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7D0S

Crystal structure of human HBO1-BRPF2 in complex with succinyl-coenzyme A

Functional Information from GO Data
ChainGOidnamespacecontents
A0004402molecular_functionhistone acetyltransferase activity
A0006355biological_processregulation of DNA-templated transcription
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues25
DetailsZN_FING: C2HC MYST-type => ECO:0000255|PROSITE-ProRule:PRU01063
ChainResidueDetails
ALEU365-TRP390

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:31827282
ChainResidueDetails
AGLU508

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:28334966, ECO:0000269|PubMed:31827282, ECO:0007744|PDB:5GK9, ECO:0007744|PDB:6MAJ, ECO:0007744|PDB:6MAK
ChainResidueDetails
ACYS368
ACYS371
AHIS384
ACYS388

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:28334966, ECO:0000269|PubMed:31827282, ECO:0007744|PDB:5GK9, ECO:0007744|PDB:6MAK
ChainResidueDetails
AILE475
AARG483
ASER512
ASER521

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000250|UniProtKB:Q9H7Z6
ChainResidueDetails
AALY432

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER506

site_idSWS_FT_FI7
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23319590
ChainResidueDetails
ALYS338

226707

PDB entries from 2024-10-30

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