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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7DYS

CryoEM structure of full length mouse TRPML2

Functional Information from GO Data
ChainGOidnamespacecontents
A0005261molecular_functionmonoatomic cation channel activity
A0005381molecular_functioniron ion transmembrane transporter activity
A0005765cellular_componentlysosomal membrane
A0005886cellular_componentplasma membrane
A0008324molecular_functionmonoatomic cation transmembrane transporter activity
A0016020cellular_componentmembrane
A0019722biological_processcalcium-mediated signaling
A0031902cellular_componentlate endosome membrane
A0032722biological_processpositive regulation of chemokine production
A0034755biological_processiron ion transmembrane transport
A0042802molecular_functionidentical protein binding
A0055037cellular_componentrecycling endosome
A0055038cellular_componentrecycling endosome membrane
A0071639biological_processpositive regulation of monocyte chemotactic protein-1 production
A0071642biological_processpositive regulation of macrophage inflammatory protein 1 alpha production
A0071651biological_processpositive regulation of chemokine (C-C motif) ligand 5 production
A0072345molecular_functionNAADP-sensitive calcium-release channel activity
A0098655biological_processmonoatomic cation transmembrane transport
A1905517biological_processmacrophage migration
A1990266biological_processneutrophil migration
A2000341biological_processregulation of chemokine (C-X-C motif) ligand 2 production
A2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
B0005261molecular_functionmonoatomic cation channel activity
B0005381molecular_functioniron ion transmembrane transporter activity
B0005765cellular_componentlysosomal membrane
B0005886cellular_componentplasma membrane
B0008324molecular_functionmonoatomic cation transmembrane transporter activity
B0016020cellular_componentmembrane
B0019722biological_processcalcium-mediated signaling
B0031902cellular_componentlate endosome membrane
B0032722biological_processpositive regulation of chemokine production
B0034755biological_processiron ion transmembrane transport
B0042802molecular_functionidentical protein binding
B0055037cellular_componentrecycling endosome
B0055038cellular_componentrecycling endosome membrane
B0071639biological_processpositive regulation of monocyte chemotactic protein-1 production
B0071642biological_processpositive regulation of macrophage inflammatory protein 1 alpha production
B0071651biological_processpositive regulation of chemokine (C-C motif) ligand 5 production
B0072345molecular_functionNAADP-sensitive calcium-release channel activity
B0098655biological_processmonoatomic cation transmembrane transport
B1905517biological_processmacrophage migration
B1990266biological_processneutrophil migration
B2000341biological_processregulation of chemokine (C-X-C motif) ligand 2 production
B2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
C0005261molecular_functionmonoatomic cation channel activity
C0005381molecular_functioniron ion transmembrane transporter activity
C0005765cellular_componentlysosomal membrane
C0005886cellular_componentplasma membrane
C0008324molecular_functionmonoatomic cation transmembrane transporter activity
C0016020cellular_componentmembrane
C0019722biological_processcalcium-mediated signaling
C0031902cellular_componentlate endosome membrane
C0032722biological_processpositive regulation of chemokine production
C0034755biological_processiron ion transmembrane transport
C0042802molecular_functionidentical protein binding
C0055037cellular_componentrecycling endosome
C0055038cellular_componentrecycling endosome membrane
C0071639biological_processpositive regulation of monocyte chemotactic protein-1 production
C0071642biological_processpositive regulation of macrophage inflammatory protein 1 alpha production
C0071651biological_processpositive regulation of chemokine (C-C motif) ligand 5 production
C0072345molecular_functionNAADP-sensitive calcium-release channel activity
C0098655biological_processmonoatomic cation transmembrane transport
C1905517biological_processmacrophage migration
C1990266biological_processneutrophil migration
C2000341biological_processregulation of chemokine (C-X-C motif) ligand 2 production
C2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
D0005261molecular_functionmonoatomic cation channel activity
D0005381molecular_functioniron ion transmembrane transporter activity
D0005765cellular_componentlysosomal membrane
D0005886cellular_componentplasma membrane
D0008324molecular_functionmonoatomic cation transmembrane transporter activity
D0016020cellular_componentmembrane
D0019722biological_processcalcium-mediated signaling
D0031902cellular_componentlate endosome membrane
D0032722biological_processpositive regulation of chemokine production
D0034755biological_processiron ion transmembrane transport
D0042802molecular_functionidentical protein binding
D0055037cellular_componentrecycling endosome
D0055038cellular_componentrecycling endosome membrane
D0071639biological_processpositive regulation of monocyte chemotactic protein-1 production
D0071642biological_processpositive regulation of macrophage inflammatory protein 1 alpha production
D0071651biological_processpositive regulation of chemokine (C-C motif) ligand 5 production
D0072345molecular_functionNAADP-sensitive calcium-release channel activity
D0098655biological_processmonoatomic cation transmembrane transport
D1905517biological_processmacrophage migration
D1990266biological_processneutrophil migration
D2000341biological_processregulation of chemokine (C-X-C motif) ligand 2 production
D2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues324
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"UniProtKB","id":"F6RG56","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues84
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"F6RG56","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues80
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"source":"UniProtKB","id":"F6RG56","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues64
DetailsRegion: {"description":"Extracellular/lumenal pore loop","evidences":[{"source":"UniProtKB","id":"Q9GZU1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues12
DetailsMotif: {"description":"Selectivity filter","evidences":[{"source":"UniProtKB","id":"F6RG56","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2026-05-27

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