7D90
human potassium-chloride co-transporter KCC3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001525 | biological_process | angiogenesis |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0006884 | biological_process | cell volume homeostasis |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
| A | 0015379 | molecular_function | potassium:chloride symporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0030424 | cellular_component | axon |
| A | 0045202 | cellular_component | synapse |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055064 | biological_process | chloride ion homeostasis |
| A | 0055075 | biological_process | potassium ion homeostasis |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0071333 | biological_process | cellular response to glucose stimulus |
| A | 0071477 | biological_process | cellular hypotonic salinity response |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| A | 1902476 | biological_process | chloride transmembrane transport |
| A | 1990573 | biological_process | potassium ion import across plasma membrane |
| B | 0001525 | biological_process | angiogenesis |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0006884 | biological_process | cell volume homeostasis |
| B | 0007268 | biological_process | chemical synaptic transmission |
| B | 0015293 | molecular_function | symporter activity |
| B | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
| B | 0015379 | molecular_function | potassium:chloride symporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0030424 | cellular_component | axon |
| B | 0045202 | cellular_component | synapse |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0055064 | biological_process | chloride ion homeostasis |
| B | 0055075 | biological_process | potassium ion homeostasis |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0071333 | biological_process | cellular response to glucose stimulus |
| B | 0071477 | biological_process | cellular hypotonic salinity response |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 1902476 | biological_process | chloride transmembrane transport |
| B | 1990573 | biological_process | potassium ion import across plasma membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1370 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:Q9UP95 |
| Chain | Residue | Details |
| A | MET1-GLY186 | |
| B | ALA597-PRO619 | |
| B | GLN664-ARG677 | |
| B | ILE717-SER1150 | |
| A | ALA240-GLU263 | |
| A | SER506-SER515 | |
| A | ALA597-PRO619 | |
| A | GLN664-ARG677 | |
| A | ILE717-SER1150 | |
| B | MET1-GLY186 | |
| B | ALA240-GLU263 | |
| B | SER506-SER515 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | TRANSMEM: Discontinuously helical => ECO:0000250|UniProtKB:Q9UP95 |
| Chain | Residue | Details |
| A | THR187-LEU208 | |
| B | THR187-LEU208 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 356 |
| Details | TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:Q9UP95 |
| Chain | Residue | Details |
| A | THR209-GLY216 | |
| A | VAL293-LEU315 | |
| A | SER365-SER484 | |
| A | GLY539-PRO569 | |
| B | THR209-GLY216 | |
| B | VAL293-LEU315 | |
| B | SER365-SER484 | |
| B | GLY539-PRO569 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 488 |
| Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:Q9UP95 |
| Chain | Residue | Details |
| A | VAL217-SER239 | |
| A | TYR678-TRP700 | |
| A | TYR701-TYR716 | |
| B | VAL217-SER239 | |
| B | PHE264-LEU292 | |
| B | ASN316-ARG338 | |
| B | TYR339-LYS364 | |
| B | PHE485-ARG505 | |
| B | ILE516-PHE538 | |
| B | TRP570-GLN596 | |
| B | THR620-ASP640 | |
| A | PHE264-LEU292 | |
| B | LEU641-LEU663 | |
| B | TYR678-TRP700 | |
| B | TYR701-TYR716 | |
| A | ASN316-ARG338 | |
| A | TYR339-LYS364 | |
| A | PHE485-ARG505 | |
| A | ILE516-PHE538 | |
| A | TRP570-GLN596 | |
| A | THR620-ASP640 | |
| A | LEU641-LEU663 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9UP95 |
| Chain | Residue | Details |
| A | ASN198 | |
| B | ASN198 | |
| B | ILE199 | |
| B | TYR283 | |
| B | PRO494 | |
| B | THR497 | |
| B | GLY498 | |
| B | ILE499 | |
| B | MET500 | |
| B | TYR654 | |
| A | ILE199 | |
| A | TYR283 | |
| A | PRO494 | |
| A | THR497 | |
| A | GLY498 | |
| A | ILE499 | |
| A | MET500 | |
| A | TYR654 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:19665974, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER32 | |
| B | SER32 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER120 | |
| A | SER148 | |
| B | SER120 | |
| B | SER148 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:34031912 |
| Chain | Residue | Details |
| A | SER736 | |
| A | SER981 | |
| B | SER736 | |
| B | SER981 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:34031912 |
| Chain | Residue | Details |
| A | THR778 | |
| B | THR778 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by OXSR1 and STK39 => ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:27485015, ECO:0000269|PubMed:34031912 |
| Chain | Residue | Details |
| A | THR991 | |
| B | THR991 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:19665974 |
| Chain | Residue | Details |
| A | SER1023 | |
| A | SER1029 | |
| B | SER1023 | |
| B | SER1029 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER1032 | |
| B | SER1032 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by OXSR1 and STK39 => ECO:0000269|PubMed:19665974 |
| Chain | Residue | Details |
| A | THR1048 | |
| B | THR1048 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:34031912 |
| Chain | Residue | Details |
| A | TYR1121 | |
| B | TYR1121 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN379 | |
| A | ASN398 | |
| A | ASN411 | |
| A | ASN428 | |
| B | ASN379 | |
| B | ASN398 | |
| B | ASN411 | |
| B | ASN428 |
