7CU1

CRYSTAL STRUCTURE OF STREPTOMYCES ALBOGRISEOLUS FLAVIN-DEPENDENT TRYPTOPHAN 6-HALOGENASE (THAL) IN COMPLEX WITH FAD and AMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004497	molecular_function	monooxygenase activity
A	0016491	molecular_function	oxidoreductase activity
B	0000166	molecular_function	nucleotide binding
B	0004497	molecular_function	monooxygenase activity
B	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	42
Details	binding site for residue FAD A 601

Chain	Residue
A	LEU11
A	ARG44
A	ILE45
A	VAL47
A	GLY48
A	GLU49
A	ALA50
A	ASP196
A	GLU197
A	MET198
A	CYS228
A	GLY12
A	SER229
A	GLY230
A	LEU234
A	ALA256
A	GLY348
A	LEU349
A	PHE353
A	PRO356
A	SER359
A	GLY361
A	GLY13
A	ILE362
A	ILE365
A	HOH732
A	HOH737
A	HOH757
A	HOH769
A	HOH771
A	HOH772
A	HOH774
A	HOH776
A	GLY14
A	HOH812
A	HOH878
A	HOH951
A	THR15
A	ALA16
A	GLU38
A	ALA39
A	ILE42

---

site_id	AC2
Number of Residues	15
Details	binding site for residue AMP B 601

Chain	Residue
A	ASN323
B	LEU11
B	GLY12
B	GLY13
B	GLU38
B	ALA39
B	THR41
B	MET198
B	CYS228
B	SER229
B	GLY230
B	ARG232
B	LEU234
B	HOH714
B	HOH846

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"30559288","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33465708","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31589794","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33465708","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SLS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CU1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33465708","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CU1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31589794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SLS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31589794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SLS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SLT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30559288","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31589794","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33465708","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6H44","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CU0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"E9P162","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Site: {"description":"Important for activity","evidences":[{"source":"UniProtKB","id":"P95480","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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