7DPT

Structural basis for ligand binding modes of CTP synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003883	molecular_function	CTP synthase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0016874	molecular_function	ligase activity
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0035167	biological_process	larval lymph gland hemopoiesis
A	0042802	molecular_function	identical protein binding
A	0044210	biological_process	'de novo' CTP biosynthetic process
A	0097268	cellular_component	cytoophidium
B	0003883	molecular_function	CTP synthase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0006541	biological_process	glutamine metabolic process
B	0016874	molecular_function	ligase activity
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0035167	biological_process	larval lymph gland hemopoiesis
B	0042802	molecular_function	identical protein binding
B	0044210	biological_process	'de novo' CTP biosynthetic process
B	0097268	cellular_component	cytoophidium
C	0003883	molecular_function	CTP synthase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0006541	biological_process	glutamine metabolic process
C	0016874	molecular_function	ligase activity
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0035167	biological_process	larval lymph gland hemopoiesis
C	0042802	molecular_function	identical protein binding
C	0044210	biological_process	'de novo' CTP biosynthetic process
C	0097268	cellular_component	cytoophidium
D	0003883	molecular_function	CTP synthase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006241	biological_process	CTP biosynthetic process
D	0006541	biological_process	glutamine metabolic process
D	0016874	molecular_function	ligase activity
D	0019856	biological_process	pyrimidine nucleobase biosynthetic process
D	0035167	biological_process	larval lymph gland hemopoiesis
D	0042802	molecular_function	identical protein binding
D	0044210	biological_process	'de novo' CTP biosynthetic process
D	0097268	cellular_component	cytoophidium

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: For GATase activity => ECO:0000255|PROSITE-ProRule:PRU00605

Chain	Residue	Details
A	CYS399
D	CYS399
D	HIS526
D	GLU528
A	HIS526
A	GLU528
B	CYS399
B	HIS526
B	GLU528
C	CYS399
C	HIS526
C	GLU528

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site_id	SWS_FT_FI2
Number of Residues	16
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:18327897

Chain	Residue	Details
A	SER567
C	SER570
C	SER571
C	SER588
D	SER567
D	SER570
D	SER571
D	SER588
A	SER570
A	SER571
A	SER588
B	SER567
B	SER570
B	SER571
B	SER588
C	SER567

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:18327897

Chain	Residue	Details
A	THR595
B	THR595
C	THR595
D	THR595

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