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7E20

Cryo EM structure of a K+-bound Na+,K+-ATPase in the E2 state

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0002026biological_processregulation of the force of heart contraction
A0002028biological_processregulation of sodium ion transport
A0005215molecular_functiontransporter activity
A0005391molecular_functionP-type sodium:potassium-exchanging transporter activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0005890cellular_componentsodium:potassium-exchanging ATPase complex
A0006813biological_processpotassium ion transport
A0006814biological_processsodium ion transport
A0006883biological_processintracellular sodium ion homeostasis
A0007231biological_processosmosensory signaling pathway
A0008217biological_processregulation of blood pressure
A0008556molecular_functionP-type potassium transmembrane transporter activity
A0009410biological_processresponse to xenobiotic stimulus
A0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
A0014069cellular_componentpostsynaptic density
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0016328cellular_componentlateral plasma membrane
A0016791molecular_functionphosphatase activity
A0016887molecular_functionATP hydrolysis activity
A0030007biological_processintracellular potassium ion homeostasis
A0030315cellular_componentT-tubule
A0030424cellular_componentaxon
A0030955molecular_functionpotassium ion binding
A0031090cellular_componentorganelle membrane
A0031402molecular_functionsodium ion binding
A0031947biological_processnegative regulation of glucocorticoid biosynthetic process
A0032991cellular_componentprotein-containing complex
A0034220biological_processmonoatomic ion transmembrane transport
A0036126cellular_componentsperm flagellum
A0036376biological_processsodium ion export across plasma membrane
A0042383cellular_componentsarcolemma
A0042470cellular_componentmelanosome
A0042995cellular_componentcell projection
A0044325molecular_functiontransmembrane transporter binding
A0045121cellular_componentmembrane raft
A0045822biological_processnegative regulation of heart contraction
A0045823biological_processpositive regulation of heart contraction
A0045989biological_processpositive regulation of striated muscle contraction
A0046872molecular_functionmetal ion binding
A0046982molecular_functionprotein heterodimerization activity
A0051087molecular_functionprotein-folding chaperone binding
A0055078biological_processsodium ion homeostasis
A0055119biological_processrelaxation of cardiac muscle
A0060047biological_processheart contraction
A0060342cellular_componentphotoreceptor inner segment membrane
A0070062cellular_componentextracellular exosome
A0071383biological_processcellular response to steroid hormone stimulus
A0086002biological_processcardiac muscle cell action potential involved in contraction
A0086009biological_processmembrane repolarization
A0086013biological_processmembrane repolarization during cardiac muscle cell action potential
A0086064biological_processcell communication by electrical coupling involved in cardiac conduction
A1902600biological_processproton transmembrane transport
A1903416biological_processresponse to glycoside
A1903561cellular_componentextracellular vesicle
A1990239molecular_functionsteroid hormone binding
A1990573biological_processpotassium ion import across plasma membrane
B0001671molecular_functionATPase activator activity
B0005391molecular_functionP-type sodium:potassium-exchanging transporter activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0005890cellular_componentsodium:potassium-exchanging ATPase complex
B0006813biological_processpotassium ion transport
B0006814biological_processsodium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0006883biological_processintracellular sodium ion homeostasis
B0007155biological_processcell adhesion
B0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
B0010468biological_processregulation of gene expression
B0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
B0014704cellular_componentintercalated disc
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0016328cellular_componentlateral plasma membrane
B0019901molecular_functionprotein kinase binding
B0023026molecular_functionMHC class II protein complex binding
B0030007biological_processintracellular potassium ion homeostasis
B0030315cellular_componentT-tubule
B0030674molecular_functionprotein-macromolecule adaptor activity
B0031090cellular_componentorganelle membrane
B0032781biological_processpositive regulation of ATP-dependent activity
B0035725biological_processsodium ion transmembrane transport
B0036126cellular_componentsperm flagellum
B0036376biological_processsodium ion export across plasma membrane
B0042383cellular_componentsarcolemma
B0044861biological_processprotein transport into plasma membrane raft
B0045087biological_processinnate immune response
B0046034biological_processATP metabolic process
B0046982molecular_functionprotein heterodimerization activity
B0050821biological_processprotein stabilization
B0051117molecular_functionATPase binding
B0055119biological_processrelaxation of cardiac muscle
B0060048biological_processcardiac muscle contraction
B0070062cellular_componentextracellular exosome
B0072659biological_processprotein localization to plasma membrane
B0086009biological_processmembrane repolarization
B0086013biological_processmembrane repolarization during cardiac muscle cell action potential
B0086064biological_processcell communication by electrical coupling involved in cardiac conduction
B0098655biological_processmonoatomic cation transmembrane transport
B1901018biological_processpositive regulation of potassium ion transmembrane transporter activity
B1902600biological_processproton transmembrane transport
B1903169biological_processregulation of calcium ion transmembrane transport
B1903278biological_processpositive regulation of sodium ion export across plasma membrane
B1903288biological_processpositive regulation of potassium ion import across plasma membrane
B1903408biological_processpositive regulation of P-type sodium:potassium-exchanging transporter activity
B1903561cellular_componentextracellular vesicle
B1990573biological_processpotassium ion import across plasma membrane
C0001671molecular_functionATPase activator activity
C0005886cellular_componentplasma membrane
C0005890cellular_componentsodium:potassium-exchanging ATPase complex
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0006814biological_processsodium ion transport
C0006883biological_processintracellular sodium ion homeostasis
C0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
C0016020cellular_componentmembrane
C0017080molecular_functionsodium channel regulator activity
C0030007biological_processintracellular potassium ion homeostasis
C0030674molecular_functionprotein-macromolecule adaptor activity
C0036376biological_processsodium ion export across plasma membrane
C0043269biological_processregulation of monoatomic ion transport
C0055085biological_processtransmembrane transport
C0070062cellular_componentextracellular exosome
C0099106molecular_functionion channel regulator activity
C1902600biological_processproton transmembrane transport
C1903408biological_processpositive regulation of P-type sodium:potassium-exchanging transporter activity
C1990573biological_processpotassium ion import across plasma membrane
Functional Information from PROSITE/UniProt
site_idPS00154
Number of Residues7
DetailsATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT
ChainResidueDetails
AASP376-THR382

site_idPS00390
Number of Residues21
DetailsATPASE_NA_K_BETA_1 Sodium and potassium ATPases beta subunits signature 1. WkkFiWNsekkefLGRTggsW
ChainResidueDetails
BTRP12-TRP32

site_idPS00391
Number of Residues16
DetailsATPASE_NA_K_BETA_2 Sodium and potassium ATPases beta subunits signature 2. RkvCRfklewLgnCSG
ChainResidueDetails
BARG146-GLY161

site_idPS01310
Number of Residues14
DetailsFXYD FXYD family signature. DpFyYDyeTVRngG
ChainResidueDetails
CASP17-GLY30

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues17
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
CGLY29-LEU46
ALYS153-ILE288
ATHR339-LEU772
ATYR824-LYS843
ATHR939-ASN951
ALEU1007-TYR1023

site_idSWS_FT_FI2
Number of Residues27
DetailsTRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255
ChainResidueDetails
BILE35-SER62
ATHR986-LYS1006
ALEU132-ALA152
AGLU289-ILE308
AVAL321-ALA338
ALYS773-ILE792
AGLY803-ALA823
ALEU844-PHE866
AHIS919-LYS938
ALYS952-TYR970

site_idSWS_FT_FI3
Number of Residues240
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
BGLU63-SER303
ALEU309-ALA320
APHE793-LEU802
APHE867-CYS918
ACYS971-PRO985

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P07340
ChainResidueDetails
BSER11

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P14094
ChainResidueDetails
BTYR101
AASP717
AASP721

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:19159218
ChainResidueDetails
BASN158
BASN193

site_idSWS_FT_FI7
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973
ChainResidueDetails
BASN265

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER16

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06685
ChainResidueDetails
ASER40
ASER47
ASER452
ASER484

site_idSWS_FT_FI10
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8VDN2
ChainResidueDetails
ASER228
ASER668
ASER675

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q8VDN2
ChainResidueDetails
ATYR260

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
ATYR542

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8VDN2
ChainResidueDetails
ALYS661

site_idSWS_FT_FI14
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000250|UniProtKB:P06685
ChainResidueDetails
ASER943

222415

PDB entries from 2024-07-10

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