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7CYN

Cryo-EM structure of human TLR7 in complex with UNC93B1

Functional Information from GO Data
ChainGOidnamespacecontents
A0007165biological_processsignal transduction
B0007165biological_processsignal transduction
C0000139cellular_componentGolgi membrane
C0000902biological_processcell morphogenesis
C0002224biological_processtoll-like receptor signaling pathway
C0002250biological_processadaptive immune response
C0002457biological_processT cell antigen processing and presentation
C0005515molecular_functionprotein binding
C0005764cellular_componentlysosome
C0005768cellular_componentendosome
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0006886biological_processintracellular protein transport
C0016020cellular_componentmembrane
C0019882biological_processantigen processing and presentation
C0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
C0032009cellular_componentearly phagosome
C0032735biological_processpositive regulation of interleukin-12 production
C0032755biological_processpositive regulation of interleukin-6 production
C0034138biological_processtoll-like receptor 3 signaling pathway
C0034154biological_processtoll-like receptor 7 signaling pathway
C0034162biological_processtoll-like receptor 9 signaling pathway
C0035325molecular_functionToll-like receptor binding
C0045087biological_processinnate immune response
C0045335cellular_componentphagocytic vesicle
C0051607biological_processdefense response to virus
D0000139cellular_componentGolgi membrane
D0000902biological_processcell morphogenesis
D0002224biological_processtoll-like receptor signaling pathway
D0002250biological_processadaptive immune response
D0002457biological_processT cell antigen processing and presentation
D0005515molecular_functionprotein binding
D0005764cellular_componentlysosome
D0005768cellular_componentendosome
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0006886biological_processintracellular protein transport
D0016020cellular_componentmembrane
D0019882biological_processantigen processing and presentation
D0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
D0032009cellular_componentearly phagosome
D0032735biological_processpositive regulation of interleukin-12 production
D0032755biological_processpositive regulation of interleukin-6 production
D0034138biological_processtoll-like receptor 3 signaling pathway
D0034154biological_processtoll-like receptor 7 signaling pathway
D0034162biological_processtoll-like receptor 9 signaling pathway
D0035325molecular_functionToll-like receptor binding
D0045087biological_processinnate immune response
D0045335cellular_componentphagocytic vesicle
D0051607biological_processdefense response to virus
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues480
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
CVAL64-MET84
CVAL428-LEU448
CPHE469-SER489
CLEU491-TYR511
DVAL64-MET84
DLYS110-ILE130
DPHE132-THR152
DTHR160-GLY180
DILE223-LEU243
DLEU285-GLY305
DLEU343-LEU363
CLYS110-ILE130
DLEU378-TRP398
DVAL403-ALA423
DVAL428-LEU448
DPHE469-SER489
DLEU491-TYR511
CPHE132-THR152
CTHR160-GLY180
CILE223-LEU243
CLEU285-GLY305
CLEU343-LEU363
CLEU378-TRP398
CVAL403-ALA423

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER547
DSER547

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER550
DSER550

site_idSWS_FT_FI4
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
CASN251
AASN534
AASN590
AASN679
AASN720
AASN799
BASN66
BASN69
BASN167
BASN202
BASN215
CASN272
BASN361
BASN413
BASN488
BASN523
BASN534
BASN590
BASN679
BASN720
BASN799
CASN449
DASN251
DASN272
DASN449
AASN413
AASN488
AASN523

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PDB entries from 2024-10-30

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