7E7I
Cryo-EM structure of human ABCA4 in the apo state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001523 | biological_process | retinoid metabolic process |
| A | 0001750 | cellular_component | photoreceptor outer segment |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005501 | molecular_function | retinoid binding |
| A | 0005502 | molecular_function | 11-cis retinal binding |
| A | 0005503 | molecular_function | all-trans retinal binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005548 | molecular_function | phospholipid transporter activity |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006649 | biological_process | phospholipid transfer to membrane |
| A | 0006869 | biological_process | lipid transport |
| A | 0007601 | biological_process | visual perception |
| A | 0007603 | biological_process | phototransduction, visible light |
| A | 0016020 | cellular_component | membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0034632 | molecular_function | retinol transmembrane transporter activity |
| A | 0034633 | biological_process | retinol transport |
| A | 0042574 | biological_process | retinal metabolic process |
| A | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| A | 0042995 | cellular_component | cell projection |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0045332 | biological_process | phospholipid translocation |
| A | 0045494 | biological_process | photoreceptor cell maintenance |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0090555 | molecular_function | phosphatidylethanolamine flippase activity |
| A | 0097381 | cellular_component | photoreceptor disc membrane |
| A | 0120202 | cellular_component | rod photoreceptor disc membrane |
| A | 0140326 | molecular_function | ATPase-coupled intramembrane lipid transporter activity |
| A | 0140327 | molecular_function | flippase activity |
| A | 0140347 | molecular_function | N-retinylidene-phosphatidylethanolamine flippase activity |
| A | 0140359 | molecular_function | ABC-type transporter activity |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGMQRKLSVAIAF |
| Chain | Residue | Details |
| A | LEU1062-PHE1076 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 982 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-GLN21 | |
| A | SER668-THR699 | |
| A | SER752-SER759 | |
| A | LEU857-GLN1376 | |
| A | PHE1749-ASN1759 | |
| A | GLU1814-LYS1831 | |
| A | LEU1895-ASP2273 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 240 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | LYS22-LEU42 | |
| A | VAL1793-LEU1813 | |
| A | LEU1832-GLN1852 | |
| A | LEU1874-LEU1894 | |
| A | PHE647-VAL667 | |
| A | TRP700-MET720 | |
| A | PHE731-LEU751 | |
| A | LEU760-PHE780 | |
| A | PHE836-TYR856 | |
| A | ILE1377-PHE1397 | |
| A | PHE1728-GLY1748 | |
| A | LEU1760-PRO1780 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 932 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:11320094 |
| Chain | Residue | Details |
| A | ARG43-SER646 | |
| A | GLY1398-ASN1727 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 94 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | HIS721-PRO730 | |
| A | ALA781-SER835 | |
| A | ALA1781-TYR1792 | |
| A | ALA1853-ASP1873 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434, ECO:0000269|PubMed:33605212, ECO:0007744|PDB:7LKZ |
| Chain | Residue | Details |
| A | GLY963 | |
| A | GLY1972 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33605212, ECO:0007744|PDB:7LKZ |
| Chain | Residue | Details |
| A | LYS1054 | |
| A | GLY2073 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by trypsin => ECO:0000250|UniProtKB:F1MWM0 |
| Chain | Residue | Details |
| A | LYS1309 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:F1MWM0 |
| Chain | Residue | Details |
| A | THR901 | |
| A | THR1313 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:F1MWM0 |
| Chain | Residue | Details |
| A | SER1185 | |
| A | SER1317 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 7 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11320094, ECO:0000269|PubMed:33605212, ECO:0007744|PDB:7LKP, ECO:0007744|PDB:7LKZ |
| Chain | Residue | Details |
| A | ASN98 | |
| A | ASN415 | |
| A | ASN444 | |
| A | ASN1469 | |
| A | ASN1529 | |
| A | ASN1588 | |
| A | ASN1662 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11320094, ECO:0000269|PubMed:33605212, ECO:0007744|PDB:7LKP |
| Chain | Residue | Details |
| A | ASN504 |
