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7DYS

CryoEM structure of full length mouse TRPML2

Functional Information from GO Data
ChainGOidnamespacecontents
A0002250biological_processadaptive immune response
A0005261molecular_functionmonoatomic cation channel activity
A0005262molecular_functioncalcium channel activity
A0005381molecular_functioniron ion transmembrane transporter activity
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005886cellular_componentplasma membrane
A0008324molecular_functionmonoatomic cation transmembrane transporter activity
A0015031biological_processprotein transport
A0032722biological_processpositive regulation of chemokine production
A0034755biological_processiron ion transmembrane transport
A0042802molecular_functionidentical protein binding
A0045087biological_processinnate immune response
A0055037cellular_componentrecycling endosome
A0055038cellular_componentrecycling endosome membrane
A0070588biological_processcalcium ion transmembrane transport
A0071639biological_processpositive regulation of monocyte chemotactic protein-1 production
A0071642biological_processpositive regulation of macrophage inflammatory protein 1 alpha production
A0071651biological_processpositive regulation of chemokine (C-C motif) ligand 5 production
A1905517biological_processmacrophage migration
A1990266biological_processneutrophil migration
A2000341biological_processregulation of chemokine (C-X-C motif) ligand 2 production
A2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
B0002250biological_processadaptive immune response
B0005261molecular_functionmonoatomic cation channel activity
B0005262molecular_functioncalcium channel activity
B0005381molecular_functioniron ion transmembrane transporter activity
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005768cellular_componentendosome
B0005886cellular_componentplasma membrane
B0008324molecular_functionmonoatomic cation transmembrane transporter activity
B0015031biological_processprotein transport
B0032722biological_processpositive regulation of chemokine production
B0034755biological_processiron ion transmembrane transport
B0042802molecular_functionidentical protein binding
B0045087biological_processinnate immune response
B0055037cellular_componentrecycling endosome
B0055038cellular_componentrecycling endosome membrane
B0070588biological_processcalcium ion transmembrane transport
B0071639biological_processpositive regulation of monocyte chemotactic protein-1 production
B0071642biological_processpositive regulation of macrophage inflammatory protein 1 alpha production
B0071651biological_processpositive regulation of chemokine (C-C motif) ligand 5 production
B1905517biological_processmacrophage migration
B1990266biological_processneutrophil migration
B2000341biological_processregulation of chemokine (C-X-C motif) ligand 2 production
B2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
C0002250biological_processadaptive immune response
C0005261molecular_functionmonoatomic cation channel activity
C0005262molecular_functioncalcium channel activity
C0005381molecular_functioniron ion transmembrane transporter activity
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005768cellular_componentendosome
C0005886cellular_componentplasma membrane
C0008324molecular_functionmonoatomic cation transmembrane transporter activity
C0015031biological_processprotein transport
C0032722biological_processpositive regulation of chemokine production
C0034755biological_processiron ion transmembrane transport
C0042802molecular_functionidentical protein binding
C0045087biological_processinnate immune response
C0055037cellular_componentrecycling endosome
C0055038cellular_componentrecycling endosome membrane
C0070588biological_processcalcium ion transmembrane transport
C0071639biological_processpositive regulation of monocyte chemotactic protein-1 production
C0071642biological_processpositive regulation of macrophage inflammatory protein 1 alpha production
C0071651biological_processpositive regulation of chemokine (C-C motif) ligand 5 production
C1905517biological_processmacrophage migration
C1990266biological_processneutrophil migration
C2000341biological_processregulation of chemokine (C-X-C motif) ligand 2 production
C2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
D0002250biological_processadaptive immune response
D0005261molecular_functionmonoatomic cation channel activity
D0005262molecular_functioncalcium channel activity
D0005381molecular_functioniron ion transmembrane transporter activity
D0005764cellular_componentlysosome
D0005765cellular_componentlysosomal membrane
D0005768cellular_componentendosome
D0005886cellular_componentplasma membrane
D0008324molecular_functionmonoatomic cation transmembrane transporter activity
D0015031biological_processprotein transport
D0032722biological_processpositive regulation of chemokine production
D0034755biological_processiron ion transmembrane transport
D0042802molecular_functionidentical protein binding
D0045087biological_processinnate immune response
D0055037cellular_componentrecycling endosome
D0055038cellular_componentrecycling endosome membrane
D0070588biological_processcalcium ion transmembrane transport
D0071639biological_processpositive regulation of monocyte chemotactic protein-1 production
D0071642biological_processpositive regulation of macrophage inflammatory protein 1 alpha production
D0071651biological_processpositive regulation of chemokine (C-C motif) ligand 5 production
D1905517biological_processmacrophage migration
D1990266biological_processneutrophil migration
D2000341biological_processregulation of chemokine (C-X-C motif) ligand 2 production
D2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues484
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:F6RG56
ChainResidueDetails
AMET1-LYS65
DMET1-LYS65
DARG310-TRP346
DGLY398-ARG419
AARG310-TRP346
AGLY398-ARG419
BMET1-LYS65
BARG310-TRP346
BGLY398-ARG419
CMET1-LYS65
CARG310-TRP346
CGLY398-ARG419

site_idSWS_FT_FI2
Number of Residues484
DetailsTRANSMEM: Helical => ECO:0000250|UniProtKB:F6RG56
ChainResidueDetails
ALEU66-SER86
BVAL377-LEU397
BPHE420-GLY440
BLEU481-PHE502
CLEU66-SER86
CTYR289-THR309
CTYR347-ILE367
CVAL377-LEU397
CPHE420-GLY440
CLEU481-PHE502
DLEU66-SER86
ATYR289-THR309
DTYR289-THR309
DTYR347-ILE367
DVAL377-LEU397
DPHE420-GLY440
DLEU481-PHE502
ATYR347-ILE367
AVAL377-LEU397
APHE420-GLY440
ALEU481-PHE502
BLEU66-SER86
BTYR289-THR309
BTYR347-ILE367

site_idSWS_FT_FI3
Number of Residues904
DetailsTOPO_DOM: Extracellular => ECO:0000250|UniProtKB:F6RG56
ChainResidueDetails
AASN87-HIS288
CLYS368-ASP376
CPRO441-ASN448
CALA470-TRP480
DASN87-HIS288
DLYS368-ASP376
DPRO441-ASN448
DALA470-TRP480
ALYS368-ASP376
APRO441-ASN448
AALA470-TRP480
BASN87-HIS288
BLYS368-ASP376
BPRO441-ASN448
BALA470-TRP480
CASN87-HIS288

site_idSWS_FT_FI4
Number of Residues80
DetailsINTRAMEM: Pore-forming => ECO:0000250|UniProtKB:F6RG56
ChainResidueDetails
ALEU449-PHE469
BLEU449-PHE469
CLEU449-PHE469
DLEU449-PHE469

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PDB entries from 2024-09-11

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