7DNJ
K63-polyUb MDA5CARDs complex
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| E | LYS27-ASP52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | SITE: Interacts with activating enzyme |
| Chain | Residue | Details |
| E | ARG54 | |
| I | ARG72 | |
| J | ARG54 | |
| J | ARG72 | |
| K | ARG54 | |
| K | ARG72 | |
| L | ARG54 | |
| L | ARG72 | |
| E | ARG72 | |
| F | ARG54 | |
| F | ARG72 | |
| G | ARG54 | |
| G | ARG72 | |
| H | ARG54 | |
| H | ARG72 | |
| I | ARG54 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | SITE: Essential for function |
| Chain | Residue | Details |
| E | HIS68 | |
| F | HIS68 | |
| G | HIS68 | |
| H | HIS68 | |
| I | HIS68 | |
| J | HIS68 | |
| K | HIS68 | |
| L | HIS68 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 |
| Chain | Residue | Details |
| E | SER65 | |
| D | LYS23 | |
| D | LYS43 | |
| F | SER65 | |
| G | SER65 | |
| H | SER65 | |
| I | SER65 | |
| J | SER65 | |
| K | SER65 | |
| L | SER65 | |
| C | LYS43 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 |
| Chain | Residue | Details |
| E | THR66 | |
| F | THR66 | |
| G | THR66 | |
| H | THR66 | |
| I | THR66 | |
| J | THR66 | |
| K | THR66 | |
| L | THR66 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742 |
| Chain | Residue | Details |
| E | GLY76 | |
| F | GLY76 | |
| G | GLY76 | |
| H | GLY76 | |
| I | GLY76 | |
| J | GLY76 | |
| K | GLY76 | |
| L | GLY76 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 |
| Chain | Residue | Details |
| E | LYS6 | |
| F | LYS6 | |
| G | LYS6 | |
| H | LYS6 | |
| I | LYS6 | |
| J | LYS6 | |
| K | LYS6 | |
| L | LYS6 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 16 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
| Chain | Residue | Details |
| I | GLY76 | |
| J | GLY76 | |
| K | GLY76 | |
| L | GLY76 | |
| E | GLY76 | |
| F | GLY76 | |
| G | GLY76 | |
| H | GLY76 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 16 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 |
| Chain | Residue | Details |
| E | LYS11 | |
| I | LYS48 | |
| J | LYS11 | |
| J | LYS48 | |
| K | LYS11 | |
| K | LYS48 | |
| L | LYS11 | |
| L | LYS48 | |
| E | LYS48 | |
| F | LYS11 | |
| F | LYS48 | |
| G | LYS11 | |
| G | LYS48 | |
| H | LYS11 | |
| H | LYS48 | |
| I | LYS11 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 |
| Chain | Residue | Details |
| E | LYS27 | |
| F | LYS27 | |
| G | LYS27 | |
| H | LYS27 | |
| I | LYS27 | |
| J | LYS27 | |
| K | LYS27 | |
| L | LYS27 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 |
| Chain | Residue | Details |
| E | LYS29 | |
| F | LYS29 | |
| G | LYS29 | |
| H | LYS29 | |
| I | LYS29 | |
| J | LYS29 | |
| K | LYS29 | |
| L | LYS29 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 |
| Chain | Residue | Details |
| E | LYS33 | |
| F | LYS33 | |
| G | LYS33 | |
| H | LYS33 | |
| I | LYS33 | |
| J | LYS33 | |
| K | LYS33 | |
| L | LYS33 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 |
| Chain | Residue | Details |
| E | LYS63 | |
| F | LYS63 | |
| G | LYS63 | |
| H | LYS63 | |
| I | LYS63 | |
| J | LYS63 | |
| K | LYS63 | |
| L | LYS63 |
