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7CXW

Structural insights into novel mechanisms of inhibition of the major b-carbonic anhydrase CafB from the pathogenic fungus Aspergillus fumigatus (C116 flipped form)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004089molecular_functioncarbonate dehydratase activity
A0005737cellular_componentcytoplasm
A0008270molecular_functionzinc ion binding
A0015976biological_processcarbon utilization
A0016829molecular_functionlyase activity
A0034599biological_processcellular response to oxidative stress
A0046872molecular_functionmetal ion binding
A0071244biological_processcellular response to carbon dioxide
B0004089molecular_functioncarbonate dehydratase activity
B0005737cellular_componentcytoplasm
B0008270molecular_functionzinc ion binding
B0015976biological_processcarbon utilization
B0016829molecular_functionlyase activity
B0034599biological_processcellular response to oxidative stress
B0046872molecular_functionmetal ion binding
B0071244biological_processcellular response to carbon dioxide
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue ACT A 301
ChainResidue
ATYR54
ASER60
AARG61
AVAL62
AILE67
AARG79
APHE197
AHOH411

site_idAC2
Number of Residues8
Detailsbinding site for residue ACT B 301
ChainResidue
BSER60
BARG61
BVAL62
BILE67
BARG79
BPHE197
BHOH423
BTYR54

Functional Information from PROSITE/UniProt
site_idPS00704
Number of Residues8
DetailsPROK_CO2_ANHYDRASE_1 Prokaryotic-type carbonic anhydrases signature 1. CSDSRVpA
ChainResidueDetails
ACYS57-ALA64

221051

PDB entries from 2024-06-12

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