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7CWE

Human Fructose-1,6-bisphosphatase 1 in APO R-state

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005975biological_processcarbohydrate metabolic process
A0005986biological_processsucrose biosynthetic process
A0006000biological_processfructose metabolic process
A0006002biological_processfructose 6-phosphate metabolic process
A0006094biological_processgluconeogenesis
A0006111biological_processregulation of gluconeogenesis
A0016208molecular_functionAMP binding
A0016311biological_processdephosphorylation
A0016787molecular_functionhydrolase activity
A0016791molecular_functionphosphatase activity
A0030308biological_processnegative regulation of cell growth
A0030388biological_processfructose 1,6-bisphosphate metabolic process
A0031667biological_processresponse to nutrient levels
A0032869biological_processcellular response to insulin stimulus
A0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
A0042578molecular_functionphosphoric ester hydrolase activity
A0042802molecular_functionidentical protein binding
A0045820biological_processnegative regulation of glycolytic process
A0046580biological_processnegative regulation of Ras protein signal transduction
A0046872molecular_functionmetal ion binding
A0048029molecular_functionmonosaccharide binding
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0070062cellular_componentextracellular exosome
A0071286biological_processcellular response to magnesium ion
A0071320biological_processcellular response to cAMP
A0071466biological_processcellular response to xenobiotic stimulus
A0071475biological_processcellular hyperosmotic salinity response
A0071477biological_processcellular hypotonic salinity response
A0097403biological_processcellular response to raffinose
A1904628biological_processcellular response to phorbol 13-acetate 12-myristate
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005975biological_processcarbohydrate metabolic process
B0005986biological_processsucrose biosynthetic process
B0006000biological_processfructose metabolic process
B0006002biological_processfructose 6-phosphate metabolic process
B0006094biological_processgluconeogenesis
B0006111biological_processregulation of gluconeogenesis
B0016208molecular_functionAMP binding
B0016311biological_processdephosphorylation
B0016787molecular_functionhydrolase activity
B0016791molecular_functionphosphatase activity
B0030308biological_processnegative regulation of cell growth
B0030388biological_processfructose 1,6-bisphosphate metabolic process
B0031667biological_processresponse to nutrient levels
B0032869biological_processcellular response to insulin stimulus
B0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
B0042578molecular_functionphosphoric ester hydrolase activity
B0042802molecular_functionidentical protein binding
B0045820biological_processnegative regulation of glycolytic process
B0046580biological_processnegative regulation of Ras protein signal transduction
B0046872molecular_functionmetal ion binding
B0048029molecular_functionmonosaccharide binding
B0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
B0070062cellular_componentextracellular exosome
B0071286biological_processcellular response to magnesium ion
B0071320biological_processcellular response to cAMP
B0071466biological_processcellular response to xenobiotic stimulus
B0071475biological_processcellular hyperosmotic salinity response
B0071477biological_processcellular hypotonic salinity response
B0097403biological_processcellular response to raffinose
B1904628biological_processcellular response to phorbol 13-acetate 12-myristate
Functional Information from PROSITE/UniProt
site_idPS00124
Number of Residues13
DetailsFBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPMA
ChainResidueDetails
AGLY274-ALA286

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:7809062, ECO:0007744|PDB:1FTA
ChainResidueDetails
AVAL18
ATHR28
ALYS113
AARG141
BVAL18
BTHR28
BLYS113
BARG141

site_idSWS_FT_FI2
Number of Residues14
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P00636
ChainResidueDetails
AASP69
BLEU121
BASN213
BARG244
BTYR265
BLYS275
AGLU98
ALEU121
AASN213
AARG244
ATYR265
ALYS275
BASP69
BGLU98

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0007744|PDB:2FHY
ChainResidueDetails
AASP119
AASP122
AGLU281
BASP119
BASP122
BGLU281

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P00637
ChainResidueDetails
AALA2
BALA2

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9QXD6
ChainResidueDetails
ALYS151
BLYS151

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9QXD6
ChainResidueDetails
ATYR216
ATYR245
BTYR216
BTYR245

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ATYR265
BTYR265

223532

PDB entries from 2024-08-07

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