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7D6D

Structural insights into membrane remodeling by SNX1

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006886biological_processintracellular protein transport
A0008289molecular_functionlipid binding
A0010008cellular_componentendosome membrane
A0014069cellular_componentpostsynaptic density
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0030027cellular_componentlamellipodium
A0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
A0031175biological_processneuron projection development
A0031623biological_processreceptor internalization
A0031901cellular_componentearly endosome membrane
A0034498biological_processearly endosome to Golgi transport
A0035091molecular_functionphosphatidylinositol binding
A0042147biological_processretrograde transport, endosome to Golgi
A0042995cellular_componentcell projection
A0043197cellular_componentdendritic spine
A0045732biological_processpositive regulation of protein catabolic process
A0048471cellular_componentperinuclear region of cytoplasm
A0072673biological_processlamellipodium morphogenesis
A0098793cellular_componentpresynapse
A0098999cellular_componentextrinsic component of postsynaptic endosome membrane
A0099092cellular_componentpostsynaptic density, intracellular component
B0005515molecular_functionprotein binding
B0005768cellular_componentendosome
B0005769cellular_componentearly endosome
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0006886biological_processintracellular protein transport
B0008289molecular_functionlipid binding
B0010008cellular_componentendosome membrane
B0014069cellular_componentpostsynaptic density
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0030027cellular_componentlamellipodium
B0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
B0031175biological_processneuron projection development
B0031623biological_processreceptor internalization
B0031901cellular_componentearly endosome membrane
B0034498biological_processearly endosome to Golgi transport
B0035091molecular_functionphosphatidylinositol binding
B0042147biological_processretrograde transport, endosome to Golgi
B0042995cellular_componentcell projection
B0043197cellular_componentdendritic spine
B0045732biological_processpositive regulation of protein catabolic process
B0048471cellular_componentperinuclear region of cytoplasm
B0072673biological_processlamellipodium morphogenesis
B0098793cellular_componentpresynapse
B0098999cellular_componentextrinsic component of postsynaptic endosome membrane
B0099092cellular_componentpostsynaptic density, intracellular component
C0005515molecular_functionprotein binding
C0005768cellular_componentendosome
C0005769cellular_componentearly endosome
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0006886biological_processintracellular protein transport
C0008289molecular_functionlipid binding
C0010008cellular_componentendosome membrane
C0014069cellular_componentpostsynaptic density
C0015031biological_processprotein transport
C0016020cellular_componentmembrane
C0030027cellular_componentlamellipodium
C0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
C0031175biological_processneuron projection development
C0031623biological_processreceptor internalization
C0031901cellular_componentearly endosome membrane
C0034498biological_processearly endosome to Golgi transport
C0035091molecular_functionphosphatidylinositol binding
C0042147biological_processretrograde transport, endosome to Golgi
C0042995cellular_componentcell projection
C0043197cellular_componentdendritic spine
C0045732biological_processpositive regulation of protein catabolic process
C0048471cellular_componentperinuclear region of cytoplasm
C0072673biological_processlamellipodium morphogenesis
C0098793cellular_componentpresynapse
C0098999cellular_componentextrinsic component of postsynaptic endosome membrane
C0099092cellular_componentpostsynaptic density, intracellular component
D0005515molecular_functionprotein binding
D0005768cellular_componentendosome
D0005769cellular_componentearly endosome
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0006886biological_processintracellular protein transport
D0008289molecular_functionlipid binding
D0010008cellular_componentendosome membrane
D0014069cellular_componentpostsynaptic density
D0015031biological_processprotein transport
D0016020cellular_componentmembrane
D0030027cellular_componentlamellipodium
D0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
D0031175biological_processneuron projection development
D0031623biological_processreceptor internalization
D0031901cellular_componentearly endosome membrane
D0034498biological_processearly endosome to Golgi transport
D0035091molecular_functionphosphatidylinositol binding
D0042147biological_processretrograde transport, endosome to Golgi
D0042995cellular_componentcell projection
D0043197cellular_componentdendritic spine
D0045732biological_processpositive regulation of protein catabolic process
D0048471cellular_componentperinuclear region of cytoplasm
D0072673biological_processlamellipodium morphogenesis
D0098793cellular_componentpresynapse
D0098999cellular_componentextrinsic component of postsynaptic endosome membrane
D0099092cellular_componentpostsynaptic density, intracellular component
E0005515molecular_functionprotein binding
E0005768cellular_componentendosome
E0005769cellular_componentearly endosome
E0005794cellular_componentGolgi apparatus
E0005829cellular_componentcytosol
E0006886biological_processintracellular protein transport
E0008289molecular_functionlipid binding
E0010008cellular_componentendosome membrane
E0014069cellular_componentpostsynaptic density
E0015031biological_processprotein transport
E0016020cellular_componentmembrane
E0030027cellular_componentlamellipodium
E0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
E0031175biological_processneuron projection development
E0031623biological_processreceptor internalization
E0031901cellular_componentearly endosome membrane
E0034498biological_processearly endosome to Golgi transport
E0035091molecular_functionphosphatidylinositol binding
E0042147biological_processretrograde transport, endosome to Golgi
E0042995cellular_componentcell projection
E0043197cellular_componentdendritic spine
E0045732biological_processpositive regulation of protein catabolic process
E0048471cellular_componentperinuclear region of cytoplasm
E0072673biological_processlamellipodium morphogenesis
E0098793cellular_componentpresynapse
E0098999cellular_componentextrinsic component of postsynaptic endosome membrane
E0099092cellular_componentpostsynaptic density, intracellular component
F0005515molecular_functionprotein binding
F0005768cellular_componentendosome
F0005769cellular_componentearly endosome
F0005794cellular_componentGolgi apparatus
F0005829cellular_componentcytosol
F0006886biological_processintracellular protein transport
F0008289molecular_functionlipid binding
F0010008cellular_componentendosome membrane
F0014069cellular_componentpostsynaptic density
F0015031biological_processprotein transport
F0016020cellular_componentmembrane
F0030027cellular_componentlamellipodium
F0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
F0031175biological_processneuron projection development
F0031623biological_processreceptor internalization
F0031901cellular_componentearly endosome membrane
F0034498biological_processearly endosome to Golgi transport
F0035091molecular_functionphosphatidylinositol binding
F0042147biological_processretrograde transport, endosome to Golgi
F0042995cellular_componentcell projection
F0043197cellular_componentdendritic spine
F0045732biological_processpositive regulation of protein catabolic process
F0048471cellular_componentperinuclear region of cytoplasm
F0072673biological_processlamellipodium morphogenesis
F0098793cellular_componentpresynapse
F0098999cellular_componentextrinsic component of postsynaptic endosome membrane
F0099092cellular_componentpostsynaptic density, intracellular component
G0005515molecular_functionprotein binding
G0005768cellular_componentendosome
G0005769cellular_componentearly endosome
G0005794cellular_componentGolgi apparatus
G0005829cellular_componentcytosol
G0006886biological_processintracellular protein transport
G0008289molecular_functionlipid binding
G0010008cellular_componentendosome membrane
G0014069cellular_componentpostsynaptic density
G0015031biological_processprotein transport
G0016020cellular_componentmembrane
G0030027cellular_componentlamellipodium
G0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
G0031175biological_processneuron projection development
G0031623biological_processreceptor internalization
G0031901cellular_componentearly endosome membrane
G0034498biological_processearly endosome to Golgi transport
G0035091molecular_functionphosphatidylinositol binding
G0042147biological_processretrograde transport, endosome to Golgi
G0042995cellular_componentcell projection
G0043197cellular_componentdendritic spine
G0045732biological_processpositive regulation of protein catabolic process
G0048471cellular_componentperinuclear region of cytoplasm
G0072673biological_processlamellipodium morphogenesis
G0098793cellular_componentpresynapse
G0098999cellular_componentextrinsic component of postsynaptic endosome membrane
G0099092cellular_componentpostsynaptic density, intracellular component
H0005515molecular_functionprotein binding
H0005768cellular_componentendosome
H0005769cellular_componentearly endosome
H0005794cellular_componentGolgi apparatus
H0005829cellular_componentcytosol
H0006886biological_processintracellular protein transport
H0008289molecular_functionlipid binding
H0010008cellular_componentendosome membrane
H0014069cellular_componentpostsynaptic density
H0015031biological_processprotein transport
H0016020cellular_componentmembrane
H0030027cellular_componentlamellipodium
H0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
H0031175biological_processneuron projection development
H0031623biological_processreceptor internalization
H0031901cellular_componentearly endosome membrane
H0034498biological_processearly endosome to Golgi transport
H0035091molecular_functionphosphatidylinositol binding
H0042147biological_processretrograde transport, endosome to Golgi
H0042995cellular_componentcell projection
H0043197cellular_componentdendritic spine
H0045732biological_processpositive regulation of protein catabolic process
H0048471cellular_componentperinuclear region of cytoplasm
H0072673biological_processlamellipodium morphogenesis
H0098793cellular_componentpresynapse
H0098999cellular_componentextrinsic component of postsynaptic endosome membrane
H0099092cellular_componentpostsynaptic density, intracellular component
I0005515molecular_functionprotein binding
I0005768cellular_componentendosome
I0005769cellular_componentearly endosome
I0005794cellular_componentGolgi apparatus
I0005829cellular_componentcytosol
I0006886biological_processintracellular protein transport
I0008289molecular_functionlipid binding
I0010008cellular_componentendosome membrane
I0014069cellular_componentpostsynaptic density
I0015031biological_processprotein transport
I0016020cellular_componentmembrane
I0030027cellular_componentlamellipodium
I0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
I0031175biological_processneuron projection development
I0031623biological_processreceptor internalization
I0031901cellular_componentearly endosome membrane
I0034498biological_processearly endosome to Golgi transport
I0035091molecular_functionphosphatidylinositol binding
I0042147biological_processretrograde transport, endosome to Golgi
I0042995cellular_componentcell projection
I0043197cellular_componentdendritic spine
I0045732biological_processpositive regulation of protein catabolic process
I0048471cellular_componentperinuclear region of cytoplasm
I0072673biological_processlamellipodium morphogenesis
I0098793cellular_componentpresynapse
I0098999cellular_componentextrinsic component of postsynaptic endosome membrane
I0099092cellular_componentpostsynaptic density, intracellular component
J0005515molecular_functionprotein binding
J0005768cellular_componentendosome
J0005769cellular_componentearly endosome
J0005794cellular_componentGolgi apparatus
J0005829cellular_componentcytosol
J0006886biological_processintracellular protein transport
J0008289molecular_functionlipid binding
J0010008cellular_componentendosome membrane
J0014069cellular_componentpostsynaptic density
J0015031biological_processprotein transport
J0016020cellular_componentmembrane
J0030027cellular_componentlamellipodium
J0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
J0031175biological_processneuron projection development
J0031623biological_processreceptor internalization
J0031901cellular_componentearly endosome membrane
J0034498biological_processearly endosome to Golgi transport
J0035091molecular_functionphosphatidylinositol binding
J0042147biological_processretrograde transport, endosome to Golgi
J0042995cellular_componentcell projection
J0043197cellular_componentdendritic spine
J0045732biological_processpositive regulation of protein catabolic process
J0048471cellular_componentperinuclear region of cytoplasm
J0072673biological_processlamellipodium morphogenesis
J0098793cellular_componentpresynapse
J0098999cellular_componentextrinsic component of postsynaptic endosome membrane
J0099092cellular_componentpostsynaptic density, intracellular component
K0005515molecular_functionprotein binding
K0005768cellular_componentendosome
K0005769cellular_componentearly endosome
K0005794cellular_componentGolgi apparatus
K0005829cellular_componentcytosol
K0006886biological_processintracellular protein transport
K0008289molecular_functionlipid binding
K0010008cellular_componentendosome membrane
K0014069cellular_componentpostsynaptic density
K0015031biological_processprotein transport
K0016020cellular_componentmembrane
K0030027cellular_componentlamellipodium
K0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
K0031175biological_processneuron projection development
K0031623biological_processreceptor internalization
K0031901cellular_componentearly endosome membrane
K0034498biological_processearly endosome to Golgi transport
K0035091molecular_functionphosphatidylinositol binding
K0042147biological_processretrograde transport, endosome to Golgi
K0042995cellular_componentcell projection
K0043197cellular_componentdendritic spine
K0045732biological_processpositive regulation of protein catabolic process
K0048471cellular_componentperinuclear region of cytoplasm
K0072673biological_processlamellipodium morphogenesis
K0098793cellular_componentpresynapse
K0098999cellular_componentextrinsic component of postsynaptic endosome membrane
K0099092cellular_componentpostsynaptic density, intracellular component
L0005515molecular_functionprotein binding
L0005768cellular_componentendosome
L0005769cellular_componentearly endosome
L0005794cellular_componentGolgi apparatus
L0005829cellular_componentcytosol
L0006886biological_processintracellular protein transport
L0008289molecular_functionlipid binding
L0010008cellular_componentendosome membrane
L0014069cellular_componentpostsynaptic density
L0015031biological_processprotein transport
L0016020cellular_componentmembrane
L0030027cellular_componentlamellipodium
L0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
L0031175biological_processneuron projection development
L0031623biological_processreceptor internalization
L0031901cellular_componentearly endosome membrane
L0034498biological_processearly endosome to Golgi transport
L0035091molecular_functionphosphatidylinositol binding
L0042147biological_processretrograde transport, endosome to Golgi
L0042995cellular_componentcell projection
L0043197cellular_componentdendritic spine
L0045732biological_processpositive regulation of protein catabolic process
L0048471cellular_componentperinuclear region of cytoplasm
L0072673biological_processlamellipodium morphogenesis
L0098793cellular_componentpresynapse
L0098999cellular_componentextrinsic component of postsynaptic endosome membrane
L0099092cellular_componentpostsynaptic density, intracellular component
M0005515molecular_functionprotein binding
M0005768cellular_componentendosome
M0005769cellular_componentearly endosome
M0005794cellular_componentGolgi apparatus
M0005829cellular_componentcytosol
M0006886biological_processintracellular protein transport
M0008289molecular_functionlipid binding
M0010008cellular_componentendosome membrane
M0014069cellular_componentpostsynaptic density
M0015031biological_processprotein transport
M0016020cellular_componentmembrane
M0030027cellular_componentlamellipodium
M0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
M0031175biological_processneuron projection development
M0031623biological_processreceptor internalization
M0031901cellular_componentearly endosome membrane
M0034498biological_processearly endosome to Golgi transport
M0035091molecular_functionphosphatidylinositol binding
M0042147biological_processretrograde transport, endosome to Golgi
M0042995cellular_componentcell projection
M0043197cellular_componentdendritic spine
M0045732biological_processpositive regulation of protein catabolic process
M0048471cellular_componentperinuclear region of cytoplasm
M0072673biological_processlamellipodium morphogenesis
M0098793cellular_componentpresynapse
M0098999cellular_componentextrinsic component of postsynaptic endosome membrane
M0099092cellular_componentpostsynaptic density, intracellular component
N0005515molecular_functionprotein binding
N0005768cellular_componentendosome
N0005769cellular_componentearly endosome
N0005794cellular_componentGolgi apparatus
N0005829cellular_componentcytosol
N0006886biological_processintracellular protein transport
N0008289molecular_functionlipid binding
N0010008cellular_componentendosome membrane
N0014069cellular_componentpostsynaptic density
N0015031biological_processprotein transport
N0016020cellular_componentmembrane
N0030027cellular_componentlamellipodium
N0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
N0031175biological_processneuron projection development
N0031623biological_processreceptor internalization
N0031901cellular_componentearly endosome membrane
N0034498biological_processearly endosome to Golgi transport
N0035091molecular_functionphosphatidylinositol binding
N0042147biological_processretrograde transport, endosome to Golgi
N0042995cellular_componentcell projection
N0043197cellular_componentdendritic spine
N0045732biological_processpositive regulation of protein catabolic process
N0048471cellular_componentperinuclear region of cytoplasm
N0072673biological_processlamellipodium morphogenesis
N0098793cellular_componentpresynapse
N0098999cellular_componentextrinsic component of postsynaptic endosome membrane
N0099092cellular_componentpostsynaptic density, intracellular component
O0005515molecular_functionprotein binding
O0005768cellular_componentendosome
O0005769cellular_componentearly endosome
O0005794cellular_componentGolgi apparatus
O0005829cellular_componentcytosol
O0006886biological_processintracellular protein transport
O0008289molecular_functionlipid binding
O0010008cellular_componentendosome membrane
O0014069cellular_componentpostsynaptic density
O0015031biological_processprotein transport
O0016020cellular_componentmembrane
O0030027cellular_componentlamellipodium
O0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
O0031175biological_processneuron projection development
O0031623biological_processreceptor internalization
O0031901cellular_componentearly endosome membrane
O0034498biological_processearly endosome to Golgi transport
O0035091molecular_functionphosphatidylinositol binding
O0042147biological_processretrograde transport, endosome to Golgi
O0042995cellular_componentcell projection
O0043197cellular_componentdendritic spine
O0045732biological_processpositive regulation of protein catabolic process
O0048471cellular_componentperinuclear region of cytoplasm
O0072673biological_processlamellipodium morphogenesis
O0098793cellular_componentpresynapse
O0098999cellular_componentextrinsic component of postsynaptic endosome membrane
O0099092cellular_componentpostsynaptic density, intracellular component
P0005515molecular_functionprotein binding
P0005768cellular_componentendosome
P0005769cellular_componentearly endosome
P0005794cellular_componentGolgi apparatus
P0005829cellular_componentcytosol
P0006886biological_processintracellular protein transport
P0008289molecular_functionlipid binding
P0010008cellular_componentendosome membrane
P0014069cellular_componentpostsynaptic density
P0015031biological_processprotein transport
P0016020cellular_componentmembrane
P0030027cellular_componentlamellipodium
P0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
P0031175biological_processneuron projection development
P0031623biological_processreceptor internalization
P0031901cellular_componentearly endosome membrane
P0034498biological_processearly endosome to Golgi transport
P0035091molecular_functionphosphatidylinositol binding
P0042147biological_processretrograde transport, endosome to Golgi
P0042995cellular_componentcell projection
P0043197cellular_componentdendritic spine
P0045732biological_processpositive regulation of protein catabolic process
P0048471cellular_componentperinuclear region of cytoplasm
P0072673biological_processlamellipodium morphogenesis
P0098793cellular_componentpresynapse
P0098999cellular_componentextrinsic component of postsynaptic endosome membrane
P0099092cellular_componentpostsynaptic density, intracellular component
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues64
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q96L94
ChainResidueDetails
APHE186
CASP188
CSER214
CARG238
DPHE186
DASP188
DSER214
DARG238
EPHE186
EASP188
ESER214
AASP188
EARG238
FPHE186
FASP188
FSER214
FARG238
GPHE186
GASP188
GSER214
GARG238
HPHE186
ASER214
HASP188
HSER214
HARG238
IPHE186
IASP188
ISER214
IARG238
JPHE186
JASP188
JSER214
AARG238
JARG238
KPHE186
KASP188
KSER214
KARG238
LPHE186
LASP188
LSER214
LARG238
MPHE186
BPHE186
MASP188
MSER214
MARG238
NPHE186
NASP188
NSER214
NARG238
OPHE186
OASP188
OSER214
BASP188
OARG238
PPHE186
PASP188
PSER214
PARG238
BSER214
BARG238
CPHE186

site_idSWS_FT_FI2
Number of Residues48
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079
ChainResidueDetails
ASER32
DSER32
DSER39
DSER58
ESER32
ESER39
ESER58
FSER32
FSER39
FSER58
GSER32
ASER39
GSER39
GSER58
HSER32
HSER39
HSER58
ISER32
ISER39
ISER58
JSER32
JSER39
ASER58
JSER58
KSER32
KSER39
KSER58
LSER32
LSER39
LSER58
MSER32
MSER39
MSER58
BSER32
NSER32
NSER39
NSER58
OSER32
OSER39
OSER58
PSER32
PSER39
PSER58
BSER39
BSER58
CSER32
CSER39
CSER58

site_idSWS_FT_FI3
Number of Residues16
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:21183079
ChainResidueDetails
ATHR41
JTHR41
KTHR41
LTHR41
MTHR41
NTHR41
OTHR41
PTHR41
BTHR41
CTHR41
DTHR41
ETHR41
FTHR41
GTHR41
HTHR41
ITHR41

site_idSWS_FT_FI4
Number of Residues16
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q13596
ChainResidueDetails
ATHR48
JTHR48
KTHR48
LTHR48
MTHR48
NTHR48
OTHR48
PTHR48
BTHR48
CTHR48
DTHR48
ETHR48
FTHR48
GTHR48
HTHR48
ITHR48

site_idSWS_FT_FI5
Number of Residues32
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q13596
ChainResidueDetails
ASER72
EGLY280
FSER72
FGLY280
GSER72
GGLY280
HSER72
HGLY280
ISER72
IGLY280
JSER72
AGLY280
JGLY280
KSER72
KGLY280
LSER72
LGLY280
MSER72
MGLY280
NSER72
NGLY280
OSER72
BSER72
OGLY280
PSER72
PGLY280
BGLY280
CSER72
CGLY280
DSER72
DGLY280
ESER72

site_idSWS_FT_FI6
Number of Residues16
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:21183079
ChainResidueDetails
AASP188
JASP188
KASP188
LASP188
MASP188
NASP188
OASP188
PASP188
BASP188
CASP188
DASP188
EASP188
FASP188
GASP188
HASP188
IASP188

site_idSWS_FT_FI7
Number of Residues16
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q13596
ChainResidueDetails
AARG237
JARG237
KARG237
LARG237
MARG237
NARG237
OARG237
PARG237
BARG237
CARG237
DARG237
EARG237
FARG237
GARG237
HARG237
IARG237

222926

PDB entries from 2024-07-24

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