7DR7

bovine 20S immunoproteasome

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000502	cellular_component	proteasome complex
1	0004175	molecular_function	endopeptidase activity
1	0004298	molecular_function	threonine-type endopeptidase activity
1	0005634	cellular_component	nucleus
1	0005737	cellular_component	cytoplasm
1	0005829	cellular_component	cytosol
1	0005839	cellular_component	proteasome core complex
1	0006508	biological_process	proteolysis
1	0019774	cellular_component	proteasome core complex, beta-subunit complex
1	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
1	0051603	biological_process	proteolysis involved in protein catabolic process
1	1990111	cellular_component	spermatoproteasome complex
2	0000502	cellular_component	proteasome complex
2	0002376	biological_process	immune system process
2	0004175	molecular_function	endopeptidase activity
2	0004298	molecular_function	threonine-type endopeptidase activity
2	0005634	cellular_component	nucleus
2	0005737	cellular_component	cytoplasm
2	0005829	cellular_component	cytosol
2	0005839	cellular_component	proteasome core complex
2	0006508	biological_process	proteolysis
2	0019774	cellular_component	proteasome core complex, beta-subunit complex
2	0019882	biological_process	antigen processing and presentation
2	0030154	biological_process	cell differentiation
2	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
2	0045444	biological_process	fat cell differentiation
2	0051603	biological_process	proteolysis involved in protein catabolic process
2	1990111	cellular_component	spermatoproteasome complex
A	0000502	cellular_component	proteasome complex
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0042802	molecular_function	identical protein binding
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0098794	cellular_component	postsynapse
B	0000502	cellular_component	proteasome complex
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0000502	cellular_component	proteasome complex
C	0001530	molecular_function	lipopolysaccharide binding
C	0002376	biological_process	immune system process
C	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0051603	biological_process	proteolysis involved in protein catabolic process
D	0000502	cellular_component	proteasome complex
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0045202	cellular_component	synapse
D	0051603	biological_process	proteolysis involved in protein catabolic process
E	0000502	cellular_component	proteasome complex
E	0000932	cellular_component	P-body
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
F	0000502	cellular_component	proteasome complex
F	0000932	cellular_component	P-body
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0051603	biological_process	proteolysis involved in protein catabolic process
G	0000502	cellular_component	proteasome complex
G	0000932	cellular_component	P-body
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0051603	biological_process	proteolysis involved in protein catabolic process
H	0000502	cellular_component	proteasome complex
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005839	cellular_component	proteasome core complex
H	0019774	cellular_component	proteasome core complex, beta-subunit complex
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0051603	biological_process	proteolysis involved in protein catabolic process
I	0000502	cellular_component	proteasome complex
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005839	cellular_component	proteasome core complex
I	0010498	biological_process	proteasomal protein catabolic process
I	0019774	cellular_component	proteasome core complex, beta-subunit complex
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0051603	biological_process	proteolysis involved in protein catabolic process
J	0000502	cellular_component	proteasome complex
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005839	cellular_component	proteasome core complex
J	0019774	cellular_component	proteasome core complex, beta-subunit complex
J	0051603	biological_process	proteolysis involved in protein catabolic process
K	0000502	cellular_component	proteasome complex
K	0001530	molecular_function	lipopolysaccharide binding
K	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005829	cellular_component	cytosol
K	0005839	cellular_component	proteasome core complex
K	0019774	cellular_component	proteasome core complex, beta-subunit complex
K	0036064	cellular_component	ciliary basal body
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0051603	biological_process	proteolysis involved in protein catabolic process
L	0000502	cellular_component	proteasome complex
L	0000932	cellular_component	P-body
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005839	cellular_component	proteasome core complex
L	0006511	biological_process	ubiquitin-dependent protein catabolic process
L	0019773	cellular_component	proteasome core complex, alpha-subunit complex
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0051603	biological_process	proteolysis involved in protein catabolic process
M	0000502	cellular_component	proteasome complex
M	0000932	cellular_component	P-body
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005839	cellular_component	proteasome core complex
M	0006511	biological_process	ubiquitin-dependent protein catabolic process
M	0019773	cellular_component	proteasome core complex, alpha-subunit complex
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0051603	biological_process	proteolysis involved in protein catabolic process
N	0000502	cellular_component	proteasome complex
N	0000932	cellular_component	P-body
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005839	cellular_component	proteasome core complex
N	0006511	biological_process	ubiquitin-dependent protein catabolic process
N	0019773	cellular_component	proteasome core complex, alpha-subunit complex
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0051603	biological_process	proteolysis involved in protein catabolic process
O	0000502	cellular_component	proteasome complex
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0005839	cellular_component	proteasome core complex
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0042802	molecular_function	identical protein binding
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0051603	biological_process	proteolysis involved in protein catabolic process
O	0098794	cellular_component	postsynapse
P	0000502	cellular_component	proteasome complex
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005839	cellular_component	proteasome core complex
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0019773	cellular_component	proteasome core complex, alpha-subunit complex
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0000502	cellular_component	proteasome complex
Q	0001530	molecular_function	lipopolysaccharide binding
Q	0002376	biological_process	immune system process
Q	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005813	cellular_component	centrosome
Q	0005839	cellular_component	proteasome core complex
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0051603	biological_process	proteolysis involved in protein catabolic process
R	0000502	cellular_component	proteasome complex
R	0005634	cellular_component	nucleus
R	0005737	cellular_component	cytoplasm
R	0005839	cellular_component	proteasome core complex
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0019773	cellular_component	proteasome core complex, alpha-subunit complex
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0045202	cellular_component	synapse
R	0051603	biological_process	proteolysis involved in protein catabolic process
S	0000502	cellular_component	proteasome complex
S	0005634	cellular_component	nucleus
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005839	cellular_component	proteasome core complex
S	0019774	cellular_component	proteasome core complex, beta-subunit complex
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0051603	biological_process	proteolysis involved in protein catabolic process
T	0000502	cellular_component	proteasome complex
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005839	cellular_component	proteasome core complex
T	0010498	biological_process	proteasomal protein catabolic process
T	0019774	cellular_component	proteasome core complex, beta-subunit complex
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0051603	biological_process	proteolysis involved in protein catabolic process
U	0000502	cellular_component	proteasome complex
U	0005634	cellular_component	nucleus
U	0005737	cellular_component	cytoplasm
U	0005839	cellular_component	proteasome core complex
U	0019774	cellular_component	proteasome core complex, beta-subunit complex
U	0051603	biological_process	proteolysis involved in protein catabolic process
V	0000502	cellular_component	proteasome complex
V	0001530	molecular_function	lipopolysaccharide binding
V	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005737	cellular_component	cytoplasm
V	0005739	cellular_component	mitochondrion
V	0005829	cellular_component	cytosol
V	0005839	cellular_component	proteasome core complex
V	0019774	cellular_component	proteasome core complex, beta-subunit complex
V	0036064	cellular_component	ciliary basal body
V	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0051603	biological_process	proteolysis involved in protein catabolic process
W	0000502	cellular_component	proteasome complex
W	0002376	biological_process	immune system process
W	0004175	molecular_function	endopeptidase activity
W	0004298	molecular_function	threonine-type endopeptidase activity
W	0005634	cellular_component	nucleus
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005839	cellular_component	proteasome core complex
W	0006508	biological_process	proteolysis
W	0019774	cellular_component	proteasome core complex, beta-subunit complex
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0051603	biological_process	proteolysis involved in protein catabolic process
W	1990111	cellular_component	spermatoproteasome complex
X	0000502	cellular_component	proteasome complex
X	0004175	molecular_function	endopeptidase activity
X	0004298	molecular_function	threonine-type endopeptidase activity
X	0005634	cellular_component	nucleus
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005839	cellular_component	proteasome core complex
X	0006508	biological_process	proteolysis
X	0019774	cellular_component	proteasome core complex, beta-subunit complex
X	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0051603	biological_process	proteolysis involved in protein catabolic process
X	1990111	cellular_component	spermatoproteasome complex
Y	0000502	cellular_component	proteasome complex
Y	0002376	biological_process	immune system process
Y	0004175	molecular_function	endopeptidase activity
Y	0004298	molecular_function	threonine-type endopeptidase activity
Y	0005634	cellular_component	nucleus
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0005839	cellular_component	proteasome core complex
Y	0006508	biological_process	proteolysis
Y	0019774	cellular_component	proteasome core complex, beta-subunit complex
Y	0019882	biological_process	antigen processing and presentation
Y	0030154	biological_process	cell differentiation
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0045444	biological_process	fat cell differentiation
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Y	1990111	cellular_component	spermatoproteasome complex
Z	0000502	cellular_component	proteasome complex
Z	0002376	biological_process	immune system process
Z	0004175	molecular_function	endopeptidase activity
Z	0004298	molecular_function	threonine-type endopeptidase activity
Z	0005634	cellular_component	nucleus
Z	0005737	cellular_component	cytoplasm
Z	0005829	cellular_component	cytosol
Z	0005839	cellular_component	proteasome core complex
Z	0006508	biological_process	proteolysis
Z	0019774	cellular_component	proteasome core complex, beta-subunit complex
Z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Z	0051603	biological_process	proteolysis involved in protein catabolic process
Z	1990111	cellular_component	spermatoproteasome complex

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdlsaStFSPdGRvfQVEYAmkA

Chain	Residue	Details
D	TYR8-ALA30
C	TYR6-ALA28
F	TYR6-ALA28
B	TYR8-ALA30
E	PHE9-ALA31
G	TYR5-ALA27
A	TYR3-ALA25

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. IGIqGpdYVLVASDrvaasnivqmkddhd.KmfkmsekilllcvGeaGD

Chain	Residue	Details
I	ILE5-ASP52
J	LEU41-ASP88
K	LEU57-ASP104
W	MET24-ASP71
2	LEU76-ASP123
H	MET12-ASP59
G	LEU35-ASP82
1	ALA43-ASP90

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000250

Chain	Residue	Details
Y	THR73
2	THR73
E	SER64
L	SER17
L	SER63
L	SER64

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:O35955

Chain	Residue	Details
Y	GLY72
2	GLY72
L	LYS102
L	LYS104
R	LYS206
R	LYS230

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P40306

Chain	Residue	Details
X	MET1
1	MET1
Z	LYS53
Z	LYS109
M	SER14
M	SER16

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P40306

Chain	Residue	Details
X	SER230
1	SER230
M	TYR24
M	TYR76

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P25787

Chain	Residue	Details
F	LYS70
F	LYS171
M	LYS70
M	LYS171
Q	LYS208

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P17220

Chain	Residue	Details
F	TYR121
M	TYR121

---