7EAL
The structure of the A20-Binding Inhibitor of NF-kB 1 in complex with di-ubiquitin
Functional Information from GO Data
Chain | GOid | namespace | contents |
B | 0002755 | biological_process | MyD88-dependent toll-like receptor signaling pathway |
B | 0043124 | biological_process | negative regulation of I-kappaB kinase/NF-kappaB signaling |
B | 0050727 | biological_process | regulation of inflammatory response |
B | 0070373 | biological_process | negative regulation of ERK1 and ERK2 cascade |
C | 0002755 | biological_process | MyD88-dependent toll-like receptor signaling pathway |
C | 0043124 | biological_process | negative regulation of I-kappaB kinase/NF-kappaB signaling |
C | 0050727 | biological_process | regulation of inflammatory response |
C | 0070373 | biological_process | negative regulation of ERK1 and ERK2 cascade |
E | 0002755 | biological_process | MyD88-dependent toll-like receptor signaling pathway |
E | 0043124 | biological_process | negative regulation of I-kappaB kinase/NF-kappaB signaling |
E | 0050727 | biological_process | regulation of inflammatory response |
E | 0070373 | biological_process | negative regulation of ERK1 and ERK2 cascade |
F | 0002755 | biological_process | MyD88-dependent toll-like receptor signaling pathway |
F | 0043124 | biological_process | negative regulation of I-kappaB kinase/NF-kappaB signaling |
F | 0050727 | biological_process | regulation of inflammatory response |
F | 0070373 | biological_process | negative regulation of ERK1 and ERK2 cascade |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | binding site for residue GOL D 201 |
Chain | Residue |
D | THR107 |
D | LEU108 |
D | LEU169 |
Functional Information from PROSITE/UniProt
site_id | PS00299 |
Number of Residues | 26 |
Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
Chain | Residue | Details |
A | LYS27-ASP52 | |
A | LYS127-ASP152 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332 |
Chain | Residue | Details |
B | THR438 | |
C | THR438 | |
E | THR438 | |
F | THR438 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
Chain | Residue | Details |
B | SER442 | |
C | SER442 | |
E | SER442 | |
F | SER442 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 |
Chain | Residue | Details |
A | SER65 | |
D | SER65 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 |
Chain | Residue | Details |
A | THR66 | |
D | THR66 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742 |
Chain | Residue | Details |
A | GLY76 | |
D | GLY76 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 |
Chain | Residue | Details |
A | LYS6 | |
D | LYS6 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
Chain | Residue | Details |
A | GLY76 | |
D | GLY76 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 |
Chain | Residue | Details |
A | LYS11 | |
A | LYS48 | |
D | LYS11 | |
D | LYS48 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 |
Chain | Residue | Details |
A | LYS27 | |
D | LYS27 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 |
Chain | Residue | Details |
A | LYS29 | |
D | LYS29 |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 |
Chain | Residue | Details |
A | LYS33 | |
D | LYS33 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 |
Chain | Residue | Details |
A | LYS63 | |
D | LYS63 |