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7D6E

Structural insights into membrane remodeling by SNX1

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006886biological_processintracellular protein transport
A0008289molecular_functionlipid binding
A0010008cellular_componentendosome membrane
A0014069cellular_componentpostsynaptic density
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0030027cellular_componentlamellipodium
A0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
A0031175biological_processneuron projection development
A0031623biological_processreceptor internalization
A0031901cellular_componentearly endosome membrane
A0034498biological_processearly endosome to Golgi transport
A0035091molecular_functionphosphatidylinositol binding
A0042147biological_processretrograde transport, endosome to Golgi
A0042995cellular_componentcell projection
A0043197cellular_componentdendritic spine
A0048471cellular_componentperinuclear region of cytoplasm
A0072673biological_processlamellipodium morphogenesis
A0098793cellular_componentpresynapse
A0098999cellular_componentextrinsic component of postsynaptic endosome membrane
A0099092cellular_componentpostsynaptic density, intracellular component
B0005515molecular_functionprotein binding
B0005768cellular_componentendosome
B0005769cellular_componentearly endosome
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0006886biological_processintracellular protein transport
B0008289molecular_functionlipid binding
B0010008cellular_componentendosome membrane
B0014069cellular_componentpostsynaptic density
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0030027cellular_componentlamellipodium
B0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
B0031175biological_processneuron projection development
B0031623biological_processreceptor internalization
B0031901cellular_componentearly endosome membrane
B0034498biological_processearly endosome to Golgi transport
B0035091molecular_functionphosphatidylinositol binding
B0042147biological_processretrograde transport, endosome to Golgi
B0042995cellular_componentcell projection
B0043197cellular_componentdendritic spine
B0048471cellular_componentperinuclear region of cytoplasm
B0072673biological_processlamellipodium morphogenesis
B0098793cellular_componentpresynapse
B0098999cellular_componentextrinsic component of postsynaptic endosome membrane
B0099092cellular_componentpostsynaptic density, intracellular component
C0005515molecular_functionprotein binding
C0005768cellular_componentendosome
C0005769cellular_componentearly endosome
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0006886biological_processintracellular protein transport
C0008289molecular_functionlipid binding
C0010008cellular_componentendosome membrane
C0014069cellular_componentpostsynaptic density
C0015031biological_processprotein transport
C0016020cellular_componentmembrane
C0030027cellular_componentlamellipodium
C0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
C0031175biological_processneuron projection development
C0031623biological_processreceptor internalization
C0031901cellular_componentearly endosome membrane
C0034498biological_processearly endosome to Golgi transport
C0035091molecular_functionphosphatidylinositol binding
C0042147biological_processretrograde transport, endosome to Golgi
C0042995cellular_componentcell projection
C0043197cellular_componentdendritic spine
C0048471cellular_componentperinuclear region of cytoplasm
C0072673biological_processlamellipodium morphogenesis
C0098793cellular_componentpresynapse
C0098999cellular_componentextrinsic component of postsynaptic endosome membrane
C0099092cellular_componentpostsynaptic density, intracellular component
D0005515molecular_functionprotein binding
D0005768cellular_componentendosome
D0005769cellular_componentearly endosome
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0006886biological_processintracellular protein transport
D0008289molecular_functionlipid binding
D0010008cellular_componentendosome membrane
D0014069cellular_componentpostsynaptic density
D0015031biological_processprotein transport
D0016020cellular_componentmembrane
D0030027cellular_componentlamellipodium
D0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
D0031175biological_processneuron projection development
D0031623biological_processreceptor internalization
D0031901cellular_componentearly endosome membrane
D0034498biological_processearly endosome to Golgi transport
D0035091molecular_functionphosphatidylinositol binding
D0042147biological_processretrograde transport, endosome to Golgi
D0042995cellular_componentcell projection
D0043197cellular_componentdendritic spine
D0048471cellular_componentperinuclear region of cytoplasm
D0072673biological_processlamellipodium morphogenesis
D0098793cellular_componentpresynapse
D0098999cellular_componentextrinsic component of postsynaptic endosome membrane
D0099092cellular_componentpostsynaptic density, intracellular component
E0005515molecular_functionprotein binding
E0005768cellular_componentendosome
E0005769cellular_componentearly endosome
E0005794cellular_componentGolgi apparatus
E0005829cellular_componentcytosol
E0006886biological_processintracellular protein transport
E0008289molecular_functionlipid binding
E0010008cellular_componentendosome membrane
E0014069cellular_componentpostsynaptic density
E0015031biological_processprotein transport
E0016020cellular_componentmembrane
E0030027cellular_componentlamellipodium
E0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
E0031175biological_processneuron projection development
E0031623biological_processreceptor internalization
E0031901cellular_componentearly endosome membrane
E0034498biological_processearly endosome to Golgi transport
E0035091molecular_functionphosphatidylinositol binding
E0042147biological_processretrograde transport, endosome to Golgi
E0042995cellular_componentcell projection
E0043197cellular_componentdendritic spine
E0048471cellular_componentperinuclear region of cytoplasm
E0072673biological_processlamellipodium morphogenesis
E0098793cellular_componentpresynapse
E0098999cellular_componentextrinsic component of postsynaptic endosome membrane
E0099092cellular_componentpostsynaptic density, intracellular component
F0005515molecular_functionprotein binding
F0005768cellular_componentendosome
F0005769cellular_componentearly endosome
F0005794cellular_componentGolgi apparatus
F0005829cellular_componentcytosol
F0006886biological_processintracellular protein transport
F0008289molecular_functionlipid binding
F0010008cellular_componentendosome membrane
F0014069cellular_componentpostsynaptic density
F0015031biological_processprotein transport
F0016020cellular_componentmembrane
F0030027cellular_componentlamellipodium
F0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
F0031175biological_processneuron projection development
F0031623biological_processreceptor internalization
F0031901cellular_componentearly endosome membrane
F0034498biological_processearly endosome to Golgi transport
F0035091molecular_functionphosphatidylinositol binding
F0042147biological_processretrograde transport, endosome to Golgi
F0042995cellular_componentcell projection
F0043197cellular_componentdendritic spine
F0048471cellular_componentperinuclear region of cytoplasm
F0072673biological_processlamellipodium morphogenesis
F0098793cellular_componentpresynapse
F0098999cellular_componentextrinsic component of postsynaptic endosome membrane
F0099092cellular_componentpostsynaptic density, intracellular component
G0005515molecular_functionprotein binding
G0005768cellular_componentendosome
G0005769cellular_componentearly endosome
G0005794cellular_componentGolgi apparatus
G0005829cellular_componentcytosol
G0006886biological_processintracellular protein transport
G0008289molecular_functionlipid binding
G0010008cellular_componentendosome membrane
G0014069cellular_componentpostsynaptic density
G0015031biological_processprotein transport
G0016020cellular_componentmembrane
G0030027cellular_componentlamellipodium
G0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
G0031175biological_processneuron projection development
G0031623biological_processreceptor internalization
G0031901cellular_componentearly endosome membrane
G0034498biological_processearly endosome to Golgi transport
G0035091molecular_functionphosphatidylinositol binding
G0042147biological_processretrograde transport, endosome to Golgi
G0042995cellular_componentcell projection
G0043197cellular_componentdendritic spine
G0048471cellular_componentperinuclear region of cytoplasm
G0072673biological_processlamellipodium morphogenesis
G0098793cellular_componentpresynapse
G0098999cellular_componentextrinsic component of postsynaptic endosome membrane
G0099092cellular_componentpostsynaptic density, intracellular component
H0005515molecular_functionprotein binding
H0005768cellular_componentendosome
H0005769cellular_componentearly endosome
H0005794cellular_componentGolgi apparatus
H0005829cellular_componentcytosol
H0006886biological_processintracellular protein transport
H0008289molecular_functionlipid binding
H0010008cellular_componentendosome membrane
H0014069cellular_componentpostsynaptic density
H0015031biological_processprotein transport
H0016020cellular_componentmembrane
H0030027cellular_componentlamellipodium
H0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
H0031175biological_processneuron projection development
H0031623biological_processreceptor internalization
H0031901cellular_componentearly endosome membrane
H0034498biological_processearly endosome to Golgi transport
H0035091molecular_functionphosphatidylinositol binding
H0042147biological_processretrograde transport, endosome to Golgi
H0042995cellular_componentcell projection
H0043197cellular_componentdendritic spine
H0048471cellular_componentperinuclear region of cytoplasm
H0072673biological_processlamellipodium morphogenesis
H0098793cellular_componentpresynapse
H0098999cellular_componentextrinsic component of postsynaptic endosome membrane
H0099092cellular_componentpostsynaptic density, intracellular component
I0005515molecular_functionprotein binding
I0005768cellular_componentendosome
I0005769cellular_componentearly endosome
I0005794cellular_componentGolgi apparatus
I0005829cellular_componentcytosol
I0006886biological_processintracellular protein transport
I0008289molecular_functionlipid binding
I0010008cellular_componentendosome membrane
I0014069cellular_componentpostsynaptic density
I0015031biological_processprotein transport
I0016020cellular_componentmembrane
I0030027cellular_componentlamellipodium
I0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
I0031175biological_processneuron projection development
I0031623biological_processreceptor internalization
I0031901cellular_componentearly endosome membrane
I0034498biological_processearly endosome to Golgi transport
I0035091molecular_functionphosphatidylinositol binding
I0042147biological_processretrograde transport, endosome to Golgi
I0042995cellular_componentcell projection
I0043197cellular_componentdendritic spine
I0048471cellular_componentperinuclear region of cytoplasm
I0072673biological_processlamellipodium morphogenesis
I0098793cellular_componentpresynapse
I0098999cellular_componentextrinsic component of postsynaptic endosome membrane
I0099092cellular_componentpostsynaptic density, intracellular component
J0005515molecular_functionprotein binding
J0005768cellular_componentendosome
J0005769cellular_componentearly endosome
J0005794cellular_componentGolgi apparatus
J0005829cellular_componentcytosol
J0006886biological_processintracellular protein transport
J0008289molecular_functionlipid binding
J0010008cellular_componentendosome membrane
J0014069cellular_componentpostsynaptic density
J0015031biological_processprotein transport
J0016020cellular_componentmembrane
J0030027cellular_componentlamellipodium
J0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
J0031175biological_processneuron projection development
J0031623biological_processreceptor internalization
J0031901cellular_componentearly endosome membrane
J0034498biological_processearly endosome to Golgi transport
J0035091molecular_functionphosphatidylinositol binding
J0042147biological_processretrograde transport, endosome to Golgi
J0042995cellular_componentcell projection
J0043197cellular_componentdendritic spine
J0048471cellular_componentperinuclear region of cytoplasm
J0072673biological_processlamellipodium morphogenesis
J0098793cellular_componentpresynapse
J0098999cellular_componentextrinsic component of postsynaptic endosome membrane
J0099092cellular_componentpostsynaptic density, intracellular component
K0005515molecular_functionprotein binding
K0005768cellular_componentendosome
K0005769cellular_componentearly endosome
K0005794cellular_componentGolgi apparatus
K0005829cellular_componentcytosol
K0006886biological_processintracellular protein transport
K0008289molecular_functionlipid binding
K0010008cellular_componentendosome membrane
K0014069cellular_componentpostsynaptic density
K0015031biological_processprotein transport
K0016020cellular_componentmembrane
K0030027cellular_componentlamellipodium
K0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
K0031175biological_processneuron projection development
K0031623biological_processreceptor internalization
K0031901cellular_componentearly endosome membrane
K0034498biological_processearly endosome to Golgi transport
K0035091molecular_functionphosphatidylinositol binding
K0042147biological_processretrograde transport, endosome to Golgi
K0042995cellular_componentcell projection
K0043197cellular_componentdendritic spine
K0048471cellular_componentperinuclear region of cytoplasm
K0072673biological_processlamellipodium morphogenesis
K0098793cellular_componentpresynapse
K0098999cellular_componentextrinsic component of postsynaptic endosome membrane
K0099092cellular_componentpostsynaptic density, intracellular component
L0005515molecular_functionprotein binding
L0005768cellular_componentendosome
L0005769cellular_componentearly endosome
L0005794cellular_componentGolgi apparatus
L0005829cellular_componentcytosol
L0006886biological_processintracellular protein transport
L0008289molecular_functionlipid binding
L0010008cellular_componentendosome membrane
L0014069cellular_componentpostsynaptic density
L0015031biological_processprotein transport
L0016020cellular_componentmembrane
L0030027cellular_componentlamellipodium
L0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
L0031175biological_processneuron projection development
L0031623biological_processreceptor internalization
L0031901cellular_componentearly endosome membrane
L0034498biological_processearly endosome to Golgi transport
L0035091molecular_functionphosphatidylinositol binding
L0042147biological_processretrograde transport, endosome to Golgi
L0042995cellular_componentcell projection
L0043197cellular_componentdendritic spine
L0048471cellular_componentperinuclear region of cytoplasm
L0072673biological_processlamellipodium morphogenesis
L0098793cellular_componentpresynapse
L0098999cellular_componentextrinsic component of postsynaptic endosome membrane
L0099092cellular_componentpostsynaptic density, intracellular component
M0005515molecular_functionprotein binding
M0005768cellular_componentendosome
M0005769cellular_componentearly endosome
M0005794cellular_componentGolgi apparatus
M0005829cellular_componentcytosol
M0006886biological_processintracellular protein transport
M0008289molecular_functionlipid binding
M0010008cellular_componentendosome membrane
M0014069cellular_componentpostsynaptic density
M0015031biological_processprotein transport
M0016020cellular_componentmembrane
M0030027cellular_componentlamellipodium
M0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
M0031175biological_processneuron projection development
M0031623biological_processreceptor internalization
M0031901cellular_componentearly endosome membrane
M0034498biological_processearly endosome to Golgi transport
M0035091molecular_functionphosphatidylinositol binding
M0042147biological_processretrograde transport, endosome to Golgi
M0042995cellular_componentcell projection
M0043197cellular_componentdendritic spine
M0048471cellular_componentperinuclear region of cytoplasm
M0072673biological_processlamellipodium morphogenesis
M0098793cellular_componentpresynapse
M0098999cellular_componentextrinsic component of postsynaptic endosome membrane
M0099092cellular_componentpostsynaptic density, intracellular component
N0005515molecular_functionprotein binding
N0005768cellular_componentendosome
N0005769cellular_componentearly endosome
N0005794cellular_componentGolgi apparatus
N0005829cellular_componentcytosol
N0006886biological_processintracellular protein transport
N0008289molecular_functionlipid binding
N0010008cellular_componentendosome membrane
N0014069cellular_componentpostsynaptic density
N0015031biological_processprotein transport
N0016020cellular_componentmembrane
N0030027cellular_componentlamellipodium
N0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
N0031175biological_processneuron projection development
N0031623biological_processreceptor internalization
N0031901cellular_componentearly endosome membrane
N0034498biological_processearly endosome to Golgi transport
N0035091molecular_functionphosphatidylinositol binding
N0042147biological_processretrograde transport, endosome to Golgi
N0042995cellular_componentcell projection
N0043197cellular_componentdendritic spine
N0048471cellular_componentperinuclear region of cytoplasm
N0072673biological_processlamellipodium morphogenesis
N0098793cellular_componentpresynapse
N0098999cellular_componentextrinsic component of postsynaptic endosome membrane
N0099092cellular_componentpostsynaptic density, intracellular component
O0005515molecular_functionprotein binding
O0005768cellular_componentendosome
O0005769cellular_componentearly endosome
O0005794cellular_componentGolgi apparatus
O0005829cellular_componentcytosol
O0006886biological_processintracellular protein transport
O0008289molecular_functionlipid binding
O0010008cellular_componentendosome membrane
O0014069cellular_componentpostsynaptic density
O0015031biological_processprotein transport
O0016020cellular_componentmembrane
O0030027cellular_componentlamellipodium
O0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
O0031175biological_processneuron projection development
O0031623biological_processreceptor internalization
O0031901cellular_componentearly endosome membrane
O0034498biological_processearly endosome to Golgi transport
O0035091molecular_functionphosphatidylinositol binding
O0042147biological_processretrograde transport, endosome to Golgi
O0042995cellular_componentcell projection
O0043197cellular_componentdendritic spine
O0048471cellular_componentperinuclear region of cytoplasm
O0072673biological_processlamellipodium morphogenesis
O0098793cellular_componentpresynapse
O0098999cellular_componentextrinsic component of postsynaptic endosome membrane
O0099092cellular_componentpostsynaptic density, intracellular component
P0005515molecular_functionprotein binding
P0005768cellular_componentendosome
P0005769cellular_componentearly endosome
P0005794cellular_componentGolgi apparatus
P0005829cellular_componentcytosol
P0006886biological_processintracellular protein transport
P0008289molecular_functionlipid binding
P0010008cellular_componentendosome membrane
P0014069cellular_componentpostsynaptic density
P0015031biological_processprotein transport
P0016020cellular_componentmembrane
P0030027cellular_componentlamellipodium
P0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
P0031175biological_processneuron projection development
P0031623biological_processreceptor internalization
P0031901cellular_componentearly endosome membrane
P0034498biological_processearly endosome to Golgi transport
P0035091molecular_functionphosphatidylinositol binding
P0042147biological_processretrograde transport, endosome to Golgi
P0042995cellular_componentcell projection
P0043197cellular_componentdendritic spine
P0048471cellular_componentperinuclear region of cytoplasm
P0072673biological_processlamellipodium morphogenesis
P0098793cellular_componentpresynapse
P0098999cellular_componentextrinsic component of postsynaptic endosome membrane
P0099092cellular_componentpostsynaptic density, intracellular component
Q0005515molecular_functionprotein binding
Q0005768cellular_componentendosome
Q0005769cellular_componentearly endosome
Q0005794cellular_componentGolgi apparatus
Q0005829cellular_componentcytosol
Q0006886biological_processintracellular protein transport
Q0008289molecular_functionlipid binding
Q0010008cellular_componentendosome membrane
Q0014069cellular_componentpostsynaptic density
Q0015031biological_processprotein transport
Q0016020cellular_componentmembrane
Q0030027cellular_componentlamellipodium
Q0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
Q0031175biological_processneuron projection development
Q0031623biological_processreceptor internalization
Q0031901cellular_componentearly endosome membrane
Q0034498biological_processearly endosome to Golgi transport
Q0035091molecular_functionphosphatidylinositol binding
Q0042147biological_processretrograde transport, endosome to Golgi
Q0042995cellular_componentcell projection
Q0043197cellular_componentdendritic spine
Q0048471cellular_componentperinuclear region of cytoplasm
Q0072673biological_processlamellipodium morphogenesis
Q0098793cellular_componentpresynapse
Q0098999cellular_componentextrinsic component of postsynaptic endosome membrane
Q0099092cellular_componentpostsynaptic density, intracellular component
R0005515molecular_functionprotein binding
R0005768cellular_componentendosome
R0005769cellular_componentearly endosome
R0005794cellular_componentGolgi apparatus
R0005829cellular_componentcytosol
R0006886biological_processintracellular protein transport
R0008289molecular_functionlipid binding
R0010008cellular_componentendosome membrane
R0014069cellular_componentpostsynaptic density
R0015031biological_processprotein transport
R0016020cellular_componentmembrane
R0030027cellular_componentlamellipodium
R0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
R0031175biological_processneuron projection development
R0031623biological_processreceptor internalization
R0031901cellular_componentearly endosome membrane
R0034498biological_processearly endosome to Golgi transport
R0035091molecular_functionphosphatidylinositol binding
R0042147biological_processretrograde transport, endosome to Golgi
R0042995cellular_componentcell projection
R0043197cellular_componentdendritic spine
R0048471cellular_componentperinuclear region of cytoplasm
R0072673biological_processlamellipodium morphogenesis
R0098793cellular_componentpresynapse
R0098999cellular_componentextrinsic component of postsynaptic endosome membrane
R0099092cellular_componentpostsynaptic density, intracellular component
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2322
DetailsDomain: {"description":"PX","evidences":[{"source":"PROSITE-ProRule","id":"PRU00147","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues3960
DetailsDomain: {"description":"BAR"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues306
DetailsRegion: {"description":"Membrane-binding amphipathic helix","evidences":[{"source":"UniProtKB","id":"Q13596","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues72
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q96L94","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues18
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17242355","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues18
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q13596","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues18
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q13596","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

239803

PDB entries from 2025-08-06

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