7DRT
Human Wntless in complex with Wnt3a
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005102 | molecular_function | signaling receptor binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0007275 | biological_process | multicellular organism development |
| A | 0016055 | biological_process | Wnt signaling pathway |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0001707 | biological_process | mesoderm formation |
| B | 0005515 | molecular_function | protein binding |
| B | 0005769 | cellular_component | early endosome |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005802 | cellular_component | trans-Golgi network |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006886 | biological_process | intracellular protein transport |
| B | 0009948 | biological_process | anterior/posterior axis specification |
| B | 0012505 | cellular_component | endomembrane system |
| B | 0016055 | biological_process | Wnt signaling pathway |
| B | 0017147 | molecular_function | Wnt-protein binding |
| B | 0030177 | biological_process | positive regulation of Wnt signaling pathway |
| B | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| B | 0030666 | cellular_component | endocytic vesicle membrane |
| B | 0030901 | biological_process | midbrain development |
| B | 0030902 | biological_process | hindbrain development |
| B | 0031017 | biological_process | exocrine pancreas development |
| B | 0031090 | cellular_component | organelle membrane |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0031901 | cellular_component | early endosome membrane |
| B | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| B | 0061355 | biological_process | Wnt protein secretion |
| B | 0061357 | biological_process | positive regulation of Wnt protein secretion |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071529 | biological_process | cementum mineralization |
| B | 0090263 | biological_process | positive regulation of canonical Wnt signaling pathway |
Functional Information from PROSITE/UniProt
| site_id | PS00246 |
| Number of Residues | 10 |
| Details | WNT1 Wnt-1 family signature. CKCHGLSGsC |
| Chain | Residue | Details |
| A | CYS203-CYS212 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Site: {"description":"Cleavage; by TIKI1 and TIKI2","evidences":[{"source":"UniProtKB","id":"P27467","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"O-palmitoleoyl serine; by PORCN","evidences":[{"source":"PubMed","id":"20826466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21244856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24292069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25731175","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21244856","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 253 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"20652957","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"20652957","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 49 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"20652957","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"20652957","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"20652957","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"20652957","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"20652957","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"20652957","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"20652957","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 131 |
| Details | Region: {"description":"Interaction with Wnt proteins","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
