7E83
CryoEM structure of the human Kv4.2-KChIP1 complex, intracellular region
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005249 | molecular_function | voltage-gated potassium channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0008076 | cellular_component | voltage-gated potassium channel complex |
| A | 0016020 | cellular_component | membrane |
| A | 0051260 | biological_process | protein homooligomerization |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005509 | molecular_function | calcium ion binding |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005249 | molecular_function | voltage-gated potassium channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006813 | biological_process | potassium ion transport |
| C | 0008076 | cellular_component | voltage-gated potassium channel complex |
| C | 0016020 | cellular_component | membrane |
| C | 0051260 | biological_process | protein homooligomerization |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005249 | molecular_function | voltage-gated potassium channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006813 | biological_process | potassium ion transport |
| D | 0008076 | cellular_component | voltage-gated potassium channel complex |
| D | 0016020 | cellular_component | membrane |
| D | 0051260 | biological_process | protein homooligomerization |
| D | 0055085 | biological_process | transmembrane transport |
| E | 0005509 | molecular_function | calcium ion binding |
| F | 0005509 | molecular_function | calcium ion binding |
| G | 0005216 | molecular_function | monoatomic ion channel activity |
| G | 0005249 | molecular_function | voltage-gated potassium channel activity |
| G | 0006811 | biological_process | monoatomic ion transport |
| G | 0006813 | biological_process | potassium ion transport |
| G | 0008076 | cellular_component | voltage-gated potassium channel complex |
| G | 0016020 | cellular_component | membrane |
| G | 0051260 | biological_process | protein homooligomerization |
| G | 0055085 | biological_process | transmembrane transport |
| H | 0005509 | molecular_function | calcium ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DINKDGYINkeEM |
| Chain | Residue | Details |
| E | ASP135-MET147 | |
| E | ASP183-PHE195 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 72 |
| Details | Region: {"description":"Interaction with KCNIP1, KCNIP2, and other family members","evidences":[{"source":"UniProtKB","id":"Q63881","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 76 |
| Details | Region: {"description":"Interaction with KCNIP1","evidences":[{"source":"UniProtKB","id":"Q63881","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | Region: {"description":"Required for dendritic targeting","evidences":[{"source":"UniProtKB","id":"Q63881","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F0J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F0J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q63881","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 140 |
| Details | Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 140 |
| Details | Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 52 |
| Details | Region: {"description":"Interaction with KCND2","evidences":[{"source":"UniProtKB","id":"Q8R426","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 32 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17057713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17187064","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
