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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7D91

Crystal Structure of the Na+,K+-ATPase in the E2P state with bound Mg2+ (P4(3)2(1)2 symmetry)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0002028biological_processregulation of sodium ion transport
A0005215molecular_functiontransporter activity
A0005391molecular_functionP-type sodium:potassium-exchanging transporter activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005886cellular_componentplasma membrane
A0005890cellular_componentsodium:potassium-exchanging ATPase complex
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0006814biological_processsodium ion transport
A0006883biological_processintracellular sodium ion homeostasis
A0008556molecular_functionP-type potassium transmembrane transporter activity
A0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016887molecular_functionATP hydrolysis activity
A0030007biological_processintracellular potassium ion homeostasis
A0030424cellular_componentaxon
A0030955molecular_functionpotassium ion binding
A0031402molecular_functionsodium ion binding
A0036376biological_processsodium ion export across plasma membrane
A0042383cellular_componentsarcolemma
A0042470cellular_componentmelanosome
A0046872molecular_functionmetal ion binding
A0051117molecular_functionATPase binding
A0055085biological_processtransmembrane transport
A0071805biological_processpotassium ion transmembrane transport
A0086009biological_processmembrane repolarization
A0090533cellular_componentcation-transporting ATPase complex
A0098797cellular_componentplasma membrane protein complex
A1902600biological_processproton transmembrane transport
A1990573biological_processpotassium ion import across plasma membrane
B0001671molecular_functionATPase activator activity
B0002376biological_processimmune system process
B0005391molecular_functionP-type sodium:potassium-exchanging transporter activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0005890cellular_componentsodium:potassium-exchanging ATPase complex
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006814biological_processsodium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0006883biological_processintracellular sodium ion homeostasis
B0007155biological_processcell adhesion
B0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
B0010468biological_processregulation of gene expression
B0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
B0014704cellular_componentintercalated disc
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0016328cellular_componentlateral plasma membrane
B0019901molecular_functionprotein kinase binding
B0030007biological_processintracellular potassium ion homeostasis
B0030315cellular_componentT-tubule
B0030674molecular_functionprotein-macromolecule adaptor activity
B0031090cellular_componentorganelle membrane
B0035725biological_processsodium ion transmembrane transport
B0036126cellular_componentsperm flagellum
B0036376biological_processsodium ion export across plasma membrane
B0042383cellular_componentsarcolemma
B0045087biological_processinnate immune response
B0046034biological_processATP metabolic process
B0050821biological_processprotein stabilization
B0051117molecular_functionATPase binding
B0055085biological_processtransmembrane transport
B0055119biological_processrelaxation of cardiac muscle
B0060048biological_processcardiac muscle contraction
B0072659biological_processprotein localization to plasma membrane
B0086009biological_processmembrane repolarization
B0141109molecular_functiontransporter activator activity
B1901381biological_processpositive regulation of potassium ion transmembrane transport
B1902307biological_processpositive regulation of sodium ion transmembrane transport
B1902600biological_processproton transmembrane transport
B1903169biological_processregulation of calcium ion transmembrane transport
B1903278biological_processpositive regulation of sodium ion export across plasma membrane
B1903288biological_processpositive regulation of potassium ion import across plasma membrane
B1990573biological_processpotassium ion import across plasma membrane
G0001671molecular_functionATPase activator activity
G0005515molecular_functionprotein binding
G0005890cellular_componentsodium:potassium-exchanging ATPase complex
G0006811biological_processmonoatomic ion transport
G0006813biological_processpotassium ion transport
G0006814biological_processsodium ion transport
G0006883biological_processintracellular sodium ion homeostasis
G0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
G0016020cellular_componentmembrane
G0030007biological_processintracellular potassium ion homeostasis
G0030674molecular_functionprotein-macromolecule adaptor activity
G0036376biological_processsodium ion export across plasma membrane
G0043269biological_processregulation of monoatomic ion transport
G0055085biological_processtransmembrane transport
G0099106molecular_functionion channel regulator activity
G1902600biological_processproton transmembrane transport
G1990573biological_processpotassium ion import across plasma membrane
Functional Information from PROSITE/UniProt
site_idPS00154
Number of Residues7
DetailsATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT
ChainResidueDetails
ABFD369-THR375
site_idPS00390
Number of Residues21
DetailsATPASE_NA_K_BETA_1 Sodium and potassium ATPases beta subunits signature 1. WkkFiWNsekkefLGRTggsW
ChainResidueDetails
BTRP12-TRP32
site_idPS00391
Number of Residues16
DetailsATPASE_NA_K_BETA_2 Sodium and potassium ATPases beta subunits signature 2. RkvCRfrlewLgnCSG
ChainResidueDetails
BARG146-GLY161
site_idPS01310
Number of Residues14
DetailsFXYD FXYD family signature. DpFyYDyeTVRngG
ChainResidueDetails
GASP17-GLY30
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues194
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues347
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues166
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsRegion: {"description":"Phosphoinositide-3 kinase binding","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues19
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues121
DetailsRegion: {"description":"Mediates interaction with SCN7A","evidences":[{"source":"UniProtKB","id":"Q8VDN2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues11
DetailsCompositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsActive site: {"description":"4-aspartylphosphate intermediate","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues3
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P06685","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8VDN2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8VDN2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P05023","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8VDN2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"UniProtKB","id":"P06685","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues27
DetailsTransmembrane: {"description":"Helical; Signal-anchor for type II membrane protein","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues112
DetailsRegion: {"description":"immunoglobulin-like","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P14094","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2025-10-29

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