7ECS
Crystal Structure of Aspergillus terreus Glutamate Dehydrogenase (AtGDH) Complexed With Malonate and NADPH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004354 | molecular_function | glutamate dehydrogenase (NADP+) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006537 | biological_process | glutamate biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004354 | molecular_function | glutamate dehydrogenase (NADP+) activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006537 | biological_process | glutamate biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004354 | molecular_function | glutamate dehydrogenase (NADP+) activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0006537 | biological_process | glutamate biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016639 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 501 |
| Chain | Residue |
| A | TRP399 |
| A | GLU403 |
| A | ARG407 |
| A | HOH628 |
| A | HOH664 |
| A | HOH834 |
| A | HOH972 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | HOH664 |
| A | HOH756 |
| A | HOH881 |
| C | ARG407 |
| A | SER398 |
| A | GLU403 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | ARG142 |
| A | ILE144 |
| A | THR148 |
| A | GOL504 |
| A | GOL504 |
| A | HOH606 |
| A | HOH622 |
| A | HOH717 |
| A | HOH913 |
| B | ASN174 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | ARG142 |
| A | ARG142 |
| A | GOL503 |
| A | GOL503 |
| A | HOH603 |
| A | HOH603 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 505 |
| Chain | Residue |
| A | ALA104 |
| A | LEU105 |
| A | GLY107 |
| A | SER414 |
| A | ASN418 |
| A | LYS448 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 506 |
| Chain | Residue |
| A | GLN12 |
| A | ASN323 |
| A | THR350 |
| A | GLN351 |
| A | HOH652 |
| A | HOH723 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 507 |
| Chain | Residue |
| A | THR447 |
| A | LYS448 |
| A | ALA451 |
| A | HOH680 |
| A | HOH838 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | binding site for residue MLI A 508 |
| Chain | Residue |
| A | GLY79 |
| A | GLY80 |
| A | GLN99 |
| A | LYS102 |
| A | LYS114 |
| A | ASP154 |
| A | ASN346 |
| A | NDP510 |
| A | HOH601 |
| A | HOH605 |
| A | HOH637 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue MLI A 509 |
| Chain | Residue |
| A | SER326 |
| A | GLY327 |
| A | GLU328 |
| A | THR350 |
| A | ALA352 |
| A | HOH614 |
| A | HOH652 |
| A | HOH889 |
| site_id | AD1 |
| Number of Residues | 35 |
| Details | binding site for residue NDP A 510 |
| Chain | Residue |
| A | HOH920 |
| A | ARG82 |
| A | HIS84 |
| A | LYS122 |
| A | ASP154 |
| A | ILE155 |
| A | GLY156 |
| A | ARG193 |
| A | THR197 |
| A | SER229 |
| A | GLY230 |
| A | ASN231 |
| A | VAL232 |
| A | ASP252 |
| A | SER253 |
| A | LYS279 |
| A | GLN284 |
| A | SER319 |
| A | ALA320 |
| A | THR321 |
| A | GLY344 |
| A | SER345 |
| A | ASN346 |
| A | ASN379 |
| A | MLI508 |
| A | HOH602 |
| A | HOH633 |
| A | HOH675 |
| A | HOH678 |
| A | HOH761 |
| A | HOH795 |
| A | HOH807 |
| A | HOH828 |
| A | HOH833 |
| A | HOH853 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 501 |
| Chain | Residue |
| B | ARG142 |
| B | GOL504 |
| B | GOL509 |
| B | HOH643 |
| B | HOH680 |
| C | ARG142 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 502 |
| Chain | Residue |
| B | TRP399 |
| B | GLU403 |
| B | ARG407 |
| B | GOL503 |
| B | HOH657 |
| B | HOH669 |
| B | HOH861 |
| B | HOH995 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 503 |
| Chain | Residue |
| A | ARG407 |
| B | SER398 |
| B | GLU403 |
| B | GOL502 |
| B | HOH647 |
| B | HOH669 |
| B | HOH714 |
| B | HOH837 |
| site_id | AD5 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 504 |
| Chain | Residue |
| A | ASN174 |
| B | GOL501 |
| B | HOH615 |
| B | HOH628 |
| B | HOH814 |
| C | ARG142 |
| C | ILE144 |
| C | THR148 |
| C | HOH677 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 505 |
| Chain | Residue |
| B | GLU217 |
| B | ALA220 |
| B | GLY221 |
| B | LYS222 |
| B | HOH626 |
| B | HOH637 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 506 |
| Chain | Residue |
| B | THR447 |
| B | LYS448 |
| B | HOH721 |
| C | HOH666 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 507 |
| Chain | Residue |
| B | GLN12 |
| B | ASN323 |
| B | THR350 |
| B | GLN351 |
| B | HOH696 |
| B | HOH713 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 508 |
| Chain | Residue |
| B | LEU105 |
| B | GLY107 |
| B | SER414 |
| B | ASN418 |
| B | LYS448 |
| site_id | AE1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 509 |
| Chain | Residue |
| B | ARG142 |
| B | ILE144 |
| B | THR148 |
| B | ARG173 |
| B | GOL501 |
| B | HOH618 |
| B | HOH752 |
| B | HOH907 |
| C | ASN174 |
| site_id | AE2 |
| Number of Residues | 10 |
| Details | binding site for residue MLI B 510 |
| Chain | Residue |
| B | SER326 |
| B | GLY327 |
| B | GLU328 |
| B | THR350 |
| B | ALA352 |
| B | HOH622 |
| B | HOH713 |
| B | HOH779 |
| B | HOH785 |
| B | HOH822 |
| site_id | AE3 |
| Number of Residues | 11 |
| Details | binding site for residue MLI B 511 |
| Chain | Residue |
| B | GLY79 |
| B | GLY80 |
| B | GLN99 |
| B | LYS102 |
| B | LYS114 |
| B | ASP154 |
| B | ASN346 |
| B | NDP512 |
| B | HOH601 |
| B | HOH609 |
| B | HOH670 |
| site_id | AE4 |
| Number of Residues | 36 |
| Details | binding site for residue NDP B 512 |
| Chain | Residue |
| B | ARG82 |
| B | HIS84 |
| B | LYS122 |
| B | ASP154 |
| B | ILE155 |
| B | GLY156 |
| B | ARG193 |
| B | THR197 |
| B | SER229 |
| B | GLY230 |
| B | ASN231 |
| B | VAL232 |
| B | ASP252 |
| B | SER253 |
| B | LYS279 |
| B | GLN284 |
| B | SER319 |
| B | ALA320 |
| B | THR321 |
| B | GLY344 |
| B | SER345 |
| B | ASN346 |
| B | ASN379 |
| B | MLI511 |
| B | HOH656 |
| B | HOH658 |
| B | HOH728 |
| B | HOH731 |
| B | HOH747 |
| B | HOH765 |
| B | HOH773 |
| B | HOH812 |
| B | HOH851 |
| B | HOH862 |
| B | HOH879 |
| B | HOH963 |
| site_id | AE5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 501 |
| Chain | Residue |
| C | TRP399 |
| C | GLU403 |
| C | ARG407 |
| C | GOL502 |
| C | HOH719 |
| C | HOH840 |
| C | HOH937 |
| site_id | AE6 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 502 |
| Chain | Residue |
| B | ARG407 |
| C | SER398 |
| C | GLU403 |
| C | GOL501 |
| C | HOH840 |
| C | HOH853 |
| C | HOH921 |
| C | HOH967 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 503 |
| Chain | Residue |
| C | LEU105 |
| C | GLY107 |
| C | SER414 |
| C | ASN418 |
| C | LYS448 |
| site_id | AE8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 504 |
| Chain | Residue |
| C | GLN12 |
| C | ASN323 |
| C | GLN351 |
| C | MLI509 |
| C | HOH611 |
| C | HOH649 |
| C | HOH688 |
| site_id | AE9 |
| Number of Residues | 10 |
| Details | binding site for residue GOL C 505 |
| Chain | Residue |
| C | HIS211 |
| C | LYS365 |
| C | ASP431 |
| C | GLY432 |
| C | GLY432 |
| C | LEU434 |
| C | PRO435 |
| C | HOH620 |
| C | HOH845 |
| C | HOH903 |
| site_id | AF1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 506 |
| Chain | Residue |
| C | ASP252 |
| C | GLY303 |
| C | GLN304 |
| C | ARG305 |
| C | NDP511 |
| C | HOH693 |
| C | HOH712 |
| C | HOH891 |
| site_id | AF2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 507 |
| Chain | Residue |
| C | VAL52 |
| C | ARG130 |
| C | LYS171 |
| C | HOH629 |
| C | HOH803 |
| C | HOH875 |
| C | HOH886 |
| C | HOH928 |
| site_id | AF3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL C 508 |
| Chain | Residue |
| C | CYS141 |
| C | LEU172 |
| C | HOH609 |
| site_id | AF4 |
| Number of Residues | 12 |
| Details | binding site for residue MLI C 509 |
| Chain | Residue |
| C | SER326 |
| C | GLY327 |
| C | GLU328 |
| C | THR350 |
| C | ALA352 |
| C | GOL504 |
| C | HOH618 |
| C | HOH619 |
| C | HOH649 |
| C | HOH688 |
| C | HOH796 |
| C | HOH976 |
| site_id | AF5 |
| Number of Residues | 10 |
| Details | binding site for residue MLI C 510 |
| Chain | Residue |
| C | GLY79 |
| C | GLY80 |
| C | GLN99 |
| C | LYS102 |
| C | LYS114 |
| C | ASN346 |
| C | NDP511 |
| C | HOH601 |
| C | HOH603 |
| C | HOH631 |
| site_id | AF6 |
| Number of Residues | 36 |
| Details | binding site for residue NDP C 511 |
| Chain | Residue |
| C | ARG82 |
| C | HIS84 |
| C | LYS122 |
| C | ASP154 |
| C | ILE155 |
| C | GLY156 |
| C | ARG193 |
| C | THR197 |
| C | SER229 |
| C | GLY230 |
| C | ASN231 |
| C | VAL232 |
| C | ASP252 |
| C | SER253 |
| C | LYS279 |
| C | GLN284 |
| C | SER319 |
| C | ALA320 |
| C | THR321 |
| C | GLY344 |
| C | SER345 |
| C | ASN346 |
| C | ASN379 |
| C | GOL506 |
| C | MLI510 |
| C | HOH645 |
| C | HOH728 |
| C | HOH747 |
| C | HOH755 |
| C | HOH769 |
| C | HOH818 |
| C | HOH841 |
| C | HOH852 |
| C | HOH881 |
| C | HOH914 |
| C | HOH949 |
Functional Information from PROSITE/UniProt
| site_id | PS00074 |
| Number of Residues | 14 |
| Details | GLFV_DEHYDROGENASE Glu / Leu / Phe / Val dehydrogenases active site. LnmGGGKgGsdfDP |
| Chain | Residue | Details |
| A | LEU108-PRO121 |
