7D90
human potassium-chloride co-transporter KCC3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001525 | biological_process | angiogenesis |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0006884 | biological_process | cell volume homeostasis |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
| A | 0015379 | molecular_function | potassium:chloride symporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0030424 | cellular_component | axon |
| A | 0045202 | cellular_component | synapse |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055064 | biological_process | chloride ion homeostasis |
| A | 0055075 | biological_process | potassium ion homeostasis |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0071333 | biological_process | cellular response to glucose stimulus |
| A | 0071477 | biological_process | cellular hypotonic salinity response |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| A | 1902476 | biological_process | chloride transmembrane transport |
| A | 1990573 | biological_process | potassium ion import across plasma membrane |
| B | 0001525 | biological_process | angiogenesis |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0006884 | biological_process | cell volume homeostasis |
| B | 0007268 | biological_process | chemical synaptic transmission |
| B | 0015293 | molecular_function | symporter activity |
| B | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
| B | 0015379 | molecular_function | potassium:chloride symporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0030424 | cellular_component | axon |
| B | 0045202 | cellular_component | synapse |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0055064 | biological_process | chloride ion homeostasis |
| B | 0055075 | biological_process | potassium ion homeostasis |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0071333 | biological_process | cellular response to glucose stimulus |
| B | 0071477 | biological_process | cellular hypotonic salinity response |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 1902476 | biological_process | chloride transmembrane transport |
| B | 1990573 | biological_process | potassium ion import across plasma membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1374 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | MET1-LEU135 | |
| B | VAL546-SER568 | |
| B | SER613-ILE629 | |
| B | LEU666-SER1150 | |
| A | MET189-VAL211 | |
| A | GLY455-LYS464 | |
| A | VAL546-SER568 | |
| A | SER613-ILE629 | |
| A | LEU666-SER1150 | |
| B | MET1-LEU135 | |
| B | MET189-VAL211 | |
| B | GLY455-LYS464 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | TRANSMEM: Discontinuously helical; Name=1 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | PHE136-ASN158 | |
| B | PHE136-ASN158 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 338 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | LEU159-GLU165 | |
| A | VAL246-GLU263 | |
| A | ASN317-GLN433 | |
| A | LEU488-ILE518 | |
| B | LEU159-GLU165 | |
| B | VAL246-GLU263 | |
| B | ASN317-GLN433 | |
| B | LEU488-ILE518 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | HIS166-PHE188 | |
| B | HIS166-PHE188 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 66 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | VAL212-GLY245 | |
| B | VAL212-GLY245 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | PHE264-ALA287 | |
| B | PHE264-ALA287 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 56 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | ILE288-ASN316 | |
| B | ILE288-ASN316 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | GLY434-LYS454 | |
| B | GLY434-LYS454 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | SER465-LEU487 | |
| B | SER465-LEU487 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 52 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | GLY519-VAL545 | |
| B | GLY519-VAL545 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | PRO569-THR589 | |
| B | PRO569-THR589 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | GLY590-HIS612 | |
| B | GLY590-HIS612 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 38 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | ALA630-PHE649 | |
| B | ALA630-PHE649 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 30 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | PHE650-THR665 | |
| B | PHE650-THR665 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y, ECO:0007744|PDB:6M22 |
| Chain | Residue | Details |
| A | SER147 | |
| B | SER148 | |
| B | ILE443 | |
| B | THR444 | |
| B | ASN446 | |
| B | LEU447 | |
| B | TRP448 | |
| B | ILE603 | |
| A | SER148 | |
| A | ILE443 | |
| A | THR444 | |
| A | ASN446 | |
| A | LEU447 | |
| A | TRP448 | |
| A | ILE603 | |
| B | SER147 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | ASN151 | |
| B | ASN151 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:19665974, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER32 | |
| B | SER32 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER120 | |
| A | SER148 | |
| B | SER120 | |
| B | SER148 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:34031912 |
| Chain | Residue | Details |
| A | SER736 | |
| A | SER981 | |
| B | SER736 | |
| B | SER981 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:34031912 |
| Chain | Residue | Details |
| A | THR778 | |
| B | THR778 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by OXSR1 and STK39 => ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:27485015, ECO:0000269|PubMed:34031912 |
| Chain | Residue | Details |
| A | THR991 | |
| B | THR991 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:19665974 |
| Chain | Residue | Details |
| A | SER1023 | |
| A | SER1029 | |
| B | SER1023 | |
| B | SER1029 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER1032 | |
| B | SER1032 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by OXSR1 and STK39 => ECO:0000269|PubMed:19665974 |
| Chain | Residue | Details |
| A | THR1048 | |
| B | THR1048 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:34031912 |
| Chain | Residue | Details |
| A | TYR1121 | |
| B | TYR1121 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN379 | |
| A | ASN398 | |
| A | ASN411 | |
| A | ASN428 | |
| B | ASN379 | |
| B | ASN398 | |
| B | ASN411 | |
| B | ASN428 |
