biological_process	transcription initiation at RNA polymerase II promoter
9	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
9	0016301	molecular_function	kinase activity
9	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
9	0050821	biological_process	protein stabilization
9	0070516	cellular_component	CAK-ERCC2 complex
9	0070985	cellular_component	transcription factor TFIIK complex
9	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000166	molecular_function	nucleotide binding
A	0000209	biological_process	protein polyubiquitination
A	0000785	cellular_component	chromatin
A	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
A	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
A	0001181	molecular_function	RNA polymerase I general transcription initiation factor activity
A	0002039	molecular_function	p53 binding
A	0003677	molecular_function	DNA binding
A	0004402	molecular_function	histone acetyltransferase activity
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005667	cellular_component	transcription regulator complex
A	0005669	cellular_component	transcription factor TFIID complex
A	0005730	cellular_component	nucleolus
A	0006325	biological_process	chromatin organization
A	0006338	biological_process	chromatin remodeling
A	0006352	biological_process	DNA-templated transcription initiation
A	0006361	biological_process	transcription initiation at RNA polymerase I promoter
A	0006366	biological_process	transcription by RNA polymerase II
A	0006367	biological_process	transcription initiation at RNA polymerase II promoter
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006974	biological_process	DNA damage response
A	0010629	biological_process	negative regulation of gene expression
A	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016922	molecular_function	nuclear receptor binding
A	0017025	molecular_function	TBP-class protein binding
A	0030901	biological_process	midbrain development
A	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0034644	biological_process	cellular response to UV
A	0042789	biological_process	mRNA transcription by RNA polymerase II
A	0043565	molecular_function	sequence-specific DNA binding
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046777	biological_process	protein autophosphorylation
A	0046982	molecular_function	protein heterodimerization activity
A	0050821	biological_process	protein stabilization
A	0051123	biological_process	RNA polymerase II preinitiation complex assembly
A	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
A	0061628	molecular_function	histone H3K27me3 reader activity
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0061631	molecular_function	ubiquitin conjugating enzyme activity
A	0061733	molecular_function	protein-lysine-acetyltransferase activity
A	0071318	biological_process	cellular response to ATP
A	0071339	cellular_component	MLL1 complex
A	0106310	molecular_function	protein serine kinase activity
A	0140046	molecular_function	histone H4K16ac reader activity
A	0140416	molecular_function	transcription regulator inhibitor activity
A	0140566	molecular_function	histone reader activity
A	0160207	biological_process	positive regulation of androgen receptor signaling pathway
A	1901796	biological_process	regulation of signal transduction by p53 class mediator
A	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
A	1902806	biological_process	regulation of cell cycle G1/S phase transition
A	1905502	molecular_function	acetyl-CoA binding
A	1905524	biological_process	negative regulation of protein autoubiquitination
A	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
B	0000086	biological_process	G2/M transition of mitotic cell cycle
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0003682	molecular_function	chromatin binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005669	cellular_component	transcription factor TFIID complex
B	0006282	biological_process	regulation of DNA repair
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006367	biological_process	transcription initiation at RNA polymerase II promoter
B	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
B	0033276	cellular_component	transcription factor TFTC complex
B	0042789	biological_process	mRNA transcription by RNA polymerase II
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0051123	biological_process	RNA polymerase II preinitiation complex assembly
B	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
B	1901562	biological_process	response to paraquat
D	0000785	cellular_component	chromatin
D	0001046	molecular_function	core promoter sequence-specific DNA binding
D	0001541	biological_process	ovarian follicle development
D	0001673	cellular_component	male germ cell nucleus
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005669	cellular_component	transcription factor TFIID complex
D	0005829	cellular_component	cytosol
D	0006282	biological_process	regulation of DNA repair
D	0006351	biological_process	DNA-templated transcription
D	0006352	biological_process	DNA-templated transcription initiation
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006366	biological_process	transcription by RNA polymerase II
D	0006367	biological_process	transcription initiation at RNA polymerase II promoter
D	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
D	0017162	molecular_function	aryl hydrocarbon receptor binding
D	0032991	cellular_component	protein-containing complex
D	0033276	cellular_component	transcription factor TFTC complex
D	0042789	biological_process	mRNA transcription by RNA polymerase II
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0046982	molecular_function	protein heterodimerization activity
D	0051123	biological_process	RNA polymerase II preinitiation complex assembly
D	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
D	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
D	0071339	cellular_component	MLL1 complex
E	0000785	cellular_component	chromatin
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005669	cellular_component	transcription factor TFIID complex
E	0005730	cellular_component	nucleolus
E	0006282	biological_process	regulation of DNA repair
E	0006352	biological_process	DNA-templated transcription initiation
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0006367	biological_process	transcription initiation at RNA polymerase II promoter
E	0015629	cellular_component	actin cytoskeleton
E	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
E	0033276	cellular_component	transcription factor TFTC complex
E	0042789	biological_process	mRNA transcription by RNA polymerase II
E	0042802	molecular_function	identical protein binding
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0051123	biological_process	RNA polymerase II preinitiation complex assembly
E	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
F	0000124	cellular_component	SAGA complex
F	0003677	molecular_function	DNA binding
F	0003713	molecular_function	transcription coactivator activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005669	cellular_component	transcription factor TFIID complex
F	0005829	cellular_component	cytosol
F	0006282	biological_process	regulation of DNA repair
F	0006352	biological_process	DNA-templated transcription initiation
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006366	biological_process	transcription by RNA polymerase II
F	0006367	biological_process	transcription initiation at RNA polymerase II promoter
F	0006915	biological_process	apoptotic process
F	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
F	0017162	molecular_function	aryl hydrocarbon receptor binding
F	0032991	cellular_component	protein-containing complex
F	0033276	cellular_component	transcription factor TFTC complex
F	0042789	biological_process	mRNA transcription by RNA polymerase II
F	0045786	biological_process	negative regulation of cell cycle
F	0045893	biological_process	positive regulation of DNA-templated transcription
F	0046695	cellular_component	SLIK (SAGA-like) complex
F	0046982	molecular_function	protein heterodimerization activity
F	0051123	biological_process	RNA polymerase II preinitiation complex assembly
F	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
F	0071339	cellular_component	MLL1 complex
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0000296	biological_process	spermine transport
G	0000976	molecular_function	transcription cis-regulatory region binding
G	0001097	molecular_function	TFIIH-class transcription factor complex binding
G	0001673	cellular_component	male germ cell nucleus
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005667	cellular_component	transcription regulator complex
G	0005669	cellular_component	transcription factor TFIID complex
G	0005737	cellular_component	cytoplasm
G	0006282	biological_process	regulation of DNA repair
G	0006325	biological_process	chromatin organization
G	0006352	biological_process	DNA-templated transcription initiation
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0006366	biological_process	transcription by RNA polymerase II
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0006469	biological_process	negative regulation of protein kinase activity
G	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
G	0030520	biological_process	estrogen receptor signaling pathway
G	0033276	cellular_component	transcription factor TFTC complex
G	0035035	molecular_function	histone acetyltransferase binding
G	0042789	biological_process	mRNA transcription by RNA polymerase II
G	0042809	molecular_function	nuclear vitamin D receptor binding
G	0045344	biological_process	negative regulation of MHC class I biosynthetic process
G	0045347	biological_process	negative regulation of MHC class II biosynthetic process
G	0045892	biological_process	negative regulation of DNA-templated transcription
G	0045893	biological_process	positive regulation of DNA-templated transcription
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0046966	molecular_function	nuclear thyroid hormone receptor binding
G	0046982	molecular_function	protein heterodimerization activity
G	0051123	biological_process	RNA polymerase II preinitiation complex assembly
G	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
G	0061628	molecular_function	histone H3K27me3 reader activity
G	0071339	cellular_component	MLL1 complex
G	0106140	molecular_function	P-TEFb complex binding
G	0140297	molecular_function	DNA-binding transcription factor binding
H	0001112	biological_process	DNA-templated transcription open complex formation
H	0001833	biological_process	inner cell mass cell proliferation
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005669	cellular_component	transcription factor TFIID complex
H	0005737	cellular_component	cytoplasm
H	0006367	biological_process	transcription initiation at RNA polymerase II promoter
H	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
H	0030154	biological_process	cell differentiation
H	0042789	biological_process	mRNA transcription by RNA polymerase II
H	0045598	biological_process	regulation of fat cell differentiation
H	0046982	molecular_function	protein heterodimerization activity
H	0048471	cellular_component	perinuclear region of cytoplasm
H	0051123	biological_process	RNA polymerase II preinitiation complex assembly
H	0051457	biological_process	maintenance of protein location in nucleus
H	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
H	0097225	cellular_component	sperm midpiece
I	0000124	cellular_component	SAGA complex
I	0000492	biological_process	box C/D snoRNP assembly
I	0000976	molecular_function	transcription cis-regulatory region binding
I	0002039	molecular_function	p53 binding
I	0003677	molecular_function	DNA binding
I	0003713	molecular_function	transcription coactivator activity
I	0004402	molecular_function	histone acetyltransferase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005669	cellular_component	transcription factor TFIID complex
I	0006282	biological_process	regulation of DNA repair
I	0006338	biological_process	chromatin remodeling
I	0006352	biological_process	DNA-templated transcription initiation
I	0006355	biological_process	regulation of DNA-templated transcription
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0006974	biological_process	DNA damage response
I	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
I	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
I	0033276	cellular_component	transcription factor TFTC complex
I	0042789	biological_process	mRNA transcription by RNA polymerase II
I	0043066	biological_process	negative regulation of apoptotic process
I	0043484	biological_process	regulation of RNA splicing
I	0045893	biological_process	positive regulation of DNA-templated transcription
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0046982	molecular_function	protein heterodimerization activity
I	0050821	biological_process	protein stabilization
I	0051117	molecular_function	ATPase binding
I	0051123	biological_process	RNA polymerase II preinitiation complex assembly
I	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
I	0060760	biological_process	positive regulation of response to cytokine stimulus
I	0070555	biological_process	response to interleukin-1
I	0070742	molecular_function	C2H2 zinc finger domain binding
I	0070761	cellular_component	pre-snoRNP complex
I	0071339	cellular_component	MLL1 complex
I	0140297	molecular_function	DNA-binding transcription factor binding
I	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
J	0000082	biological_process	G1/S transition of mitotic cell cycle
J	0000124	cellular_component	SAGA complex
J	0001673	cellular_component	male germ cell nucleus
J	0001701	biological_process	in utero embryonic development
J	0001756	biological_process	somitogenesis
J	0001889	biological_process	liver development
J	0001892	biological_process	embryonic placenta development
J	0003677	molecular_function	DNA binding
J	0004402	molecular_function	histone acetyltransferase activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005669	cellular_component	transcription factor TFIID complex
J	0005737	cellular_component	cytoplasm
J	0006282	biological_process	regulation of DNA repair
J	0006338	biological_process	chromatin remodeling
J	0006352	biological_process	DNA-templated transcription initiation
J	0006355	biological_process	regulation of DNA-templated transcription
J	0006357	biological_process	regulation of transcription by RNA polymerase II
J	0006366	biological_process	transcription by RNA polymerase II
J	0006367	biological_process	transcription initiation at RNA polymerase II promoter
J	0006915	biological_process	apoptotic process
J	0010467	biological_process	gene expression
J	0010468	biological_process	regulation of gene expression
J	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
J	0019899	molecular_function	enzyme binding
J	0030331	molecular_function	nuclear estrogen receptor binding
J	0033276	cellular_component	transcription factor TFTC complex
J	0035264	biological_process	multicellular organism growth
J	0036285	biological_process	SAGA complex assembly
J	0042789	biological_process	mRNA transcription by RNA polymerase II
J	0042802	molecular_function	identical protein binding
J	0043484	biological_process	regulation of RNA splicing
J	0045893	biological_process	positive regulation of DNA-templated transcription
J	0048371	biological_process	lateral mesodermal cell differentiation
J	0048471	cellular_component	perinuclear region of cytoplasm
J	0051123	biological_process	RNA polymerase II preinitiation complex assembly
J	0060173	biological_process	limb development
J	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
J	0065003	biological_process	protein-containing complex assembly
J	0070063	molecular_function	RNA polymerase binding
J	0070365	biological_process	hepatocyte differentiation
J	0097550	cellular_component	transcription preinitiation complex
J	1905069	biological_process	allantois development
J	1990841	molecular_function	promoter-specific chromatin binding
L	0000124	cellular_component	SAGA complex
L	0003677	molecular_function	DNA binding
L	0003713	molecular_function	transcription coactivator activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005669	cellular_component	transcription factor TFIID complex
L	0006282	biological_process	regulation of DNA repair
L	0006352	biological_process	DNA-templated transcription initiation
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0006366	biological_process	transcription by RNA polymerase II
L	0006367	biological_process	transcription initiation at RNA polymerase II promoter
L	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
L	0017025	molecular_function	TBP-class protein binding
L	0033276	cellular_component	transcription factor TFTC complex
L	0042789	biological_process	mRNA transcription by RNA polymerase II
L	0043484	biological_process	regulation of RNA splicing
L	0045893	biological_process	positive regulation of DNA-templated transcription
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0046982	molecular_function	protein heterodimerization activity
L	0051123	biological_process	RNA polymerase II preinitiation complex assembly
L	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
L	0140297	molecular_function	DNA-binding transcription factor binding
O	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005669	cellular_component	transcription factor TFIID complex
O	0005672	cellular_component	transcription factor TFIIA complex
O	0005829	cellular_component	cytosol
O	0006366	biological_process	transcription by RNA polymerase II
O	0006367	biological_process	transcription initiation at RNA polymerase II promoter
O	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
O	0017025	molecular_function	TBP-class protein binding
O	0042803	molecular_function	protein homodimerization activity
O	0045944	biological_process	positive regulation of transcription by RNA polymerase II
O	0046982	molecular_function	protein heterodimerization activity
O	0051123	biological_process	RNA polymerase II preinitiation complex assembly
O	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
O	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
P	0000785	cellular_component	chromatin
P	0000791	cellular_component	euchromatin
P	0000976	molecular_function	transcription cis-regulatory region binding
P	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
P	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
P	0000995	molecular_function	RNA polymerase III general transcription initiation factor activity
P	0001046	molecular_function	core promoter sequence-specific DNA binding
P	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
P	0001093	molecular_function	TFIIB-class transcription factor binding
P	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
P	0001188	biological_process	RNA polymerase I preinitiation complex assembly
P	0001673	cellular_component	male germ cell nucleus
P	0001674	cellular_component	female germ cell nucleus
P	0001939	cellular_component	female pronucleus
P	0001940	cellular_component	male pronucleus
P	0003677	molecular_function	DNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005668	cellular_component	RNA polymerase transcription factor SL1 complex
P	0005669	cellular_component	transcription factor TFIID complex
P	0005672	cellular_component	transcription factor TFIIA complex
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006352	biological_process	DNA-templated transcription initiation
P	0006366	biological_process	transcription by RNA polymerase II
P	0006367	biological_process	transcription initiation at RNA polymerase II promoter
P	0006383	biological_process	transcription by RNA polymerase III
P	0007283	biological_process	spermatogenesis
P	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
P	0017162	molecular_function	aryl hydrocarbon receptor binding
P	0019899	molecular_function	enzyme binding
P	0032991	cellular_component	protein-containing complex
P	0042789	biological_process	mRNA transcription by RNA polymerase II
P	0045120	cellular_component	pronucleus
P	0045893	biological_process	positive regulation of DNA-templated transcription
P	0051123	biological_process	RNA polymerase II preinitiation complex assembly
P	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
P	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
P	0140297	molecular_function	DNA-binding transcription factor binding
Q	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
Q	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
Q	0003677	molecular_function	DNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005669	cellular_component	transcription factor TFIID complex
Q	0005672	cellular_component	transcription factor TFIIA complex
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0006366	biological_process	transcription by RNA polymerase II
Q	0006367	biological_process	transcription initiation at RNA polymerase II promoter
Q	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
Q	0017025	molecular_function	TBP-class protein binding
Q	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Q	0046982	molecular_function	protein heterodimerization activity
Q	0051123	biological_process	RNA polymerase II preinitiation complex assembly
Q	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
Q	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
Q	0097550	cellular_component	transcription preinitiation complex
R	0000776	cellular_component	kinetochore
R	0000793	cellular_component	condensed chromosome
R	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
R	0000993	molecular_function	RNA polymerase II complex binding
R	0001174	biological_process	transcriptional start site selection at RNA polymerase II promoter
R	0003677	molecular_function	DNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005669	cellular_component	transcription factor TFIID complex
R	0005694	cellular_component	chromosome
R	0006352	biological_process	DNA-templated transcription initiation
R	0006366	biological_process	transcription by RNA polymerase II
R	0006367	biological_process	transcription initiation at RNA polymerase II promoter
R	0006473	biological_process	protein acetylation
R	0008270	molecular_function	zinc ion binding
R	0010467	biological_process	gene expression
R	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
R	0016407	molecular_function	acetyltransferase activity
R	0016604	cellular_component	nuclear body
R	0016740	molecular_function	transferase activity
R	0016746	molecular_function	acyltransferase activity
R	0017025	molecular_function	TBP-class protein binding
R	0019083	biological_process	viral transcription
R	0032153	cellular_component	cell division site
R	0032993	cellular_component	protein-DNA complex
R	0042585	cellular_component	germinal vesicle
R	0046872	molecular_function	metal ion binding
R	0046966	molecular_function	nuclear thyroid hormone receptor binding
R	0051123	biological_process	RNA polymerase II preinitiation complex assembly
R	0051177	biological_process	meiotic sister chromatid cohesion
R	0051225	biological_process	spindle assembly
R	0051276	biological_process	chromosome organization
R	0061733	molecular_function	protein-lysine-acetyltransferase activity
R	0070897	biological_process	transcription preinitiation complex assembly
R	0090575	cellular_component	RNA polymerase II transcription regulator complex
R	0097550	cellular_component	transcription preinitiation complex
R	0140297	molecular_function	DNA-binding transcription factor binding
R	1904798	biological_process	positive regulation of core promoter binding
R	1990114	biological_process	RNA polymerase II core complex assembly
R	1990841	molecular_function	promoter-specific chromatin binding
S	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
S	0001096	molecular_function	TFIIF-class transcription factor complex binding
S	0003677	molecular_function	DNA binding
S	0003723	molecular_function	RNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005669	cellular_component	transcription factor TFIID complex
S	0005674	cellular_component	transcription factor TFIIF complex
S	0006366	biological_process	transcription by RNA polymerase II
S	0006367	biological_process	transcription initiation at RNA polymerase II promoter
S	0006368	biological_process	transcription elongation by RNA polymerase II
S	0009615	biological_process	response to virus
S	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
S	0019211	molecular_function	phosphatase activator activity
S	0019903	molecular_function	protein phosphatase binding
S	0019904	molecular_function	protein domain specific binding
S	0030054	cellular_component	cell junction
S	0032091	biological_process	negative regulation of protein binding
S	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
S	0032991	cellular_component	protein-containing complex
S	0045944	biological_process	positive regulation of transcription by RNA polymerase II
S	1990841	molecular_function	promoter-specific chromatin binding
T	0003677	molecular_function	DNA binding
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005674	cellular_component	transcription factor TFIIF complex
T	0006366	biological_process	transcription by RNA polymerase II
T	0006367	biological_process	transcription initiation at RNA polymerase II promoter
T	0006368	biological_process	transcription elongation by RNA polymerase II
T	0015630	cellular_component	microtubule cytoskeleton
T	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
T	0016591	cellular_component	RNA polymerase II, holoenzyme
T	0045944	biological_process	positive regulation of transcription by RNA polymerase II
T	0090575	cellular_component	RNA polymerase II transcription regulator complex
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005669	cellular_component	transcription factor TFIID complex
U	0005673	cellular_component	transcription factor TFIIE complex
U	0005829	cellular_component	cytosol
U	0006366	biological_process	transcription by RNA polymerase II
U	0006367	biological_process	transcription initiation at RNA polymerase II promoter
U	0008270	molecular_function	zinc ion binding
U	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
U	0046872	molecular_function	metal ion binding
V	0001097	molecular_function	TFIIH-class transcription factor complex binding
V	0003677	molecular_function	DNA binding
V	0003723	molecular_function	RNA binding
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005669	cellular_component	transcription factor TFIID complex
V	0005673	cellular_component	transcription factor TFIIE complex
V	0005829	cellular_component	cytosol
V	0006366	biological_process	transcription by RNA polymerase II
V	0006367	biological_process	transcription initiation at RNA polymerase II promoter
V	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
c	0000122	biological_process	negative regulation of transcription by RNA polymerase II
c	0001673	cellular_component	male germ cell nucleus
c	0002039	molecular_function	p53 binding
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005669	cellular_component	transcription factor TFIID complex
c	0006325	biological_process	chromatin organization
c	0006366	biological_process	transcription by RNA polymerase II
c	0008270	molecular_function	zinc ion binding
c	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
c	0031965	cellular_component	nuclear membrane
c	0042789	biological_process	mRNA transcription by RNA polymerase II
c	0045944	biological_process	positive regulation of transcription by RNA polymerase II
c	0046872	molecular_function	metal ion binding
c	0046982	molecular_function	protein heterodimerization activity
c	0051123	biological_process	RNA polymerase II preinitiation complex assembly
c	0051457	biological_process	maintenance of protein location in nucleus
c	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
c	0140002	molecular_function	histone H3K4me3 reader activity
c	0140416	molecular_function	transcription regulator inhibitor activity
c	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
d	0000785	cellular_component	chromatin
d	0001046	molecular_function	core promoter sequence-specific DNA binding
d	0001541	biological_process	ovarian follicle development
d	0001673	cellular_component	male germ cell nucleus
d	0003677	molecular_function	DNA binding
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005669	cellular_component	transcription factor TFIID complex
d	0005829	cellular_component	cytosol
d	0006282	biological_process	regulation of DNA repair
d	0006351	biological_process	DNA-templated transcription
d	0006352	biological_process	DNA-templated transcription initiation
d	0006357	biological_process	regulation of transcription by RNA polymerase II
d	0006366	biological_process	transcription by RNA polymerase II
d	0006367	biological_process	transcription initiation at RNA polymerase II promoter
d	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
d	0017162	molecular_function	aryl hydrocarbon receptor binding
d	0032991	cellular_component	protein-containing complex
d	0033276	cellular_component	transcription factor TFTC complex
d	0042789	biological_process	mRNA transcription by RNA polymerase II
d	0045893	biological_process	positive regulation of DNA-templated transcription
d	0046982	molecular_function	protein heterodimerization activity
d	0051123	biological_process	RNA polymerase II preinitiation complex assembly
d	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
d	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
d	0071339	cellular_component	MLL1 complex
e	0000785	cellular_component	chromatin
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005669	cellular_component	transcription factor TFIID complex
e	0005730	cellular_component	nucleolus
e	0006282	biological_process	regulation of DNA repair
e	0006352	biological_process	DNA-templated transcription initiation
e	0006357	biological_process	regulation of transcription by RNA polymerase II
e	0006367	biological_process	transcription initiation at RNA polymerase II promoter
e	0015629	cellular_component	actin cytoskeleton
e	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
e	0033276	cellular_component	transcription factor TFTC complex
e	0042789	biological_process	mRNA transcription by RNA polymerase II
e	0042802	molecular_function	identical protein binding
e	0045893	biological_process	positive regulation of DNA-templated transcription
e	0051123	biological_process	RNA polymerase II preinitiation complex assembly
e	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
f	0000124	cellular_component	SAGA complex
f	0003677	molecular_function	DNA binding
f	0003713	molecular_function	transcription coactivator activity
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005669	cellular_component	transcription factor TFIID complex
f	0005829	cellular_component	cytosol
f	0006282	biological_process	regulation of DNA repair
f	0006352	biological_process	DNA-templated transcription initiation
f	0006357	biological_process	regulation of transcription by RNA polymerase II
f	0006366	biological_process	transcription by RNA polymerase II
f	0006367	biological_process	transcription initiation at RNA polymerase II promoter
f	0006915	biological_process	apoptotic process
f	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
f	0017162	molecular_function	aryl hydrocarbon receptor binding
f	0032991	cellular_component	protein-containing complex
f	0033276	cellular_component	transcription factor TFTC complex
f	0042789	biological_process	mRNA transcription by RNA polymerase II
f	0045786	biological_process	negative regulation of cell cycle
f	0045893	biological_process	positive regulation of DNA-templated transcription
f	0046695	cellular_component	SLIK (SAGA-like) complex
f	0046982	molecular_function	protein heterodimerization activity
f	0051123	biological_process	RNA polymerase II preinitiation complex assembly
f	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
f	0071339	cellular_component	MLL1 complex
i	0000124	cellular_component	SAGA complex
i	0000492	biological_process	box C/D snoRNP assembly
i	0000976	molecular_function	transcription cis-regulatory region binding
i	0002039	molecular_function	p53 binding
i	0003677	molecular_function	DNA binding
i	0003713	molecular_function	transcription coactivator activity
i	0004402	molecular_function	histone acetyltransferase activity
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005669	cellular_component	transcription factor TFIID complex
i	0006282	biological_process	regulation of DNA repair
i	0006338	biological_process	chromatin remodeling
i	0006352	biological_process	DNA-templated transcription initiation
i	0006355	biological_process	regulation of DNA-templated transcription
i	0006357	biological_process	regulation of transcription by RNA polymerase II
i	0006974	biological_process	DNA damage response
i	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
i	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
i	0033276	cellular_component	transcription factor TFTC complex
i	0042789	biological_process	mRNA transcription by RNA polymerase II
i	0043066	biological_process	negative regulation of apoptotic process
i	0043484	biological_process	regulation of RNA splicing
i	0045893	biological_process	positive regulation of DNA-templated transcription
i	0045944	biological_process	positive regulation of transcription by RNA polymerase II
i	0046982	molecular_function	protein heterodimerization activity
i	0050821	biological_process	protein stabilization
i	0051117	molecular_function	ATPase binding
i	0051123	biological_process	RNA polymerase II preinitiation complex assembly
i	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
i	0060760	biological_process	positive regulation of response to cytokine stimulus
i	0070555	biological_process	response to interleukin-1
i	0070742	molecular_function	C2H2 zinc finger domain binding
i	0070761	cellular_component	pre-snoRNP complex
i	0071339	cellular_component	MLL1 complex
i	0140297	molecular_function	DNA-binding transcription factor binding
i	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
j	0000082	biological_process	G1/S transition of mitotic cell cycle
j	0000124	cellular_component	SAGA complex
j	0001673	cellular_component	male germ cell nucleus
j	0001701	biological_process	in utero embryonic development
j	0001756	biological_process	somitogenesis
j	0001889	biological_process	liver development
j	0001892	biological_process	embryonic placenta development
j	0003677	molecular_function	DNA binding
j	0004402	molecular_function	histone acetyltransferase activity
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005669	cellular_component	transcription factor TFIID complex
j	0005737	cellular_component	cytoplasm
j	0006282	biological_process	regulation of DNA repair
j	0006338	biological_process	chromatin remodeling
j	0006352	biological_process	DNA-templated transcription initiation
j	0006355	biological_process	regulation of DNA-templated transcription
j	0006357	biological_process	regulation of transcription by RNA polymerase II
j	0006366	biological_process	transcription by RNA polymerase II
j	0006367	biological_process	transcription initiation at RNA polymerase II promoter
j	0006915	biological_process	apoptotic process
j	0010467	biological_process	gene expression
j	0010468	biological_process	regulation of gene expression
j	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
j	0019899	molecular_function	enzyme binding
j	0030331	molecular_function	nuclear estrogen receptor binding
j	0033276	cellular_component	transcription factor TFTC complex
j	0035264	biological_process	multicellular organism growth
j	0036285	biological_process	SAGA complex assembly
j	0042789	biological_process	mRNA transcription by RNA polymerase II
j	0042802	molecular_function	identical protein binding
j	0043484	biological_process	regulation of RNA splicing
j	0045893	biological_process	positive regulation of DNA-templated transcription
j	0048371	biological_process	lateral mesodermal cell differentiation
j	0048471	cellular_component	perinuclear region of cytoplasm
j	0051123	biological_process	RNA polymerase II preinitiation complex assembly
j	0060173	biological_process	limb development
j	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
j	0065003	biological_process	protein-containing complex assembly
j	0070063	molecular_function	RNA polymerase binding
j	0070365	biological_process	hepatocyte differentiation
j	0097550	cellular_component	transcription preinitiation complex
j	1905069	biological_process	allantois development
j	1990841	molecular_function	promoter-specific chromatin binding
k	0003713	molecular_function	transcription coactivator activity
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0005669	cellular_component	transcription factor TFIID complex
k	0005794	cellular_component	Golgi apparatus
k	0006366	biological_process	transcription by RNA polymerase II
k	0006367	biological_process	transcription initiation at RNA polymerase II promoter
k	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
k	0017025	molecular_function	TBP-class protein binding
k	0042789	biological_process	mRNA transcription by RNA polymerase II
k	0042809	molecular_function	nuclear vitamin D receptor binding
k	0043923	biological_process	host-mediated activation of viral transcription
k	0046966	molecular_function	nuclear thyroid hormone receptor binding
k	0046982	molecular_function	protein heterodimerization activity
k	0051123	biological_process	RNA polymerase II preinitiation complex assembly
k	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
l	0000124	cellular_component	SAGA complex
l	0003677	molecular_function	DNA binding
l	0003713	molecular_function	transcription coactivator activity
l	0005515	molecular_function	protein binding
l	0005634	cellular_component	nucleus
l	0005654	cellular_component	nucleoplasm
l	0005669	cellular_component	transcription factor TFIID complex
l	0006282	biological_process	regulation of DNA repair
l	0006352	biological_process	DNA-templated transcription initiation
l	0006355	biological_process	regulation of DNA-templated transcription
l	0006357	biological_process	regulation of transcription by RNA polymerase II
l	0006366	biological_process	transcription by RNA polymerase II
l	0006367	biological_process	transcription initiation at RNA polymerase II promoter
l	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
l	0017025	molecular_function	TBP-class protein binding
l	0033276	cellular_component	transcription factor TFTC complex
l	0042789	biological_process	mRNA transcription by RNA polymerase II
l	0043484	biological_process	regulation of RNA splicing
l	0045893	biological_process	positive regulation of DNA-templated transcription
l	0045944	biological_process	positive regulation of transcription by RNA polymerase II
l	0046982	molecular_function	protein heterodimerization activity
l	0051123	biological_process	RNA polymerase II preinitiation complex assembly
l	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
l	0140297	molecular_function	DNA-binding transcription factor binding
m	0003677	molecular_function	DNA binding
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005669	cellular_component	transcription factor TFIID complex
m	0005730	cellular_component	nucleolus
m	0006352	biological_process	DNA-templated transcription initiation
m	0006366	biological_process	transcription by RNA polymerase II
m	0006367	biological_process	transcription initiation at RNA polymerase II promoter
m	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
m	0017025	molecular_function	TBP-class protein binding
m	0042789	biological_process	mRNA transcription by RNA polymerase II
m	0046982	molecular_function	protein heterodimerization activity
m	0051123	biological_process	RNA polymerase II preinitiation complex assembly
m	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
o	0000287	molecular_function	magnesium ion binding
o	0000428	cellular_component	DNA-directed RNA polymerase complex
o	0000974	cellular_component	Prp19 complex
o	0001172	biological_process	RNA-templated transcription
o	0003676	molecular_function	nucleic acid binding
o	0003677	molecular_function	DNA binding
o	0003723	molecular_function	RNA binding
o	0003899	molecular_function	DNA-directed RNA polymerase activity
o	0003968	molecular_function	RNA-directed RNA polymerase activity
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005654	cellular_component	nucleoplasm
o	0005665	cellular_component	RNA polymerase II, core complex
o	0005694	cellular_component	chromosome
o	0005730	cellular_component	nucleolus
o	0005737	cellular_component	cytoplasm
o	0006351	biological_process	DNA-templated transcription
o	0006353	biological_process	DNA-templated transcription termination
o	0006355	biological_process	regulation of DNA-templated transcription
o	0006366	biological_process	transcription by RNA polymerase II
o	0006368	biological_process	transcription elongation by RNA polymerase II
o	0008270	molecular_function	zinc ion binding
o	0010628	biological_process	positive regulation of gene expression
o	0016740	molecular_function	transferase activity
o	0016779	molecular_function	nucleotidyltransferase activity
o	0016787	molecular_function	hydrolase activity
o	0019900	molecular_function	kinase binding
o	0031625	molecular_function	ubiquitin protein ligase binding
o	0033120	biological_process	positive regulation of RNA splicing
o	0034062	molecular_function	5'-3' RNA polymerase activity
o	0042789	biological_process	mRNA transcription by RNA polymerase II
o	0046872	molecular_function	metal ion binding
o	0050436	molecular_function	microfibril binding
o	1990841	molecular_function	promoter-specific chromatin binding
p	0000428	cellular_component	DNA-directed RNA polymerase complex
p	0001172	biological_process	RNA-templated transcription
p	0003677	molecular_function	DNA binding
p	0003899	molecular_function	DNA-directed RNA polymerase activity
p	0003968	molecular_function	RNA-directed RNA polymerase activity
p	0005634	cellular_component	nucleus
p	0005654	cellular_component	nucleoplasm
p	0006351	biological_process	DNA-templated transcription
p	0008270	molecular_function	zinc ion binding
p	0016740	molecular_function	transferase activity
p	0016779	molecular_function	nucleotidyltransferase activity
p	0016787	molecular_function	hydrolase activity
p	0032549	molecular_function	ribonucleoside binding
p	0046872	molecular_function	metal ion binding
q	0000428	cellular_component	DNA-directed RNA polymerase complex
q	0003677	molecular_function	DNA binding
q	0003899	molecular_function	DNA-directed RNA polymerase activity
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005665	cellular_component	RNA polymerase II, core complex
q	0005829	cellular_component	cytosol
q	0006351	biological_process	DNA-templated transcription
q	0006366	biological_process	transcription by RNA polymerase II
q	0046983	molecular_function	protein dimerization activity
r	0000166	molecular_function	nucleotide binding
r	0000428	cellular_component	DNA-directed RNA polymerase complex
r	0005634	cellular_component	nucleus
r	0005654	cellular_component	nucleoplasm
r	0006352	biological_process	DNA-templated transcription initiation
r	0030880	cellular_component	RNA polymerase complex
s	0000428	cellular_component	DNA-directed RNA polymerase complex
s	0003677	molecular_function	DNA binding
s	0003899	molecular_function	DNA-directed RNA polymerase activity
s	0005634	cellular_component	nucleus
s	0005654	cellular_component	nucleoplasm
s	0006351	biological_process	DNA-templated transcription
t	0000428	cellular_component	DNA-directed RNA polymerase complex
t	0001650	cellular_component	fibrillar center
t	0003677	molecular_function	DNA binding
t	0003899	molecular_function	DNA-directed RNA polymerase activity
t	0005634	cellular_component	nucleus
t	0005654	cellular_component	nucleoplasm
t	0005665	cellular_component	RNA polymerase II, core complex
t	0005666	cellular_component	RNA polymerase III complex
t	0005736	cellular_component	RNA polymerase I complex
t	0006351	biological_process	DNA-templated transcription
t	0006360	biological_process	transcription by RNA polymerase I
t	0006366	biological_process	transcription by RNA polymerase II
t	0042797	biological_process	tRNA transcription by RNA polymerase III
u	0000428	cellular_component	DNA-directed RNA polymerase complex
u	0003676	molecular_function	nucleic acid binding
u	0005634	cellular_component	nucleus
u	0006351	biological_process	DNA-templated transcription
u	0006352	biological_process	DNA-templated transcription initiation
v	0000428	cellular_component	DNA-directed RNA polymerase complex
v	0003899	molecular_function	DNA-directed RNA polymerase activity
v	0005634	cellular_component	nucleus
v	0005654	cellular_component	nucleoplasm
v	0005665	cellular_component	RNA polymerase II, core complex
v	0005666	cellular_component	RNA polymerase III complex
v	0005736	cellular_component	RNA polymerase I complex
v	0006351	biological_process	DNA-templated transcription
w	0000428	cellular_component	DNA-directed RNA polymerase complex
w	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
w	0003676	molecular_function	nucleic acid binding
w	0003899	molecular_function	DNA-directed RNA polymerase activity
w	0005634	cellular_component	nucleus
w	0005654	cellular_component	nucleoplasm
w	0005665	cellular_component	RNA polymerase II, core complex
w	0005730	cellular_component	nucleolus
w	0006283	biological_process	transcription-coupled nucleotide-excision repair
w	0006351	biological_process	DNA-templated transcription
w	0006366	biological_process	transcription by RNA polymerase II
w	0006367	biological_process	transcription initiation at RNA polymerase II promoter
w	0008270	molecular_function	zinc ion binding
w	0046872	molecular_function	metal ion binding
x	0003677	molecular_function	DNA binding
x	0003899	molecular_function	DNA-directed RNA polymerase activity
x	0006351	biological_process	DNA-templated transcription
x	0008270	molecular_function	zinc ion binding
y	0000428	cellular_component	DNA-directed RNA polymerase complex
y	0003677	molecular_function	DNA binding
y	0003899	molecular_function	DNA-directed RNA polymerase activity
y	0005634	cellular_component	nucleus
y	0005665	cellular_component	RNA polymerase II, core complex
y	0006351	biological_process	DNA-templated transcription
y	0006366	biological_process	transcription by RNA polymerase II
y	0046983	molecular_function	protein dimerization activity
z	0000428	cellular_component	DNA-directed RNA polymerase complex
z	0003677	molecular_function	DNA binding
z	0003899	molecular_function	DNA-directed RNA polymerase activity
z	0005634	cellular_component	nucleus
z	0005654	cellular_component	nucleoplasm
z	0005665	cellular_component	RNA polymerase II, core complex
z	0005666	cellular_component	RNA polymerase III complex
z	0005730	cellular_component	nucleolus
z	0005736	cellular_component	RNA polymerase I complex
z	0006351	biological_process	DNA-templated transcription
z	0006366	biological_process	transcription by RNA polymerase II
z	0008270	molecular_function	zinc ion binding
z	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DNDPSDYVEqdDI

Chain	Residue	Details
q	ASP136-ILE148

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cav..CqnvFcvdcdvfvHdsl..H

Chain	Residue	Details
2	CYS360-HIS380

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGQFATVYkArdkntnqiv.........AIKK

Chain	Residue	Details
8	LEU18-LYS42

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHrDLKpnNLLL

Chain	Residue	Details
8	ILE133-LEU145

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA

Chain	Residue	Details
o	TYR1593-ALA1599
o	TYR1671-SER1677
o	TYR1678-SER1684
o	TYR1685-SER1691
o	TYR1692-SER1698
o	TYR1699-SER1705
o	TYR1706-SER1712
o	TYR1713-SER1719
o	TYR1720-SER1726
o	TYR1727-SER1733
o	TYR1734-SER1740
o	TYR1615-SER1621
o	TYR1741-ASN1747
o	TYR1748-ASN1754
o	TYR1755-SER1761
o	TYR1762-SER1768
o	TYR1769-ASN1775
o	TYR1776-ASN1782
o	TYR1783-SER1789
o	TYR1790-SER1796
o	TYR1797-SER1803
o	TYR1818-SER1824
o	TYR1622-SER1628
o	TYR1825-SER1831
o	TYR1839-SER1845
o	TYR1853-LYS1859
o	TYR1860-LYS1866
o	TYR1867-LYS1873
o	TYR1874-THR1880
o	TYR1888-THR1894
o	TYR1902-LYS1908
o	TYR1909-THR1915
o	TYR1916-LYS1922
o	TYR1629-ASN1635
o	TYR1923-THR1929
o	TYR1930-LYS1936
o	TYR1947-THR1953
o	TYR1636-SER1642
o	TYR1643-SER1649
o	TYR1650-SER1656
o	TYR1657-SER1663
o	TYR1664-SER1670

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YVCTAPH

Chain	Residue	Details
w	TYR112-HIS118

site_id	PS00351
Number of Residues	50
Details	TFIID Transcription factor TFIID repeat signature. YnPkrFaaVImRirePRttaLIFsSGKMvctGAKseeqsrlAarkyarvV

Chain	Residue	Details
P	TYR192-VAL241
P	TYR283-LEU332

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSIRRvfiaevpiiAidwVqidaNsSvlhDEfIAhRLGLIP

Chain	Residue	Details
q	ASN32-PRO72

site_id	PS00466
Number of Residues	38
Details	ZF_TFIIS_1 Zinc finger TFIIS-type signature. CqkCghkeavffqSHSARaEDAmrlyyvCtaph.CghrW

Chain	Residue	Details
w	CYS86-TRP123

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CgHtLCesCV

Chain	Residue	Details
0	CYS26-VAL35

site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. TypFhtpvNakvvk..DYYkiItrpMdlqtLrenvrkrl..Ypsreefrehlel.IvkNSatY

Chain	Residue	Details
A	THR1402-TYR1459
A	SER1525-TYR1582

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. VATGsaDrTVRLWDV

Chain	Residue	Details
e	VAL642-VAL656
e	LEU684-ILE698
e	LEU726-ALA740

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. AvVVFDEAHN

Chain	Residue	Details
7	ALA229-ASN238

site_id	PS00782
Number of Residues	16
Details	TFIIB Transcription factor TFIIB repeat signature. GRandAIASACLYIAC

Chain	Residue	Details
R	GLY153-CYS168
R	GLY247-SER262

site_id	PS01030
Number of Residues	27
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCQECNNMLypkedkenrillyaCrnC

Chain	Residue	Details
w	PHE16-CYS42

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE

Chain	Residue	Details
s	HIS142-GLU155

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ

Chain	Residue	Details
t	THR58-GLN72

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG

Chain	Residue	Details
x	ILE2-GLY11

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. InkEdHTLgNiIksqLlkdpqVlfagYkvpHP

Chain	Residue	Details
y	ILE35-PRO66

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT

Chain	Residue	Details
p	GLY932-THR944

site_id	PS01359
Number of Residues	45
Details	ZF_PHD_1 Zinc finger PHD-type signature. CpgCnkpddgspm....................................IgCdd..Cddw.YHwpCvgimtappeemq.................................WfCpkC

Chain	Residue	Details
c	CYS868-CYS912

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	19
Details	Domain: {"description":"UIM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00213","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	44
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9DBA9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	176
Details	Domain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	34
Details	Zinc finger: {"description":"C4-type"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"A0JN27","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	437
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	160
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	3
Details	Motif: {"description":"DEVH box"}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33902107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7NVV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7NVX","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33902107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7NVV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7NVX","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	199
Details	Region: {"description":"Mediates interaction with MMS19"}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	3
Details	Motif: {"description":"DEAH box"}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	13
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31253769","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15530371","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15530371","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by CDK1 and CDK2","evidences":[{"source":"PubMed","id":"11113184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9832506","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by CDK2","evidences":[{"source":"PubMed","id":"11113184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15530371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9832506","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by CDK8","evidences":[{"source":"PubMed","id":"10993082","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	43
Details	Region: {"description":"Minimal region required to interact with TAF12","evidences":[{"source":"PubMed","id":"10594036","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	78
Details	Repeat: {"description":"WD 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	78
Details	Repeat: {"description":"WD 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	82
Details	Repeat: {"description":"WD 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	82
Details	Repeat: {"description":"WD 4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	78
Details	Repeat: {"description":"WD 5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	39
Details	Repeat: {"description":"WD 6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q63801","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q63801","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q63801","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	67
Details	Domain: {"description":"Histone-fold; involved in forming hexamer structure in TFIID complex","evidences":[{"source":"PubMed","id":"33795473","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI40
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI41
Number of Residues	1
Details	Modified residue: {"description":"N6,N6,N6-trimethyllysine; alternate","evidences":[{"source":"PubMed","id":"15099517","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16415881","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25959397","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI42
Number of Residues	177
Details	Domain: {"description":"Histone-fold","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI43
Number of Residues	152
Details	Repeat: {"description":"1"}

Chain

Residue

Details

site_id	SWS_FT_FI44
Number of Residues	153
Details	Repeat: {"description":"2"}

Chain

Residue

Details

site_id	SWS_FT_FI45
Number of Residues	19
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IYD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI46
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by TAF1","evidences":[{"source":"PubMed","id":"11278496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI47
Number of Residues	4
Details	Region: {"description":"Core promoter DNA-binding","evidences":[{"source":"PubMed","id":"10619841","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI48
Number of Residues	72
Details	Region: {"description":"Necessary for TATA box-bound TBP complex formation","evidences":[{"source":"PubMed","id":"8515820","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8516311","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI49
Number of Residues	3
Details	Region: {"description":"Core promoter DNA-binding","evidences":[{"source":"PubMed","id":"7675079","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI50
Number of Residues	3
Details	Region: {"description":"Core promoter DNA-binding","evidences":[{"source":"PubMed","id":"10619841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7675079","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI51
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00469","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11045620","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14641108","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DL6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RLY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IY6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI52
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00469","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11045620","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14641108","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DL6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RLY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI53
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine; by autocatalysis","evidences":[{"source":"PubMed","id":"12931194","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI54
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI55
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI56
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI57
Number of Residues	53
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI58
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IY6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI59
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9D902","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI60
Number of Residues	41
Details	Region: {"description":"Bridging helix","evidences":[{"source":"UniProtKB","id":"G3MZY8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI61
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"G3MZY8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI62
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P04050","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI73
Number of Residues	42
Details	Zinc finger: {"description":"TFIIS-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details