7E87
CryoEM structure of the human Kv4.2-DPP6S complex, transmembrane and intracellular region
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005249 | molecular_function | voltage-gated potassium channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0008076 | cellular_component | voltage-gated potassium channel complex |
| A | 0016020 | cellular_component | membrane |
| A | 0051260 | biological_process | protein homooligomerization |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005249 | molecular_function | voltage-gated potassium channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0008076 | cellular_component | voltage-gated potassium channel complex |
| B | 0016020 | cellular_component | membrane |
| B | 0051260 | biological_process | protein homooligomerization |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005249 | molecular_function | voltage-gated potassium channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006813 | biological_process | potassium ion transport |
| C | 0008076 | cellular_component | voltage-gated potassium channel complex |
| C | 0016020 | cellular_component | membrane |
| C | 0051260 | biological_process | protein homooligomerization |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005249 | molecular_function | voltage-gated potassium channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006813 | biological_process | potassium ion transport |
| D | 0008076 | cellular_component | voltage-gated potassium channel complex |
| D | 0016020 | cellular_component | membrane |
| D | 0051260 | biological_process | protein homooligomerization |
| D | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255 |
| Chain | Residue | Details |
| J | ILE34-LEU54 | |
| I | ILE34-LEU54 | |
| E | ILE34-LEU54 | |
| F | ILE34-LEU54 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 74 |
| Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:34552243 |
| Chain | Residue | Details |
| A | VAL207-ALA226 | |
| A | ASN282-GLY287 | |
| A | GLU346-ILE357 | |
| A | PRO378-THR380 | |
| D | VAL207-ALA226 | |
| D | ASN282-GLY287 | |
| D | GLU346-ILE357 | |
| D | PRO378-THR380 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=Segment S2 => ECO:0000269|PubMed:34552243, ECO:0007744|PDB:7F0J |
| Chain | Residue | Details |
| A | VAL227-ALA249 | |
| D | VAL227-ALA249 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 38 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:34552243 |
| Chain | Residue | Details |
| A | ALA250-ARG256 | |
| A | GLN308-ALA321 | |
| D | ALA250-ARG256 | |
| D | GLN308-ALA321 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 48 |
| Details | TRANSMEM: Helical; Name=Segment S3 => ECO:0000269|PubMed:34552243, ECO:0007744|PDB:7F0J |
| Chain | Residue | Details |
| A | PHE257-ASP281 | |
| D | PHE257-ASP281 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 38 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000269|PubMed:34552243, ECO:0007744|PDB:7F0J |
| Chain | Residue | Details |
| A | ALA288-SER307 | |
| D | ALA288-SER307 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=Segment S5 => ECO:0000269|PubMed:34552243, ECO:0007744|PDB:7F0J |
| Chain | Residue | Details |
| A | SER322-ALA345 | |
| D | SER322-ALA345 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 22 |
| Details | INTRAMEM: Helical; Name=Pore helix => ECO:0000250|UniProtKB:P63142 |
| Chain | Residue | Details |
| A | PRO358-THR369 | |
| D | PRO358-THR369 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 14 |
| Details | INTRAMEM: INTRAMEM => ECO:0000250|UniProtKB:P63142 |
| Chain | Residue | Details |
| A | THR370-VAL377 | |
| D | THR370-VAL377 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=Segment S6 => ECO:0000269|PubMed:34552243, ECO:0007744|PDB:7F0J |
| Chain | Residue | Details |
| A | ILE381-PRO403 | |
| D | ILE381-PRO403 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | BINDING: in chain A => ECO:0000269|PubMed:34552243, ECO:0007744|PDB:7F0J |
| Chain | Residue | Details |
| A | HIS105 | |
| A | CYS132 | |
| A | CYS133 | |
| D | HIS105 | |
| D | CYS132 | |
| D | CYS133 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | BINDING: in chain B => ECO:0000269|PubMed:34552243, ECO:0007744|PDB:7F0J |
| Chain | Residue | Details |
| A | CYS111 | |
| D | CYS111 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:35597238, ECO:0007744|PDB:7UK5, ECO:0007744|PDB:7UKD, ECO:0007744|PDB:7UKE, ECO:0007744|PDB:7UKF |
| Chain | Residue | Details |
| A | THR370 | |
| A | TYR373 | |
| D | THR370 | |
| D | TYR373 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:35597238, ECO:0007744|PDB:7UKC, ECO:0007744|PDB:7UKG |
| Chain | Residue | Details |
| A | LEU371 | |
| D | LEU371 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:35597238, ECO:0007744|PDB:7UK5, ECO:0007744|PDB:7UKC, ECO:0007744|PDB:7UKD, ECO:0007744|PDB:7UKE, ECO:0007744|PDB:7UKF, ECO:0007744|PDB:7UKG |
| Chain | Residue | Details |
| A | GLY372 | |
| D | GLY372 |
