7DCQ

cryo-EM structure of the DEAH-box helicase Prp2

Functional Information from GO Data

Chain	GOid	namespace	contents
x	0000166	molecular_function	nucleotide binding
x	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
x	0000398	biological_process	mRNA splicing, via spliceosome
x	0003676	molecular_function	nucleic acid binding
x	0003723	molecular_function	RNA binding
x	0003724	molecular_function	RNA helicase activity
x	0004386	molecular_function	helicase activity
x	0005515	molecular_function	protein binding
x	0005524	molecular_function	ATP binding
x	0005634	cellular_component	nucleus
x	0006397	biological_process	mRNA processing
x	0008186	molecular_function	ATP-dependent activity, acting on RNA
x	0008380	biological_process	RNA splicing
x	0016787	molecular_function	hydrolase activity
x	0016887	molecular_function	ATP hydrolysis activity
x	0022613	biological_process	ribonucleoprotein complex biogenesis
x	0034247	biological_process	snoRNA splicing
x	0071006	cellular_component	U2-type catalytic step 1 spliceosome
x	0071826	biological_process	protein-RNA complex organization

Functional Information from PROSITE/UniProt

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. ScIMIDEAHE

Chain	Residue	Details
x	SER341-GLU350

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	166
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	174
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details