7EAL

The structure of the A20-Binding Inhibitor of NF-kB 1 in complex with di-ubiquitin

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0002755	biological_process	MyD88-dependent toll-like receptor signaling pathway
B	0043124	biological_process	negative regulation of I-kappaB kinase/NF-kappaB signaling
B	0050727	biological_process	regulation of inflammatory response
B	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
C	0002755	biological_process	MyD88-dependent toll-like receptor signaling pathway
C	0043124	biological_process	negative regulation of I-kappaB kinase/NF-kappaB signaling
C	0050727	biological_process	regulation of inflammatory response
C	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
E	0002755	biological_process	MyD88-dependent toll-like receptor signaling pathway
E	0043124	biological_process	negative regulation of I-kappaB kinase/NF-kappaB signaling
E	0050727	biological_process	regulation of inflammatory response
E	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
F	0002755	biological_process	MyD88-dependent toll-like receptor signaling pathway
F	0043124	biological_process	negative regulation of I-kappaB kinase/NF-kappaB signaling
F	0050727	biological_process	regulation of inflammatory response
F	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue GOL D 201

Chain	Residue
D	THR107
D	LEU108
D	LEU169

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Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
A	LYS27-ASP52
A	LYS127-ASP152

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	150
Details	Domain: {"description":"Ubiquitin-like 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	150
Details	Domain: {"description":"Ubiquitin-like 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	174
Details	Region: {"description":"Ubiquitin-binding domain (UBD)"}

Chain

Residue

Details

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