7DV5
Human bile salt exporter ABCB11 in complex with taurocholate
Functional Information from GO Data
Chain | GOid | namespace | contents |
U | 0000139 | cellular_component | Golgi membrane |
U | 0005515 | molecular_function | protein binding |
U | 0005524 | molecular_function | ATP binding |
U | 0005768 | cellular_component | endosome |
U | 0005886 | cellular_component | plasma membrane |
U | 0006631 | biological_process | fatty acid metabolic process |
U | 0006699 | biological_process | bile acid biosynthetic process |
U | 0006805 | biological_process | xenobiotic metabolic process |
U | 0006855 | biological_process | xenobiotic transmembrane transport |
U | 0006869 | biological_process | lipid transport |
U | 0006979 | biological_process | response to oxidative stress |
U | 0008206 | biological_process | bile acid metabolic process |
U | 0008559 | molecular_function | ABC-type xenobiotic transporter activity |
U | 0009410 | biological_process | response to xenobiotic stimulus |
U | 0009986 | cellular_component | cell surface |
U | 0014070 | biological_process | response to organic cyclic compound |
U | 0015125 | molecular_function | bile acid transmembrane transporter activity |
U | 0015126 | molecular_function | canalicular bile acid transmembrane transporter activity |
U | 0015144 | molecular_function | carbohydrate transmembrane transporter activity |
U | 0015432 | molecular_function | ABC-type bile acid transporter activity |
U | 0015721 | biological_process | bile acid and bile salt transport |
U | 0015722 | biological_process | canalicular bile acid transport |
U | 0016020 | cellular_component | membrane |
U | 0016323 | cellular_component | basolateral plasma membrane |
U | 0016324 | cellular_component | apical plasma membrane |
U | 0016567 | biological_process | protein ubiquitination |
U | 0016887 | molecular_function | ATP hydrolysis activity |
U | 0031998 | biological_process | regulation of fatty acid beta-oxidation |
U | 0034219 | biological_process | carbohydrate transmembrane transport |
U | 0042632 | biological_process | cholesterol homeostasis |
U | 0043627 | biological_process | response to estrogen |
U | 0045177 | cellular_component | apical part of cell |
U | 0045471 | biological_process | response to ethanol |
U | 0046581 | cellular_component | intercellular canaliculus |
U | 0046618 | biological_process | xenobiotic export from cell |
U | 0046691 | cellular_component | intracellular canaliculus |
U | 0055037 | cellular_component | recycling endosome |
U | 0055038 | cellular_component | recycling endosome membrane |
U | 0055085 | biological_process | transmembrane transport |
U | 0055088 | biological_process | lipid homeostasis |
U | 0055091 | biological_process | phospholipid homeostasis |
U | 0070062 | cellular_component | extracellular exosome |
U | 0071466 | biological_process | cellular response to xenobiotic stimulus |
U | 0120189 | biological_process | positive regulation of bile acid secretion |
U | 0140359 | molecular_function | ABC-type transporter activity |
U | 1904251 | biological_process | regulation of bile acid metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | binding site for residue TCH U 1401 |
Chain | Residue |
U | TYR145 |
U | ILE333 |
U | LEU364 |
U | THR769 |
U | LEU1026 |
U | ARG1033 |
U | TCH1402 |
site_id | AC2 |
Number of Residues | 9 |
Details | binding site for residue TCH U 1402 |
Chain | Residue |
U | TRP330 |
U | LEU371 |
U | ARG920 |
U | PHE985 |
U | ARG1033 |
U | TYR1037 |
U | TCH1401 |
U | ARG223 |
U | ILE259 |
Functional Information from PROSITE/UniProt
site_id | PS00211 |
Number of Residues | 15 |
Details | ABC_TRANSPORTER_1 ABC transporters family signature. MSGGQKQRVAIARAL |
Chain | Residue | Details |
U | MET559-LEU573 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 240 |
Details | TRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU00441 |
Chain | Residue | Details |
U | PHE63-PHE83 | |
U | ILE891-LEU911 | |
U | ILE980-TYR1000 | |
U | LEU1012-GLY1032 | |
U | ILE148-ALA168 | |
U | GLN216-PHE236 | |
U | LEU241-LEU261 | |
U | ILE320-ALA340 | |
U | TYR354-GLY374 | |
U | LEU756-PHE776 | |
U | ILE795-LEU815 | |
U | GLY870-MET890 |
site_id | SWS_FT_FI2 |
Number of Residues | 105 |
Details | TOPO_DOM: Extracellular => ECO:0000255 |
Chain | Residue | Details |
U | GLY84-GLY147 | |
U | ARG237-LYS240 | |
U | PHE341-GLU353 | |
U | SER777-GLN794 | |
U | ARG1001-GLY1011 |
site_id | SWS_FT_FI3 |
Number of Residues | 603 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
U | ARG169-ASP215 | |
U | SER262-GLY319 | |
U | ASN375-MET755 | |
U | GLN816-GLN869 | |
U | ALA912-ASN979 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 |
Chain | Residue | Details |
U | GLY455 | |
U | GLY1113 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
U | THR586 |
site_id | SWS_FT_FI6 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
U | SER587 | |
U | SER704 | |
U | SER1214 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9QY30 |
Chain | Residue | Details |
U | SER690 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O70127 |
Chain | Residue | Details |
U | SER701 |
site_id | SWS_FT_FI9 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17082223 |
Chain | Residue | Details |
U | ASN109 | |
U | ASN116 | |
U | ASN122 | |
U | ASN125 |