7D10

Human NKCC1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0006814	biological_process	sodium ion transport
A	0006821	biological_process	chloride transport
A	0006883	biological_process	intracellular sodium ion homeostasis
A	0006884	biological_process	cell volume homeostasis
A	0006972	biological_process	hyperosmotic response
A	0007214	biological_process	gamma-aminobutyric acid signaling pathway
A	0008511	molecular_function	sodium:potassium:chloride symporter activity
A	0008519	molecular_function	ammonium channel activity
A	0009925	cellular_component	basal plasma membrane
A	0010818	biological_process	T cell chemotaxis
A	0015079	molecular_function	potassium ion transmembrane transporter activity
A	0015293	molecular_function	symporter activity
A	0015377	molecular_function	chloride:monoatomic cation symporter activity
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0016328	cellular_component	lateral plasma membrane
A	0019901	molecular_function	protein kinase binding
A	0022857	molecular_function	transmembrane transporter activity
A	0030007	biological_process	intracellular potassium ion homeostasis
A	0030321	biological_process	transepithelial chloride transport
A	0030644	biological_process	intracellular chloride ion homeostasis
A	0030659	cellular_component	cytoplasmic vesicle membrane
A	0031253	cellular_component	cell projection membrane
A	0035633	biological_process	maintenance of blood-brain barrier
A	0035725	biological_process	sodium ion transmembrane transport
A	0035865	biological_process	cellular response to potassium ion
A	0042995	cellular_component	cell projection
A	0043005	cellular_component	neuron projection
A	0043025	cellular_component	neuronal cell body
A	0044297	cellular_component	cell body
A	0044298	cellular_component	cell body membrane
A	0045795	biological_process	positive regulation of cell volume
A	0046873	molecular_function	metal ion transmembrane transporter activity
A	0051087	molecular_function	protein-folding chaperone binding
A	0051879	molecular_function	Hsp90 protein binding
A	0055064	biological_process	chloride ion homeostasis
A	0055075	biological_process	potassium ion homeostasis
A	0055078	biological_process	sodium ion homeostasis
A	0055085	biological_process	transmembrane transport
A	0061044	biological_process	negative regulation of vascular wound healing
A	0070062	cellular_component	extracellular exosome
A	0070634	biological_process	transepithelial ammonium transport
A	0071944	cellular_component	cell periphery
A	0072488	biological_process	ammonium transmembrane transport
A	0098658	biological_process	inorganic anion import across plasma membrane
A	0098659	biological_process	inorganic cation import across plasma membrane
A	0098719	biological_process	sodium ion import across plasma membrane
A	0150003	biological_process	regulation of spontaneous synaptic transmission
A	0150104	biological_process	transport across blood-brain barrier
A	1902476	biological_process	chloride transmembrane transport
A	1903561	cellular_component	extracellular vesicle
A	1904450	biological_process	positive regulation of aspartate secretion
A	1904464	biological_process	regulation of matrix metallopeptidase secretion
A	1990573	biological_process	potassium ion import across plasma membrane
A	1990869	biological_process	cellular response to chemokine
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0006814	biological_process	sodium ion transport
B	0006821	biological_process	chloride transport
B	0006883	biological_process	intracellular sodium ion homeostasis
B	0006884	biological_process	cell volume homeostasis
B	0006972	biological_process	hyperosmotic response
B	0007214	biological_process	gamma-aminobutyric acid signaling pathway
B	0008511	molecular_function	sodium:potassium:chloride symporter activity
B	0008519	molecular_function	ammonium channel activity
B	0009925	cellular_component	basal plasma membrane
B	0010818	biological_process	T cell chemotaxis
B	0015079	molecular_function	potassium ion transmembrane transporter activity
B	0015293	molecular_function	symporter activity
B	0015377	molecular_function	chloride:monoatomic cation symporter activity
B	0016020	cellular_component	membrane
B	0016323	cellular_component	basolateral plasma membrane
B	0016324	cellular_component	apical plasma membrane
B	0016328	cellular_component	lateral plasma membrane
B	0019901	molecular_function	protein kinase binding
B	0022857	molecular_function	transmembrane transporter activity
B	0030007	biological_process	intracellular potassium ion homeostasis
B	0030321	biological_process	transepithelial chloride transport
B	0030644	biological_process	intracellular chloride ion homeostasis
B	0030659	cellular_component	cytoplasmic vesicle membrane
B	0031253	cellular_component	cell projection membrane
B	0035633	biological_process	maintenance of blood-brain barrier
B	0035725	biological_process	sodium ion transmembrane transport
B	0035865	biological_process	cellular response to potassium ion
B	0042995	cellular_component	cell projection
B	0043005	cellular_component	neuron projection
B	0043025	cellular_component	neuronal cell body
B	0044297	cellular_component	cell body
B	0044298	cellular_component	cell body membrane
B	0045795	biological_process	positive regulation of cell volume
B	0046873	molecular_function	metal ion transmembrane transporter activity
B	0051087	molecular_function	protein-folding chaperone binding
B	0051879	molecular_function	Hsp90 protein binding
B	0055064	biological_process	chloride ion homeostasis
B	0055075	biological_process	potassium ion homeostasis
B	0055078	biological_process	sodium ion homeostasis
B	0055085	biological_process	transmembrane transport
B	0061044	biological_process	negative regulation of vascular wound healing
B	0070062	cellular_component	extracellular exosome
B	0070634	biological_process	transepithelial ammonium transport
B	0071944	cellular_component	cell periphery
B	0072488	biological_process	ammonium transmembrane transport
B	0098658	biological_process	inorganic anion import across plasma membrane
B	0098659	biological_process	inorganic cation import across plasma membrane
B	0098719	biological_process	sodium ion import across plasma membrane
B	0150003	biological_process	regulation of spontaneous synaptic transmission
B	0150104	biological_process	transport across blood-brain barrier
B	1902476	biological_process	chloride transmembrane transport
B	1903561	cellular_component	extracellular vesicle
B	1904450	biological_process	positive regulation of aspartate secretion
B	1904464	biological_process	regulation of matrix metallopeptidase secretion
B	1990573	biological_process	potassium ion import across plasma membrane
B	1990869	biological_process	cellular response to chemokine

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue PLM A 1301

Chain	Residue
A	TYR751
B	HIS695
B	TYR746
B	PLM1301

---

site_id	AC2
Number of Residues	2
Details	binding site for residue PLM B 1301

Chain	Residue
A	PLM1301
B	TYR751

---

site_id	AC3
Number of Residues	2
Details	binding site for residue PLM B 1302

Chain	Residue
A	LEU743
B	LEU698

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	58
Details	Transmembrane: {"description":"Discontinuously helical; Name=1","evidences":[{"source":"PubMed","id":"32081947","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33597714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36306358","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D10","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SFL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8STE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	38
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"32081947","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33597714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36306358","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D10","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SFL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8STE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	92
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"32081947","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33597714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36306358","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D10","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SFL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8STE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"32081947","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33597714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36306358","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D10","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SFL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8STE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	80
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"32081947","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33597714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36306358","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D10","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SFL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8STE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	46
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"32081947","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33597714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36306358","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D10","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SFL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8STE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"32081947","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33597714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36306358","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D10","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SFL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8STE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	34
Details	Transmembrane: {"description":"Discontinuously helical; Name=6","evidences":[{"source":"PubMed","id":"32081947","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33597714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36306358","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D10","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SFL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8STE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"32081947","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33597714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36306358","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D10","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SFL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8STE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"32081947","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33597714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36306358","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D10","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SFL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8STE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"32081947","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33597714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36306358","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D10","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SFL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8STE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	36
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"32081947","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33597714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36306358","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D10","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SFL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8STE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	34
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"32081947","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33597714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36306358","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D10","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SFL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8STE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"32081947","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33597714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36306358","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D10","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SFL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8STE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36306358","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S1X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36306358","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"36306358","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MXO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36306358","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S1Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36306358","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36306358","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36306358","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36306358","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SMP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S1X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35585053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36239040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S1X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---