7E43
Structural insights into a bifunctional peptide methionine sulfoxide reductase MsrA/B fusion protein from Helicobacter pylori
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0008113 | molecular_function | peptide-methionine (S)-S-oxide reductase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016671 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor |
| A | 0030091 | biological_process | protein repair |
| A | 0033743 | molecular_function | peptide-methionine (R)-S-oxide reductase activity |
| A | 0033744 | molecular_function | L-methionine:thioredoxin-disulfide S-oxidoreductase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0008113 | molecular_function | peptide-methionine (S)-S-oxide reductase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016671 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor |
| B | 0030091 | biological_process | protein repair |
| B | 0033743 | molecular_function | peptide-methionine (R)-S-oxide reductase activity |
| B | 0033744 | molecular_function | L-methionine:thioredoxin-disulfide S-oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 401 |
| Chain | Residue |
| B | GLY302 |
| B | HIS303 |
| B | SER318 |
| B | HOH517 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue ACT B 402 |
| Chain | Residue |
| B | TYR125 |
| B | SER44 |
| B | PHE45 |
| B | TRP46 |
| B | TYR75 |
| B | GLU85 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 401 |
| Chain | Residue |
| A | GLY302 |
| A | HIS303 |
| A | SER318 |
| A | ASN320 |
| A | HOH561 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 402 |
| Chain | Residue |
| A | SER44 |
| A | PHE45 |
| A | TRP46 |
| A | TYR75 |
| A | GLU85 |
| A | TYR125 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 123 |
| Details | Domain: {"description":"MsrB","evidences":[{"source":"PROSITE-ProRule","id":"PRU01126","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 153 |
| Details | Region: {"description":"Peptide methionine sulfoxide reductase A"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU01126","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
