7D1X

Crystal structure of 7-alpha-hydroxyl bile acid sulfotransferase (Sult2a8)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004027	molecular_function	alcohol sulfotransferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006068	biological_process	ethanol catabolic process
A	0006629	biological_process	lipid metabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0008146	molecular_function	sulfotransferase activity
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0016042	biological_process	lipid catabolic process
A	0016740	molecular_function	transferase activity
A	0030573	biological_process	bile acid catabolic process
A	0033876	molecular_function	glycochenodeoxycholate sulfotransferase activity
A	0042403	biological_process	thyroid hormone metabolic process
A	0047704	molecular_function	bile-salt sulfotransferase activity
A	0050294	molecular_function	steroid sulfotransferase activity
A	0050427	biological_process	3'-phosphoadenosine 5'-phosphosulfate metabolic process
A	0050656	molecular_function	3'-phosphoadenosine 5'-phosphosulfate binding
A	0051923	biological_process	sulfation
B	0004027	molecular_function	alcohol sulfotransferase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006068	biological_process	ethanol catabolic process
B	0006629	biological_process	lipid metabolic process
B	0006805	biological_process	xenobiotic metabolic process
B	0008146	molecular_function	sulfotransferase activity
B	0008202	biological_process	steroid metabolic process
B	0008203	biological_process	cholesterol metabolic process
B	0016042	biological_process	lipid catabolic process
B	0016740	molecular_function	transferase activity
B	0030573	biological_process	bile acid catabolic process
B	0033876	molecular_function	glycochenodeoxycholate sulfotransferase activity
B	0042403	biological_process	thyroid hormone metabolic process
B	0047704	molecular_function	bile-salt sulfotransferase activity
B	0050294	molecular_function	steroid sulfotransferase activity
B	0050427	biological_process	3'-phosphoadenosine 5'-phosphosulfate metabolic process
B	0050656	molecular_function	3'-phosphoadenosine 5'-phosphosulfate binding
B	0051923	biological_process	sulfation

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue CHD A 501

Chain	Residue
A	TYR17
A	LYS238
A	TYR18
A	HIS48
A	ALA71
A	TRP77
A	PHE80
A	LYS138
A	TYR159
A	GLU237

---

site_id	AC2
Number of Residues	18
Details	binding site for residue A3P A 502

Chain	Residue
A	LYS44
A	SER45
A	GLY46
A	THR47
A	HIS48
A	TRP49
A	ARG121
A	SER129
A	TYR184
A	ILE218
A	PHE220
A	MET223
A	MET243
A	ARG244
A	LYS245
A	GLY246
A	HOH610
A	HOH621

---

site_id	AC3
Number of Residues	5
Details	binding site for residue CHD B 501

Chain	Residue
B	TYR18
B	HIS48
B	TRP77
B	PHE80
B	PHE134

---

site_id	AC4
Number of Residues	16
Details	binding site for residue A3P B 502

Chain	Residue
B	LYS44
B	SER45
B	GLY46
B	THR47
B	HIS48
B	TRP49
B	ARG121
B	SER129
B	TYR184
B	ILE218
B	PHE220
B	MET223
B	ILE242
B	MET243
B	ARG244
B	LYS245

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"29685090","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33872606","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33872606","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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