7E3H
Crystal structure of human acetylcholinesterase in complex with donepezil
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001507 | biological_process | acetylcholine catabolic process in synaptic cleft |
| A | 0001540 | molecular_function | amyloid-beta binding |
| A | 0001919 | biological_process | regulation of receptor recycling |
| A | 0002076 | biological_process | osteoblast development |
| A | 0003990 | molecular_function | acetylcholinesterase activity |
| A | 0004104 | molecular_function | cholinesterase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005518 | molecular_function | collagen binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005604 | cellular_component | basement membrane |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006581 | biological_process | acetylcholine catabolic process |
| A | 0007155 | biological_process | cell adhesion |
| A | 0007399 | biological_process | nervous system development |
| A | 0007416 | biological_process | synapse assembly |
| A | 0009986 | cellular_component | cell surface |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017171 | molecular_function | serine hydrolase activity |
| A | 0031594 | cellular_component | neuromuscular junction |
| A | 0031623 | biological_process | receptor internalization |
| A | 0032223 | biological_process | negative regulation of synaptic transmission, cholinergic |
| A | 0042166 | molecular_function | acetylcholine binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0042982 | biological_process | amyloid precursor protein metabolic process |
| A | 0043083 | cellular_component | synaptic cleft |
| A | 0043236 | molecular_function | laminin binding |
| A | 0045202 | cellular_component | synapse |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0050714 | biological_process | positive regulation of protein secretion |
| A | 0052689 | molecular_function | carboxylic ester hydrolase activity |
| A | 0060041 | biological_process | retina development in camera-type eye |
| A | 0095500 | biological_process | acetylcholine receptor signaling pathway |
| A | 0098552 | cellular_component | side of membrane |
| A | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
| B | 0001507 | biological_process | acetylcholine catabolic process in synaptic cleft |
| B | 0001540 | molecular_function | amyloid-beta binding |
| B | 0001919 | biological_process | regulation of receptor recycling |
| B | 0002076 | biological_process | osteoblast development |
| B | 0003990 | molecular_function | acetylcholinesterase activity |
| B | 0004104 | molecular_function | cholinesterase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005518 | molecular_function | collagen binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005604 | cellular_component | basement membrane |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005634 | cellular_component | nucleus |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006581 | biological_process | acetylcholine catabolic process |
| B | 0007155 | biological_process | cell adhesion |
| B | 0007399 | biological_process | nervous system development |
| B | 0007416 | biological_process | synapse assembly |
| B | 0009986 | cellular_component | cell surface |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0017171 | molecular_function | serine hydrolase activity |
| B | 0031594 | cellular_component | neuromuscular junction |
| B | 0031623 | biological_process | receptor internalization |
| B | 0032223 | biological_process | negative regulation of synaptic transmission, cholinergic |
| B | 0042166 | molecular_function | acetylcholine binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0042982 | biological_process | amyloid precursor protein metabolic process |
| B | 0043083 | cellular_component | synaptic cleft |
| B | 0043236 | molecular_function | laminin binding |
| B | 0045202 | cellular_component | synapse |
| B | 0048471 | cellular_component | perinuclear region of cytoplasm |
| B | 0050714 | biological_process | positive regulation of protein secretion |
| B | 0052689 | molecular_function | carboxylic ester hydrolase activity |
| B | 0060041 | biological_process | retina development in camera-type eye |
| B | 0095500 | biological_process | acetylcholine receptor signaling pathway |
| B | 0098552 | cellular_component | side of membrane |
| B | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Acyl-ester intermediate"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Charge relay system"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"4EY5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"4BDT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"4EY6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"23035744","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EY4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EY5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EY6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EY7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11053835","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20408548","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23035744","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23679855","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1F8U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X8B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EY4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EY5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EY6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EY8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"23035744","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EY8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
