7DSW
Structure of a human NHE1-CHP1 complex under pH 7.5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0006885 | biological_process | regulation of pH |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0015385 | molecular_function | sodium:proton antiporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0006812 | biological_process | monoatomic cation transport |
| B | 0006814 | biological_process | sodium ion transport |
| B | 0006885 | biological_process | regulation of pH |
| B | 0015297 | molecular_function | antiporter activity |
| B | 0015385 | molecular_function | sodium:proton antiporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0055085 | biological_process | transmembrane transport |
| B | 1902600 | biological_process | proton transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:34108458, ECO:0007744|PDB:7DSW |
| Chain | Residue | Details |
| B | VAL99-VAL121 | |
| A | VAL99-VAL121 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 60 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| B | ILE122-PRO130 | |
| A | THR323-VAL328 | |
| A | SER372-HIS373 | |
| A | PHE439-LEU444 | |
| B | LEU177-LEU186 | |
| B | HIS250-ASN252 | |
| B | THR323-VAL328 | |
| B | SER372-HIS373 | |
| B | PHE439-LEU444 | |
| A | ILE122-PRO130 | |
| A | LEU177-LEU186 | |
| A | HIS250-ASN252 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 34 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:34108458, ECO:0007744|PDB:7DSW |
| Chain | Residue | Details |
| B | GLU131-GLY148 | |
| A | GLU131-GLY148 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 72 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| B | VAL149-SER158 | |
| A | TYR342-LEU350 | |
| A | GLY405-ASN410 | |
| A | ASP470-PRO475 | |
| B | GLY216-ILE222 | |
| B | GLU284-GLY287 | |
| B | TYR342-LEU350 | |
| B | GLY405-ASN410 | |
| B | ASP470-PRO475 | |
| A | VAL149-SER158 | |
| A | GLY216-ILE222 | |
| A | GLU284-GLY287 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 34 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:34108458, ECO:0007744|PDB:7DSW |
| Chain | Residue | Details |
| B | ASP159-PHE176 | |
| A | ASP159-PHE176 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 56 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:34108458, ECO:0007744|PDB:7DSW |
| Chain | Residue | Details |
| B | GLY187-GLY215 | |
| A | GLY187-GLY215 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 52 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:34108458, ECO:0007744|PDB:7DSW |
| Chain | Residue | Details |
| B | GLY223-ILE249 | |
| A | GLY223-ILE249 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 60 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:34108458, ECO:0007744|PDB:7DSW |
| Chain | Residue | Details |
| B | GLU253-TYR283 | |
| A | GLU253-TYR283 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 68 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:34108458, ECO:0007744|PDB:7DSW |
| Chain | Residue | Details |
| B | ILE288-PHE322 | |
| A | ILE288-PHE322 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:34108458, ECO:0007744|PDB:7DSW |
| Chain | Residue | Details |
| B | ILE329-ALA341 | |
| A | ILE329-ALA341 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:34108458, ECO:0007744|PDB:7DSW |
| Chain | Residue | Details |
| B | SER351-ILE371 | |
| A | SER351-ILE371 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 60 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:34108458, ECO:0007744|PDB:7DSW |
| Chain | Residue | Details |
| B | LYS374-ALA404 | |
| A | LYS374-ALA404 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 54 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:34108458, ECO:0007744|PDB:7DSW |
| Chain | Residue | Details |
| B | TRP411-LYS438 | |
| A | TRP411-LYS438 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 48 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:34108458, ECO:0007744|PDB:7DSW |
| Chain | Residue | Details |
| B | THR445-LEU469 | |
| A | THR445-LEU469 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 58 |
| Details | TRANSMEM: Helical; Name=13 => ECO:0000269|PubMed:34108458, ECO:0007744|PDB:7DSW |
| Chain | Residue | Details |
| B | MET476-LEU505 | |
| A | MET476-LEU505 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | SITE: Channel pore-lining => ECO:0000305 |
| Chain | Residue | Details |
| B | PHE161 | |
| A | PHE161 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | SITE: Not glycosylated |
| Chain | Residue | Details |
| B | ASN370 | |
| A | ASN370 |
