7DLL
Short chain dehydrogenase 2 (SCR2) crystal structure with NADPH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004090 | molecular_function | carbonyl reductase (NADPH) activity |
| A | 0005575 | cellular_component | cellular_component |
| A | 0008150 | biological_process | biological_process |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0050664 | molecular_function | oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor |
| B | 0004090 | molecular_function | carbonyl reductase (NADPH) activity |
| B | 0005575 | cellular_component | cellular_component |
| B | 0008150 | biological_process | biological_process |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0050664 | molecular_function | oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 32 |
| Details | binding site for residue NDP A 301 |
| Chain | Residue |
| A | GLY41 |
| A | ASN91 |
| A | ILE92 |
| A | ASN118 |
| A | ALA119 |
| A | GLY120 |
| A | LEU143 |
| A | THR170 |
| A | SER171 |
| A | SER172 |
| A | SER174 |
| A | SER43 |
| A | TYR187 |
| A | LYS191 |
| A | PRO216 |
| A | GLY217 |
| A | THR221 |
| A | HOH402 |
| A | HOH407 |
| A | HOH410 |
| A | HOH428 |
| A | HOH439 |
| A | GLY44 |
| A | HOH447 |
| A | HOH489 |
| A | HOH499 |
| A | GLY45 |
| A | ILE46 |
| A | ASN66 |
| A | SER67 |
| A | HIS68 |
| A | CYS90 |
| site_id | AC2 |
| Number of Residues | 28 |
| Details | binding site for residue NDP B 301 |
| Chain | Residue |
| B | GLY41 |
| B | SER43 |
| B | GLY44 |
| B | GLY45 |
| B | ILE46 |
| B | TYR65 |
| B | ASN66 |
| B | SER67 |
| B | HIS68 |
| B | CYS90 |
| B | ASN91 |
| B | ILE92 |
| B | ASN118 |
| B | ALA119 |
| B | GLY120 |
| B | LEU143 |
| B | THR170 |
| B | SER171 |
| B | SER172 |
| B | TYR187 |
| B | LYS191 |
| B | PRO216 |
| B | GLY217 |
| B | ILE219 |
| B | HOH402 |
| B | HOH452 |
| B | HOH456 |
| B | HOH490 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"G8BHG6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"G8BHG6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Lowers pKa of active site Tyr","evidences":[{"source":"UniProtKB","id":"O93868","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"35801308","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DMG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"35801308","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DLL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
