7D1X
Crystal structure of 7-alpha-hydroxyl bile acid sulfotransferase (Sult2a8)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008146 | molecular_function | sulfotransferase activity |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030573 | biological_process | bile acid catabolic process |
| A | 0050656 | molecular_function | 3'-phosphoadenosine 5'-phosphosulfate binding |
| A | 0051923 | biological_process | sulfation |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008146 | molecular_function | sulfotransferase activity |
| B | 0008202 | biological_process | steroid metabolic process |
| B | 0016042 | biological_process | lipid catabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030573 | biological_process | bile acid catabolic process |
| B | 0050656 | molecular_function | 3'-phosphoadenosine 5'-phosphosulfate binding |
| B | 0051923 | biological_process | sulfation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue CHD A 501 |
| Chain | Residue |
| A | TYR17 |
| A | LYS238 |
| A | TYR18 |
| A | HIS48 |
| A | ALA71 |
| A | TRP77 |
| A | PHE80 |
| A | LYS138 |
| A | TYR159 |
| A | GLU237 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | binding site for residue A3P A 502 |
| Chain | Residue |
| A | LYS44 |
| A | SER45 |
| A | GLY46 |
| A | THR47 |
| A | HIS48 |
| A | TRP49 |
| A | ARG121 |
| A | SER129 |
| A | TYR184 |
| A | ILE218 |
| A | PHE220 |
| A | MET223 |
| A | MET243 |
| A | ARG244 |
| A | LYS245 |
| A | GLY246 |
| A | HOH610 |
| A | HOH621 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue CHD B 501 |
| Chain | Residue |
| B | TYR18 |
| B | HIS48 |
| B | TRP77 |
| B | PHE80 |
| B | PHE134 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for residue A3P B 502 |
| Chain | Residue |
| B | LYS44 |
| B | SER45 |
| B | GLY46 |
| B | THR47 |
| B | HIS48 |
| B | TRP49 |
| B | ARG121 |
| B | SER129 |
| B | TYR184 |
| B | ILE218 |
| B | PHE220 |
| B | MET223 |
| B | ILE242 |
| B | MET243 |
| B | ARG244 |
| B | LYS245 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:29685090, ECO:0000269|PubMed:33872606 |
| Chain | Residue | Details |
| A | HIS48 | |
| B | HIS48 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33872606 |
| Chain | Residue | Details |
| A | ARG121 | |
| A | SER129 | |
| A | TYR184 | |
| A | ILE218 | |
| A | ARG244 | |
| B | LYS44 | |
| B | ARG121 | |
| B | SER129 | |
| B | TYR184 | |
| B | ILE218 | |
| B | ARG244 | |
| A | LYS44 |
