7CW2

Cryo-EM structure of Chikungunya virus in complex with Fab fragments of mAb CHK-263 (subregion around icosahedral 5-fold vertex)

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0004252	molecular_function	serine-type endopeptidase activity
a	0019028	cellular_component	viral capsid
a	0055036	cellular_component	virion membrane
A	0004252	molecular_function	serine-type endopeptidase activity
A	0019028	cellular_component	viral capsid
A	0055036	cellular_component	virion membrane
b	0005198	molecular_function	structural molecule activity
b	0019028	cellular_component	viral capsid
B	0005198	molecular_function	structural molecule activity
B	0019028	cellular_component	viral capsid
c	0004252	molecular_function	serine-type endopeptidase activity
c	0006508	biological_process	proteolysis
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis
d	0004252	molecular_function	serine-type endopeptidase activity
d	0019028	cellular_component	viral capsid
d	0055036	cellular_component	virion membrane
D	0004252	molecular_function	serine-type endopeptidase activity
D	0019028	cellular_component	viral capsid
D	0055036	cellular_component	virion membrane
e	0005198	molecular_function	structural molecule activity
e	0019028	cellular_component	viral capsid
E	0005198	molecular_function	structural molecule activity
E	0019028	cellular_component	viral capsid
f	0004252	molecular_function	serine-type endopeptidase activity
f	0006508	biological_process	proteolysis
F	0004252	molecular_function	serine-type endopeptidase activity
F	0006508	biological_process	proteolysis
g	0004252	molecular_function	serine-type endopeptidase activity
g	0019028	cellular_component	viral capsid
g	0055036	cellular_component	virion membrane
G	0004252	molecular_function	serine-type endopeptidase activity
G	0019028	cellular_component	viral capsid
G	0055036	cellular_component	virion membrane
h	0005198	molecular_function	structural molecule activity
h	0019028	cellular_component	viral capsid
H	0005198	molecular_function	structural molecule activity
H	0019028	cellular_component	viral capsid
i	0004252	molecular_function	serine-type endopeptidase activity
i	0006508	biological_process	proteolysis
I	0004252	molecular_function	serine-type endopeptidase activity
I	0006508	biological_process	proteolysis
j	0004252	molecular_function	serine-type endopeptidase activity
j	0019028	cellular_component	viral capsid
j	0055036	cellular_component	virion membrane
J	0004252	molecular_function	serine-type endopeptidase activity
J	0019028	cellular_component	viral capsid
J	0055036	cellular_component	virion membrane
k	0005198	molecular_function	structural molecule activity
k	0019028	cellular_component	viral capsid
K	0005198	molecular_function	structural molecule activity
K	0019028	cellular_component	viral capsid
l	0004252	molecular_function	serine-type endopeptidase activity
l	0006508	biological_process	proteolysis
L	0004252	molecular_function	serine-type endopeptidase activity
L	0006508	biological_process	proteolysis
m	0004252	molecular_function	serine-type endopeptidase activity
m	0019028	cellular_component	viral capsid
m	0055036	cellular_component	virion membrane
M	0004252	molecular_function	serine-type endopeptidase activity
M	0019028	cellular_component	viral capsid
M	0055036	cellular_component	virion membrane
n	0005198	molecular_function	structural molecule activity
n	0019028	cellular_component	viral capsid
N	0005198	molecular_function	structural molecule activity
N	0019028	cellular_component	viral capsid
o	0004252	molecular_function	serine-type endopeptidase activity
o	0006508	biological_process	proteolysis
O	0004252	molecular_function	serine-type endopeptidase activity
O	0006508	biological_process	proteolysis
p	0004252	molecular_function	serine-type endopeptidase activity
p	0019028	cellular_component	viral capsid
p	0055036	cellular_component	virion membrane
P	0004252	molecular_function	serine-type endopeptidase activity
P	0019028	cellular_component	viral capsid
P	0055036	cellular_component	virion membrane
q	0005198	molecular_function	structural molecule activity
q	0019028	cellular_component	viral capsid
Q	0005198	molecular_function	structural molecule activity
Q	0019028	cellular_component	viral capsid
r	0004252	molecular_function	serine-type endopeptidase activity
r	0006508	biological_process	proteolysis
R	0004252	molecular_function	serine-type endopeptidase activity
R	0006508	biological_process	proteolysis
s	0004252	molecular_function	serine-type endopeptidase activity
s	0019028	cellular_component	viral capsid
s	0055036	cellular_component	virion membrane
S	0004252	molecular_function	serine-type endopeptidase activity
S	0006508	biological_process	proteolysis
t	0005198	molecular_function	structural molecule activity
t	0019028	cellular_component	viral capsid
u	0004252	molecular_function	serine-type endopeptidase activity
u	0006508	biological_process	proteolysis
v	0004252	molecular_function	serine-type endopeptidase activity
v	0019028	cellular_component	viral capsid
v	0055036	cellular_component	virion membrane
w	0005198	molecular_function	structural molecule activity
w	0019028	cellular_component	viral capsid
x	0004252	molecular_function	serine-type endopeptidase activity
x	0006508	biological_process	proteolysis
y	0004252	molecular_function	serine-type endopeptidase activity
y	0019028	cellular_component	viral capsid
y	0055036	cellular_component	virion membrane
z	0005198	molecular_function	structural molecule activity
z	0019028	cellular_component	viral capsid

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
T	TYR192-HIS198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	45
Details	ACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01027

Chain	Residue	Details
I	HIS139
i	HIS139
i	ASP161
i	SER213
c	HIS139
c	ASP161
c	SER213
f	HIS139
f	ASP161
f	SER213
L	HIS139
I	ASP161
L	ASP161
L	SER213
O	HIS139
O	ASP161
O	SER213
R	HIS139
R	ASP161
R	SER213
l	HIS139
l	ASP161
I	SER213
l	SER213
o	HIS139
o	ASP161
o	SER213
r	HIS139
r	ASP161
r	SER213
u	HIS139
u	ASP161
u	SER213
C	HIS139
x	HIS139
x	ASP161
x	SER213
S	HIS139
S	ASP161
S	SER213
C	ASP161
C	SER213
F	HIS139
F	ASP161
F	SER213

---

site_id	SWS_FT_FI2
Number of Residues	30
Details	SITE: Involved in dimerization of the capsid protein => ECO:0000250|UniProtKB:Q86925

Chain	Residue	Details
I	TYR187
c	ASN220
f	TYR187
f	ASN220
L	TYR187
L	ASN220
O	TYR187
O	ASN220
R	TYR187
R	ASN220
l	TYR187
I	ASN220
l	ASN220
o	TYR187
o	ASN220
r	TYR187
r	ASN220
u	TYR187
u	ASN220
x	TYR187
x	ASN220
S	TYR187
C	TYR187
S	ASN220
C	ASN220
F	TYR187
F	ASN220
i	TYR187
i	ASN220
c	TYR187

---

site_id	SWS_FT_FI3
Number of Residues	15
Details	SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:P03315

Chain	Residue	Details
I	TRP261
l	TRP261
o	TRP261
r	TRP261
u	TRP261
x	TRP261
S	TRP261
C	TRP261
F	TRP261
i	TRP261
c	TRP261
f	TRP261
L	TRP261
O	TRP261
R	TRP261

---

site_id	SWS_FT_FI4
Number of Residues	45
Details	LIPID: S-palmitoyl cysteine; by host => ECO:0000250

Chain	Residue	Details
H	CYS396
h	CYS396
h	CYS416
h	CYS417
b	CYS396
b	CYS416
b	CYS417
e	CYS396
e	CYS416
e	CYS417
K	CYS396
H	CYS416
K	CYS416
K	CYS417
N	CYS396
N	CYS416
N	CYS417
Q	CYS396
Q	CYS416
Q	CYS417
k	CYS396
k	CYS416
H	CYS417
k	CYS417
n	CYS396
n	CYS416
n	CYS417
q	CYS396
q	CYS416
q	CYS417
t	CYS396
t	CYS416
t	CYS417
B	CYS396
w	CYS396
w	CYS416
w	CYS417
z	CYS396
z	CYS416
z	CYS417
B	CYS416
B	CYS417
E	CYS396
E	CYS416
E	CYS417

---

site_id	SWS_FT_FI5
Number of Residues	30
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255

Chain	Residue	Details
H	ASN263
b	ASN345
e	ASN263
e	ASN345
K	ASN263
K	ASN345
N	ASN263
N	ASN345
Q	ASN263
Q	ASN345
k	ASN263
H	ASN345
k	ASN345
n	ASN263
n	ASN345
q	ASN263
q	ASN345
t	ASN263
t	ASN345
w	ASN263
w	ASN345
z	ASN263
B	ASN263
z	ASN345
B	ASN345
E	ASN263
E	ASN345
h	ASN263
h	ASN345
b	ASN263

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