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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7CUN

The structure of human Integrator-PP2A complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0016020cellular_componentmembrane
A0016180biological_processsnRNA processing
A0031965cellular_componentnuclear membrane
A0032039cellular_componentintegrator complex
A0034243biological_processregulation of transcription elongation by RNA polymerase II
A0034474biological_processU2 snRNA 3'-end processing
A0160232cellular_componentINTAC complex
A0160240biological_processRNA polymerase II transcription initiation surveillance
B0016180biological_processsnRNA processing
B0032039cellular_componentintegrator complex
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0016180biological_processsnRNA processing
D0030674molecular_functionprotein-macromolecule adaptor activity
D0032039cellular_componentintegrator complex
D0034243biological_processregulation of transcription elongation by RNA polymerase II
D0160232cellular_componentINTAC complex
D0160240biological_processRNA polymerase II transcription initiation surveillance
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0016020cellular_componentmembrane
E0016180biological_processsnRNA processing
E0031965cellular_componentnuclear membrane
E0032039cellular_componentintegrator complex
E0034243biological_processregulation of transcription elongation by RNA polymerase II
E0034472biological_processsnRNA 3'-end processing
E0160232cellular_componentINTAC complex
E0160240biological_processRNA polymerase II transcription initiation surveillance
F0000785cellular_componentchromatin
F0004888molecular_functiontransmembrane signaling receptor activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005694cellular_componentchromosome
F0016180biological_processsnRNA processing
F0030674molecular_functionprotein-macromolecule adaptor activity
F0032039cellular_componentintegrator complex
F0034243biological_processregulation of transcription elongation by RNA polymerase II
F0034472biological_processsnRNA 3'-end processing
F0071168biological_processprotein localization to chromatin
F0160232cellular_componentINTAC complex
F0160240biological_processRNA polymerase II transcription initiation surveillance
G0000077biological_processDNA damage checkpoint signaling
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005694cellular_componentchromosome
G0005737cellular_componentcytoplasm
G0006974biological_processDNA damage response
G0016180biological_processsnRNA processing
G0016604cellular_componentnuclear body
G0032039cellular_componentintegrator complex
G0034243biological_processregulation of transcription elongation by RNA polymerase II
G0034472biological_processsnRNA 3'-end processing
G0071479biological_processcellular response to ionizing radiation
G0160232cellular_componentINTAC complex
G0160240biological_processRNA polymerase II transcription initiation surveillance
H0000785cellular_componentchromatin
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005694cellular_componentchromosome
H0016180biological_processsnRNA processing
H0032039cellular_componentintegrator complex
H0034243biological_processregulation of transcription elongation by RNA polymerase II
H0034472biological_processsnRNA 3'-end processing
H0071168biological_processprotein localization to chromatin
H0160232cellular_componentINTAC complex
H0160240biological_processRNA polymerase II transcription initiation surveillance
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0016180biological_processsnRNA processing
I0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
I0032039cellular_componentintegrator complex
I0034243biological_processregulation of transcription elongation by RNA polymerase II
I0034472biological_processsnRNA 3'-end processing
I0090101biological_processnegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
I0090287biological_processregulation of cellular response to growth factor stimulus
I0160232cellular_componentINTAC complex
I0160240biological_processRNA polymerase II transcription initiation surveillance
K0004521molecular_functionRNA endonuclease activity
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005737cellular_componentcytoplasm
K0005829cellular_componentcytosol
K0016180biological_processsnRNA processing
K0016787molecular_functionhydrolase activity
K0032039cellular_componentintegrator complex
K0034243biological_processregulation of transcription elongation by RNA polymerase II
K0034472biological_processsnRNA 3'-end processing
K0046872molecular_functionmetal ion binding
K0072562cellular_componentblood microparticle
K0160232cellular_componentINTAC complex
K0160240biological_processRNA polymerase II transcription initiation surveillance
P0000159cellular_componentprotein phosphatase type 2A complex
P0000775cellular_componentchromosome, centromeric region
P0000785cellular_componentchromatin
P0004722molecular_functionprotein serine/threonine phosphatase activity
P0005515molecular_functionprotein binding
P0005634cellular_componentnucleus
P0005694cellular_componentchromosome
P0005737cellular_componentcytoplasm
P0005739cellular_componentmitochondrion
P0005829cellular_componentcytosol
P0007059biological_processchromosome segregation
P0015630cellular_componentmicrotubule cytoskeleton
P0016020cellular_componentmembrane
P0016180biological_processsnRNA processing
P0016328cellular_componentlateral plasma membrane
P0019888molecular_functionprotein phosphatase regulator activity
P0030425cellular_componentdendrite
P0034243biological_processregulation of transcription elongation by RNA polymerase II
P0035330biological_processregulation of hippo signaling
P0035331biological_processnegative regulation of hippo signaling
P0035556biological_processintracellular signal transduction
P0040008biological_processregulation of growth
P0043005cellular_componentneuron projection
P0043025cellular_componentneuronal cell body
P0043029biological_processT cell homeostasis
P0045202cellular_componentsynapse
P0045595biological_processregulation of cell differentiation
P0046982molecular_functionprotein heterodimerization activity
P0051225biological_processspindle assembly
P0051754biological_processmeiotic sister chromatid cohesion, centromeric
P0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
P0065003biological_processprotein-containing complex assembly
P0070062cellular_componentextracellular exosome
P0090443cellular_componentFAR/SIN/STRIPAK complex
P0098978cellular_componentglutamatergic synapse
P0160232cellular_componentINTAC complex
P0160240biological_processRNA polymerase II transcription initiation surveillance
P1990405molecular_functionprotein antigen binding
Q0000159cellular_componentprotein phosphatase type 2A complex
Q0000278biological_processmitotic cell cycle
Q0000775cellular_componentchromosome, centromeric region
Q0000785cellular_componentchromatin
Q0000922cellular_componentspindle pole
Q0004721molecular_functionphosphoprotein phosphatase activity
Q0004722molecular_functionprotein serine/threonine phosphatase activity
Q0004725molecular_functionprotein tyrosine phosphatase activity
Q0005515molecular_functionprotein binding
Q0005634cellular_componentnucleus
Q0005694cellular_componentchromosome
Q0005737cellular_componentcytoplasm
Q0005739cellular_componentmitochondrion
Q0005829cellular_componentcytosol
Q0005886cellular_componentplasma membrane
Q0006357biological_processregulation of transcription by RNA polymerase II
Q0006470biological_processprotein dephosphorylation
Q0010288biological_processresponse to lead ion
Q0010719biological_processnegative regulation of epithelial to mesenchymal transition
Q0015630cellular_componentmicrotubule cytoskeleton
Q0016020cellular_componentmembrane
Q0016180biological_processsnRNA processing
Q0016787molecular_functionhydrolase activity
Q0031113biological_processregulation of microtubule polymerization
Q0034243biological_processregulation of transcription elongation by RNA polymerase II
Q0035330biological_processregulation of hippo signaling
Q0035331biological_processnegative regulation of hippo signaling
Q0035556biological_processintracellular signal transduction
Q0040008biological_processregulation of growth
Q0043029biological_processT cell homeostasis
Q0045121cellular_componentmembrane raft
Q0045202cellular_componentsynapse
Q0045595biological_processregulation of cell differentiation
Q0046872molecular_functionmetal ion binding
Q0046982molecular_functionprotein heterodimerization activity
Q0048156molecular_functiontau protein binding
Q0050811molecular_functionGABA receptor binding
Q0051321biological_processmeiotic cell cycle
Q0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Q0070062cellular_componentextracellular exosome
Q0090090biological_processnegative regulation of canonical Wnt signaling pathway
Q0090443cellular_componentFAR/SIN/STRIPAK complex
Q0097706biological_processvascular endothelial cell response to oscillatory fluid shear stress
Q0160232cellular_componentINTAC complex
Q0160240biological_processRNA polymerase II transcription initiation surveillance
Q0180006molecular_functionRNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
Q0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
Q0180008molecular_functionRNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
Q1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
Q1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
Q2000045biological_processregulation of G1/S transition of mitotic cell cycle
Functional Information from PROSITE/UniProt
site_idPS00125
Number of Residues6
DetailsSER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE
ChainResidueDetails
QLEU114-GLU119
site_idPS00039
Number of Residues9
DetailsDEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. MIDEADEfV
ChainResidueDetails
FMET627-VAL635
site_idPS00019
Number of Residues10
DetailsACTININ_1 Actinin-type actin-binding domain signature 1. QPeTYYKWDN
ChainResidueDetails
AGLN620-ASN629
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues76
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues39
DetailsRepeat: {"description":"HEAT 1"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues34
DetailsRepeat: {"description":"HEAT 4"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues38
DetailsRepeat: {"description":"HEAT 7"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues38
DetailsRepeat: {"description":"HEAT 8"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues22
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues224
DetailsDomain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues33
DetailsRepeat: {"description":"TPR 3"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues33
DetailsRepeat: {"description":"TPR 4"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q95TS5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues5
DetailsMotif: {"description":"HXHXDH motif"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues10
DetailsMotif: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"39032489","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsActive site: {"evidences":[{"source":"PubMed","id":"28396433","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32697989","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33548203","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33243860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38570683","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38570683","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33243860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38570683","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33243860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38570683","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q9VAH9","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"36454007","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues38
DetailsRepeat: {"description":"HEAT 1","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues37
DetailsRepeat: {"description":"HEAT 2","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues38
DetailsRepeat: {"description":"HEAT 3","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues37
DetailsRepeat: {"description":"HEAT 4","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues38
DetailsRepeat: {"description":"HEAT 10","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues1
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P36873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI33
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17055435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33243860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33633399","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246905

PDB entries from 2025-12-31

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