7ECS
Crystal Structure of Aspergillus terreus Glutamate Dehydrogenase (AtGDH) Complexed With Malonate and NADPH
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004353 | molecular_function | glutamate dehydrogenase [NAD(P)+] activity |
A | 0004354 | molecular_function | glutamate dehydrogenase (NADP+) activity |
A | 0005829 | cellular_component | cytosol |
A | 0006520 | biological_process | amino acid metabolic process |
A | 0006537 | biological_process | glutamate biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004353 | molecular_function | glutamate dehydrogenase [NAD(P)+] activity |
B | 0004354 | molecular_function | glutamate dehydrogenase (NADP+) activity |
B | 0005829 | cellular_component | cytosol |
B | 0006520 | biological_process | amino acid metabolic process |
B | 0006537 | biological_process | glutamate biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
C | 0000166 | molecular_function | nucleotide binding |
C | 0004353 | molecular_function | glutamate dehydrogenase [NAD(P)+] activity |
C | 0004354 | molecular_function | glutamate dehydrogenase (NADP+) activity |
C | 0005829 | cellular_component | cytosol |
C | 0006520 | biological_process | amino acid metabolic process |
C | 0006537 | biological_process | glutamate biosynthetic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | binding site for residue GOL A 501 |
Chain | Residue |
A | TRP399 |
A | GLU403 |
A | ARG407 |
A | HOH628 |
A | HOH664 |
A | HOH834 |
A | HOH972 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue GOL A 502 |
Chain | Residue |
A | HOH664 |
A | HOH756 |
A | HOH881 |
C | ARG407 |
A | SER398 |
A | GLU403 |
site_id | AC3 |
Number of Residues | 10 |
Details | binding site for residue GOL A 503 |
Chain | Residue |
A | ARG142 |
A | ILE144 |
A | THR148 |
A | GOL504 |
A | GOL504 |
A | HOH606 |
A | HOH622 |
A | HOH717 |
A | HOH913 |
B | ASN174 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue GOL A 504 |
Chain | Residue |
A | ARG142 |
A | ARG142 |
A | GOL503 |
A | GOL503 |
A | HOH603 |
A | HOH603 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue GOL A 505 |
Chain | Residue |
A | ALA104 |
A | LEU105 |
A | GLY107 |
A | SER414 |
A | ASN418 |
A | LYS448 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue GOL A 506 |
Chain | Residue |
A | GLN12 |
A | ASN323 |
A | THR350 |
A | GLN351 |
A | HOH652 |
A | HOH723 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue GOL A 507 |
Chain | Residue |
A | THR447 |
A | LYS448 |
A | ALA451 |
A | HOH680 |
A | HOH838 |
site_id | AC8 |
Number of Residues | 11 |
Details | binding site for residue MLI A 508 |
Chain | Residue |
A | GLY79 |
A | GLY80 |
A | GLN99 |
A | LYS102 |
A | LYS114 |
A | ASP154 |
A | ASN346 |
A | NDP510 |
A | HOH601 |
A | HOH605 |
A | HOH637 |
site_id | AC9 |
Number of Residues | 8 |
Details | binding site for residue MLI A 509 |
Chain | Residue |
A | SER326 |
A | GLY327 |
A | GLU328 |
A | THR350 |
A | ALA352 |
A | HOH614 |
A | HOH652 |
A | HOH889 |
site_id | AD1 |
Number of Residues | 35 |
Details | binding site for residue NDP A 510 |
Chain | Residue |
A | HOH920 |
A | ARG82 |
A | HIS84 |
A | LYS122 |
A | ASP154 |
A | ILE155 |
A | GLY156 |
A | ARG193 |
A | THR197 |
A | SER229 |
A | GLY230 |
A | ASN231 |
A | VAL232 |
A | ASP252 |
A | SER253 |
A | LYS279 |
A | GLN284 |
A | SER319 |
A | ALA320 |
A | THR321 |
A | GLY344 |
A | SER345 |
A | ASN346 |
A | ASN379 |
A | MLI508 |
A | HOH602 |
A | HOH633 |
A | HOH675 |
A | HOH678 |
A | HOH761 |
A | HOH795 |
A | HOH807 |
A | HOH828 |
A | HOH833 |
A | HOH853 |
site_id | AD2 |
Number of Residues | 6 |
Details | binding site for residue GOL B 501 |
Chain | Residue |
B | ARG142 |
B | GOL504 |
B | GOL509 |
B | HOH643 |
B | HOH680 |
C | ARG142 |
site_id | AD3 |
Number of Residues | 8 |
Details | binding site for residue GOL B 502 |
Chain | Residue |
B | TRP399 |
B | GLU403 |
B | ARG407 |
B | GOL503 |
B | HOH657 |
B | HOH669 |
B | HOH861 |
B | HOH995 |
site_id | AD4 |
Number of Residues | 8 |
Details | binding site for residue GOL B 503 |
Chain | Residue |
A | ARG407 |
B | SER398 |
B | GLU403 |
B | GOL502 |
B | HOH647 |
B | HOH669 |
B | HOH714 |
B | HOH837 |
site_id | AD5 |
Number of Residues | 9 |
Details | binding site for residue GOL B 504 |
Chain | Residue |
A | ASN174 |
B | GOL501 |
B | HOH615 |
B | HOH628 |
B | HOH814 |
C | ARG142 |
C | ILE144 |
C | THR148 |
C | HOH677 |
site_id | AD6 |
Number of Residues | 6 |
Details | binding site for residue GOL B 505 |
Chain | Residue |
B | GLU217 |
B | ALA220 |
B | GLY221 |
B | LYS222 |
B | HOH626 |
B | HOH637 |
site_id | AD7 |
Number of Residues | 4 |
Details | binding site for residue GOL B 506 |
Chain | Residue |
B | THR447 |
B | LYS448 |
B | HOH721 |
C | HOH666 |
site_id | AD8 |
Number of Residues | 6 |
Details | binding site for residue GOL B 507 |
Chain | Residue |
B | GLN12 |
B | ASN323 |
B | THR350 |
B | GLN351 |
B | HOH696 |
B | HOH713 |
site_id | AD9 |
Number of Residues | 5 |
Details | binding site for residue GOL B 508 |
Chain | Residue |
B | LEU105 |
B | GLY107 |
B | SER414 |
B | ASN418 |
B | LYS448 |
site_id | AE1 |
Number of Residues | 9 |
Details | binding site for residue GOL B 509 |
Chain | Residue |
B | ARG142 |
B | ILE144 |
B | THR148 |
B | ARG173 |
B | GOL501 |
B | HOH618 |
B | HOH752 |
B | HOH907 |
C | ASN174 |
site_id | AE2 |
Number of Residues | 10 |
Details | binding site for residue MLI B 510 |
Chain | Residue |
B | SER326 |
B | GLY327 |
B | GLU328 |
B | THR350 |
B | ALA352 |
B | HOH622 |
B | HOH713 |
B | HOH779 |
B | HOH785 |
B | HOH822 |
site_id | AE3 |
Number of Residues | 11 |
Details | binding site for residue MLI B 511 |
Chain | Residue |
B | GLY79 |
B | GLY80 |
B | GLN99 |
B | LYS102 |
B | LYS114 |
B | ASP154 |
B | ASN346 |
B | NDP512 |
B | HOH601 |
B | HOH609 |
B | HOH670 |
site_id | AE4 |
Number of Residues | 36 |
Details | binding site for residue NDP B 512 |
Chain | Residue |
B | ARG82 |
B | HIS84 |
B | LYS122 |
B | ASP154 |
B | ILE155 |
B | GLY156 |
B | ARG193 |
B | THR197 |
B | SER229 |
B | GLY230 |
B | ASN231 |
B | VAL232 |
B | ASP252 |
B | SER253 |
B | LYS279 |
B | GLN284 |
B | SER319 |
B | ALA320 |
B | THR321 |
B | GLY344 |
B | SER345 |
B | ASN346 |
B | ASN379 |
B | MLI511 |
B | HOH656 |
B | HOH658 |
B | HOH728 |
B | HOH731 |
B | HOH747 |
B | HOH765 |
B | HOH773 |
B | HOH812 |
B | HOH851 |
B | HOH862 |
B | HOH879 |
B | HOH963 |
site_id | AE5 |
Number of Residues | 7 |
Details | binding site for residue GOL C 501 |
Chain | Residue |
C | TRP399 |
C | GLU403 |
C | ARG407 |
C | GOL502 |
C | HOH719 |
C | HOH840 |
C | HOH937 |
site_id | AE6 |
Number of Residues | 8 |
Details | binding site for residue GOL C 502 |
Chain | Residue |
B | ARG407 |
C | SER398 |
C | GLU403 |
C | GOL501 |
C | HOH840 |
C | HOH853 |
C | HOH921 |
C | HOH967 |
site_id | AE7 |
Number of Residues | 5 |
Details | binding site for residue GOL C 503 |
Chain | Residue |
C | LEU105 |
C | GLY107 |
C | SER414 |
C | ASN418 |
C | LYS448 |
site_id | AE8 |
Number of Residues | 7 |
Details | binding site for residue GOL C 504 |
Chain | Residue |
C | GLN12 |
C | ASN323 |
C | GLN351 |
C | MLI509 |
C | HOH611 |
C | HOH649 |
C | HOH688 |
site_id | AE9 |
Number of Residues | 10 |
Details | binding site for residue GOL C 505 |
Chain | Residue |
C | HIS211 |
C | LYS365 |
C | ASP431 |
C | GLY432 |
C | GLY432 |
C | LEU434 |
C | PRO435 |
C | HOH620 |
C | HOH845 |
C | HOH903 |
site_id | AF1 |
Number of Residues | 8 |
Details | binding site for residue GOL C 506 |
Chain | Residue |
C | ASP252 |
C | GLY303 |
C | GLN304 |
C | ARG305 |
C | NDP511 |
C | HOH693 |
C | HOH712 |
C | HOH891 |
site_id | AF2 |
Number of Residues | 8 |
Details | binding site for residue GOL C 507 |
Chain | Residue |
C | VAL52 |
C | ARG130 |
C | LYS171 |
C | HOH629 |
C | HOH803 |
C | HOH875 |
C | HOH886 |
C | HOH928 |
site_id | AF3 |
Number of Residues | 3 |
Details | binding site for residue GOL C 508 |
Chain | Residue |
C | CYS141 |
C | LEU172 |
C | HOH609 |
site_id | AF4 |
Number of Residues | 12 |
Details | binding site for residue MLI C 509 |
Chain | Residue |
C | SER326 |
C | GLY327 |
C | GLU328 |
C | THR350 |
C | ALA352 |
C | GOL504 |
C | HOH618 |
C | HOH619 |
C | HOH649 |
C | HOH688 |
C | HOH796 |
C | HOH976 |
site_id | AF5 |
Number of Residues | 10 |
Details | binding site for residue MLI C 510 |
Chain | Residue |
C | GLY79 |
C | GLY80 |
C | GLN99 |
C | LYS102 |
C | LYS114 |
C | ASN346 |
C | NDP511 |
C | HOH601 |
C | HOH603 |
C | HOH631 |
site_id | AF6 |
Number of Residues | 36 |
Details | binding site for residue NDP C 511 |
Chain | Residue |
C | ARG82 |
C | HIS84 |
C | LYS122 |
C | ASP154 |
C | ILE155 |
C | GLY156 |
C | ARG193 |
C | THR197 |
C | SER229 |
C | GLY230 |
C | ASN231 |
C | VAL232 |
C | ASP252 |
C | SER253 |
C | LYS279 |
C | GLN284 |
C | SER319 |
C | ALA320 |
C | THR321 |
C | GLY344 |
C | SER345 |
C | ASN346 |
C | ASN379 |
C | GOL506 |
C | MLI510 |
C | HOH645 |
C | HOH728 |
C | HOH747 |
C | HOH755 |
C | HOH769 |
C | HOH818 |
C | HOH841 |
C | HOH852 |
C | HOH881 |
C | HOH914 |
C | HOH949 |
Functional Information from PROSITE/UniProt
site_id | PS00074 |
Number of Residues | 14 |
Details | GLFV_DEHYDROGENASE Glu / Leu / Phe / Val dehydrogenases active site. LnmGGGKgGsdfDP |
Chain | Residue | Details |
A | LEU108-PRO121 |