7D6E

Structural insights into membrane remodeling by SNX1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005154	molecular_function	epidermal growth factor receptor binding
A	0005158	molecular_function	insulin receptor binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005768	cellular_component	endosome
A	0005769	cellular_component	early endosome
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0006886	biological_process	intracellular protein transport
A	0008289	molecular_function	lipid binding
A	0010008	cellular_component	endosome membrane
A	0014069	cellular_component	postsynaptic density
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0030027	cellular_component	lamellipodium
A	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
A	0030904	cellular_component	retromer complex
A	0030905	cellular_component	retromer, tubulation complex
A	0031175	biological_process	neuron projection development
A	0031623	biological_process	receptor internalization
A	0031901	cellular_component	early endosome membrane
A	0031982	cellular_component	vesicle
A	0032991	cellular_component	protein-containing complex
A	0034498	biological_process	early endosome to Golgi transport
A	0035091	molecular_function	phosphatidylinositol binding
A	0042147	biological_process	retrograde transport, endosome to Golgi
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043197	cellular_component	dendritic spine
A	0045732	biological_process	positive regulation of protein catabolic process
A	0046982	molecular_function	protein heterodimerization activity
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0072673	biological_process	lamellipodium morphogenesis
A	0098793	cellular_component	presynapse
A	0098999	cellular_component	extrinsic component of postsynaptic endosome membrane
A	0099092	cellular_component	postsynaptic density, intracellular component
A	1990459	molecular_function	transferrin receptor binding
A	1990460	molecular_function	leptin receptor binding
B	0005154	molecular_function	epidermal growth factor receptor binding
B	0005158	molecular_function	insulin receptor binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005768	cellular_component	endosome
B	0005769	cellular_component	early endosome
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0006886	biological_process	intracellular protein transport
B	0008289	molecular_function	lipid binding
B	0010008	cellular_component	endosome membrane
B	0014069	cellular_component	postsynaptic density
B	0015031	biological_process	protein transport
B	0016020	cellular_component	membrane
B	0030027	cellular_component	lamellipodium
B	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
B	0030904	cellular_component	retromer complex
B	0030905	cellular_component	retromer, tubulation complex
B	0031175	biological_process	neuron projection development
B	0031623	biological_process	receptor internalization
B	0031901	cellular_component	early endosome membrane
B	0031982	cellular_component	vesicle
B	0032991	cellular_component	protein-containing complex
B	0034498	biological_process	early endosome to Golgi transport
B	0035091	molecular_function	phosphatidylinositol binding
B	0042147	biological_process	retrograde transport, endosome to Golgi
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0043197	cellular_component	dendritic spine
B	0045732	biological_process	positive regulation of protein catabolic process
B	0046982	molecular_function	protein heterodimerization activity
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0072673	biological_process	lamellipodium morphogenesis
B	0098793	cellular_component	presynapse
B	0098999	cellular_component	extrinsic component of postsynaptic endosome membrane
B	0099092	cellular_component	postsynaptic density, intracellular component
B	1990459	molecular_function	transferrin receptor binding
B	1990460	molecular_function	leptin receptor binding
C	0005154	molecular_function	epidermal growth factor receptor binding
C	0005158	molecular_function	insulin receptor binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005768	cellular_component	endosome
C	0005769	cellular_component	early endosome
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0006886	biological_process	intracellular protein transport
C	0008289	molecular_function	lipid binding
C	0010008	cellular_component	endosome membrane
C	0014069	cellular_component	postsynaptic density
C	0015031	biological_process	protein transport
C	0016020	cellular_component	membrane
C	0030027	cellular_component	lamellipodium
C	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
C	0030904	cellular_component	retromer complex
C	0030905	cellular_component	retromer, tubulation complex
C	0031175	biological_process	neuron projection development
C	0031623	biological_process	receptor internalization
C	0031901	cellular_component	early endosome membrane
C	0031982	cellular_component	vesicle
C	0032991	cellular_component	protein-containing complex
C	0034498	biological_process	early endosome to Golgi transport
C	0035091	molecular_function	phosphatidylinositol binding
C	0042147	biological_process	retrograde transport, endosome to Golgi
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0043197	cellular_component	dendritic spine
C	0045732	biological_process	positive regulation of protein catabolic process
C	0046982	molecular_function	protein heterodimerization activity
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0072673	biological_process	lamellipodium morphogenesis
C	0098793	cellular_component	presynapse
C	0098999	cellular_component	extrinsic component of postsynaptic endosome membrane
C	0099092	cellular_component	postsynaptic density, intracellular component
C	1990459	molecular_function	transferrin receptor binding
C	1990460	molecular_function	leptin receptor binding
D	0005154	molecular_function	epidermal growth factor receptor binding
D	0005158	molecular_function	insulin receptor binding
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0005768	cellular_component	endosome
D	0005769	cellular_component	early endosome
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0006886	biological_process	intracellular protein transport
D	0008289	molecular_function	lipid binding
D	0010008	cellular_component	endosome membrane
D	0014069	cellular_component	postsynaptic density
D	0015031	biological_process	protein transport
D	0016020	cellular_component	membrane
D	0030027	cellular_component	lamellipodium
D	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
D	0030904	cellular_component	retromer complex
D	0030905	cellular_component	retromer, tubulation complex
D	0031175	biological_process	neuron projection development
D	0031623	biological_process	receptor internalization
D	0031901	cellular_component	early endosome membrane
D	0031982	cellular_component	vesicle
D	0032991	cellular_component	protein-containing complex
D	0034498	biological_process	early endosome to Golgi transport
D	0035091	molecular_function	phosphatidylinositol binding
D	0042147	biological_process	retrograde transport, endosome to Golgi
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0043197	cellular_component	dendritic spine
D	0045732	biological_process	positive regulation of protein catabolic process
D	0046982	molecular_function	protein heterodimerization activity
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0072673	biological_process	lamellipodium morphogenesis
D	0098793	cellular_component	presynapse
D	0098999	cellular_component	extrinsic component of postsynaptic endosome membrane
D	0099092	cellular_component	postsynaptic density, intracellular component
D	1990459	molecular_function	transferrin receptor binding
D	1990460	molecular_function	leptin receptor binding
E	0005154	molecular_function	epidermal growth factor receptor binding
E	0005158	molecular_function	insulin receptor binding
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005764	cellular_component	lysosome
E	0005768	cellular_component	endosome
E	0005769	cellular_component	early endosome
E	0005794	cellular_component	Golgi apparatus
E	0005829	cellular_component	cytosol
E	0006886	biological_process	intracellular protein transport
E	0008289	molecular_function	lipid binding
E	0010008	cellular_component	endosome membrane
E	0014069	cellular_component	postsynaptic density
E	0015031	biological_process	protein transport
E	0016020	cellular_component	membrane
E	0030027	cellular_component	lamellipodium
E	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
E	0030904	cellular_component	retromer complex
E	0030905	cellular_component	retromer, tubulation complex
E	0031175	biological_process	neuron projection development
E	0031623	biological_process	receptor internalization
E	0031901	cellular_component	early endosome membrane
E	0031982	cellular_component	vesicle
E	0032991	cellular_component	protein-containing complex
E	0034498	biological_process	early endosome to Golgi transport
E	0035091	molecular_function	phosphatidylinositol binding
E	0042147	biological_process	retrograde transport, endosome to Golgi
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0043197	cellular_component	dendritic spine
E	0045732	biological_process	positive regulation of protein catabolic process
E	0046982	molecular_function	protein heterodimerization activity
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0072673	biological_process	lamellipodium morphogenesis
E	0098793	cellular_component	presynapse
E	0098999	cellular_component	extrinsic component of postsynaptic endosome membrane
E	0099092	cellular_component	postsynaptic density, intracellular component
E	1990459	molecular_function	transferrin receptor binding
E	1990460	molecular_function	leptin receptor binding
F	0005154	molecular_function	epidermal growth factor receptor binding
F	0005158	molecular_function	insulin receptor binding
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005764	cellular_component	lysosome
F	0005768	cellular_component	endosome
F	0005769	cellular_component	early endosome
F	0005794	cellular_component	Golgi apparatus
F	0005829	cellular_component	cytosol
F	0006886	biological_process	intracellular protein transport
F	0008289	molecular_function	lipid binding
F	0010008	cellular_component	endosome membrane
F	0014069	cellular_component	postsynaptic density
F	0015031	biological_process	protein transport
F	0016020	cellular_component	membrane
F	0030027	cellular_component	lamellipodium
F	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
F	0030904	cellular_component	retromer complex
F	0030905	cellular_component	retromer, tubulation complex
F	0031175	biological_process	neuron projection development
F	0031623	biological_process	receptor internalization
F	0031901	cellular_component	early endosome membrane
F	0031982	cellular_component	vesicle
F	0032991	cellular_component	protein-containing complex
F	0034498	biological_process	early endosome to Golgi transport
F	0035091	molecular_function	phosphatidylinositol binding
F	0042147	biological_process	retrograde transport, endosome to Golgi
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0043197	cellular_component	dendritic spine
F	0045732	biological_process	positive regulation of protein catabolic process
F	0046982	molecular_function	protein heterodimerization activity
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0072673	biological_process	lamellipodium morphogenesis
F	0098793	cellular_component	presynapse
F	0098999	cellular_component	extrinsic component of postsynaptic endosome membrane
F	0099092	cellular_component	postsynaptic density, intracellular component
F	1990459	molecular_function	transferrin receptor binding
F	1990460	molecular_function	leptin receptor binding
G	0005154	molecular_function	epidermal growth factor receptor binding
G	0005158	molecular_function	insulin receptor binding
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005764	cellular_component	lysosome
G	0005768	cellular_component	endosome
G	0005769	cellular_component	early endosome
G	0005794	cellular_component	Golgi apparatus
G	0005829	cellular_component	cytosol
G	0006886	biological_process	intracellular protein transport
G	0008289	molecular_function	lipid binding
G	0010008	cellular_component	endosome membrane
G	0014069	cellular_component	postsynaptic density
G	0015031	biological_process	protein transport
G	0016020	cellular_component	membrane
G	0030027	cellular_component	lamellipodium
G	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
G	0030904	cellular_component	retromer complex
G	0030905	cellular_component	retromer, tubulation complex
G	0031175	biological_process	neuron projection development
G	0031623	biological_process	receptor internalization
G	0031901	cellular_component	early endosome membrane
G	0031982	cellular_component	vesicle
G	0032991	cellular_component	protein-containing complex
G	0034498	biological_process	early endosome to Golgi transport
G	0035091	molecular_function	phosphatidylinositol binding
G	0042147	biological_process	retrograde transport, endosome to Golgi
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0043197	cellular_component	dendritic spine
G	0045732	biological_process	positive regulation of protein catabolic process
G	0046982	molecular_function	protein heterodimerization activity
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0072673	biological_process	lamellipodium morphogenesis
G	0098793	cellular_component	presynapse
G	0098999	cellular_component	extrinsic component of postsynaptic endosome membrane
G	0099092	cellular_component	postsynaptic density, intracellular component
G	1990459	molecular_function	transferrin receptor binding
G	1990460	molecular_function	leptin receptor binding
H	0005154	molecular_function	epidermal growth factor receptor binding
H	0005158	molecular_function	insulin receptor binding
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005764	cellular_component	lysosome
H	0005768	cellular_component	endosome
H	0005769	cellular_component	early endosome
H	0005794	cellular_component	Golgi apparatus
H	0005829	cellular_component	cytosol
H	0006886	biological_process	intracellular protein transport
H	0008289	molecular_function	lipid binding
H	0010008	cellular_component	endosome membrane
H	0014069	cellular_component	postsynaptic density
H	0015031	biological_process	protein transport
H	0016020	cellular_component	membrane
H	0030027	cellular_component	lamellipodium
H	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
H	0030904	cellular_component	retromer complex
H	0030905	cellular_component	retromer, tubulation complex
H	0031175	biological_process	neuron projection development
H	0031623	biological_process	receptor internalization
H	0031901	cellular_component	early endosome membrane
H	0031982	cellular_component	vesicle
H	0032991	cellular_component	protein-containing complex
H	0034498	biological_process	early endosome to Golgi transport
H	0035091	molecular_function	phosphatidylinositol binding
H	0042147	biological_process	retrograde transport, endosome to Golgi
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0043197	cellular_component	dendritic spine
H	0045732	biological_process	positive regulation of protein catabolic process
H	0046982	molecular_function	protein heterodimerization activity
H	0048471	cellular_component	perinuclear region of cytoplasm
H	0072673	biological_process	lamellipodium morphogenesis
H	0098793	cellular_component	presynapse
H	0098999	cellular_component	extrinsic component of postsynaptic endosome membrane
H	0099092	cellular_component	postsynaptic density, intracellular component
H	1990459	molecular_function	transferrin receptor binding
H	1990460	molecular_function	leptin receptor binding
I	0005154	molecular_function	epidermal growth factor receptor binding
I	0005158	molecular_function	insulin receptor binding
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005764	cellular_component	lysosome
I	0005768	cellular_component	endosome
I	0005769	cellular_component	early endosome
I	0005794	cellular_component	Golgi apparatus
I	0005829	cellular_component	cytosol
I	0006886	biological_process	intracellular protein transport
I	0008289	molecular_function	lipid binding
I	0010008	cellular_component	endosome membrane
I	0014069	cellular_component	postsynaptic density
I	0015031	biological_process	protein transport
I	0016020	cellular_component	membrane
I	0030027	cellular_component	lamellipodium
I	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
I	0030904	cellular_component	retromer complex
I	0030905	cellular_component	retromer, tubulation complex
I	0031175	biological_process	neuron projection development
I	0031623	biological_process	receptor internalization
I	0031901	cellular_component	early endosome membrane
I	0031982	cellular_component	vesicle
I	0032991	cellular_component	protein-containing complex
I	0034498	biological_process	early endosome to Golgi transport
I	0035091	molecular_function	phosphatidylinositol binding
I	0042147	biological_process	retrograde transport, endosome to Golgi
I	0042802	molecular_function	identical protein binding
I	0042803	molecular_function	protein homodimerization activity
I	0043197	cellular_component	dendritic spine
I	0045732	biological_process	positive regulation of protein catabolic process
I	0046982	molecular_function	protein heterodimerization activity
I	0048471	cellular_component	perinuclear region of cytoplasm
I	0072673	biological_process	lamellipodium morphogenesis
I	0098793	cellular_component	presynapse
I	0098999	cellular_component	extrinsic component of postsynaptic endosome membrane
I	0099092	cellular_component	postsynaptic density, intracellular component
I	1990459	molecular_function	transferrin receptor binding
I	1990460	molecular_function	leptin receptor binding
J	0005154	molecular_function	epidermal growth factor receptor binding
J	0005158	molecular_function	insulin receptor binding
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005764	cellular_component	lysosome
J	0005768	cellular_component	endosome
J	0005769	cellular_component	early endosome
J	0005794	cellular_component	Golgi apparatus
J	0005829	cellular_component	cytosol
J	0006886	biological_process	intracellular protein transport
J	0008289	molecular_function	lipid binding
J	0010008	cellular_component	endosome membrane
J	0014069	cellular_component	postsynaptic density
J	0015031	biological_process	protein transport
J	0016020	cellular_component	membrane
J	0030027	cellular_component	lamellipodium
J	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
J	0030904	cellular_component	retromer complex
J	0030905	cellular_component	retromer, tubulation complex
J	0031175	biological_process	neuron projection development
J	0031623	biological_process	receptor internalization
J	0031901	cellular_component	early endosome membrane
J	0031982	cellular_component	vesicle
J	0032991	cellular_component	protein-containing complex
J	0034498	biological_process	early endosome to Golgi transport
J	0035091	molecular_function	phosphatidylinositol binding
J	0042147	biological_process	retrograde transport, endosome to Golgi
J	0042802	molecular_function	identical protein binding
J	0042803	molecular_function	protein homodimerization activity
J	0043197	cellular_component	dendritic spine
J	0045732	biological_process	positive regulation of protein catabolic process
J	0046982	molecular_function	protein heterodimerization activity
J	0048471	cellular_component	perinuclear region of cytoplasm
J	0072673	biological_process	lamellipodium morphogenesis
J	0098793	cellular_component	presynapse
J	0098999	cellular_component	extrinsic component of postsynaptic endosome membrane
J	0099092	cellular_component	postsynaptic density, intracellular component
J	1990459	molecular_function	transferrin receptor binding
J	1990460	molecular_function	leptin receptor binding
K	0005154	molecular_function	epidermal growth factor receptor binding
K	0005158	molecular_function	insulin receptor binding
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005764	cellular_component	lysosome
K	0005768	cellular_component	endosome
K	0005769	cellular_component	early endosome
K	0005794	cellular_component	Golgi apparatus
K	0005829	cellular_component	cytosol
K	0006886	biological_process	intracellular protein transport
K	0008289	molecular_function	lipid binding
K	0010008	cellular_component	endosome membrane
K	0014069	cellular_component	postsynaptic density
K	0015031	biological_process	protein transport
K	0016020	cellular_component	membrane
K	0030027	cellular_component	lamellipodium
K	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
K	0030904	cellular_component	retromer complex
K	0030905	cellular_component	retromer, tubulation complex
K	0031175	biological_process	neuron projection development
K	0031623	biological_process	receptor internalization
K	0031901	cellular_component	early endosome membrane
K	0031982	cellular_component	vesicle
K	0032991	cellular_component	protein-containing complex
K	0034498	biological_process	early endosome to Golgi transport
K	0035091	molecular_function	phosphatidylinositol binding
K	0042147	biological_process	retrograde transport, endosome to Golgi
K	0042802	molecular_function	identical protein binding
K	0042803	molecular_function	protein homodimerization activity
K	0043197	cellular_component	dendritic spine
K	0045732	biological_process	positive regulation of protein catabolic process
K	0046982	molecular_function	protein heterodimerization activity
K	0048471	cellular_component	perinuclear region of cytoplasm
K	0072673	biological_process	lamellipodium morphogenesis
K	0098793	cellular_component	presynapse
K	0098999	cellular_component	extrinsic component of postsynaptic endosome membrane
K	0099092	cellular_component	postsynaptic density, intracellular component
K	1990459	molecular_function	transferrin receptor binding
K	1990460	molecular_function	leptin receptor binding
L	0005154	molecular_function	epidermal growth factor receptor binding
L	0005158	molecular_function	insulin receptor binding
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005764	cellular_component	lysosome
L	0005768	cellular_component	endosome
L	0005769	cellular_component	early endosome
L	0005794	cellular_component	Golgi apparatus
L	0005829	cellular_component	cytosol
L	0006886	biological_process	intracellular protein transport
L	0008289	molecular_function	lipid binding
L	0010008	cellular_component	endosome membrane
L	0014069	cellular_component	postsynaptic density
L	0015031	biological_process	protein transport
L	0016020	cellular_component	membrane
L	0030027	cellular_component	lamellipodium
L	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
L	0030904	cellular_component	retromer complex
L	0030905	cellular_component	retromer, tubulation complex
L	0031175	biological_process	neuron projection development
L	0031623	biological_process	receptor internalization
L	0031901	cellular_component	early endosome membrane
L	0031982	cellular_component	vesicle
L	0032991	cellular_component	protein-containing complex
L	0034498	biological_process	early endosome to Golgi transport
L	0035091	molecular_function	phosphatidylinositol binding
L	0042147	biological_process	retrograde transport, endosome to Golgi
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0043197	cellular_component	dendritic spine
L	0045732	biological_process	positive regulation of protein catabolic process
L	0046982	molecular_function	protein heterodimerization activity
L	0048471	cellular_component	perinuclear region of cytoplasm
L	0072673	biological_process	lamellipodium morphogenesis
L	0098793	cellular_component	presynapse
L	0098999	cellular_component	extrinsic component of postsynaptic endosome membrane
L	0099092	cellular_component	postsynaptic density, intracellular component
L	1990459	molecular_function	transferrin receptor binding
L	1990460	molecular_function	leptin receptor binding
M	0005154	molecular_function	epidermal growth factor receptor binding
M	0005158	molecular_function	insulin receptor binding
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005764	cellular_component	lysosome
M	0005768	cellular_component	endosome
M	0005769	cellular_component	early endosome
M	0005794	cellular_component	Golgi apparatus
M	0005829	cellular_component	cytosol
M	0006886	biological_process	intracellular protein transport
M	0008289	molecular_function	lipid binding
M	0010008	cellular_component	endosome membrane
M	0014069	cellular_component	postsynaptic density
M	0015031	biological_process	protein transport
M	0016020	cellular_component	membrane
M	0030027	cellular_component	lamellipodium
M	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
M	0030904	cellular_component	retromer complex
M	0030905	cellular_component	retromer, tubulation complex
M	0031175	biological_process	neuron projection development
M	0031623	biological_process	receptor internalization
M	0031901	cellular_component	early endosome membrane
M	0031982	cellular_component	vesicle
M	0032991	cellular_component	protein-containing complex
M	0034498	biological_process	early endosome to Golgi transport
M	0035091	molecular_function	phosphatidylinositol binding
M	0042147	biological_process	retrograde transport, endosome to Golgi
M	0042802	molecular_function	identical protein binding
M	0042803	molecular_function	protein homodimerization activity
M	0043197	cellular_component	dendritic spine
M	0045732	biological_process	positive regulation of protein catabolic process
M	0046982	molecular_function	protein heterodimerization activity
M	0048471	cellular_component	perinuclear region of cytoplasm
M	0072673	biological_process	lamellipodium morphogenesis
M	0098793	cellular_component	presynapse
M	0098999	cellular_component	extrinsic component of postsynaptic endosome membrane
M	0099092	cellular_component	postsynaptic density, intracellular component
M	1990459	molecular_function	transferrin receptor binding
M	1990460	molecular_function	leptin receptor binding
N	0005154	molecular_function	epidermal growth factor receptor binding
N	0005158	molecular_function	insulin receptor binding
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0005764	cellular_component	lysosome
N	0005768	cellular_component	endosome
N	0005769	cellular_component	early endosome
N	0005794	cellular_component	Golgi apparatus
N	0005829	cellular_component	cytosol
N	0006886	biological_process	intracellular protein transport
N	0008289	molecular_function	lipid binding
N	0010008	cellular_component	endosome membrane
N	0014069	cellular_component	postsynaptic density
N	0015031	biological_process	protein transport
N	0016020	cellular_component	membrane
N	0030027	cellular_component	lamellipodium
N	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
N	0030904	cellular_component	retromer complex
N	0030905	cellular_component	retromer, tubulation complex
N	0031175	biological_process	neuron projection development
N	0031623	biological_process	receptor internalization
N	0031901	cellular_component	early endosome membrane
N	0031982	cellular_component	vesicle
N	0032991	cellular_component	protein-containing complex
N	0034498	biological_process	early endosome to Golgi transport
N	0035091	molecular_function	phosphatidylinositol binding
N	0042147	biological_process	retrograde transport, endosome to Golgi
N	0042802	molecular_function	identical protein binding
N	0042803	molecular_function	protein homodimerization activity
N	0043197	cellular_component	dendritic spine
N	0045732	biological_process	positive regulation of protein catabolic process
N	0046982	molecular_function	protein heterodimerization activity
N	0048471	cellular_component	perinuclear region of cytoplasm
N	0072673	biological_process	lamellipodium morphogenesis
N	0098793	cellular_component	presynapse
N	0098999	cellular_component	extrinsic component of postsynaptic endosome membrane
N	0099092	cellular_component	postsynaptic density, intracellular component
N	1990459	molecular_function	transferrin receptor binding
N	1990460	molecular_function	leptin receptor binding
O	0005154	molecular_function	epidermal growth factor receptor binding
O	0005158	molecular_function	insulin receptor binding
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005764	cellular_component	lysosome
O	0005768	cellular_component	endosome
O	0005769	cellular_component	early endosome
O	0005794	cellular_component	Golgi apparatus
O	0005829	cellular_component	cytosol
O	0006886	biological_process	intracellular protein transport
O	0008289	molecular_function	lipid binding
O	0010008	cellular_component	endosome membrane
O	0014069	cellular_component	postsynaptic density
O	0015031	biological_process	protein transport
O	0016020	cellular_component	membrane
O	0030027	cellular_component	lamellipodium
O	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
O	0030904	cellular_component	retromer complex
O	0030905	cellular_component	retromer, tubulation complex
O	0031175	biological_process	neuron projection development
O	0031623	biological_process	receptor internalization
O	0031901	cellular_component	early endosome membrane
O	0031982	cellular_component	vesicle
O	0032991	cellular_component	protein-containing complex
O	0034498	biological_process	early endosome to Golgi transport
O	0035091	molecular_function	phosphatidylinositol binding
O	0042147	biological_process	retrograde transport, endosome to Golgi
O	0042802	molecular_function	identical protein binding
O	0042803	molecular_function	protein homodimerization activity
O	0043197	cellular_component	dendritic spine
O	0045732	biological_process	positive regulation of protein catabolic process
O	0046982	molecular_function	protein heterodimerization activity
O	0048471	cellular_component	perinuclear region of cytoplasm
O	0072673	biological_process	lamellipodium morphogenesis
O	0098793	cellular_component	presynapse
O	0098999	cellular_component	extrinsic component of postsynaptic endosome membrane
O	0099092	cellular_component	postsynaptic density, intracellular component
O	1990459	molecular_function	transferrin receptor binding
O	1990460	molecular_function	leptin receptor binding
P	0005154	molecular_function	epidermal growth factor receptor binding
P	0005158	molecular_function	insulin receptor binding
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0005764	cellular_component	lysosome
P	0005768	cellular_component	endosome
P	0005769	cellular_component	early endosome
P	0005794	cellular_component	Golgi apparatus
P	0005829	cellular_component	cytosol
P	0006886	biological_process	intracellular protein transport
P	0008289	molecular_function	lipid binding
P	0010008	cellular_component	endosome membrane
P	0014069	cellular_component	postsynaptic density
P	0015031	biological_process	protein transport
P	0016020	cellular_component	membrane
P	0030027	cellular_component	lamellipodium
P	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
P	0030904	cellular_component	retromer complex
P	0030905	cellular_component	retromer, tubulation complex
P	0031175	biological_process	neuron projection development
P	0031623	biological_process	receptor internalization
P	0031901	cellular_component	early endosome membrane
P	0031982	cellular_component	vesicle
P	0032991	cellular_component	protein-containing complex
P	0034498	biological_process	early endosome to Golgi transport
P	0035091	molecular_function	phosphatidylinositol binding
P	0042147	biological_process	retrograde transport, endosome to Golgi
P	0042802	molecular_function	identical protein binding
P	0042803	molecular_function	protein homodimerization activity
P	0043197	cellular_component	dendritic spine
P	0045732	biological_process	positive regulation of protein catabolic process
P	0046982	molecular_function	protein heterodimerization activity
P	0048471	cellular_component	perinuclear region of cytoplasm
P	0072673	biological_process	lamellipodium morphogenesis
P	0098793	cellular_component	presynapse
P	0098999	cellular_component	extrinsic component of postsynaptic endosome membrane
P	0099092	cellular_component	postsynaptic density, intracellular component
P	1990459	molecular_function	transferrin receptor binding
P	1990460	molecular_function	leptin receptor binding
Q	0005154	molecular_function	epidermal growth factor receptor binding
Q	0005158	molecular_function	insulin receptor binding
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0005764	cellular_component	lysosome
Q	0005768	cellular_component	endosome
Q	0005769	cellular_component	early endosome
Q	0005794	cellular_component	Golgi apparatus
Q	0005829	cellular_component	cytosol
Q	0006886	biological_process	intracellular protein transport
Q	0008289	molecular_function	lipid binding
Q	0010008	cellular_component	endosome membrane
Q	0014069	cellular_component	postsynaptic density
Q	0015031	biological_process	protein transport
Q	0016020	cellular_component	membrane
Q	0030027	cellular_component	lamellipodium
Q	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
Q	0030904	cellular_component	retromer complex
Q	0030905	cellular_component	retromer, tubulation complex
Q	0031175	biological_process	neuron projection development
Q	0031623	biological_process	receptor internalization
Q	0031901	cellular_component	early endosome membrane
Q	0031982	cellular_component	vesicle
Q	0032991	cellular_component	protein-containing complex
Q	0034498	biological_process	early endosome to Golgi transport
Q	0035091	molecular_function	phosphatidylinositol binding
Q	0042147	biological_process	retrograde transport, endosome to Golgi
Q	0042802	molecular_function	identical protein binding
Q	0042803	molecular_function	protein homodimerization activity
Q	0043197	cellular_component	dendritic spine
Q	0045732	biological_process	positive regulation of protein catabolic process
Q	0046982	molecular_function	protein heterodimerization activity
Q	0048471	cellular_component	perinuclear region of cytoplasm
Q	0072673	biological_process	lamellipodium morphogenesis
Q	0098793	cellular_component	presynapse
Q	0098999	cellular_component	extrinsic component of postsynaptic endosome membrane
Q	0099092	cellular_component	postsynaptic density, intracellular component
Q	1990459	molecular_function	transferrin receptor binding
Q	1990460	molecular_function	leptin receptor binding
R	0005154	molecular_function	epidermal growth factor receptor binding
R	0005158	molecular_function	insulin receptor binding
R	0005515	molecular_function	protein binding
R	0005737	cellular_component	cytoplasm
R	0005764	cellular_component	lysosome
R	0005768	cellular_component	endosome
R	0005769	cellular_component	early endosome
R	0005794	cellular_component	Golgi apparatus
R	0005829	cellular_component	cytosol
R	0006886	biological_process	intracellular protein transport
R	0008289	molecular_function	lipid binding
R	0010008	cellular_component	endosome membrane
R	0014069	cellular_component	postsynaptic density
R	0015031	biological_process	protein transport
R	0016020	cellular_component	membrane
R	0030027	cellular_component	lamellipodium
R	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
R	0030904	cellular_component	retromer complex
R	0030905	cellular_component	retromer, tubulation complex
R	0031175	biological_process	neuron projection development
R	0031623	biological_process	receptor internalization
R	0031901	cellular_component	early endosome membrane
R	0031982	cellular_component	vesicle
R	0032991	cellular_component	protein-containing complex
R	0034498	biological_process	early endosome to Golgi transport
R	0035091	molecular_function	phosphatidylinositol binding
R	0042147	biological_process	retrograde transport, endosome to Golgi
R	0042802	molecular_function	identical protein binding
R	0042803	molecular_function	protein homodimerization activity
R	0043197	cellular_component	dendritic spine
R	0045732	biological_process	positive regulation of protein catabolic process
R	0046982	molecular_function	protein heterodimerization activity
R	0048471	cellular_component	perinuclear region of cytoplasm
R	0072673	biological_process	lamellipodium morphogenesis
R	0098793	cellular_component	presynapse
R	0098999	cellular_component	extrinsic component of postsynaptic endosome membrane
R	0099092	cellular_component	postsynaptic density, intracellular component
R	1990459	molecular_function	transferrin receptor binding
R	1990460	molecular_function	leptin receptor binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2322
Details	Domain: {"description":"PX","evidences":[{"source":"PROSITE-ProRule","id":"PRU00147","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3960
Details	Domain: {"description":"BAR"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	306
Details	Region: {"description":"Membrane-binding amphipathic helix","evidences":[{"source":"UniProtKB","id":"Q13596","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q96L94","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	18
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17242355","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	18
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q13596","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	18
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q13596","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---