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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7DTU

Human Calcium-Sensing Receptor bound with L-Trp

Functional Information from GO Data
ChainGOidnamespacecontents
A0001503biological_processossification
A0002931biological_processresponse to ischemia
A0004930molecular_functionG protein-coupled receptor activity
A0005178molecular_functionintegrin binding
A0005509molecular_functioncalcium ion binding
A0005513biological_processdetection of calcium ion
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006874biological_processintracellular calcium ion homeostasis
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0007254biological_processJNK cascade
A0007635biological_processchemosensory behavior
A0008284biological_processpositive regulation of cell population proliferation
A0009653biological_processanatomical structure morphogenesis
A0009986cellular_componentcell surface
A0010038biological_processresponse to metal ion
A0010628biological_processpositive regulation of gene expression
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0016597molecular_functionamino acid binding
A0019901molecular_functionprotein kinase binding
A0030424cellular_componentaxon
A0032024biological_processpositive regulation of insulin secretion
A0032782biological_processbile acid secretion
A0035729biological_processcellular response to hepatocyte growth factor stimulus
A0042311biological_processvasodilation
A0042734cellular_componentpresynaptic membrane
A0042803molecular_functionprotein homodimerization activity
A0043025cellular_componentneuronal cell body
A0043679cellular_componentaxon terminus
A0044325molecular_functiontransmembrane transporter binding
A0045907biological_processpositive regulation of vasoconstriction
A0046872molecular_functionmetal ion binding
A0048754biological_processbranching morphogenesis of an epithelial tube
A0050927biological_processpositive regulation of positive chemotaxis
A0051592biological_processresponse to calcium ion
A0051924biological_processregulation of calcium ion transport
A0060613biological_processfat pad development
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0071305biological_processcellular response to vitamin D
A0071333biological_processcellular response to glucose stimulus
A0071404biological_processcellular response to low-density lipoprotein particle stimulus
A0071456biological_processcellular response to hypoxia
A0071774biological_processresponse to fibroblast growth factor
A0090280biological_processpositive regulation of calcium ion import
A0098978cellular_componentglutamatergic synapse
A0099505biological_processregulation of presynaptic membrane potential
A0140582biological_processadenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway
A1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
A1901653biological_processcellular response to peptide
A1902476biological_processchloride transmembrane transport
B0001503biological_processossification
B0002931biological_processresponse to ischemia
B0004930molecular_functionG protein-coupled receptor activity
B0005178molecular_functionintegrin binding
B0005509molecular_functioncalcium ion binding
B0005513biological_processdetection of calcium ion
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006874biological_processintracellular calcium ion homeostasis
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
B0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007254biological_processJNK cascade
B0007635biological_processchemosensory behavior
B0008284biological_processpositive regulation of cell population proliferation
B0009653biological_processanatomical structure morphogenesis
B0009986cellular_componentcell surface
B0010038biological_processresponse to metal ion
B0010628biological_processpositive regulation of gene expression
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0016597molecular_functionamino acid binding
B0019901molecular_functionprotein kinase binding
B0030424cellular_componentaxon
B0032024biological_processpositive regulation of insulin secretion
B0032782biological_processbile acid secretion
B0035729biological_processcellular response to hepatocyte growth factor stimulus
B0042311biological_processvasodilation
B0042734cellular_componentpresynaptic membrane
B0042803molecular_functionprotein homodimerization activity
B0043025cellular_componentneuronal cell body
B0043679cellular_componentaxon terminus
B0044325molecular_functiontransmembrane transporter binding
B0045907biological_processpositive regulation of vasoconstriction
B0046872molecular_functionmetal ion binding
B0048754biological_processbranching morphogenesis of an epithelial tube
B0050927biological_processpositive regulation of positive chemotaxis
B0051592biological_processresponse to calcium ion
B0051924biological_processregulation of calcium ion transport
B0060613biological_processfat pad development
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0071305biological_processcellular response to vitamin D
B0071333biological_processcellular response to glucose stimulus
B0071404biological_processcellular response to low-density lipoprotein particle stimulus
B0071456biological_processcellular response to hypoxia
B0071774biological_processresponse to fibroblast growth factor
B0090280biological_processpositive regulation of calcium ion import
B0098978cellular_componentglutamatergic synapse
B0099505biological_processregulation of presynaptic membrane potential
B0140582biological_processadenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway
B1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
B1901653biological_processcellular response to peptide
B1902476biological_processchloride transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00979
Number of Residues19
DetailsG_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VaNLLgLFyIPQVSyASSS
ChainResidueDetails
AVAL153-SER171
site_idPS00980
Number of Residues25
DetailsG_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCFeCveCpdgeYsdet.DasACnkC
ChainResidueDetails
ACYS561-CYS585
site_idPS00981
Number of Residues11
DetailsG_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. FNEAKfITFSM
ChainResidueDetails
APHE801-MET811
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues50
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues38
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues62
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues46
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues38
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues30
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues332
DetailsRegion: {"description":"Ligand-binding 1 (LB1)","evidences":[{"source":"PubMed","id":"17360426","evidenceCode":"ECO:0000303"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues270
DetailsRegion: {"description":"Ligand-binding 2 (LB2)","evidences":[{"source":"PubMed","id":"17360426","evidenceCode":"ECO:0000303"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues140
DetailsRegion: {"description":"Cysteine-rich (CR)","evidences":[{"source":"PubMed","id":"17360426","evidenceCode":"ECO:0000303"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues30
DetailsRegion: {"description":"Intracellular loop 3 (ICL3)","evidences":[{"source":"PubMed","id":"38632411","evidenceCode":"ECO:0000303"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34467854","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7E6T","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34467854","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7E6T","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34467854","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7E6T","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SZF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues2
DetailsSite: {"description":"Important for ability of agonist AMG 416 to activate G-protein-coupled receptor activity","evidences":[{"source":"PubMed","id":"26290606","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues10
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DTT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

239803

PDB entries from 2025-08-06

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