7DX3
S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 1 (1 up RBD and no PD bound)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0016020 | cellular_component | membrane |
A | 0019031 | cellular_component | viral envelope |
A | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
A | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
A | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
A | 0055036 | cellular_component | virion membrane |
A | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
B | 0016020 | cellular_component | membrane |
B | 0019031 | cellular_component | viral envelope |
B | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
B | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
B | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
B | 0055036 | cellular_component | virion membrane |
B | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
C | 0016020 | cellular_component | membrane |
C | 0019031 | cellular_component | viral envelope |
C | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
C | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
C | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
C | 0055036 | cellular_component | virion membrane |
C | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3597 |
Details | TOPO_DOM: Extracellular => ECO:0000255|HAMAP-Rule:MF_04099 |
Chain | Residue | Details |
A | GLN14-PRO1213 | |
B | GLN14-PRO1213 | |
C | GLN14-PRO1213 |
site_id | SWS_FT_FI2 |
Number of Residues | 60 |
Details | TRANSMEM: Helical => ECO:0000255|HAMAP-Rule:MF_04099 |
Chain | Residue | Details |
A | TRP1214-LEU1234 | |
B | TRP1214-LEU1234 | |
C | TRP1214-LEU1234 |
site_id | SWS_FT_FI3 |
Number of Residues | 114 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255|HAMAP-Rule:MF_04099 |
Chain | Residue | Details |
A | CYS1235-THR1273 | |
B | CYS1235-THR1273 | |
C | CYS1235-THR1273 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | SITE: Cleavage; by host furin => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32362314, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
Chain | Residue | Details |
A | ARG685 | |
B | ARG685 | |
C | ARG685 |
site_id | SWS_FT_FI5 |
Number of Residues | 3 |
Details | SITE: Cleavage; by host TMPRSS2 or CTSL => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
Chain | Residue | Details |
A | ARG815 | |
B | ARG815 | |
C | ARG815 |
site_id | SWS_FT_FI6 |
Number of Residues | 15 |
Details | LIPID: S-palmitoyl cysteine; by host ZDHHC20 => ECO:0000269|PubMed:34599882 |
Chain | Residue | Details |
A | CYS1235 | |
B | CYS1243 | |
C | CYS1235 | |
C | CYS1236 | |
C | CYS1240 | |
C | CYS1241 | |
C | CYS1243 | |
A | CYS1236 | |
A | CYS1240 | |
A | CYS1241 | |
A | CYS1243 | |
B | CYS1235 | |
B | CYS1236 | |
B | CYS1240 | |
B | CYS1241 |
site_id | SWS_FT_FI7 |
Number of Residues | 15 |
Details | LIPID: S-palmitoyl cysteine; by host ZDHHC20; partial => ECO:0000269|PubMed:34599882 |
Chain | Residue | Details |
A | CYS1247 | |
B | CYS1254 | |
C | CYS1247 | |
C | CYS1248 | |
C | CYS1250 | |
C | CYS1253 | |
C | CYS1254 | |
A | CYS1248 | |
A | CYS1250 | |
A | CYS1253 | |
A | CYS1254 | |
B | CYS1247 | |
B | CYS1248 | |
B | CYS1250 | |
B | CYS1253 |
site_id | SWS_FT_FI8 |
Number of Residues | 9 |
Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
Chain | Residue | Details |
A | ASN17 | |
A | ASN1158 | |
A | ASN1173 | |
B | ASN17 | |
B | ASN1158 | |
B | ASN1173 | |
C | ASN17 | |
C | ASN1158 | |
C | ASN1173 |
site_id | SWS_FT_FI9 |
Number of Residues | 15 |
Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
Chain | Residue | Details |
A | ASN61 | |
B | ASN1074 | |
C | ASN61 | |
C | ASN122 | |
C | ASN717 | |
C | ASN801 | |
C | ASN1074 | |
A | ASN122 | |
A | ASN717 | |
A | ASN801 | |
A | ASN1074 | |
B | ASN61 | |
B | ASN122 | |
B | ASN717 | |
B | ASN801 |
site_id | SWS_FT_FI10 |
Number of Residues | 9 |
Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
Chain | Residue | Details |
A | ASN74 | |
A | ASN149 | |
A | ASN1194 | |
B | ASN74 | |
B | ASN149 | |
B | ASN1194 | |
C | ASN74 | |
C | ASN149 | |
C | ASN1194 |
site_id | SWS_FT_FI11 |
Number of Residues | 21 |
Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
Chain | Residue | Details |
A | ASN165 | |
B | ASN331 | |
B | ASN343 | |
B | ASN616 | |
B | ASN657 | |
B | ASN1098 | |
C | ASN165 | |
C | ASN282 | |
C | ASN331 | |
C | ASN343 | |
C | ASN616 | |
A | ASN282 | |
C | ASN657 | |
C | ASN1098 | |
A | ASN331 | |
A | ASN343 | |
A | ASN616 | |
A | ASN657 | |
A | ASN1098 | |
B | ASN165 | |
B | ASN282 |
site_id | SWS_FT_FI12 |
Number of Residues | 6 |
Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
Chain | Residue | Details |
A | ASN234 | |
A | ASN709 | |
B | ASN234 | |
B | ASN709 | |
C | ASN234 | |
C | ASN709 |
site_id | SWS_FT_FI13 |
Number of Residues | 3 |
Details | CARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391 |
Chain | Residue | Details |
A | THR323 | |
B | THR323 | |
C | THR323 |
site_id | SWS_FT_FI14 |
Number of Residues | 3 |
Details | CARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391 |
Chain | Residue | Details |
A | SER325 | |
B | SER325 | |
C | SER325 |
site_id | SWS_FT_FI15 |
Number of Residues | 3 |
Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
Chain | Residue | Details |
A | ASN603 | |
B | ASN603 | |
C | ASN603 |
site_id | SWS_FT_FI16 |
Number of Residues | 6 |
Details | CARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583 |
Chain | Residue | Details |
A | THR676 | |
A | THR678 | |
B | THR676 | |
B | THR678 | |
C | THR676 | |
C | THR678 |
site_id | SWS_FT_FI17 |
Number of Residues | 3 |
Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
Chain | Residue | Details |
A | ASN1134 | |
B | ASN1134 | |
C | ASN1134 |