7E84

CryoEM structure of human Kv4.2-KChIP1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0016020	cellular_component	membrane
A	0051260	biological_process	protein homooligomerization
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0005249	molecular_function	voltage-gated potassium channel activity
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0016020	cellular_component	membrane
B	0051260	biological_process	protein homooligomerization
B	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0005249	molecular_function	voltage-gated potassium channel activity
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0008076	cellular_component	voltage-gated potassium channel complex
D	0016020	cellular_component	membrane
D	0051260	biological_process	protein homooligomerization
D	0055085	biological_process	transmembrane transport
E	0005509	molecular_function	calcium ion binding
G	0005216	molecular_function	monoatomic ion channel activity
G	0005249	molecular_function	voltage-gated potassium channel activity
G	0006811	biological_process	monoatomic ion transport
G	0006813	biological_process	potassium ion transport
G	0008076	cellular_component	voltage-gated potassium channel complex
G	0016020	cellular_component	membrane
G	0051260	biological_process	protein homooligomerization
G	0055085	biological_process	transmembrane transport
H	0005509	molecular_function	calcium ion binding
J	0005509	molecular_function	calcium ion binding
L	0005509	molecular_function	calcium ion binding

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DINKDGYINkeEM

Chain	Residue	Details
E	ASP135-MET147
E	ASP183-PHE195

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	TRANSMEM: Helical; Name=Segment S1 => ECO:0000250|UniProtKB:P63142

Chain	Residue	Details
A	MET183-VAL204
H	ASP135
H	ASN137
H	ASP139
H	TYR141
H	GLU146
H	ASP183
H	ASN185
H	ASP187
H	GLU194
J	ASP135
B	MET183-VAL204
J	ASN137
J	ASP139
J	TYR141
J	GLU146
J	ASP183
J	ASN185
J	ASP187
J	GLU194
L	ASP135
L	ASN137
D	MET183-VAL204
L	ASP139
L	TYR141
L	GLU146
L	ASP183
L	ASN185
L	ASP187
L	GLU194
G	MET183-VAL204
E	GLU146
E	ASP183
E	ASN185
E	ASP187
E	GLU194

---

site_id	SWS_FT_FI2
Number of Residues	192
Details	TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:P63142

Chain	Residue	Details
A	GLU205-ALA228
D	THR280-SER286
D	TYR344-ILE357
D	PRO378-LYS384
G	GLU205-ALA228
G	THR280-SER286
G	TYR344-ILE357
G	PRO378-LYS384
A	THR280-SER286
A	TYR344-ILE357
A	PRO378-LYS384
B	GLU205-ALA228
B	THR280-SER286
B	TYR344-ILE357
B	PRO378-LYS384
D	GLU205-ALA228

---

site_id	SWS_FT_FI3
Number of Residues	84
Details	TRANSMEM: Helical; Name=Segment S2 => ECO:0000250|UniProtKB:P63142

Chain	Residue	Details
A	PHE229-ALA250
B	PHE229-ALA250
D	PHE229-ALA250
G	PHE229-ALA250

---

site_id	SWS_FT_FI4
Number of Residues	96
Details	TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P63142

Chain	Residue	Details
A	ALA251-VAL261
A	SER307-ALA321
B	ALA251-VAL261
B	SER307-ALA321
D	ALA251-VAL261
D	SER307-ALA321
G	ALA251-VAL261
G	SER307-ALA321

---

site_id	SWS_FT_FI5
Number of Residues	68
Details	TRANSMEM: Helical; Name=Segment S3 => ECO:0000250|UniProtKB:P63142

Chain	Residue	Details
A	MET262-MET279
B	MET262-MET279
D	MET262-MET279
G	MET262-MET279

---

site_id	SWS_FT_FI6
Number of Residues	76
Details	TRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000250|UniProtKB:P63142

Chain	Residue	Details
A	GLY287-HIS306
B	GLY287-HIS306
D	GLY287-HIS306
G	GLY287-HIS306

---

site_id	SWS_FT_FI7
Number of Residues	84
Details	TRANSMEM: Helical; Name=Segment S5 => ECO:0000250|UniProtKB:P63142

Chain	Residue	Details
A	SER322-PHE343
B	SER322-PHE343
D	SER322-PHE343
G	SER322-PHE343

---

site_id	SWS_FT_FI8
Number of Residues	44
Details	INTRAMEM: Helical; Name=Pore helix => ECO:0000250|UniProtKB:P63142

Chain	Residue	Details
A	PRO358-THR369
B	PRO358-THR369
D	PRO358-THR369
G	PRO358-THR369

---

site_id	SWS_FT_FI9
Number of Residues	28
Details	INTRAMEM: INTRAMEM => ECO:0000250|UniProtKB:P63142

Chain	Residue	Details
A	THR370-VAL377
B	THR370-VAL377
D	THR370-VAL377
G	THR370-VAL377

---

site_id	SWS_FT_FI10
Number of Residues	112
Details	TRANSMEM: Helical; Name=Segment S6 => ECO:0000250|UniProtKB:P63142

Chain	Residue	Details
A	ILE385-TYR413
B	ILE385-TYR413
D	ILE385-TYR413
G	ILE385-TYR413

---

site_id	SWS_FT_FI11
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q63881

Chain	Residue	Details
A	HIS105
G	HIS105
G	CYS132
G	CYS133
A	CYS132
A	CYS133
B	HIS105
B	CYS132
B	CYS133
D	HIS105
D	CYS132
D	CYS133

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q63881

Chain	Residue	Details
A	THR38
B	THR38
D	THR38
G	THR38

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q63881

Chain	Residue	Details
A	SER438
B	SER438
D	SER438
G	SER438

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