Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7D14

Mouse KCC2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0006821	biological_process	chloride transport
A	0006884	biological_process	cell volume homeostasis
A	0006971	biological_process	hypotonic response
A	0007268	biological_process	chemical synaptic transmission
A	0007612	biological_process	learning
A	0008519	molecular_function	ammonium channel activity
A	0009410	biological_process	response to xenobiotic stimulus
A	0015108	molecular_function	chloride transmembrane transporter activity
A	0015293	molecular_function	symporter activity
A	0015377	molecular_function	chloride:monoatomic cation symporter activity
A	0015379	molecular_function	potassium:chloride symporter activity
A	0016020	cellular_component	membrane
A	0019901	molecular_function	protein kinase binding
A	0022857	molecular_function	transmembrane transporter activity
A	0030425	cellular_component	dendrite
A	0030644	biological_process	intracellular chloride ion homeostasis
A	0032502	biological_process	developmental process
A	0032590	cellular_component	dendrite membrane
A	0035264	biological_process	multicellular organism growth
A	0040040	biological_process	thermosensory behavior
A	0043005	cellular_component	neuron projection
A	0043025	cellular_component	neuronal cell body
A	0043204	cellular_component	perikaryon
A	0046872	molecular_function	metal ion binding
A	0051452	biological_process	intracellular pH reduction
A	0055064	biological_process	chloride ion homeostasis
A	0055075	biological_process	potassium ion homeostasis
A	0055085	biological_process	transmembrane transport
A	0060996	biological_process	dendritic spine development
A	0071805	biological_process	potassium ion transmembrane transport
A	0071944	cellular_component	cell periphery
A	0072488	biological_process	ammonium transmembrane transport
A	0098970	biological_process	postsynaptic neurotransmitter receptor diffusion trapping
A	0098978	cellular_component	glutamatergic synapse
A	0099634	cellular_component	postsynaptic specialization membrane
A	0150052	biological_process	regulation of postsynapse assembly
A	1902476	biological_process	chloride transmembrane transport
A	1990573	biological_process	potassium ion import across plasma membrane
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0006821	biological_process	chloride transport
B	0006884	biological_process	cell volume homeostasis
B	0006971	biological_process	hypotonic response
B	0007268	biological_process	chemical synaptic transmission
B	0007612	biological_process	learning
B	0008519	molecular_function	ammonium channel activity
B	0009410	biological_process	response to xenobiotic stimulus
B	0015108	molecular_function	chloride transmembrane transporter activity
B	0015293	molecular_function	symporter activity
B	0015377	molecular_function	chloride:monoatomic cation symporter activity
B	0015379	molecular_function	potassium:chloride symporter activity
B	0016020	cellular_component	membrane
B	0019901	molecular_function	protein kinase binding
B	0022857	molecular_function	transmembrane transporter activity
B	0030425	cellular_component	dendrite
B	0030644	biological_process	intracellular chloride ion homeostasis
B	0032502	biological_process	developmental process
B	0032590	cellular_component	dendrite membrane
B	0035264	biological_process	multicellular organism growth
B	0040040	biological_process	thermosensory behavior
B	0043005	cellular_component	neuron projection
B	0043025	cellular_component	neuronal cell body
B	0043204	cellular_component	perikaryon
B	0046872	molecular_function	metal ion binding
B	0051452	biological_process	intracellular pH reduction
B	0055064	biological_process	chloride ion homeostasis
B	0055075	biological_process	potassium ion homeostasis
B	0055085	biological_process	transmembrane transport
B	0060996	biological_process	dendritic spine development
B	0071805	biological_process	potassium ion transmembrane transport
B	0071944	cellular_component	cell periphery
B	0072488	biological_process	ammonium transmembrane transport
B	0098970	biological_process	postsynaptic neurotransmitter receptor diffusion trapping
B	0098978	cellular_component	glutamatergic synapse
B	0099634	cellular_component	postsynaptic specialization membrane
B	0150052	biological_process	regulation of postsynapse assembly
B	1902476	biological_process	chloride transmembrane transport
B	1990573	biological_process	potassium ion import across plasma membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	128
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"UniProtKB","id":"Q9H2X9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	126
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	56
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"UniProtKB","id":"Q9H2X9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"UniProtKB","id":"Q9H2X9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	34
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"UniProtKB","id":"Q9H2X9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	46
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"UniProtKB","id":"Q9H2X9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"UniProtKB","id":"Q9H2X9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"UniProtKB","id":"Q9H2X9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"UniProtKB","id":"Q9H2X9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	32
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"UniProtKB","id":"Q9H2X9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	28
Details	Region: {"description":"Scissor helix","evidences":[{"source":"UniProtKB","id":"Q9H2X9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9H2X9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by OXSR1 and STK39","evidences":[{"source":"PubMed","id":"19665974","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)