7E13

Caprylic acid targets a serine hydroxymethyltransferase to kill horseweed

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004372	molecular_function	glycine hydroxymethyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0006730	biological_process	one-carbon metabolic process
A	0016740	molecular_function	transferase activity
A	0019264	biological_process	glycine biosynthetic process from serine
A	0030170	molecular_function	pyridoxal phosphate binding
A	0035999	biological_process	tetrahydrofolate interconversion
A	0046653	biological_process	tetrahydrofolate metabolic process
B	0004372	molecular_function	glycine hydroxymethyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0006730	biological_process	one-carbon metabolic process
B	0016740	molecular_function	transferase activity
B	0019264	biological_process	glycine biosynthetic process from serine
B	0030170	molecular_function	pyridoxal phosphate binding
B	0035999	biological_process	tetrahydrofolate interconversion
B	0046653	biological_process	tetrahydrofolate metabolic process
C	0004372	molecular_function	glycine hydroxymethyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0006730	biological_process	one-carbon metabolic process
C	0016740	molecular_function	transferase activity
C	0019264	biological_process	glycine biosynthetic process from serine
C	0030170	molecular_function	pyridoxal phosphate binding
C	0035999	biological_process	tetrahydrofolate interconversion
C	0046653	biological_process	tetrahydrofolate metabolic process
D	0004372	molecular_function	glycine hydroxymethyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0006730	biological_process	one-carbon metabolic process
D	0016740	molecular_function	transferase activity
D	0019264	biological_process	glycine biosynthetic process from serine
D	0030170	molecular_function	pyridoxal phosphate binding
D	0035999	biological_process	tetrahydrofolate interconversion
D	0046653	biological_process	tetrahydrofolate metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue PLP A 601

Chain	Residue
A	SER144
A	THR279
A	HIS281
A	LYS282
B	TYR98
B	GLY326
B	GLY327
A	GLY145
A	SER146
A	HIS173
A	SER175
A	SER228
A	ASP253
A	ALA255
A	HIS256

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site_id	AC2
Number of Residues	15
Details	binding site for residue PLP B 601

Chain	Residue
A	TYR98
A	GLY326
A	GLY327
B	SER144
B	GLY145
B	SER146
B	HIS173
B	ALA227
B	SER228
B	ASP253
B	ALA255
B	HIS256
B	THR279
B	HIS281
B	LYS282

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site_id	AC3
Number of Residues	15
Details	binding site for residue PLP C 601

Chain	Residue
C	SER144
C	GLY145
C	SER146
C	HIS173
C	ALA227
C	SER228
C	ASP253
C	ALA255
C	HIS256
C	THR279
C	HIS281
C	LYS282
D	TYR98
D	GLY326
D	GLY327

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Functional Information from PROSITE/UniProt

site_id	PS00096
Number of Residues	17
Details	SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. DVvTTTTHKSLrGPRGA

Chain	Residue	Details
A	ASP274-ALA290

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