7DX7
Trypsin-digested S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 1 (1 up RBD and 1 PD bound)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016020 | cellular_component | membrane |
| A | 0019031 | cellular_component | viral envelope |
| A | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| A | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| A | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| A | 0055036 | cellular_component | virion membrane |
| A | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| B | 0016020 | cellular_component | membrane |
| B | 0019031 | cellular_component | viral envelope |
| B | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| B | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| B | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| B | 0055036 | cellular_component | virion membrane |
| B | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| C | 0016020 | cellular_component | membrane |
| C | 0019031 | cellular_component | viral envelope |
| C | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| C | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| C | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| C | 0055036 | cellular_component | virion membrane |
| C | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| D | 0001618 | molecular_function | virus receptor activity |
| D | 0001817 | biological_process | regulation of cytokine production |
| D | 0002003 | biological_process | angiotensin maturation |
| D | 0003051 | biological_process | angiotensin-mediated drinking behavior |
| D | 0003081 | biological_process | regulation of systemic arterial blood pressure by renin-angiotensin |
| D | 0004175 | molecular_function | endopeptidase activity |
| D | 0004180 | molecular_function | carboxypeptidase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005615 | cellular_component | extracellular space |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005788 | cellular_component | endoplasmic reticulum lumen |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0005929 | cellular_component | cilium |
| D | 0006508 | biological_process | proteolysis |
| D | 0008237 | molecular_function | metallopeptidase activity |
| D | 0008241 | molecular_function | peptidyl-dipeptidase activity |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0009986 | cellular_component | cell surface |
| D | 0015827 | biological_process | tryptophan transport |
| D | 0016020 | cellular_component | membrane |
| D | 0016324 | cellular_component | apical plasma membrane |
| D | 0019058 | biological_process | viral life cycle |
| D | 0019065 | biological_process | receptor-mediated endocytosis of virus by host cell |
| D | 0019229 | biological_process | regulation of vasoconstriction |
| D | 0022898 | biological_process | regulation of transmembrane transporter activity |
| D | 0030666 | cellular_component | endocytic vesicle membrane |
| D | 0031526 | cellular_component | brush border membrane |
| D | 0042127 | biological_process | regulation of cell population proliferation |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0042995 | cellular_component | cell projection |
| D | 0045121 | cellular_component | membrane raft |
| D | 0046718 | biological_process | symbiont entry into host cell |
| D | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0048662 | biological_process | negative regulation of smooth muscle cell proliferation |
| D | 0050727 | biological_process | regulation of inflammatory response |
| D | 0051957 | biological_process | positive regulation of amino acid transport |
| D | 0060135 | biological_process | maternal process involved in female pregnancy |
| D | 0060452 | biological_process | positive regulation of cardiac muscle contraction |
| D | 0061025 | biological_process | membrane fusion |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 0070373 | biological_process | negative regulation of ERK1 and ERK2 cascade |
| D | 0097746 | biological_process | blood vessel diameter maintenance |
| D | 0098670 | biological_process | entry receptor-mediated virion attachment to host cell |
| D | 1903598 | biological_process | positive regulation of gap junction assembly |
| D | 1903779 | biological_process | regulation of cardiac conduction |
| D | 1905737 | biological_process | positive regulation of L-proline import across plasma membrane |
| D | 2000272 | biological_process | negative regulation of signaling receptor activity |
| D | 2000379 | biological_process | positive regulation of reactive oxygen species metabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ |
| Chain | Residue | Details |
| D | THR371-GLN380 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 722 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| D | GLN18-SER740 | |
| B | GLN14-PRO1213 | |
| C | GLN14-PRO1213 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU01354 |
| Chain | Residue | Details |
| D | ILE741-ILE761 | |
| B | TRP1214-LEU1234 | |
| C | TRP1214-LEU1234 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 43 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| D | PHE762-PHE805 | |
| B | CYS1235-THR1273 | |
| C | CYS1235-THR1273 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895, ECO:0000305|PubMed:27217402 |
| Chain | Residue | Details |
| D | GLU375 | |
| B | ARG685 | |
| C | ARG685 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895 |
| Chain | Residue | Details |
| D | HIS505 | |
| B | ARG815 | |
| C | ARG815 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895, ECO:0000305|PubMed:19021774 |
| Chain | Residue | Details |
| D | ARG169 | |
| B | CYS1243 | |
| C | CYS1235 | |
| C | CYS1236 | |
| C | CYS1240 | |
| C | CYS1241 | |
| C | CYS1243 | |
| D | TRP477 | |
| D | LYS481 | |
| A | CYS1241 | |
| A | CYS1243 | |
| B | CYS1235 | |
| B | CYS1236 | |
| B | CYS1240 | |
| B | CYS1241 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:14754895 |
| Chain | Residue | Details |
| D | ARG273 | |
| B | CYS1254 | |
| C | CYS1247 | |
| C | CYS1248 | |
| C | CYS1250 | |
| C | CYS1253 | |
| C | CYS1254 | |
| D | HIS345 | |
| D | TYR515 | |
| A | CYS1253 | |
| A | CYS1254 | |
| B | CYS1247 | |
| B | CYS1248 | |
| B | CYS1250 | |
| B | CYS1253 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895 |
| Chain | Residue | Details |
| D | HIS374 | |
| D | HIS378 | |
| D | GLU402 | |
| B | ASN17 | |
| B | ASN1158 | |
| B | ASN1173 | |
| C | ASN17 | |
| C | ASN1158 | |
| C | ASN1173 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498 |
| Chain | Residue | Details |
| D | TYR781 | |
| B | ASN1074 | |
| C | ASN61 | |
| C | ASN122 | |
| C | ASN717 | |
| C | ASN801 | |
| C | ASN1074 | |
| A | ASN122 | |
| A | ASN717 | |
| A | ASN801 | |
| A | ASN1074 | |
| B | ASN61 | |
| B | ASN122 | |
| B | ASN717 | |
| B | ASN801 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498 |
| Chain | Residue | Details |
| D | SER783 | |
| A | ASN149 | |
| A | ASN1194 | |
| B | ASN74 | |
| B | ASN149 | |
| B | ASN1194 | |
| C | ASN74 | |
| C | ASN149 | |
| C | ASN1194 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895 |
| Chain | Residue | Details |
| D | ASN53 | |
| B | ASN331 | |
| B | ASN343 | |
| B | ASN616 | |
| B | ASN657 | |
| B | ASN1098 | |
| C | ASN165 | |
| C | ASN282 | |
| C | ASN331 | |
| C | ASN343 | |
| C | ASN616 | |
| D | ASN322 | |
| C | ASN657 | |
| C | ASN1098 | |
| A | ASN331 | |
| A | ASN343 | |
| A | ASN616 | |
| A | ASN657 | |
| A | ASN1098 | |
| B | ASN165 | |
| B | ASN282 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:19901337 |
| Chain | Residue | Details |
| D | ASN90 | |
| A | ASN709 | |
| B | ASN234 | |
| B | ASN709 | |
| C | ASN234 | |
| C | ASN709 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895 |
| Chain | Residue | Details |
| D | ASN103 | |
| D | ASN432 | |
| C | THR323 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19901337 |
| Chain | Residue | Details |
| D | ASN546 | |
| B | SER325 | |
| C | SER325 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| D | ASN690 | |
| B | ASN603 | |
| C | ASN603 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36876523 |
| Chain | Residue | Details |
| D | LYS788 | |
| A | THR678 | |
| B | THR676 | |
| B | THR678 | |
| C | THR676 | |
| C | THR678 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | ASN1134 | |
| B | ASN1134 | |
| C | ASN1134 |
