7E3F

Crystal structure of Trypanosoma brucei cathepsin B Y217C/S275C mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0005615	cellular_component	extracellular space
A	0005764	cellular_component	lysosome
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
A	0010608	biological_process	post-transcriptional regulation of gene expression
A	0016787	molecular_function	hydrolase activity
A	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00139
Number of Residues	12
Details	THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QSaCGSCWAvAA

Chain	Residue	Details
A	GLN116-ALA127

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site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. GGHAVRLVGWG

Chain	Residue	Details
A	GLY280-GLY290

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