7D61

Cryo-EM Structure of human CALHM5 in the presence of EDTA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005261	molecular_function	monoatomic cation channel activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0098655	biological_process	monoatomic cation transmembrane transport
A	1904669	biological_process	ATP export
B	0005261	molecular_function	monoatomic cation channel activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0098655	biological_process	monoatomic cation transmembrane transport
B	1904669	biological_process	ATP export
C	0005261	molecular_function	monoatomic cation channel activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0098655	biological_process	monoatomic cation transmembrane transport
C	1904669	biological_process	ATP export
D	0005261	molecular_function	monoatomic cation channel activity
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0098655	biological_process	monoatomic cation transmembrane transport
D	1904669	biological_process	ATP export
E	0005261	molecular_function	monoatomic cation channel activity
E	0005515	molecular_function	protein binding
E	0005886	cellular_component	plasma membrane
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0098655	biological_process	monoatomic cation transmembrane transport
E	1904669	biological_process	ATP export
F	0005261	molecular_function	monoatomic cation channel activity
F	0005515	molecular_function	protein binding
F	0005886	cellular_component	plasma membrane
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0098655	biological_process	monoatomic cation transmembrane transport
F	1904669	biological_process	ATP export
G	0005261	molecular_function	monoatomic cation channel activity
G	0005515	molecular_function	protein binding
G	0005886	cellular_component	plasma membrane
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0098655	biological_process	monoatomic cation transmembrane transport
G	1904669	biological_process	ATP export
H	0005261	molecular_function	monoatomic cation channel activity
H	0005515	molecular_function	protein binding
H	0005886	cellular_component	plasma membrane
H	0016020	cellular_component	membrane
H	0034220	biological_process	monoatomic ion transmembrane transport
H	0098655	biological_process	monoatomic cation transmembrane transport
H	1904669	biological_process	ATP export
I	0005261	molecular_function	monoatomic cation channel activity
I	0005515	molecular_function	protein binding
I	0005886	cellular_component	plasma membrane
I	0016020	cellular_component	membrane
I	0034220	biological_process	monoatomic ion transmembrane transport
I	0098655	biological_process	monoatomic cation transmembrane transport
I	1904669	biological_process	ATP export
J	0005261	molecular_function	monoatomic cation channel activity
J	0005515	molecular_function	protein binding
J	0005886	cellular_component	plasma membrane
J	0016020	cellular_component	membrane
J	0034220	biological_process	monoatomic ion transmembrane transport
J	0098655	biological_process	monoatomic cation transmembrane transport
J	1904669	biological_process	ATP export
K	0005261	molecular_function	monoatomic cation channel activity
K	0005515	molecular_function	protein binding
K	0005886	cellular_component	plasma membrane
K	0016020	cellular_component	membrane
K	0034220	biological_process	monoatomic ion transmembrane transport
K	0098655	biological_process	monoatomic cation transmembrane transport
K	1904669	biological_process	ATP export

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	462
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	MET1-LYS15
E	ASN71-VAL99
F	MET1-LYS15
F	ASN71-VAL99
G	MET1-LYS15
G	ASN71-VAL99
H	MET1-LYS15
H	ASN71-VAL99
I	MET1-LYS15
I	ASN71-VAL99
J	MET1-LYS15
A	ASN71-VAL99
J	ASN71-VAL99
K	MET1-LYS15
K	ASN71-VAL99
B	MET1-LYS15
B	ASN71-VAL99
C	MET1-LYS15
C	ASN71-VAL99
D	MET1-LYS15
D	ASN71-VAL99
E	MET1-LYS15

---

site_id	SWS_FT_FI2
Number of Residues	231
Details	TRANSMEM: Helical; Name=S1 => ECO:0000269|PubMed:33298887, ECO:0007744|PDB:7D60

Chain	Residue	Details
A	THR16-VAL37
J	THR16-VAL37
K	THR16-VAL37
B	THR16-VAL37
C	THR16-VAL37
D	THR16-VAL37
E	THR16-VAL37
F	THR16-VAL37
G	THR16-VAL37
H	THR16-VAL37
I	THR16-VAL37

---

site_id	SWS_FT_FI3
Number of Residues	561
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
A	ALA38-THR45
E	SER130-SER174
F	ALA38-THR45
F	SER130-SER174
G	ALA38-THR45
G	SER130-SER174
H	ALA38-THR45
H	SER130-SER174
I	ALA38-THR45
I	SER130-SER174
J	ALA38-THR45
A	SER130-SER174
J	SER130-SER174
K	ALA38-THR45
K	SER130-SER174
B	ALA38-THR45
B	SER130-SER174
C	ALA38-THR45
C	SER130-SER174
D	ALA38-THR45
D	SER130-SER174
E	ALA38-THR45

---

site_id	SWS_FT_FI4
Number of Residues	264
Details	TRANSMEM: Helical; Name=S2 => ECO:0000269|PubMed:33298887, ECO:0007744|PDB:7D60

Chain	Residue	Details
A	GLU46-ASN70
J	GLU46-ASN70
K	GLU46-ASN70
B	GLU46-ASN70
C	GLU46-ASN70
D	GLU46-ASN70
E	GLU46-ASN70
F	GLU46-ASN70
G	GLU46-ASN70
H	GLU46-ASN70
I	GLU46-ASN70

---

site_id	SWS_FT_FI5
Number of Residues	319
Details	TRANSMEM: Helical; Name=S3 => ECO:0000269|PubMed:33298887, ECO:0007744|PDB:7D60

Chain	Residue	Details
A	LEU100-MET129
J	LEU100-MET129
K	LEU100-MET129
B	LEU100-MET129
C	LEU100-MET129
D	LEU100-MET129
E	LEU100-MET129
F	LEU100-MET129
G	LEU100-MET129
H	LEU100-MET129
I	LEU100-MET129

---

site_id	SWS_FT_FI6
Number of Residues	275
Details	TRANSMEM: Helical; Name=S4 => ECO:0000269|PubMed:33298887, ECO:0007744|PDB:7D60

Chain	Residue	Details
A	LEU175-TYR200
J	LEU175-TYR200
K	LEU175-TYR200
B	LEU175-TYR200
C	LEU175-TYR200
D	LEU175-TYR200
E	LEU175-TYR200
F	LEU175-TYR200
G	LEU175-TYR200
H	LEU175-TYR200
I	LEU175-TYR200

---

site_id	SWS_FT_FI7
Number of Residues	33
Details	BINDING: BINDING => ECO:0000269|PubMed:33298887, ECO:0007744|PDB:7D60

Chain	Residue	Details
A	LYS15
D	LYS15
D	GLN102
D	ARG202
E	LYS15
E	GLN102
E	ARG202
F	LYS15
F	GLN102
F	ARG202
G	LYS15
A	GLN102
G	GLN102
G	ARG202
H	LYS15
H	GLN102
H	ARG202
I	LYS15
I	GLN102
I	ARG202
J	LYS15
J	GLN102
A	ARG202
J	ARG202
K	LYS15
K	GLN102
K	ARG202
B	LYS15
B	GLN102
B	ARG202
C	LYS15
C	GLN102
C	ARG202

---

site_id	SWS_FT_FI8
Number of Residues	22
Details	BINDING: BINDING => ECO:0000269|PubMed:33298887

Chain	Residue	Details
A	ARG32
E	VAL37
F	ARG32
F	VAL37
G	ARG32
G	VAL37
H	ARG32
H	VAL37
I	ARG32
I	VAL37
J	ARG32
A	VAL37
J	VAL37
K	ARG32
K	VAL37
B	ARG32
B	VAL37
C	ARG32
C	VAL37
D	ARG32
D	VAL37
E	ARG32

---

site_id	SWS_FT_FI9
Number of Residues	11
Details	BINDING: BINDING => ECO:0000269|PubMed:33298887, ECO:0007744|PDB:7D61

Chain	Residue	Details
A	ASN121
J	ASN121
K	ASN121
B	ASN121
C	ASN121
D	ASN121
E	ASN121
F	ASN121
G	ASN121
H	ASN121
I	ASN121

---