Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7DTC

voltage-gated sodium channel Nav1.5-E1784K

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001518	cellular_component	voltage-gated sodium channel complex
A	0002027	biological_process	regulation of heart rate
A	0003161	biological_process	cardiac conduction system development
A	0003231	biological_process	cardiac ventricle development
A	0003360	biological_process	brainstem development
A	0005216	molecular_function	monoatomic ion channel activity
A	0005248	molecular_function	voltage-gated sodium channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005272	molecular_function	sodium channel activity
A	0005515	molecular_function	protein binding
A	0005516	molecular_function	calmodulin binding
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005783	cellular_component	endoplasmic reticulum
A	0005886	cellular_component	plasma membrane
A	0005901	cellular_component	caveola
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0009986	cellular_component	cell surface
A	0010765	biological_process	positive regulation of sodium ion transport
A	0014704	cellular_component	intercalated disc
A	0014894	biological_process	response to denervation involved in regulation of muscle adaptation
A	0016020	cellular_component	membrane
A	0016328	cellular_component	lateral plasma membrane
A	0017134	molecular_function	fibroblast growth factor binding
A	0019899	molecular_function	enzyme binding
A	0019901	molecular_function	protein kinase binding
A	0019904	molecular_function	protein domain specific binding
A	0021537	biological_process	telencephalon development
A	0021549	biological_process	cerebellum development
A	0030018	cellular_component	Z disc
A	0030315	cellular_component	T-tubule
A	0030506	molecular_function	ankyrin binding
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034702	cellular_component	monoatomic ion channel complex
A	0035725	biological_process	sodium ion transmembrane transport
A	0042383	cellular_component	sarcolemma
A	0042475	biological_process	odontogenesis of dentin-containing tooth
A	0044325	molecular_function	transmembrane transporter binding
A	0045760	biological_process	positive regulation of action potential
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050679	biological_process	positive regulation of epithelial cell proliferation
A	0050998	molecular_function	nitric-oxide synthase binding
A	0051899	biological_process	membrane depolarization
A	0055085	biological_process	transmembrane transport
A	0055117	biological_process	regulation of cardiac muscle contraction
A	0060048	biological_process	cardiac muscle contraction
A	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
A	0060371	biological_process	regulation of atrial cardiac muscle cell membrane depolarization
A	0060372	biological_process	regulation of atrial cardiac muscle cell membrane repolarization
A	0060373	biological_process	regulation of ventricular cardiac muscle cell membrane depolarization
A	0070161	cellular_component	anchoring junction
A	0071277	biological_process	cellular response to calcium ion
A	0086002	biological_process	cardiac muscle cell action potential involved in contraction
A	0086004	biological_process	regulation of cardiac muscle cell contraction
A	0086005	biological_process	ventricular cardiac muscle cell action potential
A	0086006	molecular_function	voltage-gated sodium channel activity involved in cardiac muscle cell action potential
A	0086010	biological_process	membrane depolarization during action potential
A	0086012	biological_process	membrane depolarization during cardiac muscle cell action potential
A	0086014	biological_process	atrial cardiac muscle cell action potential
A	0086015	biological_process	SA node cell action potential
A	0086016	biological_process	AV node cell action potential
A	0086043	biological_process	bundle of His cell action potential
A	0086045	biological_process	membrane depolarization during AV node cell action potential
A	0086046	biological_process	membrane depolarization during SA node cell action potential
A	0086047	biological_process	membrane depolarization during Purkinje myocyte cell action potential
A	0086048	biological_process	membrane depolarization during bundle of His cell action potential
A	0086060	molecular_function	voltage-gated sodium channel activity involved in AV node cell action potential
A	0086061	molecular_function	voltage-gated sodium channel activity involved in bundle of His cell action potential
A	0086062	molecular_function	voltage-gated sodium channel activity involved in Purkinje myocyte action potential
A	0086063	molecular_function	voltage-gated sodium channel activity involved in SA node cell action potential
A	0086067	biological_process	AV node cell to bundle of His cell communication
A	0086091	biological_process	regulation of heart rate by cardiac conduction
A	0097110	molecular_function	scaffold protein binding
A	0098912	biological_process	membrane depolarization during atrial cardiac muscle cell action potential
A	1902305	biological_process	regulation of sodium ion transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat I","evidences":[{"source":"UniProtKB","id":"P15389","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	296
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat I","evidences":[{"source":"UniProtKB","id":"P15389","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	135
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat I","evidences":[{"source":"UniProtKB","id":"P15389","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat I","evidences":[{"source":"UniProtKB","id":"P15389","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat I","evidences":[{"source":"UniProtKB","id":"P15389","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	75
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"UniProtKB","id":"P15389","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat I","evidences":[{"source":"UniProtKB","id":"P15389","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat II","evidences":[{"source":"UniProtKB","id":"P15389","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat II","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat II","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	14
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat II","evidences":[{"source":"UniProtKB","id":"P15389","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat II","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	28
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat II","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat III","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat III","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat III","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat III","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat III","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat III","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat IV","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat IV","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat IV","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat IV","evidences":[{"source":"UniProtKB","id":"P15389","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	28
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat IV","evidences":[{"source":"UniProtKB","id":"P15389","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat IV","evidences":[{"source":"UniProtKB","id":"P15389","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"19666841","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	13
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"UniProtKB","id":"P15389","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)