7CW3

Cryo-EM structure of Chikungunya virus in complex with mAb CHK-263 IgG (subregion around icosahedral 2-fold vertex)

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0004252	molecular_function	serine-type endopeptidase activity
a	0019028	cellular_component	viral capsid
a	0055036	cellular_component	virion membrane
A	0004252	molecular_function	serine-type endopeptidase activity
A	0019028	cellular_component	viral capsid
A	0055036	cellular_component	virion membrane
b	0005198	molecular_function	structural molecule activity
b	0019028	cellular_component	viral capsid
B	0005198	molecular_function	structural molecule activity
B	0019028	cellular_component	viral capsid
c	0004252	molecular_function	serine-type endopeptidase activity
c	0019028	cellular_component	viral capsid
c	0055036	cellular_component	virion membrane
C	0004252	molecular_function	serine-type endopeptidase activity
C	0019028	cellular_component	viral capsid
C	0055036	cellular_component	virion membrane
d	0005198	molecular_function	structural molecule activity
d	0019028	cellular_component	viral capsid
D	0005198	molecular_function	structural molecule activity
D	0019028	cellular_component	viral capsid
e	0004252	molecular_function	serine-type endopeptidase activity
e	0019028	cellular_component	viral capsid
e	0055036	cellular_component	virion membrane
E	0004252	molecular_function	serine-type endopeptidase activity
E	0019028	cellular_component	viral capsid
E	0055036	cellular_component	virion membrane
f	0005198	molecular_function	structural molecule activity
f	0019028	cellular_component	viral capsid
F	0005198	molecular_function	structural molecule activity
F	0019028	cellular_component	viral capsid
g	0004252	molecular_function	serine-type endopeptidase activity
g	0019028	cellular_component	viral capsid
g	0055036	cellular_component	virion membrane
G	0004252	molecular_function	serine-type endopeptidase activity
G	0019028	cellular_component	viral capsid
G	0055036	cellular_component	virion membrane
h	0005198	molecular_function	structural molecule activity
h	0019028	cellular_component	viral capsid
H	0005198	molecular_function	structural molecule activity
H	0019028	cellular_component	viral capsid
i	0004252	molecular_function	serine-type endopeptidase activity
i	0019028	cellular_component	viral capsid
i	0055036	cellular_component	virion membrane
I	0004252	molecular_function	serine-type endopeptidase activity
I	0019028	cellular_component	viral capsid
I	0055036	cellular_component	virion membrane
j	0005198	molecular_function	structural molecule activity
j	0019028	cellular_component	viral capsid
J	0005198	molecular_function	structural molecule activity
J	0019028	cellular_component	viral capsid
K	0004252	molecular_function	serine-type endopeptidase activity
K	0019028	cellular_component	viral capsid
K	0055036	cellular_component	virion membrane
L	0005198	molecular_function	structural molecule activity
L	0019028	cellular_component	viral capsid
M	0004252	molecular_function	serine-type endopeptidase activity
M	0019028	cellular_component	viral capsid
M	0055036	cellular_component	virion membrane
N	0005198	molecular_function	structural molecule activity
N	0019028	cellular_component	viral capsid
O	0004252	molecular_function	serine-type endopeptidase activity
O	0019028	cellular_component	viral capsid
O	0055036	cellular_component	virion membrane
P	0005198	molecular_function	structural molecule activity
P	0019028	cellular_component	viral capsid
Q	0004252	molecular_function	serine-type endopeptidase activity
Q	0019028	cellular_component	viral capsid
Q	0055036	cellular_component	virion membrane
R	0005198	molecular_function	structural molecule activity
R	0019028	cellular_component	viral capsid
s	0004252	molecular_function	serine-type endopeptidase activity
s	0006508	biological_process	proteolysis
S	0004252	molecular_function	serine-type endopeptidase activity
S	0019028	cellular_component	viral capsid
S	0055036	cellular_component	virion membrane
t	0004252	molecular_function	serine-type endopeptidase activity
t	0006508	biological_process	proteolysis
T	0005198	molecular_function	structural molecule activity
T	0019028	cellular_component	viral capsid
U	0004252	molecular_function	serine-type endopeptidase activity
U	0019028	cellular_component	viral capsid
U	0055036	cellular_component	virion membrane
V	0005198	molecular_function	structural molecule activity
V	0019028	cellular_component	viral capsid
W	0004252	molecular_function	serine-type endopeptidase activity
W	0019028	cellular_component	viral capsid
W	0055036	cellular_component	virion membrane
X	0005198	molecular_function	structural molecule activity
X	0019028	cellular_component	viral capsid
Y	0004252	molecular_function	serine-type endopeptidase activity
Y	0019028	cellular_component	viral capsid
Y	0055036	cellular_component	virion membrane
Z	0005198	molecular_function	structural molecule activity
Z	0019028	cellular_component	viral capsid

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
n	TYR192-HIS198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01027

Chain	Residue	Details
s	HIS29
X	VAL364-MET384
V	VAL364-MET384
Z	VAL364-MET384
T	VAL364-MET384
d	VAL364-MET384
b	VAL364-MET384
R	VAL364-MET384
P	VAL364-MET384
N	VAL364-MET384
s	ASP51
s	SER103
t	HIS29
t	ASP51
t	SER103
j	VAL364-MET384
h	VAL364-MET384
f	VAL364-MET384

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Involved in dimerization of the capsid protein => ECO:0000250|UniProtKB:Q86925

Chain	Residue	Details
s	TYR77
X	CYS385-ALA419
V	CYS385-ALA419
Z	CYS385-ALA419
T	CYS385-ALA419
d	CYS385-ALA419
b	CYS385-ALA419
R	CYS385-ALA419
P	CYS385-ALA419
N	CYS385-ALA419
s	ASN110
t	TYR77
t	ASN110
L	CYS385-ALA419
J	CYS385-ALA419
j	CYS385-ALA419
h	CYS385-ALA419
f	CYS385-ALA419

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:P03315

Chain	Residue	Details
s	TRP151
X	ALA419
V	ALA419
Z	ALA419
T	ALA419
d	ALA419
b	ALA419
R	ALA419
P	ALA419
N	ALA419
t	TRP151
H	ALA419
F	ALA419
L	ALA419
J	ALA419
j	ALA419
h	ALA419
f	ALA419

---

site_id	SWS_FT_FI4
Number of Residues	54
Details	LIPID: S-palmitoyl cysteine; by host => ECO:0000250

Chain	Residue	Details
B	CYS392
F	CYS392
F	CYS412
F	CYS413
L	CYS392
L	CYS412
L	CYS413
J	CYS392
J	CYS412
J	CYS413
j	CYS392
B	CYS412
j	CYS412
j	CYS413
h	CYS392
h	CYS412
h	CYS413
f	CYS392
f	CYS412
f	CYS413
X	CYS392
X	CYS412
B	CYS413
X	CYS413
V	CYS392
V	CYS412
V	CYS413
Z	CYS392
Z	CYS412
Z	CYS413
T	CYS392
T	CYS412
T	CYS413
D	CYS392
d	CYS392
d	CYS412
d	CYS413
b	CYS392
b	CYS412
b	CYS413
R	CYS392
R	CYS412
R	CYS413
P	CYS392
D	CYS412
P	CYS412
P	CYS413
N	CYS392
N	CYS412
N	CYS413
D	CYS413
H	CYS392
H	CYS412
H	CYS413

---

site_id	SWS_FT_FI5
Number of Residues	36
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255

Chain	Residue	Details
B	ASN259
L	ASN341
J	ASN259
J	ASN341
j	ASN259
j	ASN341
h	ASN259
h	ASN341
f	ASN259
f	ASN341
X	ASN259
B	ASN341
X	ASN341
V	ASN259
V	ASN341
Z	ASN259
Z	ASN341
T	ASN259
T	ASN341
d	ASN259
d	ASN341
b	ASN259
D	ASN259
b	ASN341
R	ASN259
R	ASN341
P	ASN259
P	ASN341
N	ASN259
N	ASN341
D	ASN341
H	ASN259
H	ASN341
F	ASN259
F	ASN341
L	ASN259

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