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7E57

Crystal structure of murine GITR-GITRL complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0002250biological_processadaptive immune response
A0002309biological_processT cell proliferation involved in immune response
A0002376biological_processimmune system process
A0002687biological_processpositive regulation of leukocyte migration
A0005102molecular_functionsignaling receptor binding
A0005125molecular_functioncytokine activity
A0005164molecular_functiontumor necrosis factor receptor binding
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005886cellular_componentplasma membrane
A0006955biological_processimmune response
A0007165biological_processsignal transduction
A0009986cellular_componentcell surface
A0010759biological_processpositive regulation of macrophage chemotaxis
A0016020cellular_componentmembrane
A0032649biological_processregulation of type II interferon production
A0032675biological_processregulation of interleukin-6 production
A0032680biological_processregulation of tumor necrosis factor production
A0032733biological_processpositive regulation of interleukin-10 production
A0032735biological_processpositive regulation of interleukin-12 production
A0032813molecular_functiontumor necrosis factor receptor superfamily binding
A0033209biological_processtumor necrosis factor-mediated signaling pathway
A0035741biological_processactivated CD4-positive, alpha-beta T cell proliferation
A0042129biological_processregulation of T cell proliferation
A0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
A0042802molecular_functionidentical protein binding
A0043254biological_processregulation of protein-containing complex assembly
A0045785biological_processpositive regulation of cell adhesion
A0050729biological_processpositive regulation of inflammatory response
A0051092biological_processpositive regulation of NF-kappaB transcription factor activity
A0060255biological_processregulation of macromolecule metabolic process
A0071637biological_processregulation of monocyte chemotactic protein-1 production
A0080090biological_processregulation of primary metabolic process
A0090026biological_processpositive regulation of monocyte chemotaxis
A2000329biological_processnegative regulation of T-helper 17 cell lineage commitment
A2000348biological_processregulation of CD40 signaling pathway
A2000508biological_processregulation of dendritic cell chemotaxis
B0002250biological_processadaptive immune response
B0002309biological_processT cell proliferation involved in immune response
B0002376biological_processimmune system process
B0002687biological_processpositive regulation of leukocyte migration
B0005102molecular_functionsignaling receptor binding
B0005125molecular_functioncytokine activity
B0005164molecular_functiontumor necrosis factor receptor binding
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005886cellular_componentplasma membrane
B0006955biological_processimmune response
B0007165biological_processsignal transduction
B0009986cellular_componentcell surface
B0010759biological_processpositive regulation of macrophage chemotaxis
B0016020cellular_componentmembrane
B0032649biological_processregulation of type II interferon production
B0032675biological_processregulation of interleukin-6 production
B0032680biological_processregulation of tumor necrosis factor production
B0032733biological_processpositive regulation of interleukin-10 production
B0032735biological_processpositive regulation of interleukin-12 production
B0032813molecular_functiontumor necrosis factor receptor superfamily binding
B0033209biological_processtumor necrosis factor-mediated signaling pathway
B0035741biological_processactivated CD4-positive, alpha-beta T cell proliferation
B0042129biological_processregulation of T cell proliferation
B0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
B0042802molecular_functionidentical protein binding
B0043254biological_processregulation of protein-containing complex assembly
B0045785biological_processpositive regulation of cell adhesion
B0050729biological_processpositive regulation of inflammatory response
B0051092biological_processpositive regulation of NF-kappaB transcription factor activity
B0060255biological_processregulation of macromolecule metabolic process
B0071637biological_processregulation of monocyte chemotactic protein-1 production
B0080090biological_processregulation of primary metabolic process
B0090026biological_processpositive regulation of monocyte chemotaxis
B2000329biological_processnegative regulation of T-helper 17 cell lineage commitment
B2000348biological_processregulation of CD40 signaling pathway
B2000508biological_processregulation of dendritic cell chemotaxis
C0005031molecular_functiontumor necrosis factor receptor activity
C0005886cellular_componentplasma membrane
C0043066biological_processnegative regulation of apoptotic process
D0005031molecular_functiontumor necrosis factor receptor activity
D0005886cellular_componentplasma membrane
D0043066biological_processnegative regulation of apoptotic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues9
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues78
DetailsRepeat: {"description":"TNFR-Cys 2"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues80
DetailsRepeat: {"description":"TNFR-Cys 3"}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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