7DTC
voltage-gated sodium channel Nav1.5-E1784K
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001518 | cellular_component | voltage-gated sodium channel complex |
| A | 0002027 | biological_process | regulation of heart rate |
| A | 0003161 | biological_process | cardiac conduction system development |
| A | 0003231 | biological_process | cardiac ventricle development |
| A | 0003360 | biological_process | brainstem development |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005248 | molecular_function | voltage-gated sodium channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005272 | molecular_function | sodium channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005516 | molecular_function | calmodulin binding |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005901 | cellular_component | caveola |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0009986 | cellular_component | cell surface |
| A | 0010765 | biological_process | positive regulation of sodium ion transport |
| A | 0014704 | cellular_component | intercalated disc |
| A | 0014894 | biological_process | response to denervation involved in regulation of muscle adaptation |
| A | 0016020 | cellular_component | membrane |
| A | 0016328 | cellular_component | lateral plasma membrane |
| A | 0017134 | molecular_function | fibroblast growth factor binding |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0021537 | biological_process | telencephalon development |
| A | 0021549 | biological_process | cerebellum development |
| A | 0030018 | cellular_component | Z disc |
| A | 0030315 | cellular_component | T-tubule |
| A | 0030506 | molecular_function | ankyrin binding |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042383 | cellular_component | sarcolemma |
| A | 0042475 | biological_process | odontogenesis of dentin-containing tooth |
| A | 0044325 | molecular_function | transmembrane transporter binding |
| A | 0045760 | biological_process | positive regulation of action potential |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0050679 | biological_process | positive regulation of epithelial cell proliferation |
| A | 0050998 | molecular_function | nitric-oxide synthase binding |
| A | 0051899 | biological_process | membrane depolarization |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0055117 | biological_process | regulation of cardiac muscle contraction |
| A | 0060048 | biological_process | cardiac muscle contraction |
| A | 0060307 | biological_process | regulation of ventricular cardiac muscle cell membrane repolarization |
| A | 0060371 | biological_process | regulation of atrial cardiac muscle cell membrane depolarization |
| A | 0060372 | biological_process | regulation of atrial cardiac muscle cell membrane repolarization |
| A | 0060373 | biological_process | regulation of ventricular cardiac muscle cell membrane depolarization |
| A | 0070161 | cellular_component | anchoring junction |
| A | 0071277 | biological_process | cellular response to calcium ion |
| A | 0086002 | biological_process | cardiac muscle cell action potential involved in contraction |
| A | 0086004 | biological_process | regulation of cardiac muscle cell contraction |
| A | 0086005 | biological_process | ventricular cardiac muscle cell action potential |
| A | 0086006 | molecular_function | voltage-gated sodium channel activity involved in cardiac muscle cell action potential |
| A | 0086010 | biological_process | membrane depolarization during action potential |
| A | 0086012 | biological_process | membrane depolarization during cardiac muscle cell action potential |
| A | 0086014 | biological_process | atrial cardiac muscle cell action potential |
| A | 0086015 | biological_process | SA node cell action potential |
| A | 0086016 | biological_process | AV node cell action potential |
| A | 0086043 | biological_process | bundle of His cell action potential |
| A | 0086045 | biological_process | membrane depolarization during AV node cell action potential |
| A | 0086046 | biological_process | membrane depolarization during SA node cell action potential |
| A | 0086047 | biological_process | membrane depolarization during Purkinje myocyte cell action potential |
| A | 0086048 | biological_process | membrane depolarization during bundle of His cell action potential |
| A | 0086060 | molecular_function | voltage-gated sodium channel activity involved in AV node cell action potential |
| A | 0086061 | molecular_function | voltage-gated sodium channel activity involved in bundle of His cell action potential |
| A | 0086062 | molecular_function | voltage-gated sodium channel activity involved in Purkinje myocyte action potential |
| A | 0086063 | molecular_function | voltage-gated sodium channel activity involved in SA node cell action potential |
| A | 0086067 | biological_process | AV node cell to bundle of His cell communication |
| A | 0086091 | biological_process | regulation of heart rate by cardiac conduction |
| A | 0097110 | molecular_function | scaffold protein binding |
| A | 0098912 | biological_process | membrane depolarization during atrial cardiac muscle cell action potential |
| A | 1902305 | biological_process | regulation of sodium ion transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1073 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-VAL129 | |
| A | ASP1471-GLN1528 | |
| A | ALA1581-ASN1589 | |
| A | LYS1641-LEU1650 | |
| A | LEU1772-VAL2016 | |
| A | GLY180-PHE188 | |
| A | LYS237-LYS249 | |
| A | MET414-THR719 | |
| A | ALA770-TYR775 | |
| A | TRP822-ALA838 | |
| A | PHE942-GLU1203 | |
| A | ALA1260-THR1268 | |
| A | GLU1318-ALA1330 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S1 of repeat I => ECO:0000250|UniProtKB:P15389 |
| Chain | Residue | Details |
| A | HIS130-ALA149 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 296 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | GLN150-THR157 | |
| A | GLY1292-GLY1297 | |
| A | PHE1356-VAL1400 | |
| A | ASP1423-TYR1445 | |
| A | GLU1548-ASN1558 | |
| A | GLN1613-PRO1619 | |
| A | ALA1680-PHE1697 | |
| A | GLY1715-PRO1745 | |
| A | VAL210-SER216 | |
| A | MET273-SER357 | |
| A | GLN379-GLY386 | |
| A | HIS738-GLU746 | |
| A | GLY797-VAL806 | |
| A | PHE861-PHE884 | |
| A | TRP904-GLN912 | |
| A | ASP1226-LYS1236 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S2 of repeat I => ECO:0000250|UniProtKB:P15389 |
| Chain | Residue | Details |
| A | LYS158-ARG179 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S3 of repeat I => ECO:0000250|UniProtKB:P15389 |
| Chain | Residue | Details |
| A | LEU189-PHE209 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S4 of repeat I => ECO:0000250|UniProtKB:P15389 |
| Chain | Residue | Details |
| A | ALA217-LEU236 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S5 of repeat I => ECO:0000250|UniProtKB:P15389 |
| Chain | Residue | Details |
| A | LEU250-PHE272 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 75 |
| Details | INTRAMEM: Pore-forming => ECO:0000250|UniProtKB:P15389 |
| Chain | Residue | Details |
| A | PHE358-TYR378 | |
| A | PHE885-MET903 | |
| A | ASN1401-MET1422 | |
| A | ALA1698-ASP1714 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000250|UniProtKB:P15389 |
| Chain | Residue | Details |
| A | LYS387-ALA413 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000250|UniProtKB:P15389 |
| Chain | Residue | Details |
| A | ASP720-GLU737 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | GLU747-ILE769 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | TYR776-LEU796 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 14 |
| Details | TRANSMEM: Helical; Name=S4 of repeat II => ECO:0000250|UniProtKB:P15389 |
| Chain | Residue | Details |
| A | LEU807-SER821 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | LEU839-LEU860 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | SER913-SER941 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | HIS1204-GLU1225 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | VAL1237-VAL1259 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ASN1269-LEU1291 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S4 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | PRO1298-PHE1317 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ILE1331-LEU1355 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | MET1446-ILE1470 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ALA1529-VAL1547 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ILE1559-ALA1580 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | SER1590-ILE1612 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S4 of repeat IV => ECO:0000250|UniProtKB:P15389 |
| Chain | Residue | Details |
| A | THR1620-ALA1640 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000250|UniProtKB:P15389 |
| Chain | Residue | Details |
| A | MET1651-PHE1679 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000250|UniProtKB:P15389 |
| Chain | Residue | Details |
| A | ALA1746-ILE1771 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:23092124 |
| Chain | Residue | Details |
| A | SER36 | |
| A | SER667 | |
| A | SER457 | |
| A | SER460 | |
| A | SER483 | |
| A | SER484 | |
| A | SER497 | |
| A | SER510 | |
| A | SER571 | |
| A | SER664 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:23092124 |
| Chain | Residue | Details |
| A | THR38 |
| site_id | SWS_FT_FI30 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P15389 |
| Chain | Residue | Details |
| A | THR486 |
| site_id | SWS_FT_FI31 |
| Number of Residues | 3 |
| Details | MOD_RES: Omega-N-methylarginine; alternate => ECO:0000269|PubMed:21726068 |
| Chain | Residue | Details |
| A | ARG513 | |
| A | ARG526 | |
| A | ARG680 |
| site_id | SWS_FT_FI32 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9JJV9 |
| Chain | Residue | Details |
| A | SER539 |
| site_id | SWS_FT_FI33 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKC => ECO:0000305|PubMed:19666841 |
| Chain | Residue | Details |
| A | SER1503 |
| site_id | SWS_FT_FI34 |
| Number of Residues | 13 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN214 | |
| A | ASN1374 | |
| A | ASN1380 | |
| A | ASN1388 | |
| A | ASN1736 | |
| A | ASN283 | |
| A | ASN288 | |
| A | ASN291 | |
| A | ASN328 | |
| A | ASN740 | |
| A | ASN803 | |
| A | ASN864 | |
| A | ASN1365 |
| site_id | SWS_FT_FI35 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000250|UniProtKB:P15389 |
| Chain | Residue | Details |
| A | ASN318 |
